AutismKB 2.0

Annotation Detail for TP63


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Basic Information Top
Gene Symbol:TP63 ( AIS,B(p51A),B(p51B),EEC3,KET,LMS,NBP,OFC8,RHS,SHFM4,TP53CP,TP53L,TP73L,p40,p51,p53CP,p63,p73H,p73L )
Gene Full Name: tumor protein p63
Band: 3q28
Quick LinksEntrez ID:8626; OMIM: 603273; Uniprot ID:P63_HUMAN; ENSEMBL ID: ENSG00000073282; HGNC ID: 15979
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200101Direct p53 effectors
Pathway IDPathway Name
P04398p53 pathway feedback loops 2
P00029Huntington disease
P00059p53 pathway
P04397p53 pathway by glucose deprivation
P04392P53 pathway feedback loops 1
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
proliferative potential of keratinocytes
blastic crisis
CANCER
NEUROLOGICAL
urinary bladder cancer
Brain imaging
Desease Name
Brain imaging
Lung adenocarcinoma
Urinary bladder cancer
Desease Name
Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3
Limb-mammary syndrome
Hay-Wells syndrome
Rapp-Hodgkin syndrome
Split-hand/foot malformation, type 4
ADULT syndrome
Orofacial cleft 8
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased expression of TP63 proteinincreases expression 15607904
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TP63 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of TP63 proteinincreases expression 16483693
D047310 Apigenin Apigenin results in increased expression of TP63 proteinincreases expression 19397994
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of TP63 mRNAaffects expression 17331233
C043561 chrysin chrysin results in increased expression of TP63 proteinincreases expression 18331776
19397994
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of TP63 proteinincreases expression 16439099
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TP63 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TP63 mRNAincreases expression 19619570
D019833 Genistein Genistein results in increased expression of TP63 mRNAincreases expression 15256057
D019833 Genistein Genistein results in decreased expression of TP63decreases expression 12929590
C006552 kaempferol kaempferol results in increased expression of TP63 proteinincreases expression 18331776
19397994
D047311 Luteolin Luteolin results in increased expression of TP63 proteinincreases expression 19397994
18331776
C040015 myricetin myricetin results in increased expression of TP63 proteinincreases expression 19397994
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of TP63 mRNAdecreases expression 17616710
D011794 Quercetin Quercetin results in increased expression of TP63 proteinincreases expression 18331776
19397994
C017947 sodium arsenite sodium arsenite affects the expression of TP63 mRNAaffects expression 20056578
C017947 sodium arsenite sodium arsenite affects the expression of TP63 proteinaffects expression 20056578
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TP63 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TP63 mRNAincreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9014514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma marker/mechanism 20871597
MESH:D000230 Adenocarcinoma Estradiol 4.4911473722
MESH:D000230 Adenocarcinoma Genistein 4.4911473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9617306315 16712894
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5215469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1210965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2717084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0315336622
MESH:D001327 Autoimmune Diseases Quercetin 4.4519761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001941 Breast Diseases marker/mechanism 11462173
MESH:D001943 Breast Neoplasms Apigenin 3.8017132221 16541309
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.8017129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 3.8017289903 16675129 17261762 19861407 14630087 18497071 12948864 17018787
MESH:D001943 Breast Neoplasms Genistein 3.8017200150 16541309 16873071
MESH:D001943 Breast Neoplasms kaempferol 3.8016756079
MESH:D001943 Breast Neoplasms Quercetin 3.8018628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.8020435547
MESH:D002105 Cadmium Poisoning Quercetin 5.6116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.9416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.9416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.9416924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.9419519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.9416507464 17306315 15276417
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0017234771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3918572023
MESH:D006332 Cardiomegaly Quercetin 6.8519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 7.9216332659
MESH:D002318 Cardiovascular Diseases kaempferol 7.9216756079
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.8119524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002971 Cleft Lip marker/mechanism 16688749
MESH:D002972 Cleft Palate marker/mechanism 11462173
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 15340226 12621046 15668235 8697196
MESH:D003110 Colonic Neoplasms Genistein 3.9417182828
MESH:D003110 Colonic Neoplasms Quercetin 3.9415741050 11134977 16640504 17191121 17148506 19056647 19440933
MESH:D015179 Colorectal Neoplasms marker/mechanism 15875781
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities marker/mechanism 10227294
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5912952375 16002989
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7519496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:C536189 Ectrodactyly-cleft lip/palate syndrome marker/mechanism 11462173
OMIM:604292 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3 marker/mechanism 12161593
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.0616402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.0616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.6215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 12.6211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 12.6211473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7815264214 15547733 16510608 16704527 15547721 15150132 16805852 15623463 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D052776 Female Urogenital Diseases marker/mechanism 16002989
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6716611131 15751030 16002989 16513791 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Quercetin 8.9019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9020067830
MESH:D005532 Foot Deformities, Congenital marker/mechanism 11462173
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.9816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.9816452187
MESH:D005909 Glioblastoma Genistein 12.2716598420
MESH:D005909 Glioblastoma myricetin 12.2719804834
MESH:D005909 Glioblastoma Quercetin 12.2719804834
MESH:D005910 Glioma Quercetin 3.0617643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006228 Hand Deformities, Congenital marker/mechanism 11462173
MESH:C535847 Hay-Wells syndrome marker/mechanism
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9316120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 15340226 16959395 18606429 16354765
MESH:D006943 Hyperglycemia kaempferol 10.0018262572
MESH:D006943 Hyperglycemia Quercetin 10.0018262572 11834736
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4814722030 12960047
MESH:D006973 Hypertension Quercetin 5.2618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2618850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.6216002989
MESH:D007246 Infertility Diethylstilbestrol 4.3915036965
MESH:D007248 Infertility, Male sodium arsenite 3.0115346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.5716624496
MESH:D007333 Insulin Resistance Estradiol 2.9816627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007627 Keloid Quercetin 5.0017086741
MESH:D007674 Kidney Diseases Estradiol 10.2515618244
MESH:D007674 Kidney Diseases Quercetin 10.2516962696
MESH:D007674 Kidney Diseases sodium arsenite 10.2520008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.6215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 7.6215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1017184923
MESH:D007938 Leukemia Genistein 10.8017468513 18980019
MESH:D007938 Leukemia kaempferol 10.8017468513
MESH:D007938 Leukemia Quercetin 10.8017468513
MESH:D017880 Limb Deformities, Congenital marker/mechanism 10227294
MESH:C535903 Limb-mammary syndrome marker/mechanism 11462173
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0017823541
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.0012741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0012878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 10.8315890375 16712894
MESH:D008113 Liver Neoplasms Quercetin 10.8318980244
MESH:D008113 Liver Neoplasms sodium arsenite 10.8315276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8316984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 5.9819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D008171 Lung Diseases sodium arsenite 3.1919095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0617365036
MESH:D008175 Lung Neoplasms marker/mechanism 20871597
MESH:D008175 Lung Neoplasms Quercetin 3.4616280456
MESH:D008175 Lung Neoplasms sodium arsenite 3.4615276417 16712894 17077188 19931552 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4611884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5816002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1416891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1414578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008545 Melanoma sodium arsenite 2.0319082730 16487513
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1916966607 16166281 18303189
MESH:D009203 Myocardial Infarction Genistein 6.0317141266
MESH:D009203 Myocardial Infarction Quercetin 6.0319595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.4116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.4117141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 14.4119207477
MESH:D009362 Neoplasm Metastasis marker/mechanism 15875781
MESH:D009369 Neoplasms Diethylstilbestrol 8.4815313581
MESH:D009369 Neoplasms Quercetin 8.4815185748
MESH:D009369 Neoplasms sodium arsenite 8.4811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 23.7911399458
MESH:D009421 Nervous System Malformations Estradiol 23.7916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 23.7916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.7914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1612854658
MESH:D020078 Neurogenic Inflammation Quercetin 4.3917929310
MESH:D010024 Osteoporosis Genistein 7.7419401787
MESH:D010024 Osteoporosis kaempferol 7.7416756079
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.2516169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.2519495926
MESH:D010051 Ovarian Neoplasms Estradiol 15.1019401270
MESH:D010051 Ovarian Neoplasms Genistein 15.1019005980
MESH:D010051 Ovarian Neoplasms Luteolin 15.1019005980
MESH:D010051 Ovarian Neoplasms Quercetin 15.1019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 15.1017306315 15276417
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.5611550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7116977796 15687265
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Quercetin 4.0019056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.7417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7411399792 11118676 11222880 11896295
MESH:C538052 Propping Zerres syndrome marker/mechanism
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Apigenin 1.9017132221
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9017136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Genistein 1.9015256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 1.9014715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9016039940
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0415814490 17322281 17975199 17365031
MESH:C535289 Rapp-Hodgkin syndrome marker/mechanism 15748593 19239083 19676059
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.6116862918
MESH:D012868 Skin Abnormalities marker/mechanism 10227294
MESH:D012878 Skin Neoplasms sodium arsenite 5.6319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.7716709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
OMIM:605289 SPLIT-HAND/FOOT MALFORMATION 4 marker/mechanism 16688749
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3212958204 17575124
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.5117306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.5116720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.5111723127 16452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.6316175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.6311813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1015809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4816002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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