AutismKB 2.0

Annotation Detail for ASMTL


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Basic Information Top
Gene Symbol:ASMTL ( ASMTLX,ASMTLY,ASTML )
Gene Full Name: acetylserotonin O-methyltransferase-like
Band: Xp22.3 and Yp11.3
Quick LinksEntrez ID:8623; OMIM: 300162,400011; Uniprot ID:ASML_HUMAN; ENSEMBL ID: ENSG00000169093; HGNC ID: 751
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006780 bisphenol A bisphenol A results in increased expression of ASMTL mRNAincreases expression 20678512
D002330 Carmustine Carmustine results in decreased expression of ASMTL mRNAdecreases expression 15980968
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of ASMTL mRNAaffects cotreatment|affects expression 17330099
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of ASMTL proteindecreases expression 18959786
D012402 Rotenone Rotenone results in increased expression of ASMTL mRNAincreases expression 19013527
D012643 Selenium Selenium results in increased expression of ASMTL mRNAincreases expression 19244175
D014635 Valproic Acid Valproic Acid results in increased expression of ASMTL mRNAincreases expression 19101580
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of ASMTL mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918177632 17507914 18396377 18316065 18940202 18558336 16609825 18985861 18775368 17157402 15238991 17688650 19232924 19460635 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001862 Bone Resorption bisphenol A 4.1011985600
MESH:D001932 Brain Neoplasms Carmustine 4.6116187019
MESH:D001943 Breast Neoplasms bisphenol A 2.1517123778
MESH:D001943 Breast Neoplasms decitabine 2.1518320071 19208741
MESH:D001943 Breast Neoplasms vorinostat 2.1516144943
MESH:D002278 Carcinoma in Situ bisphenol A 5.3317123778
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003704 Dementia Methylmercury Compounds 5.2416140633
MESH:D003967 Diarrhea vorinostat 4.7720479100
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2015131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2019641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005221 Fatigue vorinostat 5.9320479100
MESH:D005234 Fatty Liver Valproic Acid 3.5414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D005909 Glioblastoma Carmustine 4.0716187019
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007333 Insulin Resistance bisphenol A 3.4416393666
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007938 Leukemia decitabine 3.1819235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2419117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1218704418 18206229 18460780 19387464 17679729 19010910
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.1216294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.9920479100
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008545 Melanoma Carmustine 3.8712393984
MESH:D008545 Melanoma decitabine 3.8716505122 17785578
MESH:D008569 Memory Disorders Methylmercury Compounds 5.1918436314
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009069 Movement Disorders Methylmercury Compounds 5.5918436314
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.9219157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.9217596541
MESH:D009325 Nausea vorinostat 5.9020479100
MESH:D009369 Neoplasms decitabine 2.8119470736 19116145 17925555
MESH:D009410 Nerve Degeneration Rotenone 4.0617356569 15790535 18619942
MESH:D009421 Nervous System Malformations bisphenol A 4.2511399458 16427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.278888407 16359493
MESH:D010049 Ovarian Diseases bisphenol A 5.3311985600
MESH:D010051 Ovarian Neoplasms decitabine 2.7119331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D010300 Parkinson Disease Rotenone 3.0516140633 18619942 18191903 16412576 15451049 19232380 19114014 11445065 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 4.3015574749 18197244 15927086 15795934
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.5710548101
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 18.5718436314
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 18.5720603192
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.7216740699
MESH:D011471 Prostatic Neoplasms vorinostat 3.7217218635
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D011629 Puberty, Precocious bisphenol A 5.1210548101
MESH:D012208 Rhabdomyosarcoma decitabine 11.8619155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.8619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8916876388 15475178 14763951 11738929 17978042 11044598 3137016 1511512
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019966 Substance-Related Disorders bisphenol A 4.3216684133 16045194
MESH:D013921 Thrombocytopenia vorinostat 5.2020479100
MESH:D013964 Thyroid Neoplasms decitabine 3.5117967635
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8017616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014591 Uterine Diseases bisphenol A 5.3814652134
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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