AutismKB 2.0

Annotation Detail for AOC3


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Basic Information Top
Gene Symbol:AOC3 ( HPAO,SSAO,VAP-1,VAP1 )
Gene Full Name: amine oxidase, copper containing 3 (vascular adhesion protein 1)
Band: 17q21.31
Quick LinksEntrez ID:8639; OMIM: 603735; Uniprot ID:AOC3_HUMAN; ENSEMBL ID: ENSG00000131471; HGNC ID: 550
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00360Phenylalanine metabolism
hsa00410beta-Alanine metabolism
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
No data
No data
Pathway IDPathway Name
P02766Phenylethylamine degradation
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AOC3 mRNAaffects expression 21346803
D000499 Allylamine AOC3 protein affects the metabolism of Allylamineaffects metabolic processing 11543647
D000499 Allylamine AOC3 protein affects the metabolism of Allylamineaffects metabolic processing 11543647
D000499 Allylamine AOC3 protein affects the metabolism of and results in increased oxidation of Allylamineaffects metabolic processing|increases oxidation 10406932
D000499 Allylamine AOC3 protein results in decreased susceptibility to Allylaminedecreases response to substance 10406932
C010059 carbamylhydrazine carbamylhydrazine results in decreased activity of AOC3 proteindecreases activity 11543647
C010059 carbamylhydrazine carbamylhydrazine results in decreased activity of AOC3 proteindecreases activity 11543647
10406932
D004041 Dietary Fats Dietary Fats results in decreased expression of AOC3 mRNAdecreases expression 18042831
D005557 Formaldehyde AOC3 protein affects the metabolism of Formaldehydeaffects metabolic processing 15128865
C027451 methylamine AOC3 protein results in decreased amination of methylaminedecreases amination 15128865
C027451 methylamine mofegiline inhibits the reaction [AOC3 protein results in decreased amination of methylamine]decreases amination|decreases reaction 15128865
C058000 mofegiline mofegiline inhibits the reaction [AOC3 protein results in decreased amination of methylamine]decreases amination|decreases reaction 15128865
C058000 mofegiline mofegiline results in decreased activity of AOC3 proteindecreases activity 15128865
D009002 Monomethylhydrazine Monomethylhydrazine results in decreased activity of AOC3 proteindecreases activity 8583353
C041786 palm oil palm oil results in decreased expression of AOC3 mRNAdecreases expression 18042831
D011344 Procarbazine Procarbazine results in decreased activity of AOC3 proteindecreases activity 8583353
D011794 Quercetin Quercetin results in decreased expression of AOC3 mRNAdecreases expression 15309432
C025643 vinclozolin vinclozolin affects the expression of AOC3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000743 Anemia, Hemolytic Quercetin 4.3517084956
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1315336622
MESH:D001327 Autoimmune Diseases Quercetin 4.5519761891
MESH:D001943 Breast Neoplasms Dietary Fats 2.2120435547
MESH:D001943 Breast Neoplasms Formaldehyde 2.2115986119
MESH:D001943 Breast Neoplasms Procarbazine 2.2111921183
MESH:D001943 Breast Neoplasms Quercetin 2.2118628248
MESH:D002105 Cadmium Poisoning Quercetin 5.7216962696
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1916705839
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.1912508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0917234771
MESH:D006332 Cardiomegaly Quercetin 3.3719794523
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.846135515
MESH:D016770 Ciliophora Infections Formaldehyde 5.8212113305
MESH:D003110 Colonic Neoplasms Quercetin 2.4319440933 15741050 17148506 17191121 11134977 16640504 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918095365 18852136
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D017449 Dermatitis, Allergic Contact Formaldehyde 4.8415932584 12081698 14996049 15059100 16958921
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8219496084
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0021346803 18551238
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D005141 Eyelid Diseases Formaldehyde 6.5514996049
MESH:D005234 Fatty Liver Dietary Fats 3.3518296743 19004024 19551842 17967931
MESH:D005355 Fibrosis Dietary Fats 9.4418296743
MESH:D005355 Fibrosis Quercetin 9.4419474275
MESH:D005393 Fish Diseases Formaldehyde 5.7812113305
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005909 Glioblastoma Quercetin 3.4619804834
MESH:D005910 Glioma Quercetin 3.0917643826
MESH:D006689 Hodgkin Disease Procarbazine 5.6417606976 16135485
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia Quercetin 4.1318262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Quercetin 2.8918356687
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Dietary Fats 2.4820412841
MESH:D007251 Influenza, Human Quercetin 4.6816624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1718457598 11836018
MESH:D007627 Keloid Quercetin 5.0917086741
MESH:D007674 Kidney Diseases Quercetin 3.1516962696
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0716705839
MESH:D007938 Leukemia Quercetin 3.2017468513
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.1912741479
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.847678174
MESH:D008113 Liver Neoplasms Quercetin 4.8418980244
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.306135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.3019519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D008325 Mammary Neoplasms, Experimental Procarbazine 5.2311921183
MESH:D009203 Myocardial Infarction Quercetin 3.0319595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.8819207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009369 Neoplasms Quercetin 2.8415185748
MESH:D020078 Neurogenic Inflammation Quercetin 4.4817929310
MESH:D009669 Nose Neoplasms Formaldehyde 11.124038687
MESH:D009669 Nose Neoplasms Procarbazine 11.129385384
MESH:D009765 Obesity Dietary Fats 2.3120132043 18457598 20518802 19632207 17217161 16723640 21332399 11836018 18674790
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3419495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7619005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8816965848
MESH:D011230 Precancerous Conditions Quercetin 4.0819056647
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0519015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Quercetin 3.5814715546 17292933
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D012554 Schistosomiasis japonica Quercetin 5.7216862918
MESH:D012595 Scleroderma, Systemic Formaldehyde 5.9814979077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3316049721
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.3316720314
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
KEGG:00410 beta-Alanine metabolism
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
KEGG:00360 Phenylalanine metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00780 antagonist Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
DB01275 antagonist BiDil Antihypertensive Agents;Vasodilator Agents
DB04334 - 6-hydroxydopa quinone
DB07566 - 2,6-DICHLORO-N-IMIDAZOLIDIN-2-YLIDENEANILINE
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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