AutismKB 2.0

Annotation Detail for MADD


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Basic Information Top
Gene Symbol:MADD ( DENN,FLJ35600,FLJ36300,IG20,KIAA0358,RAB3GEP )
Gene Full Name: MAP-kinase activating death domain
Band: 11p11.2
Quick LinksEntrez ID:8567; OMIM: 603584; Uniprot ID:MADD_HUMAN; ENSEMBL ID: ENSG00000110514; HGNC ID: 6766
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200148Caspase cascade in apoptosis
200100Ceramide signaling pathway
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HDL cholesterol
fasting glucose-related traits
METABOLIC
Desease Name
HDL cholesterol
Fasting glucose-related traits
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MADD mRNAaffects expression 21346803
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of MADD mRNAincreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MADD mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MADD mRNAdecreases expression 18247414
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of MADD mRNAdecreases expression 20360939
D004958 Estradiol Estradiol results in increased expression of MADD mRNAincreases expression 16705744
D019833 Genistein Genistein results in decreased expression of MADD mRNAdecreases expression 16705744
D009538 Nicotine Nicotine results in decreased expression of MADD mRNAdecreases expression 18247414
C059514 resveratrol resveratrol results in decreased expression of MADD mRNAdecreases expression 12002526
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MADD mRNAdecreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D058186 Acute Kidney Injury resveratrol 4.0216538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3220464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.3211473722
MESH:D000230 Adenocarcinoma Genistein 7.3211473722
MESH:D000236 Adenoma Benzo(a)pyrene 11.756695378
MESH:D000236 Adenoma Diethylnitrosamine 11.756695378 10737359
MESH:D000236 Adenoma resveratrol 11.7515688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.8616434500 19052882 18056438 17620307 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8616835633
MESH:D000544 Alzheimer Disease Nicotine 4.8116627626
MESH:D000544 Alzheimer Disease resveratrol 4.8116162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001169 Arthritis, Experimental resveratrol 3.6017115116
MESH:D050197 Atherosclerosis resveratrol 3.3716873680 17967414
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D002545 Brain Ischemia resveratrol 4.5217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0317474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.0317474063
MESH:D001943 Breast Neoplasms Estradiol 3.0319861407 17261762 17289903 12948864 18497071 17018787 14630087 16675129
MESH:D001943 Breast Neoplasms Genistein 3.0316541309 17200150 16873071
MESH:D001943 Breast Neoplasms resveratrol 3.0317534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1416705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1419539802 16807293 16935385 21159647 20432363 20007298 19171122 17428255 18691550 19383236 3084413 19107877 16502159 17173139 18506893 16830150 17978847 20935162 18056438 20512989 19208518 11831363 18393292 19822196 19919837 20524982 20214788 17162532 20727157 16698587 17055752 18978308 16878318 20101231 19052882 16779866 16328049 19519916 16681979 3581430 20514400 19394651 16569478 19335982 18788625 20084675 10672840 18785209 18210153 16540662 17761372 16288022 18971187 18494052 19701751 18665156 17138121 10737359 19418558
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.1416924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 9.1416227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8316675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8720419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.8716227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 7.9016332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.9015458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.876135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.872727394 17174075 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.8718566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.8416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 15668235 12621046 15340226 8697196
MESH:D003092 Colitis resveratrol 4.3416474422
MESH:D003110 Colonic Neoplasms Genistein 4.0217182828
MESH:D003110 Colonic Neoplasms resveratrol 4.0216338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9116873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.3316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3317107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.5319279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.5316286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D020821 Dystonic Disorders Nicotine 6.1617881519
MESH:D004487 Edema resveratrol 7.448985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2217872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.8711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.8711473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0617923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3521071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005909 Glioblastoma Genistein 3.3616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D006561 Herpes Simplex resveratrol 4.4216876885
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 16959395 8697196 18606429 15340226
MESH:D006937 Hypercholesterolemia resveratrol 4.1817188708
MESH:D006949 Hyperlipidemias resveratrol 4.2116873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4617488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8617600658
MESH:D007249 Inflammation Diethylnitrosamine 8.8218785209
MESH:D007249 Inflammation resveratrol 8.8216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8212878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.8116624496
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Estradiol 2.6715618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D007938 Leukemia Genistein 3.1017468513 18980019
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6816087638
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9118665156 18407596 18522880 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5717823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.877678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.8721137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.872422723 12771043 19254457 15885732 19426721 20434301 19294768 19255062 18644402 19833225 19690152 19850985 19090486 16942905 15175105 9163691 18978307 19256749 19499222 19996281 20101389 20583210 18754104 20137499 20501860 10737359 19638242 20492335 21278145 21167192 20452335 20405173 18648771 19073162 12112319 21047994 18977376 19427195 19812893 19551842 20118626 2862719 19642983 21071580
MESH:D008113 Liver Neoplasms resveratrol 14.8719812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.392876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.3918079962 19519916 16267830 18282651 19009564 18093689 18544905 21159647 19539802 18253720 17174075 16842330 18775883 18308698 19004024 19126423 9362446 17942915 2563599 18164116 3124819 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3912151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4420464547 6695378 18569708 20064080 17053015 18816296 20869020 18520028 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4420970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4419555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4815688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.6716891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.6712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 10.6711606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008659 Metabolic Diseases resveratrol 4.5517112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma resveratrol 3.5817164350 17049120 16490592 16267019 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1117962980
MESH:D009203 Myocardial Infarction Genistein 6.2117141266
MESH:D009203 Myocardial Infarction resveratrol 6.2116525036 17015251 17188708 16456233 16317513 17125593
MESH:D017202 Myocardial Ischemia resveratrol 9.4717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.9516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.9517141266
MESH:D009205 Myocarditis resveratrol 5.0017322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.629029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6711141357
MESH:D009369 Neoplasms Nicotine 5.6716365874
MESH:D009374 Neoplasms, Experimental resveratrol 4.218985016
MESH:D009389 Neovascularization, Pathologic Estradiol 11.1717289903
MESH:D009389 Neovascularization, Pathologic Nicotine 11.1716365874
MESH:D009421 Nervous System Malformations Estradiol 17.5711399458 16427766
MESH:D009421 Nervous System Malformations Genistein 17.5716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.5714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.0120387270
MESH:D019636 Neurodegenerative Diseases resveratrol 9.0117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.7816169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.7817513867
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms Genistein 5.0519005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.4016679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4011896295 11399792 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0616740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0615378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms resveratrol 2.0616731767 17804756 17718901 17675339 15767336 17636462
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8516325855
MESH:D015427 Reperfusion Injury resveratrol 3.3515827377 16314181 17520802 16317513 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7118551238
MESH:D012640 Seizures Nicotine 6.7117873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8710029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 9.878985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8716192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.372093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3718456281
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6416321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.8516720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.6617979512 18041664 18305452 15735609
MESH:D014062 Tongue Neoplasms resveratrol 4.3716227395
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8116049721
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 8.8111144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8117053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2617473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3317044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5217488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30523
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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