AutismKB 2.0

Annotation Detail for TNFSF11


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Basic Information Top
Gene Symbol:TNFSF11 ( CD254,ODF,OPGL,OPTB2,RANKL,TRANCE,hRANKL2,sOdf )
Gene Full Name: tumor necrosis factor (ligand) superfamily, member 11
Band: 13q14
Quick LinksEntrez ID:8600; OMIM: 602642; Uniprot ID:TNF11_HUMAN; ENSEMBL ID: ENSG00000120659; HGNC ID: 11926
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200124IL6-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
Desease Name
Bone mineral density (hip)
Bone mineral density (spine)
Desease Name
Osteopetrosis, autosomal recessive 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of TNFSF11 mRNAaffects expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TNFSF11 mRNAaffects expression 16483693
D000677 Amsacrine Amsacrine results in decreased expression of TNFSF11 mRNAdecreases expression 11459812
D001151 Arsenic [Arsenic co-treated with Fluorides] results in decreased expression of TNFSF11 mRNAaffects cotreatment|decreases expression 19962721
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TNFSF11 mRNAdecreases expression 17530438
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 17306214
D003345 Corticosterone [Corticosterone co-treated with PTH protein] results in decreased expression of TNFSF11 mRNAaffects cotreatment|decreases expression 17476578
D003345 Corticosterone Corticosterone results in increased expression of TNFSF11 mRNAincreases expression 17476578
D003474 Curcumin Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]decreases reaction|increases activity 15129424
D003474 Curcumin Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]decreases reaction|increases expression 15129424
D003474 Curcumin Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]decreases reaction|increases expression 18719352
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TNFSF11 mRNA]decreases expression|decreases reaction 11007951
C014347 decitabine decitabine promotes the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]increases expression|increases reaction 17008384
C014347 decitabine decitabine results in increased expression of TNFSF11 mRNAincreases expression 17008384
D003907 Dexamethasone [Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 proteinaffects cotreatment|decreases expression 16079895
D002117 Calcitriol Calcitriol results in increased expression of TNFSF11 mRNAincreases expression 17293108
D002117 Calcitriol Calcitriol results in increased expression of TNFSF11 mRNAincreases expression 16813520
11113387
D002117 Calcitriol menatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 11113387
D002117 Calcitriol Calcitriol results in increased expression of TNFSF11 mRNAincreases expression 17352647
D002117 Calcitriol Calcitriol results in increased expression of TNFSF11 proteinincreases expression 17352647
D004144 Diosgenin Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]decreases reaction|increases expression 16331273
D004144 Diosgenin Diosgenin results in decreased activity of TNFSF11 proteindecreases activity 16331273
D004958 Estradiol Estradiol results in increased expression of TNFSF11 mRNAincreases expression 19401787
D004967 Estrogens Estrogens results in decreased expression of TNFSF11 mRNAdecreases expression 16005483
D005047 Etoposide Etoposide results in decreased expression of TNFSF11 mRNAdecreases expression 11459812
C074031 exenatide exenatide results in decreased expression of TNFSF11 mRNAdecreases expression 19586609
D005459 Fluorides [Arsenic co-treated with Fluorides] results in decreased expression of TNFSF11 mRNAaffects cotreatment|decreases expression 19962721
D005665 Furosemide Furosemide affects the expression of TNFSF11 mRNAaffects expression 17497460
D019833 Genistein Genistein results in decreased expression of TNFSF11 mRNAdecreases expression 11459812
D019833 Genistein Genistein results in increased expression of TNFSF11 mRNAincreases expression 19401787
D019812 Heparan Sulfate Proteoglycans [Heparan Sulfate Proteoglycans binds to and results in increased activity of FGF2 protein] which results in increased expression of TNFSF11 proteinaffects binding|increases activity|increases expression 15334457
C056599 icariin icariin results in decreased expression of TNFSF11 mRNAdecreases expression 19747809
C056599 icariin NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]decreases expression|decreases reaction 19747809
C513449 icarisid II icarisid II results in decreased expression of TNFSF11 mRNAdecreases expression 17764702
C499403 icaritin icaritin results in decreased expression of TNFSF11 mRNAdecreases expression 17764702
C006552 kaempferol kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]decreases reaction|increases expression 16434028
C006552 kaempferol kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]decreases reaction|increases expression 16434028
C006552 kaempferol kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]decreases reaction|increases expression 16434028
C030814 menatetrenone menatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 11113387
D016912 Levonorgestrel Levonorgestrel results in decreased expression of TNFSF11 mRNAdecreases expression 16114553
C010722 nylestriol nylestriol results in decreased expression of TNFSF11 mRNAdecreases expression 16114553
C034364 ozagrel ozagrel results in decreased expression of TNFSF11 mRNAdecreases expression 18264100
C084656 paricalcitol paricalcitol results in increased expression of TNFSF11 mRNAincreases expression 17352647
C084656 paricalcitol paricalcitol results in increased expression of TNFSF11 proteinincreases expression 17352647
C093973 PD 98059 PD 98059 inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 17306214
D010424 Pentobarbital Pentobarbital results in decreased expression of TNFSF11 mRNAdecreases expression 16978161
D010656 Phenylephrine bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 17306214
D010656 Phenylephrine PD 98059 inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 17306214
D010656 Phenylephrine Phenylephrine results in increased expression of TNFSF11 mRNAincreases expression 17306214
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 17306214
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TNFSF11 mRNAaffects binding|decreases expression|increases activity 19710929
C025299 polyphenols polyphenols results in decreased expression of TNFSF11 mRNAdecreases expression 16293270
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]decreases reaction|increases expression 17306214
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]decreases reaction|increases expression 16434028
19495926
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]decreases reaction|increases expression 19495926
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]decreases reaction|increases expression 16434028
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]decreases reaction|increases expression 19495926
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 19495926
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]decreases reaction|increases expression 16434028
D011794 Quercetin Quercetin results in decreased activity of TNFSF11 proteindecreases activity 19495926
C443401 quercetin 3-O-glucuronide quercetin 3-O-glucuronide results in decreased activity of TNFSF11 proteindecreases activity 19495926
D020849 Raloxifene Raloxifene results in decreased expression of TNFSF11 mRNAdecreases expression 16005483
C059514 resveratrol [resveratrol co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CD14 mRNAaffects cotreatment|increases expression 16267019
C059514 resveratrol [resveratrol co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CSF1R mRNAaffects cotreatment|increases expression 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of ITGAL mRNA]affects cotreatment|decreases expression|decreases reaction 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased activity of ACP5 protein]affects cotreatment|decreases reaction|increases activity 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]affects cotreatment|decreases reaction|increases expression 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]affects cotreatment|decreases reaction|increases expression 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A mRNA]affects cotreatment|decreases reaction|increases expression 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A protein]affects cotreatment|decreases reaction|increases expression 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased localization of RELA protein]affects cotreatment|decreases reaction|increases localization 16267019
C059514 resveratrol resveratrol results in increased expression of TNFSF11 mRNAincreases expression 16813520
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
C084904 Ro 41-5253 Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
C017947 sodium arsenite sodium arsenite results in decreased expression of TNFSF11 mRNAdecreases expression 16014739
C099410 TAPI-2 TAPI-2 inhibits the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]decreases expression|decreases reaction 14753746
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TNFSF11 mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TNFSF11 mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNFSF11 mRNAincreases expression 15972635
15310856
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of TNFSF11 mRNAincreases expression 17306214
D013792 Thalidomide [Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 proteinaffects cotreatment|decreases expression 16079895
C024587 thromboxane A2, carbocyclic thromboxane A2, carbocyclic results in increased expression of TNFSF11 mRNAincreases expression 18264100
D014212 Tretinoin Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
D014212 Tretinoin Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 17291456
C011559 tributyltin Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]decreases reaction|increases expression 17291456
C011559 tributyltin tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 17291456
C030665 triphenyltin triphenyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]decreases reaction|increases expression 17291456
C057693 troglitazone troglitazone results in decreased expression of TNFSF11 mRNAdecreases expression 16813520
D009536 Niacinamide Niacinamide results in decreased expression of TNFSF11 mRNAdecreases expression 16813520
D002762 Cholecalciferol Cholecalciferol promotes the reaction [[RXRB protein binds to VDR protein] which binds to TNFSF11 promoter]affects binding|increases reaction 17008384
D002762 Cholecalciferol Cholecalciferol results in increased expression of TNFSF11 mRNAincreases expression 17008384
D002762 Cholecalciferol decitabine promotes the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]increases expression|increases reaction 17008384
D024482 Vitamin K 2 Vitamin K 2 results in decreased expression of TNFSF11 mRNAdecreases expression 19675304
D024483 Vitamin K 3 Vitamin K 3 results in decreased expression of TNFSF11 mRNAdecreases expression 19675304
C088658 zoledronic acid ADAM17 protein promotes the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]decreases expression|increases reaction 14753746
C088658 zoledronic acid TAPI-2 inhibits the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]decreases expression|decreases reaction 14753746
C088658 zoledronic acid zoledronic acid affects the expression of TNFSF11 proteinaffects expression 17041912
C088658 zoledronic acid zoledronic acid results in decreased expression of TNFSF11 proteindecreases expression 14753746
D015054 Zymosan NCF1 protein affects the reaction [Zymosan affects the expression of TNFSF11 mRNA]affects expression|affects reaction 14507659
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.7614514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 6.768333272
MESH:D000138 Acidosis Ammonium Chloride 2.9718287403
MESH:D058186 Acute Kidney Injury resveratrol 7.3116538975
MESH:D058186 Acute Kidney Injury zoledronic acid 7.3119715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.5818653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.8920200999
MESH:D000230 Adenocarcinoma arsenic trioxide 6.0119825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.0111473722
MESH:D000230 Adenocarcinoma Genistein 6.0111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.613712494
MESH:D000236 Adenoma resveratrol 5.6115688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 7.9416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.9416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1015276417
MESH:D018246 Adrenocortical Adenoma Arsenic 11.7817306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 11.7817306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.0317308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4817887948
MESH:D000505 Alopecia Tretinoin 3.1415955085
MESH:D000544 Alzheimer Disease Curcumin 8.0715590663
MESH:D000544 Alzheimer Disease icariin 8.0719782061 19858766
MESH:D000544 Alzheimer Disease Raloxifene 8.0715800139
MESH:D000544 Alzheimer Disease resveratrol 8.0716183991 16162502
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 3.9616510725
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D000740 Anemia Zymosan 7.2818664788
MESH:D000743 Anemia, Hemolytic Quercetin 3.7117084956
MESH:D001008 Anxiety Disorders Pentobarbital 4.2518313124 11141031
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6017460149
MESH:D020261 Arsenic Poisoning Arsenic 2.6718414634 16251483 12569548 16835338
MESH:D001169 Arthritis, Experimental Dexamethasone 18.9417659584
MESH:D001169 Arthritis, Experimental resveratrol 18.9417115116
MESH:D001169 Arthritis, Experimental Thalidomide 18.949598899
MESH:D001169 Arthritis, Experimental Tretinoin 18.9416412693
MESH:D001169 Arthritis, Experimental Zymosan 18.9415944321 15142272 15188379 16872482 17659584
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1316807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1316292516
MESH:D001249 Asthma Tretinoin 2.1416456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.3815336622
MESH:D050197 Atherosclerosis Arsenic 12.6919371607 12928151
MESH:D050197 Atherosclerosis Curcumin 12.6918704882
MESH:D050197 Atherosclerosis quercetin 3-O-glucuronide 12.6918199750
MESH:D050197 Atherosclerosis resveratrol 12.6916873680 17967414
MESH:D001327 Autoimmune Diseases Cholecalciferol 14.8416142846
MESH:D001327 Autoimmune Diseases Curcumin 14.8419761891
MESH:D001327 Autoimmune Diseases Quercetin 14.8419761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.4111289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 17.5916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.5912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.5916197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1915340226
MESH:D001847 Bone Diseases icariin 5.8118295595
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3615746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.5614601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.4116778634 19442620 11697798 16121404 15867366 17312309
MESH:D001862 Bone Resorption zoledronic acid 4.1718404659 15845617 16769263 8053405 11869084 18496637
MESH:D001919 Bradycardia Phenylephrine 3.9615306635
MESH:D001930 Brain Injuries Raloxifene 3.9016580743
MESH:D002545 Brain Ischemia Curcumin 13.8416770732
MESH:D002545 Brain Ischemia icariin 13.8419303870
MESH:D002545 Brain Ischemia resveratrol 13.8417600658
MESH:D001932 Brain Neoplasms Curcumin 3.4317596214
MESH:D001943 Breast Neoplasms Calcitriol 9.8611237771
MESH:D001943 Breast Neoplasms Curcumin 9.8618593918 16243823 18462866 19250217
MESH:D001943 Breast Neoplasms decitabine 9.8618320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 9.8618497071 14630087 17289903 12948864 17018787 19861407 16675129 17261762
MESH:D001943 Breast Neoplasms Etoposide 9.8616322251
MESH:D001943 Breast Neoplasms Genistein 9.8616541309 17200150 16873071
MESH:D001943 Breast Neoplasms kaempferol 9.8616756079
MESH:D001943 Breast Neoplasms Quercetin 9.8618628248
MESH:D001943 Breast Neoplasms Raloxifene 9.8617952589 15758505 17242785 17893378 16837676 15775269 17261762 15572757 16912660 17440819 17049068 17595753
MESH:D001943 Breast Neoplasms resveratrol 9.8616393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 9.8616166294 16443354 16873071
MESH:D001943 Breast Neoplasms zoledronic acid 9.8618695136 16096432
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7811589617
MESH:D002105 Cadmium Poisoning Quercetin 4.9416962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8716111702
MESH:D002277 Carcinoma Curcumin 6.7118593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.7116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.2315504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5516168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 25.933581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Arsenic 25.9316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 25.9316217749 15073043 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Estradiol 25.9316924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 25.9315341023
MESH:D006528 Carcinoma, Hepatocellular Genistein 25.9316924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 25.9312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 25.9319321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 25.9316507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 25.9316313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 25.931917145
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 2 25.9317270033
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0016675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.1518414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 5.1519233551
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.3817234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2719014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.767296757
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 5.7618507039
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6012490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 22.2615504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 22.2611237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 22.2618462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 22.2619215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 22.2616227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 22.2618572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 22.2618922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 22.2616051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 7.9518640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.9517572228
MESH:D006332 Cardiomegaly Phenylephrine 9.3917124262 11179087 11754973 17287366 15728586 16170337
MESH:D006332 Cardiomegaly Quercetin 9.3919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.3916120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 18.2415738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Genistein 18.2416332659
MESH:D002318 Cardiovascular Diseases kaempferol 18.2416756079
MESH:D002318 Cardiovascular Diseases Raloxifene 18.2415775269
MESH:D002318 Cardiovascular Diseases resveratrol 18.2415458977
MESH:D002340 Carotid Artery Diseases Arsenic 3.8016973168 18022660
MESH:D002386 Cataract Tretinoin 2.7217460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 8.757505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.7518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 8.7520056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.0916835633
MESH:D018281 Cholangiocarcinoma Thalidomide 8.0918291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 15.7319486331 9022650
MESH:D002779 Cholestasis Diosgenin 15.7316105132
MESH:D002779 Cholestasis Levonorgestrel 15.7315861022
MESH:D002779 Cholestasis pirinixic acid 15.7319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.818697196 15340226 16354765 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 4.819407595
MESH:D003072 Cognition Disorders Raloxifene 4.0415800139
MESH:D003092 Colitis Curcumin 18.1818200517 16804969 16782535
MESH:D003092 Colitis resveratrol 18.1816474422
MESH:D003092 Colitis Thalidomide 18.1816680017
MESH:D003092 Colitis Tretinoin 18.1817035595
MESH:D003103 Coloboma Curcumin 4.0218809619
MESH:D003110 Colonic Neoplasms Curcumin 14.9516340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 14.9517616700
MESH:D003110 Colonic Neoplasms Dexamethasone 14.9515824018
MESH:D003110 Colonic Neoplasms Genistein 14.9517182828
MESH:D003110 Colonic Neoplasms polyphenols 14.9516293270
MESH:D003110 Colonic Neoplasms Quercetin 14.9519440933 17191121 16640504 19056647 15741050 17148506 11134977
MESH:D003110 Colonic Neoplasms resveratrol 14.9516338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.1820501625
MESH:D015179 Colorectal Neoplasms decitabine 4.1818981723
MESH:D015179 Colorectal Neoplasms Quercetin 4.1818095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 4.1816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5614669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 10.6818497527
MESH:D016510 Corneal Neovascularization Thalidomide 10.689301478
MESH:D003327 Coronary Disease resveratrol 3.3516507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6212609071
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.709200351
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.3610525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.3617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.3620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Thalidomide 6.369200351
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.369224671 17551590 9211117 8800419 14991402 9125849 9664655 16925845 9142499 10589399
MESH:D016638 Critical Illness Estrogens 5.3516670151
MESH:D003424 Crohn Disease Thalidomide 3.8516078585
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5515213294
MESH:D003865 Depressive Disorder, Major Raloxifene 3.6617474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.1814531868 11298694 11906362 2524372 18759878 8970840 8156756 12868966
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 5.1812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.953621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental exenatide 11.4419586609
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 11.4419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 11.4416873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 14.7918403477
MESH:D003924 Diabetes Mellitus, Type 2 exenatide 14.7919586609
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 14.7916647724
MESH:D003924 Diabetes Mellitus, Type 2 Niacinamide 14.7919647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 14.7917107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 14.7916023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.0612601628
MESH:D003928 Diabetic Nephropathies Curcumin 17.3418204486
MESH:D003928 Diabetic Nephropathies Estradiol 17.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 17.3417308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies resveratrol 17.3416286809
MESH:D003967 Diarrhea Dexamethasone 3.157237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.747440962 1440618 6679447 16192314 18289764 18648102 9328219 6482804 9653073 9022650 11289319 8291058 18692083
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.7419370779
MESH:D056486 Drug-Induced Liver Injury Prazosin 9.7418071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.7420420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 9.7414986274
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.4917351913
MESH:D004417 Dyspnea Furosemide 4.3416935035
MESH:D004485 Eczema Dexamethasone 3.9012438553
MESH:D004487 Edema bisindolylmaleimide I 33.698273558
MESH:D004487 Edema Dexamethasone 33.6919703484
MESH:D004487 Edema Furosemide 33.6911834646
MESH:D004487 Edema pirinixic acid 33.6912083418
MESH:D004487 Edema Raloxifene 33.6915860553
MESH:D004487 Edema resveratrol 33.698985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 33.6911000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 33.6915177302 7812673 9599246 8113982 8273558 16716910 11698051
MESH:D004487 Edema Zymosan 33.697907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.9416714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.9418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 12.2815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 12.2815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 12.2817872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5119294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.0016402032
MESH:D016889 Endometrial Neoplasms Estradiol 10.1019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 10.1011473722
MESH:D016889 Endometrial Neoplasms Tretinoin 10.1016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5110568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.2717923197
MESH:D007172 Erectile Dysfunction icariin 4.8716281085 15329286
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 3.843581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 3.8412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.3311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.339664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 14.4915073043
MESH:D005234 Fatty Liver Curcumin 14.4919297423
MESH:D005234 Fatty Liver pirinixic acid 14.4920131406 19236843
MESH:D005234 Fatty Liver Raloxifene 14.4917473493
MESH:D005264 Femoral Fractures zoledronic acid 5.2316234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8811858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.416705139
MESH:D005355 Fibrosis Curcumin 16.4818705752
MESH:D005355 Fibrosis Quercetin 16.4819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.4820067830
MESH:D005355 Fibrosis Tretinoin 16.4817994277
MESH:D005534 Foot Diseases Arsenic 4.956392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7016904648
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1218462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.0916452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.7012701121
MESH:D005909 Glioblastoma Curcumin 13.6317596214
MESH:D005909 Glioblastoma Genistein 13.6316598420
MESH:D005909 Glioblastoma Quercetin 13.6319804834
MESH:D005909 Glioblastoma Tretinoin 13.6317312396
MESH:D005910 Glioma Quercetin 5.6217643826
MESH:D005910 Glioma Thalidomide 5.6216327979
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.497505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 10.5818829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 10.5819215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 10.5816096774
MESH:D034381 Hearing Loss Furosemide 4.3217868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.3910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.3914991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.1111110106
MESH:D006333 Heart Failure Furosemide 6.0216845234 12660669 16011733
MESH:D006333 Heart Failure pirinixic acid 6.0220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.776705139
MESH:D006505 Hepatitis Zymosan 7.7719110552
MESH:D006529 Hepatomegaly pirinixic acid 6.3619772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.3612621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.4617701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.837520565
MESH:D006558 Herpes Genitalis Estradiol 4.4315709030
MESH:D006561 Herpes Simplex Amsacrine 13.2910809021
MESH:D006561 Herpes Simplex Etoposide 13.2910809021
MESH:D006561 Herpes Simplex resveratrol 13.2916876885
MESH:D006689 Hodgkin Disease Etoposide 6.0015147373 17606976 18180244 16135485 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.0012676792
MESH:D019584 Hot Flashes Estradiol 3.1517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4415340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Prazosin 10.6912727271
MESH:D006930 Hyperalgesia Tretinoin 10.6916870215
MESH:D006930 Hyperalgesia zoledronic acid 10.6916769263
MESH:D006934 Hypercalcemia marker/mechanism 15845617
MESH:D006934 Hypercalcemia Furosemide 9.5317652376
MESH:D006934 Hypercalcemia zoledronic acid 9.5319622757 18089816
MESH:D053565 Hypercalciuria Furosemide 5.0617652376
MESH:D006937 Hypercholesterolemia Curcumin 7.6218704882
MESH:D006937 Hypercholesterolemia resveratrol 7.6217188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9916778211
MESH:D006943 Hyperglycemia kaempferol 18.2518262572
MESH:D006943 Hyperglycemia pirinixic acid 18.2520558911
MESH:D006943 Hyperglycemia Quercetin 18.2518262572 11834736
MESH:D006943 Hyperglycemia triphenyltin 18.2510522495
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.9417050553
MESH:D006949 Hyperlipidemias resveratrol 3.4916873680
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.2715086907
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.3615034207
MESH:D006973 Hypertension Arsenic 17.159931084 16076760 11953799
MESH:D006973 Hypertension Dexamethasone 17.1517042910
MESH:D006973 Hypertension Phenylephrine 17.1512717712 8949925
MESH:D006973 Hypertension Quercetin 17.1518356687
MESH:D006973 Hypertension Raloxifene 17.1517577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 17.1518850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.7116612254
MESH:D015228 Hypertriglyceridemia triphenyltin 5.4410522495
MESH:D006984 Hypertrophy Phenylephrine 4.0212791704 18502941
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7817488730
MESH:D006987 Hypesthesia Arsenic 4.9516093927
MESH:D006996 Hypocalcemia zoledronic acid 5.5912669777
MESH:C537153 Hypomagnesemia primary Furosemide 5.0611041285
MESH:D007019 Hypoproteinemia Furosemide 5.2716096441
MESH:D007022 Hypotension Furosemide 4.0811041285
MESH:D007024 Hypotension, Orthostatic Furosemide 4.8115811171
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.0717600658
MESH:D007246 Infertility triphenyltin 5.4615205045
MESH:D007248 Infertility, Male decitabine 5.5317581917
MESH:D007248 Infertility, Male sodium arsenite 5.5312646999 15346721
MESH:D007249 Inflammation bisindolylmaleimide I 26.428273558
MESH:D007249 Inflammation Curcumin 26.4216956363 18403477 17151092
MESH:D007249 Inflammation Dexamethasone 26.428960868 11099482
MESH:D007249 Inflammation polyphenols 26.4216366677
MESH:D007249 Inflammation resveratrol 26.4216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 26.4212878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 26.4215177302 7812673 8273558 7562506 11698051
MESH:D007249 Inflammation Thalidomide 26.4216134734
MESH:D007249 Inflammation Zymosan 26.428014878 11289658
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9418596194 18200517
MESH:D007251 Influenza, Human Quercetin 9.1916624496
MESH:D007251 Influenza, Human resveratrol 9.1916624496
MESH:D007333 Insulin Resistance Estradiol 10.2316627594 16393666
MESH:D007333 Insulin Resistance exenatide 10.2319586609
MESH:D007333 Insulin Resistance pirinixic acid 10.2316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1917994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.7010783313
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.2417553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.418074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.1616580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.1617551590 15992940
MESH:D007627 Keloid Quercetin 4.3817086741
MESH:D007642 Keratosis Arsenic 4.4016930632 12749816
MESH:D007674 Kidney Diseases Estradiol 11.4915618244
MESH:D007674 Kidney Diseases Furosemide 11.4911041285
MESH:D007674 Kidney Diseases Quercetin 11.4916962696
MESH:D007674 Kidney Diseases sodium arsenite 11.4920008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 5.756582329
MESH:D007680 Kidney Neoplasms Estradiol 5.7515610895
MESH:D007859 Learning Disorders icariin 4.7519782061
MESH:D007889 Leiomyoma Curcumin 9.3318555241
MESH:D007889 Leiomyoma Raloxifene 9.3316973256
MESH:D007898 Leishmaniasis, Visceral Thalidomide 3.8816514283
MESH:D007938 Leukemia arsenic trioxide 24.7115070760
MESH:D007938 Leukemia Curcumin 24.7118462866
MESH:D007938 Leukemia decitabine 24.7118980019 19235587
MESH:D007938 Leukemia Genistein 24.7117468513 18980019
MESH:D007938 Leukemia kaempferol 24.7117468513
MESH:D007938 Leukemia Quercetin 24.7117468513
MESH:D007938 Leukemia Tretinoin 24.7117143497
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.5416085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell marker/mechanism 16270354
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 13.3012560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 13.3016106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 13.3018089816
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 9.7616972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 9.7616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.9814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 12.9319077051
MESH:D007951 Leukemia, Myeloid decitabine 12.9319117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 12.9316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Amsacrine 10.1415148258 18043129
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 10.1420471514 16467208 17050201 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 10.1418206229 17679729 19387464 18460780 19010910 18704418
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 10.1418720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 10.1419850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 14.8417339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 14.8417869043 17712046 15622746 12018890 16891316 15336539 17217047 12712474 11161223 16823087 15213294 17107899 16966277 16330433 19225113 9834237 12679006 11468182 17649720 16112521 19075265 15748426 16331271 19035177 19642359
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 14.8416087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 14.849834237 19029980 17217047 17506722 17339181 16331271 17649720 16935935 17107899 12679006 17712046 17301526 16891316 19225113 15748426 17361223 16823087 19075265 17294898 16788101 19035177 16766008 19642359 17368321 16140955
MESH:D015458 Leukemia, T-Cell arsenic trioxide 9.8416882451
MESH:D015458 Leukemia, T-Cell Curcumin 9.8416106398
MESH:D017880 Limb Deformities, Congenital Thalidomide 7.0910473037
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.099224671
MESH:D008103 Liver Cirrhosis Thalidomide 3.6617174718 16943688
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.809327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 13.6117355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 13.6116718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 13.6114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 13.6117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 13.6115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 13.6112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.6112878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 13.6115465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 13.6118397230 16248980
MESH:D008107 Liver Diseases Arsenic 5.6211134558
MESH:D008107 Liver Diseases Curcumin 5.6216956363
MESH:D008107 Liver Diseases polyphenols 5.6216698588
MESH:D008113 Liver Neoplasms Arsenic 17.8116368122
MESH:D008113 Liver Neoplasms arsenic trioxide 17.8114682389
MESH:D008113 Liver Neoplasms pirinixic acid 17.8116377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 17.8118980244
MESH:D008113 Liver Neoplasms resveratrol 17.8119321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 17.8115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.8116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.903712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.9020377131
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.9019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.9012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.8915213294
MESH:D008171 Lung Diseases sodium arsenite 2.7619095001
MESH:D008175 Lung Neoplasms Arsenic 11.1717976673 17306315 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 11.1711798837 19825857
MESH:D008175 Lung Neoplasms Curcumin 11.1716243823 19359593 18462866
MESH:D008175 Lung Neoplasms Dexamethasone 11.1715824018 11195469
MESH:D008175 Lung Neoplasms Quercetin 11.1716280456
MESH:D008175 Lung Neoplasms sodium arsenite 11.1715276417 16712894 17077188 17306315 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.1711884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 11.1711807781
MESH:D008223 Lymphoma Curcumin 10.1818462866
MESH:D008223 Lymphoma decitabine 10.1819470736
MESH:D008223 Lymphoma Etoposide 10.1812556972 12854902
MESH:D016393 Lymphoma, B-Cell resveratrol 3.7517088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.3814749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1216173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.6615688416
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 18.3912807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 18.3911408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 18.3914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 18.3911606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 18.398985016
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 18.3917312309
MESH:D020149 Manganese Poisoning Estradiol 3.8819453300
MESH:D008527 Medulloblastoma Tretinoin 2.5217453147
MESH:D008545 Melanoma Curcumin 13.1917885582 18462866
MESH:D008545 Melanoma decitabine 13.1917785578 16505122
MESH:D008545 Melanoma resveratrol 13.1917992120
MESH:D008545 Melanoma sodium arsenite 13.1916487513 19082730
MESH:D008545 Melanoma Thalidomide 13.1912829675 16098027 17089043
MESH:D008545 Melanoma Tretinoin 13.1916752155
MESH:D008545 Melanoma Vitamin K 3 13.1919082730
MESH:D008569 Memory Disorders Curcumin 8.3017263510
MESH:D008569 Memory Disorders icariin 8.3019782061
MESH:D008591 Meningomyelocele Tretinoin 3.8516940565
MESH:D008654 Mesothelioma zoledronic acid 3.4816675582
MESH:D008659 Metabolic Diseases resveratrol 3.8417112576
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.9515863610
MESH:D009101 Multiple Myeloma arsenic trioxide 32.2914977855 19549372 15949261 11468182 19417148
MESH:D009101 Multiple Myeloma Curcumin 32.2919372569
MESH:D009101 Multiple Myeloma decitabine 32.2918172295
MESH:D009101 Multiple Myeloma Dexamethasone 32.2915867202 15744524 16118317
MESH:D009101 Multiple Myeloma Raloxifene 32.2916497877
MESH:D009101 Multiple Myeloma resveratrol 32.2917049120 16267019 16490592 17164350 14749477 17935668
MESH:D009101 Multiple Myeloma Thalidomide 32.2919372569 15939924 16445831 19112201 15741222 17168659 19112817 15867202 15920492 15744524
MESH:D009101 Multiple Myeloma zoledronic acid 32.2919621390 18089719 16996129
MESH:D009102 Multiple Organ Failure Zymosan 4.6615259001 12879239 15834315 15241586 17724436 18160304 12130978 15213630 10890648 10479408
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.4517962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.4517962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9316239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 19.2016882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 19.2019157545 19010910 18608210 16882708
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 19.209809623
MESH:D009190 Myelodysplastic Syndromes Thalidomide 19.2018720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 19.2017596541
MESH:D009203 Myocardial Infarction Genistein 11.2217141266
MESH:D009203 Myocardial Infarction pirinixic acid 11.2219151258
MESH:D009203 Myocardial Infarction Quercetin 11.2219595682
MESH:D009203 Myocardial Infarction resveratrol 11.2216317513 17188708 17015251 16456233 17125593 16525036
MESH:D017202 Myocardial Ischemia Arsenic 12.5415371236
MESH:D017202 Myocardial Ischemia resveratrol 12.5417125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 12.5412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.4916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.4917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 16.4916411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 16.4919207477
MESH:D009205 Myocarditis resveratrol 4.1717322642
MESH:D009232 Myxoma Raloxifene 4.9516343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.4616624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.4618495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.183581430
MESH:D009362 Neoplasm Metastasis zoledronic acid 5.1815867366 19139120 17312309
MESH:D009369 Neoplasms decitabine 12.2517925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 12.2517405874
MESH:D009369 Neoplasms Quercetin 12.2515185748
MESH:D009369 Neoplasms sodium arsenite 12.2511559025
MESH:D009369 Neoplasms Tretinoin 12.2516594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 7.328985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.3220056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 3.9312497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1417289903
MESH:D009397 Nephrocalcinosis Furosemide 5.2715086907
MESH:D009421 Nervous System Malformations Estradiol 24.8216427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.8216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.8214600291
MESH:D009421 Nervous System Malformations Thalidomide 24.8216859833
MESH:D009421 Nervous System Malformations Tretinoin 24.829125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0318462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 18.456679447
MESH:D009436 Neural Tube Defects Arsenic 18.4516620997
MESH:D009436 Neural Tube Defects arsenic trioxide 18.4510525206
MESH:D009436 Neural Tube Defects sodium arsenite 18.4512854658
MESH:D009436 Neural Tube Defects Tretinoin 18.459142499
MESH:D019636 Neurodegenerative Diseases resveratrol 3.3217652729
MESH:D020078 Neurogenic Inflammation Arsenic 14.6517056641
MESH:D020078 Neurogenic Inflammation Quercetin 14.6517929310
MESH:D020078 Neurogenic Inflammation resveratrol 14.6517929310
MESH:D053206 Nocturnal Enuresis Furosemide 5.2717945291
MESH:D009765 Obesity Curcumin 3.9819297423
MESH:D009765 Obesity pirinixic acid 3.9820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.914026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.413988306
MESH:D010014 Osteolysis zoledronic acid 4.7815867366
MESH:D010022 Osteopetrosis marker/mechanism 17632511
OMIM:259710 OSTEOPETROSIS, AUTOSOMAL RECESSIVE 2 marker/mechanism
MESH:D010024 Osteoporosis therapeutic 17882678
MESH:D010024 Osteoporosis Curcumin 37.4418719352
MESH:D010024 Osteoporosis exenatide 37.4419586609
MESH:D010024 Osteoporosis Genistein 37.4419401787
MESH:D010024 Osteoporosis icariin 37.4419747809 18236786
MESH:D010024 Osteoporosis kaempferol 37.4416756079
MESH:D010024 Osteoporosis Levonorgestrel 37.4412665316
MESH:D010024 Osteoporosis nylestriol 37.4412665316
MESH:D010024 Osteoporosis Raloxifene 37.4419059307 17882678 15775268
MESH:D010024 Osteoporosis zoledronic acid 37.4417882678
MESH:D015663 Osteoporosis, Postmenopausal Genistein 19.5516169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 19.5519495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 19.5515579764 17893378 17823083 15758505
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 19.5517513867
MESH:D010051 Ovarian Neoplasms Arsenic 30.9017306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 30.9016624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 30.9019020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 30.9019259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 30.9019401270
MESH:D010051 Ovarian Neoplasms Genistein 30.9019005980
MESH:D010051 Ovarian Neoplasms Quercetin 30.9019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 30.9015276417 17306315
MESH:D010051 Ovarian Neoplasms Thalidomide 30.9016288038
MESH:D010051 Ovarian Neoplasms Tretinoin 30.9016936753
MESH:D010146 Pain Tretinoin 5.5716870215
MESH:D010146 Pain zoledronic acid 5.5716475674
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 20.9715580305
MESH:D010190 Pancreatic Neoplasms Curcumin 20.9717440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 20.9719294695
MESH:D010190 Pancreatic Neoplasms Etoposide 20.9719003803
MESH:D010190 Pancreatic Neoplasms Quercetin 20.9716965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 20.9715976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 20.9715976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.487296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.4818922899 12065085 18404319 8330346
MESH:D010235 Paraganglioma arsenic trioxide 3.6119927285
MESH:D010291 Paresis Thalidomide 5.709200351
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6412520081
MESH:D010391 Pemphigoid, Bullous Niacinamide 5.8411026799
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.4015371236 6392382 16905509
MESH:D010538 Peritonitis Zymosan 4.3118977430 15259001 19641140 15979727 18557954 18760300 17826846 17371808 11985352 14761945 19088179
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.876228378
MESH:D011141 Polyuria Furosemide 5.0617945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0018163543
MESH:D011230 Precancerous Conditions Quercetin 3.4819056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.7721297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 6.7717031469
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 7.6316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.6311118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.1517616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.1915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3520887781
MESH:D011471 Prostatic Neoplasms Arsenic 6.1516140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 6.1519131511
MESH:D011471 Prostatic Neoplasms Calcitriol 6.1518247401 16644109 15754350 12479363 16289102
MESH:D011471 Prostatic Neoplasms Cholecalciferol 6.1517024972
MESH:D011471 Prostatic Neoplasms Curcumin 6.1512497104 10851300 15129424 18769126 18156803 11398177 18226269
MESH:D011471 Prostatic Neoplasms Estradiol 6.1516740699
MESH:D011471 Prostatic Neoplasms Etoposide 6.1517172428
MESH:D011471 Prostatic Neoplasms Genistein 6.1516925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Quercetin 6.1514715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 6.1516536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms resveratrol 6.1517675339 17718901 17804756 16731767 17636462 15767336
MESH:D011471 Prostatic Neoplasms sodium arsenite 6.1516039940
MESH:D011471 Prostatic Neoplasms Thalidomide 6.1516729912
MESH:D011471 Prostatic Neoplasms zoledronic acid 6.1519103299 12438248
MESH:D011507 Proteinuria Arsenic 7.4721343184
MESH:D011507 Proteinuria Tretinoin 7.4716636307
MESH:D011536 Prurigo Thalidomide 5.7012755975
MESH:D011537 Pruritus Levonorgestrel 4.8015861022
MESH:D011625 Pterygium Tretinoin 4.2016723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.0119168576
MESH:D011658 Pulmonary Fibrosis troglitazone 3.6418162602
MESH:D011693 Purpura Raloxifene 4.9515770314
MESH:D012021 Reflex, Abnormal Pentobarbital 5.4310930210
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9816325855
MESH:D015427 Reperfusion Injury Furosemide 9.1716526316
MESH:D015427 Reperfusion Injury pirinixic acid 9.1719058328
MESH:D015427 Reperfusion Injury resveratrol 9.1715827377 17520802 17058453 16314181 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 12.2018379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 12.2018379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 12.2015912074 12394941 16096441
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.923692021
MESH:D012208 Rhabdomyosarcoma decitabine 9.1319155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.1316116481 16283617
MESH:D012509 Sarcoma Curcumin 3.6018462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 14.1716646077
MESH:D012512 Sarcoma, Ewing's Etoposide 14.1714601052
MESH:D012512 Sarcoma, Ewing's zoledronic acid 14.1716121404
MESH:D012554 Schistosomiasis japonica Quercetin 4.9416862918
MESH:D019873 Schnitzler Syndrome Thalidomide 5.3516096327
MESH:D012640 Seizures Pentobarbital 3.5010087439 9754883
MESH:D018805 Sepsis Curcumin 8.0618389075
MESH:D018805 Sepsis Zymosan 8.0611441115
MESH:D012852 Sinusitis Phenylephrine 4.117327846
MESH:D012871 Skin Diseases Arsenic 2.5719834688 17548696 16702368 17453740 6392382 16353154 16759981 15952646 17050553 17938729 18709164
MESH:D012878 Skin Neoplasms Arsenic 18.4017029826 16251483 17050553 19538983 15504454 17976673
MESH:D012878 Skin Neoplasms resveratrol 18.408985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 18.4018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.4016192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 18.4012065085 11807781 8985016 18404319 8330346
MESH:D012878 Skin Neoplasms Tretinoin 18.4016467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3312854658
MESH:D013272 Stomach Diseases Dexamethasone 3.7315472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.5417007042
MESH:D013274 Stomach Neoplasms decitabine 5.5419037991
MESH:D013274 Stomach Neoplasms Furosemide 5.5417052386
MESH:D013274 Stomach Neoplasms Tretinoin 5.5417261132
MESH:D013274 Stomach Neoplasms troglitazone 5.5415930296
MESH:D013276 Stomach Ulcer Curcumin 9.2416631530 19188055
MESH:D013276 Stomach Ulcer Dexamethasone 9.2415138204
MESH:D013276 Stomach Ulcer Thalidomide 9.2415138204
MESH:D020521 Stroke Raloxifene 3.3516837676
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9616321402
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.469754883 11529278
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.6517997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 13.341399818 3712494 6587162 7505956 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 13.3419014326
MESH:D013964 Thyroid Neoplasms decitabine 13.3417967635
MESH:D013964 Thyroid Neoplasms Tretinoin 13.3417045167 16026305
MESH:D013978 Tibial Fractures Estradiol 11.7019048282
MESH:D013978 Tibial Fractures Raloxifene 11.7019048282
MESH:D014062 Tongue Neoplasms resveratrol 8.1916227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.1916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.3715213294
MESH:D014376 Tuberculosis Tretinoin 2.8416040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 23.738074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 23.7317976673 17306315 15987713 11144890 19429237 19322015 18640142
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 23.7312845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 23.7318593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 23.7319087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 23.7316720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 23.7317572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 23.7311723127 17306315 16712894 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 4.6718462866
MESH:D002583 Uterine Cervical Neoplasms resveratrol 12.9017473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 12.9011813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 12.9016129372
MESH:D014594 Uterine Neoplasms resveratrol 3.5817044934
MESH:D014604 Uveal Neoplasms decitabine 10.8217785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.8216752155
MESH:D014605 Uveitis Dexamethasone 10.281336536
MESH:D014605 Uveitis Zymosan 10.2811006244
MESH:D014652 Vascular Diseases Arsenic 16.8317056641
MESH:D014652 Vascular Diseases sodium arsenite 16.8317056641
MESH:D014652 Vascular Diseases Thalidomide 16.8315741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6016837676
MESH:D020246 Venous Thrombosis Levonorgestrel 5.0815869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7317488730
MESH:D014820 Vitiligo Tretinoin 3.4916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 4.9516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6415886252
MESH:D009396 Wilms Tumor Tretinoin 3.4616287080
MESH:D014947 Wounds and Injuries Estrogens 4.2511172683
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04380 Osteoclast differentiation
KEGG:05323 Rheumatoid arthritis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36619
    • No data
    Releated disease ID Related disease Name
    PA445190Osteoporosis
    PA445180Osteogenesis Imperfecta
    PA443536Bone Diseases, Metabolic
    PA445188Osteopetrosis
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00480 antagonist Lenalidomide Antineoplastic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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