AutismKB 2.0

Annotation Detail for RUNX3


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Basic Information Top
Gene Symbol:RUNX3 ( AML2,CBFA3,FLJ34510,MGC16070,PEBP2aC )
Gene Full Name: runt-related transcription factor 3
Band: 1p36.11
Quick LinksEntrez ID:864; OMIM: 600210; Uniprot ID:RUNX3_HUMAN; ENSEMBL ID: ENSG00000020633; HGNC ID: 10473
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2052Infection
2098Esophageal disease
2164Barrett's esophagus
Desease Name
Celiac Disease
IMMUNE
Desease Name
Celiac disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RUNX3 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of RUNX3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RUNX3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RUNX3 mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine affects the methylation of RUNX3 geneaffects methylation 18058463
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RUNX3 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RUNX3 mRNAincreases expression 20064835
C014347 decitabine decitabine affects the methylation of RUNX3 promoteraffects methylation 17571247
19087683
17488656
C014347 decitabine decitabine results in increased expression of RUNX3 mRNAincreases expression 16367923
19087683
D002945 Cisplatin RUNX3 protein results in increased susceptibility to Cisplatinincreases response to substance 15756676
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of RUNX3 mRNAaffects cotreatment|increases expression 18164116
D004317 Doxorubicin RUNX3 protein results in decreased export of Doxorubicindecreases export 15756676
D004317 Doxorubicin RUNX3 protein results in increased susceptibility to Doxorubicinincreases response to substance 15756676
D005047 Etoposide RUNX3 protein results in increased susceptibility to Etoposideincreases response to substance 15756676
D005419 Flavonoids Flavonoids results in increased expression of RUNX3 mRNAincreases expression 18035473
D016685 Mitomycin RUNX3 protein results in increased susceptibility to Mitomycinincreases response to substance 15756676
D008942 Mitoxantrone RUNX3 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in increased expression of RUNX3 mRNAincreases expression 15674844
D012643 Selenium Selenium results in increased expression of RUNX3 proteinincreases expression 18583539
D018038 Sodium Selenite Sodium Selenite results in increased expression of RUNX3 mRNAincreases expression 18175754
D014750 Vincristine RUNX3 protein results in increased susceptibility to Vincristineincreases response to substance 15756676
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.897525203
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.9017670903 15814532 12690470
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.1620464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 10.1611798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 10.1617418594
MESH:D000230 Adenocarcinoma Vincristine 10.1619825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.673712494
MESH:D000236 Adenoma Benzo(a)pyrene 15.676695378
MESH:D000236 Adenoma beta-Naphthoflavone 15.6719389873
MESH:D000236 Adenoma Diethylnitrosamine 15.676695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.8418056438 17620307 17162532 19061943 16434500 19052882
MESH:D000419 Albuminuria Doxorubicin 4.4821441931
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001249 Asthma Mustard Gas 2.6910378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9611289319 1440618
MESH:D001768 Blister Mustard Gas 5.1019167455
MESH:D019046 Bone Marrow Neoplasms Cisplatin 20.0614601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 20.0614601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 20.0614601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7517150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9417474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 2.9419526202 18382427
MESH:D001943 Breast Neoplasms decitabine 2.9418320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9417474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.9416096432 18382427 16115903 15939500 19526202 15634643 16264153 17983394 18628466 16935488 11325840 15993339 15994142 16595493 17369602 18234424 15692762 16322301 15136595 16826403 17426702 18695136 15668708 15567936
MESH:D001943 Breast Neoplasms Etoposide 2.9416322251
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9217687719 10378619
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7516051944
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.777296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.773084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.7717982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7718210153 19383236 16328049 19107877 19052882 19701751 16878318 16807293 19919837 20084675 18665156 19822196 16935385 20101231 20432363 21159647 20214788 17173139 19208518 18785209 16681979 17978847 16502159 17162532 10737359 11831363 20727157 18506893 16569478 18393292 10672840 16779866 18788625 19335982 18056438 3581430 20514400 19171122 17055752 18978308 19418558 19394651 17761372 20512989 18691550 20524982 3084413 16830150 18971187 17138121 18494052 20007298 20935162 16540662 16698587 19539802 16288022 19519916 17428255
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.7717876044 16234567 18059187 16023760
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0112023789 16685392
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.797296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.791485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vincristine 10.7916201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.1820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 14.186189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell decitabine 14.1819215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.186189445
MESH:D002294 Carcinoma, Squamous Cell Vincristine 14.186189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.4816269455 16651473 17382496 17351982 15792986 17519947 16952015 17308081 16731534 17329180 16278810 16364871 17007740 15476868 15811867 16612575 15505089 18627295 17928571 16242529 17924179 17131338 16109756 17974986 16455267
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.2914694615
MESH:D002386 Cataract Acetaminophen 7.2910977129
MESH:D002446 Celiac Disease marker/mechanism 20190752
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.547505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.5421159647 7505956 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6319052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.1019486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6915894690
MESH:D003092 Colitis Selenium 3.7217936198
MESH:D003110 Colonic Neoplasms decitabine 2.3217616700
MESH:D015179 Colorectal Neoplasms Azacitidine 4.8219934284
MESH:D015179 Colorectal Neoplasms Cisplatin 4.8215273666
MESH:D015179 Colorectal Neoplasms decitabine 4.8218981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8218259882 18802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.1015095906
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7411906362 12868966 11298694 2524372 8970840 14531868 18759878 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.433621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7216285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1720387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.419328219 6679447 18692083 18289764 9022650 16192314 6482804 7440962 11289319 18648102 9653073 1440618 8291058
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 18.4121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.4117562736 18713872 19923254 19416960 16227642 12392966 16109766 11529661 12594235 10663392 11834606 16393943 19370779 11743745 15619225 11739529 10915739 14550746 19739265 10774834 11421492 12540782 11287661 12153990 19420014 14725611 17906064 16781746 19085960 11461765 19164858 15968718 18071297 12958197 17522070 16177239 16485898 12705907 16081117 2444490 14986274
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.4119107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 18.4117416283
MESH:D056486 Drug-Induced Liver Injury Selenium 18.4115131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 18.4115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Cisplatin 8.3512649298 15033597 12231392 19839026
MESH:D004362 Drug Toxicity Doxorubicin 8.3518602426
MESH:D004487 Edema Mustard Gas 3.2511402378 11428631 11428647 9260866
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0619294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4117359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1018037988
MESH:D004890 Erythema Mustard Gas 5.109357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms marker/mechanism 18058463
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.183581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1816530937
MESH:D004938 Esophageal Neoplasms Cisplatin 7.1815173087 15464296 17638652 16481741 16785472
MESH:D005234 Fatty Liver Diethylnitrosamine 3.1221071580 20387270
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5319069698
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005909 Glioblastoma marker/mechanism 16909125
MESH:D005909 Glioblastoma Doxorubicin 3.3117150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.8015464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 12.8019215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.8015692506
MESH:D034381 Hearing Loss Cisplatin 4.2419898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3615464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6220471113
MESH:D006331 Heart Diseases Doxorubicin 7.9112587719 17875725 16144979 16244371 18006777 16707910 16330681 18674790 16879835 16244372 14766674 17888722 16495754
MESH:D006331 Heart Diseases Mitoxantrone 7.9116019553
MESH:D006333 Heart Failure Doxorubicin 7.1117481944
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8415692506
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.456705139
MESH:D006561 Herpes Simplex Etoposide 4.5010809021
MESH:D006689 Hodgkin Disease Cisplatin 17.1216200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 17.1218501091 15147373 17606976
MESH:D006689 Hodgkin Disease Etoposide 17.1218180244 16200630 16135485 15147373 17606976
MESH:D006689 Hodgkin Disease Vincristine 17.1216135485 16794504 17606976 15147373
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D007248 Infertility, Male decitabine 3.1617581917
MESH:D007249 Inflammation Diethylnitrosamine 8.2318785209
MESH:D007249 Inflammation Flavonoids 8.2317296493
MESH:D007249 Inflammation Mustard Gas 8.2311428631 9357497 9260866 17524151 11428647 8975870 11402378 11428620 16001271
MESH:D007251 Influenza, Human Selenium 4.1416624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.2314714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0815464296
MESH:D007674 Kidney Diseases Acetaminophen 9.9415629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 9.9419839026 18289764 12231392 15190930 12649298
MESH:D007674 Kidney Diseases Doxorubicin 9.9415369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.7816707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.7816518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.916582329
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7411231351
MESH:D007938 Leukemia Azacitidine 6.6619148494
MESH:D007938 Leukemia decitabine 6.6618980019 19235587
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1016085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7618172266
MESH:D007951 Leukemia, Myeloid Azacitidine 9.7019077051
MESH:D007951 Leukemia, Myeloid decitabine 9.7018454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 18206229
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.2717596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.2718206229 19010910 18704418 17679729 19387464 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4118055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.1319299654
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7919638242 18407596 18665156 20032147 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1416439617 16595196
MESH:D008107 Liver Diseases Acetaminophen 3.8519014921 12969438 12587719 19784758 11587558 16611625 16610002 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1816871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.5821137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 10.5819389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.5819833225 18978307 12771043 19812893 19642983 19551842 20434301 20501860 21167192 20101389 21047994 2422723 21278145 20118626 20137499 18977376 19638242 18754104 21071580 18648771 20583210 19294768 10737359 19254457 16942905 18644402 20405173 19090486 19073162 15175105 19690152 19996281 15885732 19427195 19255062 19850985 12112319 20452335 19256749 19426721 9163691 19499222 2862719 20492335
MESH:D008113 Liver Neoplasms Mitomycin 10.5815113037
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.831399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.8318164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.8318308698 17174075 3124819 18544905 18253720 19539802 17854601 2563599 16842330 16267830 19126423 19519916 17942915 19004024 18079962 18775883 18282651 19009564 18093689 9362446 18164116 21159647
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.8316842330 17085340
MESH:D008171 Lung Diseases Mustard Gas 3.4018702808 18161513
MESH:D008175 Lung Neoplasms Azacitidine 10.6021224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.6018520028 18816296 20464547 20135361 17053015 20869020 18569708 6695378 20064080
MESH:D008175 Lung Neoplasms Cisplatin 10.6017225452 11798837 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.6020970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 10.606189445 17418594
MESH:D008175 Lung Neoplasms Mustard Gas 10.603148597 8781369
MESH:D008175 Lung Neoplasms Vincristine 10.606189445 19825857
MESH:D008223 Lymphoma decitabine 12.4219470736
MESH:D008223 Lymphoma Doxorubicin 12.4216098063
MESH:D008223 Lymphoma Etoposide 12.4212854902 12556972
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0014737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5015621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.0515458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0515318939
MESH:D008545 Melanoma Cisplatin 5.1816248763 11135225 12374674 16432458 18505091 12393984 17761969 18176117 16809738 12883367 15577323 18332650 17023156
MESH:D008545 Melanoma decitabine 5.1816505122 17785578
MESH:D008545 Melanoma Doxorubicin 5.1816827129
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.8915990972
MESH:D018328 Melanoma, Amelanotic Vincristine 11.8915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Cisplatin 10.1117638057
MESH:D008654 Mesothelioma Doxorubicin 10.1117638057
MESH:D008654 Mesothelioma Selenium 10.1115107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4415792986
MESH:D009006 Monosomy Azacitidine 6.0319299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D052016 Mucositis Doxorubicin 4.7317415656
MESH:D009101 Multiple Myeloma Azacitidine 7.5319549372 18443271
MESH:D009101 Multiple Myeloma decitabine 7.5318172295
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.6919805378 17596541 17611569 18720364
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6919157545 18608210 16882708 19010910
MESH:D009203 Myocardial Infarction Doxorubicin 6.3615857846 19429709
MESH:D009203 Myocardial Infarction Vincristine 6.3617284715
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.363581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.363581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.3618259882
MESH:D009369 Neoplasms Benzo(a)pyrene 11.6811141357
MESH:D009369 Neoplasms Cisplatin 11.6816773208
MESH:D009369 Neoplasms decitabine 11.6819116145 19470736 17925555
MESH:D009369 Neoplasms Mitoxantrone 11.6816640825
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4415464296
MESH:D009401 Nephrosis Doxorubicin 4.7016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9415640375 16889571
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D009447 Neuroblastoma Cisplatin 7.038761367
MESH:D009447 Neuroblastoma Doxorubicin 7.0315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9920387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 11.628761367
MESH:D017599 Neuroectodermal Tumors Vincristine 11.6212837982
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D009503 Neutropenia Mustard Gas 3.917688884 16761898
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.934026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 8.9314694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D012516 Osteosarcoma Doxorubicin 4.0615930896
MESH:D010051 Ovarian Neoplasms Cisplatin 5.0919769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms decitabine 5.0919259094 19331143
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 16.1119003803
MESH:D010190 Pancreatic Neoplasms decitabine 16.1119294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 16.1116540662
MESH:D010190 Pancreatic Neoplasms Etoposide 16.1119003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 16.1115113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2415464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1017983394
MESH:D010954 Plasmacytoma Selenium 4.8315087411
MESH:D010997 Pleural Neoplasms Cisplatin 13.7517638057
MESH:D010997 Pleural Neoplasms Doxorubicin 13.7517638057
MESH:D011041 Poisoning Mustard Gas 3.7315727166
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.492563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.5821297632
MESH:D055728 Primary Myelofibrosis decitabine 4.6617616702
MESH:D011471 Prostatic Neoplasms Azacitidine 1.9018324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9016729912 15897917 16868541 18437689 15749863 16888761
MESH:D011471 Prostatic Neoplasms Etoposide 1.9017172428
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.9018760546
MESH:D011537 Pruritus Mustard Gas 4.0318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9017720292 17894541 17620002 17266442 10334151
MESH:D051437 Renal Insufficiency Cisplatin 10.1715464296
MESH:D051437 Renal Insufficiency Doxorubicin 10.1717922066
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.3419155313
MESH:D012509 Sarcoma Doxorubicin 3.9318313854 16767912 17203757 17710206 15675481 15625365
MESH:D012512 Sarcoma, Ewing's Cisplatin 17.0214601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 17.0214601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 17.0214601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7317846226
MESH:D012871 Skin Diseases Mustard Gas 2.7015451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7010029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 5.7015692506
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2915464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5017203757 16767912 15625365
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.692093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.6915958060 17522103 18396642
MESH:D013274 Stomach Neoplasms decitabine 4.6919037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6918456281
MESH:D015173 Supratentorial Neoplasms Vincristine 5.8112837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.5715464296 17225452
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.701399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms decitabine 16.7017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.707505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.7016010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.558074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.5517053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 15.5515464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.5519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.5517653716
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.1516803524
MESH:D014604 Uveal Neoplasms decitabine 4.8617785578
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5515577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1617678736 17334414 17638931 16364871
MESH:D014839 Vomiting Cisplatin 4.6611897121
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34886
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA128406956fluorouracil
    PA450198leucovorin
    PA450205levamisole
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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