AutismKB 2.0

Annotation Detail for DCHS1


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Basic Information Top
Gene Symbol:DCHS1 ( CDH25,CDHR6,FIB1,FLJ11790,KIAA1773,PCDH16 )
Gene Full Name: dachsous 1 (Drosophila)
Band: 11p15.4
Quick LinksEntrez ID:8642; OMIM: 603057; Uniprot ID:PCD16_HUMAN; ENSEMBL ID: ENSG00000166341; HGNC ID: 13681
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DCHS1 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of DCHS1 mRNAaffects expression 17484886
C014347 decitabine decitabine results in increased expression of DCHS1 mRNAincreases expression 19194470
D004041 Dietary Fats Dietary Fats results in increased expression of DCHS1 mRNAincreases expression 18042831
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of DCHS1 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DCHS1 mRNAdecreases expression 17557909
D007657 Ketone Bodies Ketone Bodies results in decreased expression of DCHS1 mRNAdecreases expression 16807920
C041786 palm oil palm oil results in increased expression of DCHS1 mRNAincreases expression 18042831
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of DCHS1 mRNAaffects cotreatment|decreases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DCHS1 mRNAincreases expression 18495758
16443690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.6415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715845082 15665606 15380490
MESH:D001943 Breast Neoplasms decitabine 2.3818320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 2.3820435547
MESH:D001943 Breast Neoplasms Estradiol 2.3816675129 17289903 18497071 19861407 17018787 17261762 14630087 12948864
MESH:D001943 Breast Neoplasms Progesterone 2.3815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916011737 15721981 10355542 15700767 18705752 15673190 16050911 16227642 16097048 3786805 16124888 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.653084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6516924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6319215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017681005 16919318 11677210 16105132 17333356 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 12621046 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3910915739 12705907 16081117 11739529 19739265 14725611 11287661 12392966 11461765 12153990 11421492 11743745 16109766 10774834 17522070 16781746 15968718 14550746 17906064 10663392 18071297 15619225 19416960 19370779 12958197 16485898 19923254 17562736 11834606 18713872 19420014 12540782 19164858 11529661 16227642 16393943 2444490 19085960 12594235 16177239 14986274
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3915998439 7179309 16177239 10915739 15968718 6884620 6623471 15027814 7120509 10092053 11566570 16227642 3786805 7440962 3732212 9327722 19085960 2869522 19336974 21278145 4309450 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.7017692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3819294695
MESH:D016889 Endometrial Neoplasms Estradiol 3.0918566989 19148513 11473722
MESH:D004715 Endometriosis Progesterone 9.4716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.479294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.1316239168 61145 17595544 12631006 19224547 12795759 16045604 15959796
MESH:D005234 Fatty Liver Dietary Fats 14.1319551842 18296743 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0718705752
MESH:D005355 Fibrosis Dietary Fats 16.0718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0720067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6019215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male decitabine 7.0917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0917937319
MESH:D007249 Inflammation Dietary Fats 8.7920412841
MESH:D007249 Inflammation Progesterone 8.7915869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.7311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.7316393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1215610895
MESH:D007938 Leukemia decitabine 3.1519235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1718454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4017679729 18704418 18460780 18206229 19010910 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9211408273 17334410 16943688 17157831 11903743 21278145 16221502 17174718 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5314716833 17922224 14748882 12546737 18277467 17698563 12609069 18395914 14724832 12389079 16136751 16015684 18395095 12667390 11481614 15370692 20821823 17805973 17481882 17708605 18472094 17557913 12649538 18054572 17869086 17721639 16033810 15818738 15931870 14512876 18472332 12632514 16097048 15338365 18420326 18006644 17900296 18418968 12958196 18205269 15996030 10355542 18429990 17823541 18263696 18412020 18705752 18279442 15057751 15925388 16116963 14620537 17631135 17525996 12632512 12898905 16192424 13678700 16011737 12445418 17640975 17714472 17944888 18376398 15052691 16638106 18317297 18210741 18187930 15730626 18339082 14716496 15362042 17761835 17976157 12666154 17766677 18251166 16027843 16248980 12445421 15673190 15123356 18156304 15959796 18166357 18481824 12741479 15893842 12586293 15650968 15876570 17565644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0319014921 12969438 19784758 16611625 12587719 16610002 11587558 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0317285989 15830285 15720792 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008223 Lymphoma decitabine 3.5419470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4117203775 11408345 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4111408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009101 Multiple Myeloma decitabine 3.4618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4718608210 16882708 19157545 19010910
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009369 Neoplasms decitabine 2.7817925555 19116145 19470736
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 10.1416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Dietary Fats 2.3220132043 18674790 21332399 18457598 17217161 20518802 16723640 19632207 11836018
MESH:D010051 Ovarian Neoplasms decitabine 8.2119259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 8.2119401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.2117393432 16525653
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8219294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11118676 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.9417616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5919155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.5216503802 15862959
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4617967635
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7819087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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