AutismKB 2.0

Annotation Detail for KLF7


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Basic Information Top
Gene Symbol:KLF7 ( UKLF )
Gene Full Name: Kruppel-like factor 7 (ubiquitous)
Band: 2q33.3
Quick LinksEntrez ID:8609; OMIM: 604865; Uniprot ID:KLF7_HUMAN; ENSEMBL ID: ENSG00000118263; HGNC ID: 6350
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
diabetes, type 2
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KLF7 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KLF7 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF7 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KLF7 mRNAincreases expression 15953391
D017313 Fenretinide Fenretinide results in increased expression of KLF7 mRNAincreases expression 15958647
D010126 Ozone Ozone results in decreased expression of KLF7 mRNAdecreases expression 12763052
D018038 Sodium Selenite Sodium Selenite results in decreased expression of KLF7 mRNAdecreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of KLF7 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF7 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KLF7 mRNAdecreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KLF7 mRNAincreases expression 17942748
C066075 vanadium pentoxide vanadium pentoxide results in increased expression of KLF7 mRNAincreases expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.7614692618
MESH:D000230 Adenocarcinoma Fenretinide 4.7610697514
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001932 Brain Neoplasms Fenretinide 4.5816187019
MESH:D001943 Breast Neoplasms Fenretinide 1.9516601279
MESH:D001943 Breast Neoplasms Tamoxifen 1.9518425577 19011961 19244106 17893378 16873071 19142967 20005174 17049068 18984771 18351453 20390343 19189210 19103187 19084267 17242785 18815881 18997820 18629630 19059307 16202921 21152245 11161223 17261762 19115204 19200415 15668708 18821012 19487384 20065188 19155303 19289846 15565566 19066611 19189212 16273361 20544844 17440819 19221464 20859285 18855134 16818667 19288272 20135344 19410462 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8718315731 19059883 18417511 17626835 15516495 16777450 14754758
MESH:D001991 Bronchitis vanadium pentoxide 6.6117459161
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.833084413
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 4.8317159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8316924424
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.2316274795
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.8116154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517333356 16105132 15861022 17681005 11677210 16919318 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 8697196 15668235 15340226 12621046
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6917273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5116393943 11287661 11529661 10915739 12392966 19416960 15619225 16081117 17562736 11834606 19420014 16781746 16485898 11739529 18713872 19085960 12594235 14986274 10663392 12958197 2444490 16109766 19164858 14725611 10774834 19739265 19923254 16227642 12153990 18071297 19370779 17906064 14550746 12705907 12540782 16177239 11743745 15968718 11461765 11421492 17522070
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1919155303 16202921 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005234 Fatty Liver Tamoxifen 8.5114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Fenretinide 4.0416187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tamoxifen 5.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2612878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2418625569
MESH:D007972 Leukoplakia, Oral Fenretinide 6.4216707609
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 12587719 19460945 16611625 12969438 11587558 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 4.6516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases Ozone 3.5319066396 8266340
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Ozone 5.117614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 5.1118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.1111884234 19555203
MESH:D008175 Lung Neoplasms vanadium pentoxide 5.1112376484
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 6.8310697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.8319196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Fenretinide 3.7216270382
MESH:D008545 Melanoma Tamoxifen 3.7219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D009062 Mouth Neoplasms Fenretinide 4.5016274795
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms Fenretinide 3.3917353921 15958647
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 6.0216303764
MESH:D010051 Ovarian Neoplasms Fenretinide 3.2916133793
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.4215580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D011014 Pneumonia Ozone 4.7318007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Fenretinide 2.6517024972
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration Fenretinide 4.5816303925
MESH:D012878 Skin Neoplasms Fenretinide 6.2216467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.2216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 5.6816720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6816712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.7916154183
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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