AutismKB 2.0

Annotation Detail for RGS20


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Basic Information Top
Gene Symbol:RGS20 ( RGSZ1,ZGAP1 )
Gene Full Name: regulator of G-protein signaling 20
Band: 8q11.23
Quick LinksEntrez ID:8601; OMIM: 607193; Uniprot ID:RGS20_HUMAN; ENSEMBL ID: ENSG00000147509; HGNC ID: 14600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RGS20 proteinaffects expression 20106945
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of RGS20 mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RGS20 mRNAincreases expression 20106945
D002104 Cadmium Cadmium results in increased expression of RGS20 mRNAincreases expression 21172416
D004178 Diquat Diquat results in increased expression of RGS20 mRNAincreases expression 21172416
D018038 Sodium Selenite Sodium Selenite results in decreased expression of RGS20 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RGS20 mRNAincreases expression 20106945
D019772 Topotecan RGS20 protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.246695378
MESH:D000236 Adenoma beta-Naphthoflavone 7.2419389873
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D050197 Atherosclerosis Cadmium 3.7715687053
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8717474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9812907637 21507988 12619106
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Cadmium 3.8517332340
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Diquat 6.7718445702 18164269
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.7715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.7720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Diquat 5.9515046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8211294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007248 Infertility, Male Diquat 4.444850670
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Cadmium 3.6316226777 16962696 16322080
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.3718177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.3721137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.3719389873 21295105
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.718603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.7118164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4820135361 18520028 18569708 20064080 6695378 20869020 20464547 17053015 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009447 Neuroblastoma Topotecan 3.9615176712
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.7215687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6217292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.6217075824
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6218760546
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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