AutismKB 2.0

Annotation Detail for AKR1C3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AKR1C3 ( DD3,DDX,HA1753,HAKRB,HAKRe,HSD17B5,KIAA0119,PGFS,hluPGFS )
Gene Full Name: aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Band: 10p15.1
Quick LinksEntrez ID:8644; OMIM: 603966; Uniprot ID:AK1C3_HUMAN; ENSEMBL ID: ENSG00000196139; HGNC ID: 386
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-378androgen biosynthesis
PWY66-380estrogen biosynthesis
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
METABOLIC
lung cancer
testosterone
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C119129 18alpha-glycyrrhetinic acid 18alpha-glycyrrhetinic acid affects the activity of AKR1C3 proteinaffects activity 11165023
C031903 1-UFT protocol AKR1C3 protein results in increased susceptibility to 1-UFT protocolincreases response to substance 16734730
C520534 2'-hydroxyflavanone 2'-hydroxyflavanone results in decreased activity of AKR1C3 proteindecreases activity 19007764
C429845 7-hydroxyflavone 7-hydroxyflavone results in decreased activity of AKR1C3 proteindecreases activity 19007764
C005399 9,10-phenanthrenequinone AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinoneincreases metabolic processing 17950253
C005399 9,10-phenanthrenequinone AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinoneincreases reduction 19442656
C005399 9,10-phenanthrenequinone [AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxidesincreases abundance|increases reduction 19442656
C005399 9,10-phenanthrenequinone Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]decreases reaction|increases metabolic processing 17950253
C005399 9,10-phenanthrenequinone Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]decreases reaction|increases metabolic processing 17950253
C005399 9,10-phenanthrenequinone N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]decreases reaction|increases metabolic processing 17950253
D000735 Androstenedione AKR1C3 protein results in increased reduction of Androstenedioneincreases reduction 17950253
D000735 Androstenedione Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]decreases reaction|increases reduction 17950253
D000735 Androstenedione Indomethacin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]decreases reaction|increases reduction 17950253
D000735 Androstenedione N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]decreases reaction|increases reduction 17950253
D047310 Apigenin Apigenin results in decreased activity of AKR1C3 proteindecreases activity 16023337
C006632 arsenic trioxide arsenic trioxide results in increased expression of AKR1C3 mRNAincreases expression 19128835
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of AKR1C3 mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of AKR1C3 mRNAincreases expression 20106945
C095105 bexarotene bexarotene results in increased expression of AKR1C3 mRNAincreases expression 17178900
C004541 biochanin A biochanin A results in decreased activity of AKR1C3 proteindecreases activity 19007764
C110904 capecitabine AKR1C3 protein results in increased susceptibility to capecitabineincreases response to substance 16734730
D003375 Coumestrol Coumestrol results in decreased activity of AKR1C3 proteindecreases activity 19007764
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of AKR1C3 mRNAincreases expression 19665456
D004054 Diethylstilbestrol sodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of AKR1C3 mRNA]increases expression|increases reaction 19665456
C025034 doxifluridine AKR1C3 protein results in increased susceptibility to doxifluridineincreases response to substance 16734730
D004317 Doxorubicin AKR1C3 protein affects the reduction of Doxorubicinaffects reduction 18635746
C108373 dutasteride dutasteride results in increased expression of AKR1C3 mRNAincreases expression 16806904
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of AKR1C3 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of AKR1C3 mRNAdecreases expression 19619570
D015025 Zearalenone Zearalenone results in decreased activity of AKR1C3 proteindecreases activity 16023337
D005439 Flufenamic Acid Flufenamic Acid binds to AKR1C3 proteinaffects binding 14996743
D005439 Flufenamic Acid Flufenamic Acid results in decreased activity of AKR1C3 proteindecreases activity 19007764
19442656
D005472 Fluorouracil AKR1C3 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005472 Fluorouracil Fluorouracil affects the expression of AKR1C3 mRNAaffects expression 16584549
C071834 glycidamide glycidamide results in increased expression of AKR1C3 mRNAincreases expression 17822822
D007213 Indomethacin Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]decreases reaction|increases metabolic processing 17950253
D007213 Indomethacin Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]decreases reaction|increases reduction 17950253
D007213 Indomethacin Indomethacin analog results in decreased activity of AKR1C3 proteindecreases activity 17950253
D007213 Indomethacin Indomethacin binds to AKR1C3 proteinaffects binding 14996743
D007213 Indomethacin Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]decreases reaction|increases metabolic processing 17950253
D007213 Indomethacin Indomethacin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]decreases reaction|increases reduction 17950253
D007213 Indomethacin Indomethacin results in decreased activity of AKR1C3 proteindecreases activity 17950253
D007213 Indomethacin Indomethacin results in decreased activity of AKR1C3 proteindecreases activity 19442656
19007764
C526888 N-(4-chlorobenzoyl)melatonin N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]decreases reaction|increases metabolic processing 17950253
C526888 N-(4-chlorobenzoyl)melatonin N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]decreases reaction|increases reduction 17950253
C526888 N-(4-chlorobenzoyl)melatonin N-(4-chlorobenzoyl)melatonin results in decreased activity of AKR1C3 proteindecreases activity 17950253
C005273 naringenin naringenin results in decreased activity of AKR1C3 proteindecreases activity 19007764
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of AKR1C3 mRNAincreases expression 17681415
D011794 Quercetin Quercetin results in decreased activity of AKR1C3 proteindecreases activity 19007764
D011794 Quercetin Quercetin results in decreased activity of AKR1C3 proteindecreases activity 16023337
C079198 S 1 (combination) AKR1C3 protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
C440975 silybin silybin results in decreased activity of AKR1C3 proteindecreases activity 19007764
C017947 sodium arsenite sodium arsenite results in increased expression of AKR1C3 mRNAincreases expression 19696165
12727804
C017947 sodium arsenite sodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of AKR1C3 mRNA]increases expression|increases reaction 19665456
D013481 Superoxides [AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxidesincreases abundance|increases reduction 19442656
D014284 Triiodothyronine Triiodothyronine results in increased expression of AKR1C3 mRNAincreases expression 15507505
D013739 Testosterone AKR1C3 promoter SNP results in increased abundance of Testosteroneincreases abundance 16263811
C004648 testosterone enanthate testosterone enanthate affects the expression of AKR1C3 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of AKR1C3 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AKR1C3 mRNAdecreases expression 19619570
D014501 Uranium Uranium affects the expression of AKR1C3 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of AKR1C3 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4615322242 11752688 14514962
MESH:D058186 Acute Kidney Injury Superoxides 4.7518460982
MESH:D000230 Adenocarcinoma arsenic trioxide 15.6419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.6420464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 15.6417418594
MESH:D000230 Adenocarcinoma Estradiol 15.6411473722
MESH:D000230 Adenocarcinoma Fluorouracil 15.6417638652
MESH:D000230 Adenocarcinoma Indomethacin 15.6416537180
MESH:D000236 Adenoma Benzo(a)pyrene 9.936695378
MESH:D000236 Adenoma beta-Naphthoflavone 9.9319389873
MESH:D000236 Adenoma Indomethacin 9.9311497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.9916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5016712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.1721441931
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9717225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6117627676 15579461
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1115469931
MESH:D000740 Anemia Fluorouracil 7.5516511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5511748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8917084956
MESH:D000756 Anemia, Sideroblastic Superoxides 5.2716910769
MESH:D000987 Antisocial Personality Disorder Testosterone 5.457506515
MESH:D001014 Aortic Aneurysm Indomethacin 4.4710231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.4319183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.4310388637
MESH:D018771 Arthralgia Indomethacin 4.772160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7311248219
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5815336622
MESH:D001327 Autoimmune Diseases Quercetin 4.0219761891
MESH:D001477 Bartter Syndrome Indomethacin 4.6010684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.7916206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3014601052
MESH:D001929 Brain Edema Indomethacin 4.6211481608
MESH:D002545 Brain Ischemia Indomethacin 4.0312524144
MESH:D001932 Brain Neoplasms Doxorubicin 3.4717150277
MESH:D001943 Breast Neoplasms Apigenin 10.4816541309 17132221
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 10.4817474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 10.4816344269 16818667
MESH:D001943 Breast Neoplasms capecitabine 10.4818473752 12972520
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.4817129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 10.4818234424 15634643 16096432 15692762 15668708 16826403 15994142 15993339 11325840 18695136 17369602 17426702 18628466 15567936 16115903 16322301 17983394 16935488 18382427 16595493 15136595 16264153 15939500 19526202
MESH:D001943 Breast Neoplasms dutasteride 10.4816806904
MESH:D001943 Breast Neoplasms Estradiol 10.4816675129 18497071 12948864 17289903 17018787 19861407 14630087 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 10.4816595493 16110121 19217205 18357371 18608205 16557594 15136595
MESH:D001943 Breast Neoplasms Indomethacin 10.4817401462
MESH:D001943 Breast Neoplasms Quercetin 10.4818628248
MESH:D001943 Breast Neoplasms Testosterone 10.4817261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.4820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9711589617
MESH:D002056 Burns Indomethacin 4.3210459503
MESH:D002100 Cachexia Indomethacin 4.6111239499 16537180 15141370 15625704
MESH:D002105 Cadmium Poisoning Quercetin 5.1416962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.0116051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.0116051944
MESH:D002277 Carcinoma Fluorouracil 7.1617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1616835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.6014691202 16217749 15073043 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 15.6016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 15.6016023760 16234567 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.6016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.6017971768 17045692 16799960 18930000 17088986 16332177
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 15.6016391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 15.6019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.6015276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9614736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.7616247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 5.7618212800 18347146
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4719014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.7516201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.7518695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 9.7517341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.4220419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.426189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 16.4216757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 16.4212636206 15482327
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 16.4215984520
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.4218572023
MESH:D006332 Cardiomegaly Quercetin 6.0519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.0518670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2716952015 17329180 15811867 17308081 15792986 17007740 16731534 15476868 16278810 17519947 15505089 17131338 17351982 16364871 16651473 16612575 16109756 16242529 17928571 17974986 18627295 17382496 16269455 17924179 16455267
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8016243910 17334414
MESH:D002471 Cell Transformation, Neoplastic marker/mechanism 19696165
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.8418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 5.8420056578 19524636
MESH:D002659 Child Development Disorders, Pervasive Androstenedione 6.4521398041
MESH:D002659 Child Development Disorders, Pervasive Testosterone 6.4520678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8316835633
MESH:D002764 Cholecystitis Indomethacin 4.7711181007
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9315340226 8697196 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 5.4317169374 18772588 17016597 16340194 17287894 17725105 17172411 16510598 17018589 15001691
MESH:D003110 Colonic Neoplasms Indomethacin 5.4315637740 15786552 15963497 15936596 15625704 11260862
MESH:D003110 Colonic Neoplasms Quercetin 5.4319056647 11134977 16640504 17148506 17191121 19440933 15741050
MESH:D015179 Colorectal Neoplasms arsenic trioxide 7.8020501625
MESH:D015179 Colorectal Neoplasms capecitabine 7.8018473752 18448328
MESH:D015179 Colorectal Neoplasms Doxorubicin 7.8018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 7.8017594712 20501625 18288408 18448328 18949393 16524972 16331619 17094418 17255274 17695437 15289873 18802399 17016601 16391804 14970324 18509181 17454858 16282729 17401013 15148649 18383874 16303861
MESH:D015179 Colorectal Neoplasms Indomethacin 7.8018059344 11197048 17054584 12606626
MESH:D015179 Colorectal Neoplasms Quercetin 7.8018852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7317141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8112609071
MESH:D003329 Coronary Vasospasm capecitabine 5.4317465463
MESH:D018352 Coronavirus Infections Indomethacin 5.3217302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.3310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3310048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1812952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.4016733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7315213294
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4219496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0819279558
MESH:D003967 Diarrhea Indomethacin 3.437907874 7237001
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 3.4617416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.4620420201
MESH:D004362 Drug Toxicity Doxorubicin 7.1418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.1411462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7518446180 16326151 18043480 12774134 17190690 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.7711535926 10671773 17045617 17202747 17351913 11595431 11595415 16699067 11991626 17329845 17151854
MESH:D004487 Edema Indomethacin 9.5910653021 19703484 8273558 7907874 7990266 16100529 8985016
MESH:D004487 Edema perfluorooctanoic acid 9.5917259670 12083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.5911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5018230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3016402032
MESH:D016889 Endometrial Neoplasms marker/mechanism 16338060
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.0215700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.0217359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.0218566989 11473722 19148513
MESH:D004715 Endometriosis Indomethacin 7.9415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.9410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7518037988
MESH:D019446 Endotoxemia Indomethacin 4.1118509659
MESH:D004751 Enteritis Indomethacin 4.3517763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6017980183
MESH:D004802 Eosinophilia Indomethacin 3.6711298111
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.4712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.4716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.4716337965 16481741 15173087 17638652 16785472
MESH:D004938 Esophageal Neoplasms Indomethacin 9.4711005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005234 Fatty Liver arsenic trioxide 2.9515073043
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4116002989 16611131 15751030 16534752 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D005334 Fever Indomethacin 3.7811852909 17627676 10431976
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1919069698
MESH:D005354 Fibrosarcoma Indomethacin 4.5010962813
MESH:D005355 Fibrosis Indomethacin 12.6717994277
MESH:D005355 Fibrosis Quercetin 12.6719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6720067830
MESH:D005391 Firesetting Behavior Testosterone 5.457506515
MESH:D005499 Folliculitis Indomethacin 4.7711298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 10.5416904648
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 10.5419093184
MESH:D005756 Gastritis Indomethacin 4.3515046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.5016452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.5016452187
MESH:D005909 Glioblastoma biochanin A 19.5516598420
MESH:D005909 Glioblastoma Doxorubicin 19.5517150277
MESH:D005909 Glioblastoma Indomethacin 19.5512870263
MESH:D005909 Glioblastoma Quercetin 19.5519804834
MESH:D005909 Glioblastoma Testosterone 19.5517162496
MESH:D005910 Glioma Fluorouracil 9.0316145905
MESH:D005910 Glioma Indomethacin 9.0318371953 16487511
MESH:D005910 Glioma Quercetin 9.0317643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9711849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006073 Gout Indomethacin 4.9611248219
MESH:D006258 Head and Neck Neoplasms Doxorubicin 16.3515692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 16.3515102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 16.3515482327
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 16.3515984520 18607998
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7311294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.2116244371 16244372 18674790 16495754 16707910 17875725 16144979 18006777 14766674 16330681 17888722 16879835 12587719
MESH:D006333 Heart Failure Doxorubicin 3.1017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5515692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2215633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3115135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 7.393609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3916120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006628 Hirsutism Testosterone 5.2517019078
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3417440010
MESH:D006689 Hodgkin Disease Doxorubicin 6.3918501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.3912676792
MESH:D019584 Hot Flashes Estradiol 3.3517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6416354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Indomethacin 7.2312727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.2312083418
MESH:D034321 Hyperamylasemia Indomethacin 5.3217883296
MESH:D017588 Hyperandrogenism Testosterone 4.9117019078
MESH:D006940 Hyperemia Indomethacin 4.6112524144
MESH:D006943 Hyperglycemia Quercetin 3.6918262572 11834736
MESH:D020138 Hyperhomocysteinemia Superoxides 4.9412615666
MESH:D006949 Hyperlipidemias Indomethacin 3.8017546600
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0514722030 12960047
MESH:D006973 Hypertension Quercetin 4.6918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6918670907 18850075
MESH:D007006 Hypogonadism Testosterone 4.3112002444
MESH:D007018 Hypopituitarism Testosterone 5.8017426086
MESH:D007021 Hypospadias Diethylstilbestrol 4.1916002989
MESH:D007077 Ileal Diseases Indomethacin 4.6210574470 18306037
MESH:D007079 Ileitis Indomethacin 4.9610647630 16133968 10651667
MESH:D007174 Impulse Control Disorders Testosterone 5.457506515
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9716133044
MESH:D007246 Infertility Diethylstilbestrol 3.9815036965
MESH:D007248 Infertility, Male Coumestrol 6.6016892005
MESH:D007248 Infertility, Male sodium arsenite 6.6012646999 15346721
MESH:D007249 Inflammation Indomethacin 7.213291741 7812673 12568917
MESH:D007249 Inflammation perfluorooctanoic acid 7.2112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.2112878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.1116624496
MESH:D007333 Insulin Resistance Estradiol 2.7116393666 16627594
MESH:D007410 Intestinal Diseases Indomethacin 9.2215831440 10210152 11686837 18236018 11855677 11713966 17994277 17329856 15610444
MESH:D007410 Intestinal Diseases Superoxides 9.2210210152
MESH:D019586 Intracranial Hypertension Indomethacin 4.9715241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9816580747
MESH:D007579 Jejunal Diseases Indomethacin 4.6216133968 10574470 18306037
MESH:D007627 Keloid Quercetin 4.5717086741
MESH:D007674 Kidney Diseases Doxorubicin 16.6115699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 16.6115618244
MESH:D007674 Kidney Diseases Indomethacin 16.6117190690
MESH:D007674 Kidney Diseases Quercetin 16.6116962696
MESH:D007674 Kidney Diseases sodium arsenite 16.6120008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8016707910
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.6715003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 10.6715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 10.6716985049
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6817184923
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5912228301 10320625 11703811
MESH:D007938 Leukemia arsenic trioxide 5.8015070760
MESH:D007938 Leukemia Quercetin 5.8017468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7516085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.5914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.5910785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8120471514 17050201 16467208 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.8118360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9612679006 16891316 12018890 11161223 15622746 15213294 17869043 11468182 16330433 16966277 16331271 16112521 9834237 17649720 15748426 16823087 17217047 19225113 15336539 17107899 19642359 19075265 17712046 19035177 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9816882451
MESH:D007964 Leukocytosis Indomethacin 4.9716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3217980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.838812269
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3211479899
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 10.0316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.0314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 10.0318194892
MESH:D008106 Liver Cirrhosis, Experimental naringenin 10.0314709902
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.0312741479
MESH:D008106 Liver Cirrhosis, Experimental silybin 10.0316169303
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.0312878042
MESH:D008107 Liver Diseases naringenin 3.8516945181
MESH:D008113 Liver Neoplasms arsenic trioxide 26.9514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.9520195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 26.9519389873 21295105
MESH:D008113 Liver Neoplasms Diethylstilbestrol 26.9515890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 26.9518383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 26.9514757943 18709148
MESH:D008113 Liver Neoplasms Quercetin 26.9518980244
MESH:D008113 Liver Neoplasms sodium arsenite 26.9516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.9516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.0120377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.0118164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 16.0116842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 16.0119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.0112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0515213294
MESH:D008171 Lung Diseases sodium arsenite 2.9119095001
MESH:D008175 Lung Neoplasms arsenic trioxide 16.6611798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 16.6620135361 18816296 17053015 18569708 6695378 20869020 18520028 20064080 20464547
MESH:D008175 Lung Neoplasms bexarotene 16.6617849452
MESH:D008175 Lung Neoplasms Doxorubicin 16.666189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 16.6615246190
MESH:D008175 Lung Neoplasms Indomethacin 16.6616537180 11497255 11053908
MESH:D008175 Lung Neoplasms Quercetin 16.6616280456
MESH:D008175 Lung Neoplasms silybin 16.6616788158
MESH:D008175 Lung Neoplasms sodium arsenite 16.6619931552 17077188 16712894 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.6611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7515166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.8115700306
MESH:D008223 Lymphoma Doxorubicin 6.8116098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1815621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7611161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1116002989
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 8.6119196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.6115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.6111807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D008545 Melanoma Doxorubicin 3.2216827129
MESH:D008545 Melanoma sodium arsenite 3.2216487513 19082730
MESH:D008654 Mesothelioma Doxorubicin 2.9017638057
MESH:D008881 Migraine Disorders Indomethacin 3.4011903285
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1515792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.6816381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.6818986760 16757204
MESH:D009062 Mouth Neoplasms Indomethacin 12.6812636206
MESH:D052016 Mucositis Doxorubicin 4.4017415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8311468182 19417148 19549372 14977855 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9116882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 5.4415857846 19429709
MESH:D009203 Myocardial Infarction Quercetin 5.4419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5616810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.5619207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5916624393
MESH:D009362 Neoplasm Metastasis capecitabine 8.8412972520
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.8418259882
MESH:D009362 Neoplasm Metastasis Indomethacin 8.8416537180 11239499 11053908
MESH:D009369 Neoplasms Benzo(a)pyrene 20.9211141357
MESH:D009369 Neoplasms capecitabine 20.9216374040
MESH:D009369 Neoplasms Diethylstilbestrol 20.9215313581
MESH:D009369 Neoplasms Fluorouracil 20.9216928823 18600527 18239605
MESH:D009369 Neoplasms naringenin 20.9215185748
MESH:D009369 Neoplasms Quercetin 20.9215185748
MESH:D009369 Neoplasms sodium arsenite 20.9211559025
MESH:D009374 Neoplasms, Experimental Indomethacin 8.0015625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.0020056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3819196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009401 Nephrosis Doxorubicin 4.3816636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6715640375 16889571
MESH:D009421 Nervous System Malformations Diethylstilbestrol 14.2111399458
MESH:D009421 Nervous System Malformations Estradiol 14.2116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 6.4710525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.4712854658
MESH:D009447 Neuroblastoma Doxorubicin 3.0515555623
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.6212349958
MESH:D020078 Neurogenic Inflammation Quercetin 4.0017929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1716436463
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.579802331
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.776374098
MESH:D010003 Osteoarthritis Indomethacin 3.437009135
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.8619495926
MESH:D012516 Osteosarcoma Doxorubicin 3.8015930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.1716624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 10.1719401270
MESH:D010051 Ovarian Neoplasms Quercetin 10.1719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.1715276417 17306315
MESH:D010146 Pain Indomethacin 3.1613679232 17627676 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.2812538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 7.8015580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.8019003803 16500647 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Quercetin 7.8016965848
MESH:D010195 Pancreatitis Indomethacin 3.5615028970 17883296
MESH:D010235 Paraganglioma arsenic trioxide 3.8019927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3216537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010437 Peptic Ulcer Indomethacin 4.7511148446
MESH:D010518 Periodontitis Indomethacin 4.5117225004
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7517983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.2916977796 15687265
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7517638057
MESH:D011085 Polycystic Ovary Syndrome marker/mechanism 16263811
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Quercetin 3.6519056647
MESH:D047928 Premature Birth Indomethacin 4.7417000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.0617184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 14.0617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.0611896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 9.6920887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 18306354 17507624
MESH:D011471 Prostatic Neoplasms Apigenin 4.0117132221
MESH:D011471 Prostatic Neoplasms arsenic trioxide 4.0119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.0117292933
MESH:D011471 Prostatic Neoplasms biochanin A 4.0112111696
MESH:D011471 Prostatic Neoplasms Coumestrol 4.0116921512
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.0115846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.0115897917 16868541 16888761 16729912 15749863 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 4.0116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.0118626508 19082440
MESH:D011471 Prostatic Neoplasms Quercetin 4.0114715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.0116039940
MESH:D011507 Proteinuria Indomethacin 3.8011849393
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6818722050 15538739 16160472 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 3.8417922066
MESH:D015427 Reperfusion Injury Superoxides 4.3218460982
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012509 Sarcoma Doxorubicin 3.6518313854 16767912 15675481 17203757 15625365 17710206
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.0316646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.0314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4017846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.1416862918
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.8016631401
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.9510029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 11.9515692506
MESH:D012878 Skin Neoplasms sodium arsenite 11.9519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.9516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1815625365 16767912 17203757
MESH:D013088 Spermatocele Diethylstilbestrol 4.3116002989 16709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4912854658
MESH:D013272 Stomach Diseases Indomethacin 4.0316184426 10486359 15038085 10215738 16280098 10192188 17207306 17160473 18209964 15472012 17638125 16113693 18545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.9217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.9220155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 5.9217172411 17522103 19084572 18396642 15786421 16424979 19015929 17498489 16951190 18567086
MESH:D013274 Stomach Neoplasms Indomethacin 5.9215609394
MESH:D013274 Stomach Neoplasms S 1 (combination) 5.9218553229 16557585 18506536
MESH:D013276 Stomach Ulcer Indomethacin 3.2516397915 10878458 11523592 18431645 15138204 17627676 16150113 17135157 12498302 18543354 12467913 10423059 11145282 10750652 15255614 1323529 15104355 16755016 12500499 16169175 18237397 11729361 12077510 18726076 14567935 16631530 16252198 12787963 18087811 18193104 11595431 17895592 11595415 18299717 17977527 17918041 18209962 11906479 18181030 17654042 16934674 17657623
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.3819014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.3816010429 17909728
MESH:D013964 Thyroid Neoplasms Indomethacin 10.3814736730 18791128 11352223
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6516280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5715213294
MESH:D014456 Ulcer Indomethacin 4.5010574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 17.7312973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 17.7317053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 17.7316452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 17.7317653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 17.7316720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 17.7316712894 17306315 11723127 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.9416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.9416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.9411813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.7714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.7015809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0516513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 4.0317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8417638931 16364871 17334414 17678736
MESH:D014839 Vomiting Indomethacin 4.3511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24679
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445425Prostatic Neoplasms
    Releated drug ID Related drug Name
    PA449412doxorubicin
    PA165291922doxorubicinol
    PA448871celecoxib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01093 - Synotic Otic Solution Free Radical Scavengers;Analgesics, Non-Narcotic;Solvents;Cryoprotective Agents
    DB01536 agonist 4-Androstenedione
    DB01698 - Rutin
    DB02056 - (5e,13e)-9,15-Dihydroxy-11-Oxoprosta-5,13-Dien-1-Oicacid
    DB02266 - Flufenamic Acid Anti-inflammatory Agents
    DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB03684 - 2-Methyl-2,4-Pentanediol
    DB04184 - Acetate Ion Indicators and Reagents
    DB06863 - (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE
    DB07386 - 4-ANDROSTENE-3-17-DIONE
    DB07700 - 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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