AutismKB 2.0

Annotation Detail for PRKRA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PRKRA ( DYT16,PACT,RAX )
Gene Full Name: protein kinase, interferon-inducible double stranded RNA dependent activator
Band: 2q31.2
Quick LinksEntrez ID:8575; OMIM: 603424; Uniprot ID:PRKRA_HUMAN; ENSEMBL ID: ENSG00000180228; HGNC ID: 9438
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200100Ceramide signaling pathway
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PRKRA mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PRKRA mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of PRKRA mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of PRKRA mRNAincreases expression 16202921
C041786 palm oil palm oil results in decreased expression of PRKRA mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of PRKRA mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1220435547
MESH:D001943 Breast Neoplasms Estradiol 2.1219861407 12948864 14630087 18497071 16675129 17261762 17289903 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.737296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7316924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.367505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3618566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.6219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.6219176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.212524372 8156756 8970840 18759878 11906362 11298694 12868966 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.966482804 9022650 18692083 9328219 11289319 8291058 18289764 7440962 6679447 9653073 1440618 16192314 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.962444490 16227642 16485898 11529661 19164858 11834606 16109766 19739265 12392966 19416960 12594235 11461765 19085960 18071297 19370779 11287661 16081117 14550746 16393943 10663392 17562736 14986274 12958197 10915739 11739529 12705907 16177239 12540782 19420014 15968718 11743745 11421492 19923254 16781746 10774834 17522070 15619225 14725611 18713872 12153990 17906064
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004421 Dystonia marker/mechanism
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.1718566989 11473722 19148513
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Dietary Fats 8.8018296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 8.8019236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4119772884 18467677 19176532 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 13.4318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 13.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.4316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 6.4315629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.4315618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.266582329
MESH:D007680 Kidney Neoplasms Estradiol 8.2615610895
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008107 Liver Diseases Acetaminophen 1.6912587719 19784758 16611625 12969438 16610002 19014921 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9115890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.711399818 6587162 598648 3712494
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7416891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.0616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations Estradiol 4.0311399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 4.6411836018 17217161 16723640 21332399 18457598 18674790 20518802 20132043 19632207
MESH:D009765 Obesity pirinixic acid 4.6420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.121399818 7505956 6587162 6582329 3712494
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33780
    • No data
    No data
    Releated drug ID Related drug Name
    PA449780glutathione
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved