AutismKB 2.0

Annotation Detail for PDE8B


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Basic Information Top
Gene Symbol:PDE8B ( ADSD,FLJ11212,PPNAD3 )
Gene Full Name: phosphodiesterase 8B
Band: 5q13.3
Quick LinksEntrez ID:8622; OMIM: 603390; Uniprot ID:PDE8B_HUMAN; ENSEMBL ID: ENSG00000113231; HGNC ID: 8794
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
hypothyroidism
No data
Desease Name
Pigmented nodular adrenocortical disease, primary, 3
Striatal degeneration, autosomal dominant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PDE8B proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PDE8B mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDE8B mRNAdecreases expression 19150397
20018196
D016572 Cyclosporine Cyclosporine results in decreased expression of PDE8B mRNAdecreases expression 20106945
C459562 L-826,141 L-826,141 results in decreased activity of PDE8B proteindecreases activity 15901792
D008094 Lithium Lithium results in decreased expression of PDE8B mRNAdecreases expression 20222156
C076029 olanzapine olanzapine results in increased expression of PDE8B mRNAincreases expression 20222156
C424423 Roflumilast Roflumilast results in decreased activity of PDE8B proteindecreases activity 15901792
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDE8B mRNAdecreases expression 20106945
C035964 trequinsin trequinsin results in decreased activity of PDE8B proteindecreases activity 15901792
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000312 Adrenal Hyperplasia, Congenital marker/mechanism
MESH:D000544 Alzheimer Disease Lithium 3.5019621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder olanzapine 3.3617069543 18685284
MESH:D001714 Bipolar Disorder Lithium 4.4019153942 20338123 20046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9721507988 12619106 12907637
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002389 Catatonia olanzapine 6.5116772815 18071103
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 8697196 15668235 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D007644 Darier Disease Lithium 6.1520338123
MESH:D002658 Developmental Disabilities olanzapine 4.8017069543
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.9619244398
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.7520471113
MESH:D006330 Heart Defects, Congenital Lithium 11.7519638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.7511294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16354765 8697196 16959395 18606429
MESH:D006963 Hyperphagia olanzapine 6.4717933447
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4318776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.7218177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7221137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.158603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1512151625
MESH:D008133 Long QT Syndrome olanzapine 4.8620210726
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4520464547 17053015 20869020 18520028 18816296 20064080 18569708 20135361 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4511884234 19555203
MESH:D001523 Mental Disorders olanzapine 4.8716856516
MESH:D008659 Metabolic Diseases olanzapine 5.5619142110
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009203 Myocardial Infarction Lithium 3.9816288908
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009765 Obesity olanzapine 3.7518515891
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011595 Psychomotor Agitation olanzapine 5.8018685284
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012559 Schizophrenia olanzapine 3.4520521326 20107430 17726453
MESH:D012640 Seizures Lithium 4.0919660546
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013226 Status Epilepticus Lithium 6.0519951488 19570321 19430551
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
OMIM:609161 STRIATAL DEGENERATION, AUTOSOMAL DOMINANT marker/mechanism
MESH:D017180 Tachycardia, Ventricular olanzapine 5.5320210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain olanzapine 5.3217933447 20107430 19434072
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:00230 Purine metabolism
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33142
    • No data
    Releated disease ID Related disease Name
    PA445856Thyroid Diseases
    PA447321Depressive Disorder, Major
    PA444544Hyperplasia
    Releated drug ID Related drug Name
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00920 antagonist Ketotifen Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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