AutismKB 2.0

Annotation Detail for CHRD


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Basic Information Top
Gene Symbol:CHRD ( MGC133038 )
Gene Full Name: chordin
Band: 3q27.1
Quick LinksEntrez ID:8646; OMIM: 603475; Uniprot ID:CHRD_HUMAN; ENSEMBL ID: ENSG00000090539; HGNC ID: 1949
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04350TGF-beta signaling pathway
No data
Pathway IDPathway Name
200123BMP receptor signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CHRD mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CHRD mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CHRD mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CHRD mRNAaffects expression 16483693
D004958 Estradiol Estradiol affects the expression of CHRD mRNAaffects expression 14699072
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of CHRD mRNAincreases expression 12832660
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CHRD mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of CHRD mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of CHRD mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000419 Albuminuria Raloxifene 4.8317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Estradiol 1.9412948864 17261762 17289903 14630087 16675129 18497071 19861407 17018787
MESH:D001943 Breast Neoplasms Raloxifene 1.9417049068 17952589 15572757 17595753 17893378 17440819 16912660 16837676 15758505 17261762 17242785 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 1.9419244106 16202921 17261762 15668708 18821012 19189210 18984771 19142967 11161223 19189212 18629630 18855134 19066611 19011961 20390343 18351453 18997820 19084267 21152245 17893378 19289846 19221464 19059307 15565566 19288272 18815881 18425577 19410462 20859285 16873071 17242785 17440819 20065188 19487384 16818667 20544844 20005174 21138602 19103187 19115204 19200415 17049068 19155303 20135344 16273361
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.163084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1616924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.1616924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.1517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.1517572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.126135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1218566989
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.5212912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 8.7818590720 15500046 12927374 18164287 16629650 15913567 19486331 7624871
MESH:D002779 Cholestasis pirinixic acid 8.7819176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 6.1710220858 19407337
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Estradiol 16.1219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.1217451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.1219279558
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 9.477624871 18289764 17522070 20133375
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4718713872 19739265 11743745 16081117 11739529 19416960 18071297 10915739 12705907 16109766 17906064 11461765 16227642 14725611 19420014 16781746 19923254 16177239 11421492 11287661 12392966 15968718 12958197 19085960 10663392 14986274 12153990 19370779 12594235 2444490 17522070 16485898 11529661 15619225 14550746 19164858 16393943 12540782 11834606 17562736 10774834
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 7.5812083418
MESH:D004487 Edema Raloxifene 7.5815860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0519031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.8218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.8219155303 17893378 20544844 16202921
MESH:D005234 Fatty Liver pirinixic acid 14.3820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 14.3817473493
MESH:D005234 Fatty Liver Tamoxifen 14.3814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 4.9318590720
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 18467677 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Raloxifene 2.9315787275 17577099
MESH:D007249 Inflammation Tamoxifen 2.4519457130
MESH:D007333 Insulin Resistance Estradiol 7.6216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.6216306350
MESH:D007674 Kidney Diseases Acetaminophen 6.2515629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.2515618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.2316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.2316705839
MESH:D007680 Kidney Neoplasms Estradiol 19.2315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 19.2318625569
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5618564211
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 4.4517184895
MESH:D008107 Liver Diseases Acetaminophen 4.4516611625 19460945 19784758 12969438 11587558 19014921 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.797678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.7915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.7916684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.666135515 2876784 2876786
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.3916827153 14580682 19196722 11731420 19196723
MESH:D020149 Manganese Poisoning Estradiol 13.7319453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.7319453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5816497877
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 3.8916427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010024 Osteoporosis Raloxifene 3.5119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 6.1720133375
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5516536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5515067354
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D013088 Spermatocele Tamoxifen 4.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.9520133375
MESH:D013978 Tibial Fractures Estradiol 14.8019048282
MESH:D013978 Tibial Fractures Raloxifene 14.8019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.5316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.5316049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.5317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.5316712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
Pathway ID Pathway Name
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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