AutismKB 2.0

Annotation Detail for RUNX1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RUNX1 ( AML1,AML1-EVI-1,AMLCR1,CBFA2,EVI-1,PEBP2aB )
Gene Full Name: runt-related transcription factor 1
Band: 21q22.12
Quick LinksEntrez ID:861; OMIM: 151385; Uniprot ID:RUNX1_HUMAN; ENSEMBL ID: ENSG00000159216; HGNC ID: 10471
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00004Chronic myeloid leukemia (CML)
H00003Acute myeloid leukemia (AML)
H00001Acute lymphoblastic leukemia (ALL) (Precursor B lymphoblastic leukemia)
Desease IDDesease Name
1781Rheumatoid arthritis
1797Vitamin D deficiency
1859Ovarian cancer
1983Down syndrome
1841Stomach cancer
2051Leukemia
2114Thrombocytopenia
2173Hematopoietic system disease
2188Bone marrow disease
2239Lymphoma
2247Osteomyelitis
Desease Name
CANCER
Asthma
IMMUNE
Leukemia, Myeloid, Acute
myeloblastic leukemias
No data
Desease Name
Leukemia, acute myeloid
Platelet disorder, familial, with associated myeloid malignancy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of RUNX1 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RUNX1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RUNX1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RUNX1 mRNAaffects expression 16483693
D001194 Asbestos Asbestos affects the expression of RUNX1 mRNAaffects expression 17297452
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of RUNX1 mRNAaffects expression 17331233
D001374 Azacitidine Azacitidine promotes the reaction [RUNX1 protein binds to KIR2DL2 promoter]affects binding|increases reaction 18945643
D001374 Azacitidine Azacitidine promotes the reaction [RUNX1 protein binds to KIR2DL4 promoter]affects binding|increases reaction 18945643
C020711 beryllium sulfate beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter]affects binding|increases reaction 16314022
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNAaffects binding|increases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in increased expression of RUNX1 mRNAincreases expression 20105288
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of RUNX1 mRNAdecreases expression 15171707
D002117 Calcitriol Calcitriol results in decreased expression of RUNX1 mRNAdecreases expression 16002434
D004317 Doxorubicin RUNX1 gene mutant form results in increased susceptibility to Doxorubicinincreases response to substance 15217836
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RUNX1 mRNAincreases expression 17557909
D005047 Etoposide RUNX1 gene mutant form results in increased susceptibility to Etoposideincreases response to substance 15217836
D006918 Hydroxyurea Hydroxyurea results in increased expression of RUNX1 protein mutant formincreases expression 16532439
C051890 irinotecan irinotecan metabolite results in decreased expression of RUNX1 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of RUNX1 mRNAdecreases expression 15956246
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of RUNX1 mRNAincreases expression 17616710
D013629 Tamoxifen Tamoxifen results in increased expression of RUNX1 mRNAincreases expression 15590111
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RUNX1 mRNAincreases expression 19933214
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNAaffects binding|increases expression 20105288
D001335 Vehicle Emissions Vehicle Emissions results in increased expression of RUNX1 mRNAincreases expression 19465080
C025643 vinclozolin vinclozolin affects the expression of RUNX1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D000230 Adenocarcinoma Doxorubicin 4.2617418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2316835633
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3315469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5219015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid marker/mechanism
MESH:D050197 Atherosclerosis Asbestos 4.1318795166
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.6514601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.6514601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms Calcitriol 3.6811237771
MESH:D001943 Breast Neoplasms Cobalt 3.6815986119
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6817129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 3.6817369602 15993339 16322301 15692762 11325840 15136595 17426702 15994142 16935488 16096432 15634643 18382427 16595493 16264153 16115903 15567936 18628466 16826403 15668708 15939500 17983394 19526202 18234424 18695136
MESH:D001943 Breast Neoplasms Etoposide 3.6816322251
MESH:D001943 Breast Neoplasms Tamoxifen 3.6816273361 19011961 19103187 16202921 20135344 19189212 19288272 19221464 19289846 15668708 18997820 16873071 18425577 19200415 20859285 19084267 19155303 18815881 20390343 20544844 18855134 19142967 18629630 15565566 19059307 19189210 20005174 17893378 18821012 21152245 18984771 17440819 17242785 19115204 20065188 17261762 19487384 19066611 16818667 17049068 11161223 19244106 18351453 19410462 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6820435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3519066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.613084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.6116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.6118059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.6116924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0916201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.7611237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.766189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2816120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4317131338 17974986 16242529 16651473 15811867 15505089 17007740 17924179 16364871 16269455 15792986 18627295 16455267 17519947 17382496 16278810 17329180 16109756 16612575 16731534 16952015 15476868 17308081 17928571 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8917334414 16243910
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7616919318 17110522 16105132 11677210 17681005 17333356 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 15668235 8697196 12621046 15340226
MESH:D003110 Colonic Neoplasms irinotecan 2.5717287894 17725105
MESH:D015179 Colorectal Neoplasms Azacitidine 3.5719934284
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5718802399 18259882
MESH:D015179 Colorectal Neoplasms irinotecan 3.5715273666 17159606 16391804 18259882 17454858 16303861 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.8816002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 10.8814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2119031437
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.8915059100 16823706 11298694
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5814550746 18071297 11421492 16109766 12958197 14725611 19923254 16781746 10774834 19739265 16227642 10663392 15968718 10915739 19085960 11287661 12153990 17906064 19420014 11461765 11529661 19416960 12594235 16177239 12540782 16081117 15619225 18713872 12392966 12705907 11743745 19164858 17522070 11834606 11739529 14986274 16393943 2444490 17562736 19370779 16485898
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.5817416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.4915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.4919031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.9716804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.9717359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.9716202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7416704527 15547733 15547721 16805852 15623463 15878914 15150132 16510608 15264214
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.2315345470
MESH:D005234 Fatty Liver Tamoxifen 7.2314986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.9116002989 16513791 16534752 15751030 16611131
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.9116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3814745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.9319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.9319069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8020067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1516417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7916452187
MESH:D005909 Glioblastoma Doxorubicin 3.2517150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4315692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2511294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.3816330681 16244372 12587719 18006777 18674790 17875725 16879835 16495754 14766674 16144979 16707910 16244371 17888722
MESH:D006333 Heart Failure Doxorubicin 3.2517481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 16120746 12621046
MESH:D006561 Herpes Simplex Etoposide 4.4110809021
MESH:D006689 Hodgkin Disease Doxorubicin 7.3118501091 15147373 17606976
MESH:D006689 Hodgkin Disease Etoposide 7.3116135485 16200630 17606976 18180244 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2914722030 12960047
MESH:D006973 Hypertension Cobalt 5.4217039479
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4218850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 10.7416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.7416569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.2115036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3317937319
MESH:D007248 Infertility, Male vinclozolin 6.3316467254
MESH:D007249 Inflammation Tamoxifen 4.6319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007674 Kidney Diseases Acetaminophen 5.7712587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 5.7716775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7516705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.7515003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Tamoxifen 11.7518625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9117184923
MESH:D007938 Leukemia Azacitidine 3.6219148494
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D007951 Leukemia, Myeloid Azacitidine 9.8119077051
MESH:D007951 Leukemia, Myeloid Hydroxyurea 9.8116532439
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 18206229
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.9718720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0519299654
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5816417039
MESH:D008064 Lipidoses Tamoxifen 3.0515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.3916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.3918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3912878042
MESH:D008107 Liver Diseases Acetaminophen 1.5911587558 16611625 12587719 12969438 19014921 19460945 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1016871587 17185352
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.1115890375 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 7.1116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.1116984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.6017085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6012151625
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.716434250
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8717365036
MESH:D008175 Lung Neoplasms Asbestos 8.3312111688
MESH:D008175 Lung Neoplasms Azacitidine 8.3321224363
MESH:D008175 Lung Neoplasms Doxorubicin 8.3317418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 8.3318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3319555203 11884234
MESH:D008175 Lung Neoplasms Vehicle Emissions 8.339255578
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0015166399
MESH:D008223 Lymphoma Diethylstilbestrol 12.0815700306
MESH:D008223 Lymphoma Doxorubicin 12.0816098063
MESH:D008223 Lymphoma Etoposide 12.0812854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3616002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6119428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.8215458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.8211731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.4019453300
MESH:D008545 Melanoma Doxorubicin 3.3316827129
MESH:D008545 Melanoma Tamoxifen 3.3312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008654 Mesothelioma Asbestos 10.0818709470 16319530 18310086 16564556 16919927
MESH:D008654 Mesothelioma Asbestos, Crocidolite 10.0816166281 16966607 18303189
MESH:D008654 Mesothelioma Doxorubicin 10.0817638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D009006 Monosomy Azacitidine 5.9319299654
MESH:D052016 Mucositis Doxorubicin 11.9117415656
MESH:D052016 Mucositis irinotecan 11.9117159606
MESH:D009101 Multiple Myeloma Azacitidine 3.8618443271 19549372
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.9217611569 17596541 19805378 18720364
MESH:D009203 Myocardial Infarction Doxorubicin 2.8915857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7118551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.2618259882
MESH:D009362 Neoplasm Metastasis irinotecan 9.2618259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.2619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Diethylstilbestrol 2.7015313581
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8519189210 19200415 19196722
MESH:D009401 Nephrosis Doxorubicin 4.6216636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8716889571 15640375
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.1511399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1514600291
MESH:D009447 Neuroblastoma Doxorubicin 6.9015555623
MESH:D009447 Neuroblastoma irinotecan 6.908761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.588761367
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2912819281 16049721
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Etoposide 3.2219003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5215687265 16977796
OMIM:601399 PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY marker/mechanism
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7410923243
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D015452 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma marker/mechanism 15217836
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.3917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.3911399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.3918220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7818220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6315572423
MESH:D011471 Prostatic Neoplasms marker/mechanism 17909013
MESH:D011471 Prostatic Neoplasms Azacitidine 1.8918324645
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8916644109 16289102 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8915846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8916729912 15749863 15897917 16888761 18437689 16868541
MESH:D011471 Prostatic Neoplasms Etoposide 1.8917172428
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011472 Prostatitis vinclozolin 4.7818629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.1117365031 17975199 17322281 15814490
MESH:D011658 Pulmonary Fibrosis Cobalt 6.116434250
MESH:D051437 Renal Insufficiency Doxorubicin 4.0717922066
MESH:D012135 Respiratory Sounds Vehicle Emissions 5.0618950799
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012509 Sarcoma Doxorubicin 3.8617710206 15625365 18313854 16767912 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.0616326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 10.0614601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4318551238
MESH:D012878 Skin Neoplasms Doxorubicin 5.4515692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4216767912 15625365 17203757
MESH:D013088 Spermatocele Diethylstilbestrol 19.2616709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 19.2616709447
MESH:D013088 Spermatocele Tamoxifen 19.2616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8919457130
MESH:D013274 Stomach Neoplasms irinotecan 2.8015723263
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.8017575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.2616010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.2116049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.2116712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.2117653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.2117572228 16712894 8653321
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 15.2111144890
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1610091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.9815809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9814692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0716364871 17334414 17638931 17678736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:05220 Chronic myeloid leukemia
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34884
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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