AutismKB 2.0

Annotation Detail for SSNA1


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Basic Information Top
Gene Symbol:SSNA1 ( N14,NA-14,NA14 )
Gene Full Name: Sjogren syndrome nuclear autoantigen 1
Band: 9q34.3
Quick LinksEntrez ID:8636; OMIM: 610882; Uniprot ID:SSNA1_HUMAN; ENSEMBL ID: ENSG00000176101; HGNC ID: 11321
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
No data
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of SSNA1 mRNAaffects expression 18648102
D012643 Selenium Selenium results in increased expression of SSNA1 mRNAincreases expression 19244175
D014303 Trinitrotoluene Trinitrotoluene affects the expression of SSNA1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.937525203
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.983712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.891440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.783581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D002386 Cataract Trinitrotoluene 4.1015817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.479022650 19486331
MESH:D003092 Colitis Selenium 4.4317936198
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.8215095906
MESH:D003490 Cyanosis Trinitrotoluene 5.5718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.4412868966 8970840 2524372 11298694 8156756 11906362 14531868 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.022952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.9818289764 18692083 6679447 9653073 9328219 9022650 1440618 18648102 16192314 6482804 11289319 7440962 8291058
MESH:D056486 Drug-Induced Liver Injury Selenium 6.9815131321
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.9818551238 21346803
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006333 Heart Failure Selenium 3.3217162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006529 Hepatomegaly Trinitrotoluene 4.8815817613
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007248 Infertility, Male Trinitrotoluene 3.9512150543
MESH:D007251 Influenza, Human Selenium 5.0616624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.899022650 8074119
MESH:D007676 Kidney Failure, Chronic Selenium 4.3716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.786587162 598648 3712494 1399818
MESH:D008325 Mammary Neoplasms, Experimental Selenium 3.0215318939
MESH:D008654 Mesothelioma Selenium 2.9315107826
MESH:D009336 Necrosis Trinitrotoluene 5.5118551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.186679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.744026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 10.7412819281 14694615 17852074
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D010954 Plasmacytoma Selenium 5.7615087411
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012640 Seizures Trinitrotoluene 3.7218551238
MESH:D013163 Splenomegaly Trinitrotoluene 5.8515817613
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.226587162 7505956 3712494 6582329 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.418074119
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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