AutismKB 2.0

Annotation Detail for DENR


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Basic Information Top
Gene Symbol:DENR ( DRP,DRP1,SMAP-3 )
Gene Full Name: density-regulated protein
Band: 12q24.31
Quick LinksEntrez ID:8562; OMIM: 604550; Uniprot ID:DENR_HUMAN; ENSEMBL ID: ENSG00000139726; HGNC ID: 2769
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DENR mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DENR mRNAaffects expression 17562736
C051890 irinotecan irinotecan analog results in decreased expression of DENR mRNAdecreases expression 18927307
D011794 Quercetin Quercetin results in increased expression of DENR mRNAincreases expression 19729006
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DENR mRNAdecreases expression 17101203
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of DENR mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.8219761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Quercetin 2.1018628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1020435547
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.807296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.803084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.8012508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D006332 Cardiomegaly Quercetin 7.3219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3216120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3819486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 8697196 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms irinotecan 4.1917725105 17287894
MESH:D003110 Colonic Neoplasms Quercetin 4.1911134977 17148506 15741050 19440933 19056647 16640504 17191121
MESH:D015179 Colorectal Neoplasms irinotecan 2.8617454858 18259882 18509181 16391804 15273666 17159606 16303861
MESH:D015179 Colorectal Neoplasms Quercetin 2.8618095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.218156756 18759878 11906362 14531868 12868966 11298694 8970840 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 9.6919496084
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 9.6916684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.567440962 6679447 8291058 9328219 11289319 18289764 1440618 18692083 9653073 18648102 16192314 6482804 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5610774834 16485898 15619225 12705907 19923254 12392966 10663392 11834606 12153990 19370779 2444490 19085960 18713872 14986274 19420014 16227642 12594235 12958197 19164858 16393943 11529661 10915739 17906064 18071297 12540782 17562736 11739529 11287661 14550746 16081117 11743745 19416960 19739265 15968718 16109766 17522070 11461765 16781746 16177239 14725611 11421492
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Quercetin 10.1919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.1920067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma Quercetin 3.5819804834
MESH:D005910 Glioma Quercetin 3.1517643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia Quercetin 4.3411834736 18262572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Quercetin 5.5618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5618850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007674 Kidney Diseases Acetaminophen 6.6212587719 15629191
MESH:D007674 Kidney Diseases Quercetin 6.6216962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.5212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5212878042
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 16611625 19014921 16610002 12969438 12587719 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Quercetin 4.8918980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.926587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.9219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.9212151625
MESH:D008175 Lung Neoplasms Quercetin 2.4916280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4919555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D052016 Mucositis irinotecan 5.4717159606
MESH:D009203 Myocardial Infarction Quercetin 3.1019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.0319207477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.273581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.2718259882
MESH:D009369 Neoplasms Quercetin 2.9215185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009447 Neuroblastoma irinotecan 3.628761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.198761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.7117929310
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8119005980
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9416965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Quercetin 4.2719056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Quercetin 3.5514715546 17292933
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126587162 6582329 1399818 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.548074119
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.5416720314
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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