AutismKB 2.0

Annotation Detail for ABCB11


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Basic Information Top
Gene Symbol:ABCB11 ( ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP )
Gene Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Band: 2q31.1
Quick LinksEntrez ID:8647; OMIM: 603201; Uniprot ID:ABCBB_HUMAN; ENSEMBL ID: ENSG00000073734; HGNC ID: 42
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa02010ABC transporters
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500828Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
500831Recycling of bile acids and salts
Related Diseases/Disorders Top
No data
No data
Desease Name
other metabolic traits
fasting plasma glucose
PHARMACOGENOMIC
cholestasis
METABOLIC
plasma glucose, basal hepatic glucose and increased insulin release
cholestasis, drug-induced hepatotoxicity
No data
Desease Name
Cholestasis, benign recurrent intrahepatic, 2
Cholestasis, progressive familial intrahepatic 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester affects the localization of and affects the activity of ABCB11 proteinaffects activity|affects localization 15763547
C466800 1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane 1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane results in decreased expression of ABCB11 mRNAdecreases expression 15254889
C002029 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol 17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol results in increased expression of ABCB11 mRNAincreases expression 17275934
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABCB11 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ABCB11 mRNAaffects expression 21346803
C095489 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ABCB11 protein affects the transport of 4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneaffects transport 12739759
C464660 6-ethylchenodeoxycholic acid 6-ethylchenodeoxycholic acid promotes the reaction [PRMT1 protein binds to ABCB11 promoter]affects binding|increases reaction 15911693
C464660 6-ethylchenodeoxycholic acid 6-ethylchenodeoxycholic acid results in increased expression of ABCB11 mRNAincreases expression 15911693
C464660 6-ethylchenodeoxycholic acid 6-ethylchenodeoxycholic acid results in increased expression of ABCB11 mRNAincreases expression 15644430
D000082 Acetaminophen Acetaminophen affects the expression of ABCB11 mRNAaffects expression 17562736
D000082 Acetaminophen [Acetaminophen co-treated with Sodium Chloride] results in decreased expression of ABCB11 mRNAaffects cotreatment|decreases expression 17934960
D000082 Acetaminophen Acetaminophen results in decreased expression of ABCB11 mRNAdecreases expression 17522070
D000255 Adenosine Triphosphate Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]increases reaction|increases uptake 18245269
D000255 Adenosine Triphosphate Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]increases reaction|increases uptake 18245269
C031442 Agkistrodon venoms Agkistrodon venoms results in increased expression of ABCB11 mRNAincreases expression 15844712
D017962 alpha-Linolenic Acid alpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]increases expression|increases reaction 15307955
D016718 Arachidonic Acid Arachidonic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]increases expression|increases reaction 15307955
C065179 atorvastatin atorvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C065179 atorvastatin atorvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C095105 bexarotene bexarotene results in increased expression of ABCB11 mRNAincreases expression 16648578
D001629 Bezafibrate Bezafibrate results in decreased expression of ABCB11 mRNAdecreases expression 15447978
D001647 Bile Acids and Salts ABCB11 protein affects the export of Bile Acids and Saltsaffects export 15696852
D001647 Bile Acids and Salts ABCB11 protein affects the secretion of Bile Acids and Saltsaffects secretion 15841457
D001647 Bile Acids and Salts ABCB11 protein affects the transport of Bile Acids and Saltsaffects transport 12663868
15582136
D001647 Bile Acids and Salts Bile Acids and Salts analog results in increased expression of ABCB11 mRNAincreases expression 15145977
D001647 Bile Acids and Salts Bile Acids and Salts results in increased expression of ABCB11 mRNAincreases expression 12705905
D001647 Bile Acids and Salts pregna-4,17-diene-3,16-dione inhibits the reaction [Bile Acids and Salts results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 12705905
D001647 Bile Acids and Salts ABCB11 protein results in increased secretion of Bile Acids and Saltsincreases secretion 14570929
D001647 Bile Acids and Salts Bile Acids and Salts promotes the reaction [PRKCA protein results in increased phosphorylation of ABCB11 protein]increases phosphorylation|increases reaction 11343252
D001647 Bile Acids and Salts Bile Acids and Salts results in increased activity of ABCB11 proteinincreases activity 11343252
D001647 Bile Acids and Salts Bile Acids and Salts results in increased expression of ABCB11 mRNAincreases expression 12135489
D001647 Bile Acids and Salts ABCB11 protein affects the export of Bile Acids and Saltsaffects export 15826951
D001647 Bile Acids and Salts ABCB11 protein affects the transport of Bile Acids and Saltsaffects transport 15901796
C472645 blebbistatin blebbistatin results in decreased localization of ABCB11 proteindecreases localization 15826951
C086232 bosentan bosentan metabolite results in decreased activity of ABCB11 proteindecreases activity 11309550
C086232 bosentan bosentan results in decreased activity of ABCB11 proteindecreases activity 15465654
15509663
11309550
D020122 tert-Butylhydroperoxide 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein]affects localization|decreases reaction 16452108
D020122 tert-Butylhydroperoxide Bucladesine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein]affects localization|decreases reaction 16452108
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide affects the localization of ABCB11 proteinaffects localization 16452108
C085925 calcein AM ABCB11 protein affects the export of calcein AMaffects export 10617675
C085925 calcein AM ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]affects export|decreases reaction 10617675
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ABCB11 mRNAdecreases expression 17522070
C086276 cerivastatin cerivastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C086276 cerivastatin cerivastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid results in increased expression of ABCB11 mRNAincreases expression 12519787
16423920
14684751
12525500
D002635 Chenodeoxycholic Acid LG 100268 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 12519787
D002635 Chenodeoxycholic Acid [pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 12525500
D002635 Chenodeoxycholic Acid ABCB11 protein affects the transport of Chenodeoxycholic Acidaffects transport 15297262
D002725 Chloroform Chloroform results in decreased expression of ABCB11 mRNAdecreases expression 17522070
D020355 Cholates Cholates results in increased expression of ABCB11 mRNAincreases expression 14684751
D020355 Cholates ABCB11 protein affects the transport of Cholatesaffects transport 15297262
D002777 Cholestanols Cholestanols analog results in increased expression of ABCB11 mRNAincreases expression 15145977
D002784 Cholesterol ABCB11 protein results in increased secretion of Cholesterolincreases secretion 14570929
D002791 Cholesterol, Dietary [Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 14684380
D019826 Cholic Acid Cholic Acid results in increased expression of ABCB11 mRNAincreases expression 12971955
15466244
11438506
15694933
D019826 Cholic Acid Cholic Acid results in increased expression of ABCB11 proteinincreases expression 15466244
11438506
D019826 Cholic Acid [Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 14684380
D019826 Cholic Acid Cholic Acid results in increased expression of ABCB11 mRNAincreases expression 14684380
C072313 cholyl-lysylfluorescein ABCB11 protein affects the secretion of cholyl-lysylfluoresceinaffects secretion 12865277
C019304 ciprofibrate ciprofibrate results in decreased expression of ABCB11 proteindecreases expression 12381268
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCB11 mRNAaffects cotreatment|affects expression 17602206
D003023 Cloxacillin Cloxacillin results in decreased activity of ABCB11 proteindecreases activity 15618715
D003023 Cloxacillin Cloxacillin results in decreased activity of ABCB11 proteindecreases activity 15618715
D003078 Colchicine Colchicine affects the localization of ABCB11 proteinaffects localization 15304119
12702492
C030123 coumarin coumarin affects the expression of ABCB11 mRNAaffects expression 16963487
D016572 Cyclosporine Cyclosporine results in decreased activity of ABCB11 proteindecreases activity 15618715
12739759
D016572 Cyclosporine Cyclosporine results in decreased activity of ABCB11 proteindecreases activity 11343252
D016572 Cyclosporine Cyclosporine affects the localization of ABCB11 proteinaffects localization 12563113
D016572 Cyclosporine Cyclosporine results in decreased activity of ABCB11 proteindecreases activity 15618715
D016572 Cyclosporine Cyclosporine results in decreased expression of ABCB11 mRNAdecreases expression 19224547
D003840 Deoxycholic Acid Deoxycholic Acid results in increased expression of ABCB11 mRNAincreases expression 14684751
D003994 Bucladesine Bucladesine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein]affects localization|decreases reaction 16452108
D004041 Dietary Fats Dietary Fats results in decreased expression of ABCB11 mRNAdecreases expression 17640958
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCB11 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ABCB11 mRNAdecreases expression 19638242
C110423 dihydrofluorescein ABCB11 protein affects the transport of dihydrofluoresceinaffects transport 12739759
C050898 ditekiren ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]affects export|decreases reaction 10617675
D004281 Docosahexaenoic Acids Docosahexaenoic Acids promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]increases expression|increases reaction 15307955
D004731 Endotoxins Endotoxins inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 15456840
D004918 Erythromycin Estolate Erythromycin Estolate results in decreased expression of ABCB11 mRNAdecreases expression 17522070
C025483 estradiol-17 beta-glucuronide estradiol-17 beta-glucuronide affects the localization of ABCB11 proteinaffects localization 12893835
12702498
C025483 estradiol-17 beta-glucuronide estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 proteinaffects activity|affects localization 15763547
D004958 Estradiol Estradiol results in decreased expression of ABCB11 mRNAdecreases expression 12135489
D004997 Ethinyl Estradiol ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]decreases expression|increases reaction 16606610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ABCB11 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ABCB11 mRNAdecreases expression 16606610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ABCB11 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ABCB11 mRNAdecreases expression 17108234
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ABCB11 proteindecreases expression 12187295
D004997 Ethinyl Estradiol Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]decreases expression|decreases reaction 12187295
C093230 fexofenadine Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]increases reaction|increases uptake 18245269
C093230 fexofenadine Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]increases reaction|increases uptake 18245269
C065180 fluvastatin fluvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C065180 fluvastatin fluvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C039281 furan furan results in decreased expression of ABCB11 mRNAdecreases expression 15120968
D005672 Fusidic Acid Fusidic Acid results in decreased activity of ABCB11 proteindecreases activity 12106615
D005905 Glyburide Glyburide results in decreased activity of ABCB11 proteindecreases activity 15618715
D005905 Glyburide Glyburide results in decreased activity of ABCB11 proteindecreases activity 11343252
D005905 Glyburide Glyburide results in decreased activity of ABCB11 proteindecreases activity 15465654
D005999 Glycochenodeoxycholic Acid ABCB11 protein affects the transport of Glycochenodeoxycholic Acidaffects transport 15297262
D006000 Glycocholic Acid ABCB11 protein affects the transport of Glycocholic Acidaffects transport 15791618
D006000 Glycocholic Acid ABCB11 protein affects the transport of Glycocholic Acidaffects transport 15297262
C024033 glycoursodeoxycholic acid ABCB11 protein affects the transport of glycoursodeoxycholic acidaffects transport 15297262
C018562 guggulu extract guggulu extract results in increased expression of ABCB11 mRNAincreases expression 12525500
C412815 GW 4064 alpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]increases expression|increases reaction 15307955
C412815 GW 4064 Arachidonic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]increases expression|increases reaction 15307955
C412815 GW 4064 Docosahexaenoic Acids promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]increases expression|increases reaction 15307955
C412815 GW 4064 GW 4064 results in increased expression of ABCB11 mRNAincreases expression 15911693
12519787
12525500
15307955
C412815 GW 4064 LG 100268 inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 12519787
C412815 GW 4064 [pregna-4,17-diene-3,16-dione co-treated with GW 4064] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 12525500
C412815 GW 4064 GW 4064 results in increased expression of ABCB11 mRNAincreases expression 14623915
15644430
D019307 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein]affects localization|decreases reaction 16452108
C095104 LG 100268 LG 100268 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 12519787
C095104 LG 100268 LG 100268 inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 12519787
C095104 LG 100268 LG 100268 inhibits the reaction [[NR1H4 protein binds to RXRA protein] which binds to ABCB11 promoter]affects binding|decreases reaction 12519787
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of ABCB11 proteindecreases expression 15205115
D008070 Lipopolysaccharides Lipopolysaccharides affects the expression of ABCB11 proteinaffects expression 15778272
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of ABCB11 mRNAdecreases expression 15313196
15312235
15778272
D008070 Lipopolysaccharides Lipopolysaccharides affects the localization of and results in decreased expression of ABCB11 proteinaffects localization|decreases expression 12706339
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of ABCB11 mRNAdecreases expression 15205389
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of ABCB11 proteindecreases expression 12795754
D008767 Methylmercury Compounds Methylmercury Compounds affects the expression of ABCB11 mRNAaffects expression 16966085
C026483 midecamycin midecamycin results in decreased activity of ABCB11 proteindecreases activity 15618715
C026483 midecamycin midecamycin results in decreased activity of ABCB11 proteindecreases activity 15618715
D015735 Mifepristone Mifepristone results in increased expression of ABCB11 mRNAincreases expression 15456840
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNAincreases expression 19407337
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNAdecreases expression 18187559
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNAdecreases expression 17522070
C051752 nefazodone nefazodone results in decreased activity of ABCB11 proteindecreases activity 16410371
C026209 oltipraz oltipraz results in decreased expression of ABCB11 mRNAdecreases expression 16837569
D010590 Phalloidine Phalloidine results in decreased localization of ABCB11 proteindecreases localization 12169763
D010634 Phenobarbital Phenobarbital results in decreased expression of ABCB11 mRNAdecreases expression 16837569
D010703 Phorbol Esters Phorbol Esters promotes the reaction [PRKCA protein results in increased phosphorylation of ABCB11 protein]increases phosphorylation|increases reaction 11343252
D010703 Phorbol Esters Phorbol Esters affects the localization of ABCB11 proteinaffects localization 14679204
D010713 Phosphatidylcholines ABCB11 protein results in increased secretion of Phosphatidylcholinesincreases secretion 14570929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ABCB11 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ABCB11 mRNAdecreases expression 18445702
C108475 pitavastatin pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C108475 pitavastatin pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C410026 PKI 166 PKI 166 metabolite inhibits the reaction [ABCB11 protein affects the uptake of Taurocholic Acid]affects uptake|decreases reaction 15280219
C410026 PKI 166 PKI 166 metabolite results in decreased activity of ABCB11 proteindecreases activity 15280219
D017035 Pravastatin ABCB11 protein affects the import of Pravastatinaffects import 15901796
D017035 Pravastatin Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D017035 Pravastatin ABCB11 protein affects the import of Pravastatinaffects import 15901796
D017035 Pravastatin Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C023617 pregna-4,17-diene-3,16-dione [pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 12525500
C023617 pregna-4,17-diene-3,16-dione [pregna-4,17-diene-3,16-dione co-treated with GW 4064] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 12525500
C023617 pregna-4,17-diene-3,16-dione pregna-4,17-diene-3,16-dione inhibits the reaction [Bile Acids and Salts results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 12705905
C023617 pregna-4,17-diene-3,16-dione pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 12705905
C023617 pregna-4,17-diene-3,16-dione pregna-4,17-diene-3,16-dione results in increased expression of ABCB11 mRNAincreases expression 12525500
D011285 Pregnenolone Carbonitrile Endotoxins inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB11 mRNA]decreases reaction|increases expression 15456840
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in increased expression of ABCB11 mRNAincreases expression 15456840
D012293 Rifampin Rifampin results in decreased expression of ABCB11 mRNAdecreases expression 16837569
D012293 Rifampin Rifampin results in decreased expression of ABCB11 mRNAdecreases expression 12135489
C023808 rifamycin SV rifamycin SV results in decreased activity of ABCB11 proteindecreases activity 11343252
C120596 Ro 47-8634 Ro 47-8634 results in decreased activity of ABCB11 proteindecreases activity 11309550
C422923 rosuvastatin rosuvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C422923 rosuvastatin rosuvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C440975 silybin silybin affects the localization of and affects the activity of ABCB11 proteinaffects activity|affects localization 15763547
C063287 simvastatin acid simvastatin acid inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
C063287 simvastatin acid simvastatin acid inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D012965 Sodium Chloride [Acetaminophen co-treated with Sodium Chloride] results in decreased expression of ABCB11 mRNAaffects cotreatment|decreases expression 17934960
D018038 Sodium Selenite Sodium Selenite results in decreased expression of ABCB11 mRNAdecreases expression 18175754
D013024 Soybean Oil Soybean Oil affects the expression of ABCB11 mRNAaffects expression 15770074
D013311 Streptozocin Streptozocin results in increased activity of ABCB11 proteinincreases activity 12055592
D013629 Tamoxifen Tamoxifen results in decreased activity of ABCB11 proteindecreases activity 12739759
D013629 Tamoxifen Tamoxifen results in decreased expression of ABCB11 mRNAdecreases expression 19224547
D013629 Tamoxifen Tamoxifen results in increased expression of ABCB11 mRNAincreases expression 12135489
D013654 Taurine Taurine results in increased expression of ABCB11 proteinincreases expression 12706339
D013655 Taurochenodeoxycholic Acid ABCB11 protein affects the transport of Taurochenodeoxycholic Acidaffects transport 11343252
D013655 Taurochenodeoxycholic Acid ABCB11 protein affects the transport of Taurochenodeoxycholic Acidaffects transport 15297262
D013655 Taurochenodeoxycholic Acid Taurochenodeoxycholic Acid results in increased expression of ABCB11 proteinincreases expression 11672435
D013656 Taurocholic Acid ABCB11 protein affects the import of Taurocholic Acidaffects import 15901796
D013656 Taurocholic Acid ABCB11 protein affects the transport of Taurocholic Acidaffects transport 15791618
16039748
D013656 Taurocholic Acid atorvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid cerivastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid fluvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid rosuvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid simvastatin acid inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid ABCB11 protein affects the export of Taurocholic Acidaffects export 11447010
D013656 Taurocholic Acid ABCB11 protein affects the transport of Taurocholic Acidaffects transport 14724752
14672610
12518026
D013656 Taurocholic Acid ABCB11 protein mutant form affects the transport of Taurocholic Acidaffects transport 14672610
D013656 Taurocholic Acid ABCB11 protein results in decreased uptake of Taurocholic Aciddecreases uptake 10617675
D013656 Taurocholic Acid ABCB11 protein affects the import of Taurocholic Acidaffects import 15901796
D013656 Taurocholic Acid ABCB11 protein affects the transport of Taurocholic Acidaffects transport 15297262
D013656 Taurocholic Acid ABCB11 protein results in increased secretion of Taurocholic Acidincreases secretion 15209631
D013656 Taurocholic Acid atorvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid cerivastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid fluvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid PKI 166 metabolite inhibits the reaction [ABCB11 protein affects the uptake of Taurocholic Acid]affects uptake|decreases reaction 15280219
D013656 Taurocholic Acid Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid rosuvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid simvastatin acid inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]affects import|decreases reaction 15901796
D013656 Taurocholic Acid ABCB11 protein affects the secretion of Taurocholic Acidaffects secretion 12865277
D013656 Taurocholic Acid ABCB11 protein affects the transport of Taurocholic Acidaffects transport 15465654
12642476
12518026
D013656 Taurocholic Acid Taurocholic Acid results in increased expression of ABCB11 proteinincreases expression 11113123
D013656 Taurocholic Acid Taurocholic Acid results in increased expression of and results in increased activity of ABCB11 proteinincreases activity|increases expression 12644037
D013657 Taurodeoxycholic Acid ABCB11 protein results in increased abundance of Taurodeoxycholic Acidincreases abundance 14570929
D013658 Taurolithocholic Acid Taurolithocholic Acid affects the localization of ABCB11 proteinaffects localization 12865277
D013658 Taurolithocholic Acid Taurolithocholic Acid affects the localization of and affects the activity of ABCB11 proteinaffects activity|affects localization 15763547
C037351 tauromuricholic acid tauromuricholic acid results in increased expression of ABCB11 proteinincreases expression 11672435
C037351 tauromuricholic acid tauromuricholic acid results in increased expression of and results in increased activity of ABCB11 proteinincreases activity|increases expression 12644037
C031655 tauroursodeoxycholic acid ABCB11 protein affects the transport of tauroursodeoxycholic acidaffects transport 15297262
C031655 tauroursodeoxycholic acid tauroursodeoxycholic acid results in increased expression of ABCB11 proteinincreases expression 11672435
C031655 tauroursodeoxycholic acid tauroursodeoxycholic acid results in increased expression of and results in increased activity of ABCB11 proteinincreases activity|increases expression 12644037
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ABCB11 mRNAdecreases expression 16837569
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCB11 mRNAaffects cotreatment|increases expression 17942748
D013752 Tetracycline Tetracycline results in decreased expression of ABCB11 mRNAdecreases expression 17522070
19224547
C474453 tetrahydroxy-5-cholan-24-oic acid ABCB11 gene mutant form results in increased abundance of tetrahydroxy-5-cholan-24-oic acidincreases abundance 12562825
C080287 thymeleatoxin thymeleatoxin affects the localization of ABCB11 proteinaffects localization 14679204
C057693 troglitazone troglitazone results in decreased activity of ABCB11 proteindecreases activity 15509663
15465654
D014425 Turpentine Turpentine results in decreased expression of ABCB11 mRNAdecreases expression 15313196
D014580 Ursodeoxycholic Acid Ursodeoxycholic Acid results in increased expression of ABCB11 mRNAincreases expression 14684751
D014580 Ursodeoxycholic Acid Ursodeoxycholic Acid results in increased expression of ABCB11 mRNAincreases expression 11438506
D014580 Ursodeoxycholic Acid Ursodeoxycholic Acid results in increased expression of ABCB11 proteinincreases expression 11438506
D014580 Ursodeoxycholic Acid ABCB11 protein affects the transport of Ursodeoxycholic Acidaffects transport 15297262
D014580 Ursodeoxycholic Acid Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]decreases expression|decreases reaction 12187295
D014634 Valinomycin Valinomycin results in decreased activity of ABCB11 proteindecreases activity 12739759
D014638 Vanadates Vanadates results in decreased activity of ABCB11 proteindecreases activity 11343252
D014747 Vinblastine ABCB11 protein results in decreased uptake of Vinblastinedecreases uptake 10617675
D014747 Vinblastine ABCB11 protein results in increased export of Vinblastineincreases export 10617675
C009687 wortmannin wortmannin affects the localization of ABCB11 proteinaffects localization 12702492
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.6314745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 5.376195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 5.3715322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.0317505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 6.2811850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 6.2818653653
MESH:D000210 Acute-Phase Reaction Turpentine 5.2816044259
MESH:D000230 Adenocarcinoma Estradiol 3.1211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.1214692618
MESH:D000236 Adenoma Diethylnitrosamine 2.2710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.5917620307 19052882 17162532 19061943 18056438 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.5917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.5916835633
OMIM:607154 ALLERGIC RHINITIS fexofenadine 4.9316037679
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 3.6020157255
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.1611748828
MESH:D000799 Angioedema Acetaminophen 2.9310982225
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 12.1615552841
MESH:D001161 Arteriosclerosis Dietary Fats 12.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 12.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.0515885639
MESH:D050197 Atherosclerosis Cholesterol 3.6516632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1918445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.1918582451
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 2.1918582451
MESH:D001528 Behcet Syndrome Colchicine 5.2315870978
MESH:D001778 Blood Coagulation Disorders pirinixic acid 6.0619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 6.0612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.8815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.1215746008
MESH:D001943 Breast Neoplasms bexarotene 2.7716818667 16344269
MESH:D001943 Breast Neoplasms Dietary Fats 2.7720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.7717474063
MESH:D001943 Breast Neoplasms Estradiol 2.7712948864 19861407 17018787 17261762 18497071 16675129 14630087 17289903
MESH:D001943 Breast Neoplasms LG 100268 2.7716818667
MESH:D001943 Breast Neoplasms Tamoxifen 2.7719115204 21152245 19142967 19200415 18855134 20859285 20135344 20390343 16202921 19410462 11161223 19189212 20544844 18815881 18629630 17893378 15565566 19189210 15668708 17440819 18821012 19487384 20005174 21138602 19155303 19221464 19289846 19084267 19244106 16873071 18984771 19011961 19103187 19288272 17242785 17261762 16818667 16273361 20065188 17049068 18997820 18351453 19066611 18425577 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.5716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 2.9115673190 16097048 15721981 16011737 16227642 16124888 3786805 15700767 10355542 16192424 16050911 18705752
MESH:D002276 Carcinoid Tumor Streptozocin 4.6916051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.0616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.6319066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 12.5416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 12.5416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.543084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 12.5418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 12.5417055752 18393292 20214788 16288022 18506893 16779866 16502159 19539802 16698587 18210153 18978308 17978847 19208518 19052882 20727157 19822196 20514400 3084413 16935385 17761372 19919837 19701751 10672840 3581430 16878318 19171122 16328049 19335982 16569478 17138121 16540662 17173139 16830150 21159647 18788625 10737359 16807293 19107877 19383236 18785209 17162532 20101231 20007298 18056438 16681979 18691550 11831363 20432363 18494052 19394651 17428255 20084675 18971187 20935162 19519916 19418558 20512989 20524982 18665156
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.5416924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 12.5417173139 20007298 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.5416924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 2.8316247446
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.271485588
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.8217572228
MESH:D006332 Cardiomegaly atorvastatin 5.2618360054
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.2616120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 5.7510977129
MESH:D002386 Cataract Adenosine Triphosphate 5.7515003327
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.486135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.4812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.4817174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.374080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 6.7319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 6.7316835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.2912912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 22.397624871 18590720 15500046 12927374 16629650 15913567 19486331 18164287
MESH:D002779 Cholestasis Cyclosporine 22.3919486331
MESH:D002779 Cholestasis estradiol-17 beta-glucuronide 22.3912893835
MESH:D002779 Cholestasis Ethinyl Estradiol 22.3917681005 11677210 17110522 15861022 17333356 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 22.3919176532
MESH:D002779 Cholestasis Ursodeoxycholic Acid 22.3916487557
MESH:C535931 Cholestasis, benign recurrent intrahepatic 2 marker/mechanism
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 11.6319407337 10220858
MESH:D002780 Cholestasis, Intrahepatic Ursodeoxycholic Acid 11.6314728856
MESH:C535934 Cholestasis, progressive familial intrahepatic 2 marker/mechanism
MESH:D019457 Chromosome Breakage Sodium Selenite 3.8715894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.6415340226 15668235 16354765 12621046 8697196
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 3.3816213893
MESH:D015179 Colorectal Neoplasms Vinblastine 2.7818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.2817141729 14669216
MESH:D003324 Coronary Artery Disease atorvastatin 3.7316368305
MESH:D003327 Coronary Disease fluvastatin 4.1616142594
MESH:D003384 Coxsackievirus Infections bosentan 5.6920392896
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2310048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 7.9918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 7.9918551238
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 3.8919747007
MESH:D003704 Dementia Methylmercury Compounds 4.1816140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.4819031437
MESH:D003866 Depressive Disorder nefazodone 5.1318083778 16410371
MESH:D003876 Dermatitis, Atopic fexofenadine 5.5117133778
MESH:D003876 Dermatitis, Atopic pirinixic acid 5.5118249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 6.9916285004
MESH:D003920 Diabetes Mellitus Streptozocin 6.9916285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 3.7312083368 12644472 19496084 19298542 18715473 12093613 15831366 8740154 18603373 17442507 11055810 15298345 16286809 1374869 15862027 7637645 17874149 6379147 11260395 19960420 19586609 16684804 12446591 2177838
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.2718603373
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 10.0319647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 10.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 10.0319586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 10.0317107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 10.0316023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.7612601628
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 10.6316025228
MESH:D058065 Diabetic Cardiomyopathies Taurine 10.6316025228
MESH:D003928 Diabetic Nephropathies Estradiol 10.6319279558
MESH:D003928 Diabetic Nephropathies Streptozocin 10.6319682444 19960420
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.6319279558
MESH:D003930 Diabetic Retinopathy Streptozocin 4.5717662242
MESH:D003967 Diarrhea Endotoxins 4.247907874 7237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 30.3517522070 7624871 20133375 18289764
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 30.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 30.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 30.3511421492 15619225 14725611 11739529 16781746 17906064 12705907 18713872 12958197 10915739 15968718 11287661 19416960 10663392 18071297 14550746 11461765 12153990 17522070 11529661 19164858 19739265 19370779 11743745 14986274 12540782 2444490 19085960 10774834 16081117 12594235 19420014 16177239 16109766 16227642 12392966 16393943 19923254 16485898 11834606 17562736
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 30.3511566570 7179309 15998439 15027814 3732212 6884620 9327722 10915739 10092053 19085960 17522070 15968718 3786805 16177239 19336974 2869522 6623471 21278145 7120509 7440962 4309450 16227642
MESH:D056486 Drug-Induced Liver Injury Chloroform 30.352862719 7440962 3732212 17522070 7120509 6884620 6623471 3104120
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 30.3519107877
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 30.3517522070 14998559
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 30.3515131321
MESH:D056486 Drug-Induced Liver Injury Taurine 30.359328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 30.3520420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 30.3517522070
MESH:D056486 Drug-Induced Liver Injury troglitazone 30.3514986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.0611462148
MESH:D050171 Dyslipidemias Dietary Fats 2.7618367378
MESH:D004421 Dystonia Phenobarbital 3.171851702
MESH:D004487 Edema Arachidonic Acid 6.9311698051 9599246 16716910 7990266 9831321 15177302
MESH:D004487 Edema pirinixic acid 6.9312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 2.9915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 6.1212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 6.1219031437
MESH:D016889 Endometrial Neoplasms Estradiol 5.2118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.2119155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Mifepristone 6.5116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.519294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.5115328337 15821434 17637181
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.233659116
MESH:D004828 Epilepsies, Partial Phenobarbital 2.973922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.3520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 2.776401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.133659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.2016302075
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 5.6411346197
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.3011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.9015959796 61145 12795759 16045604 12631006 17595544 16239168 19224547
MESH:D005234 Fatty Liver Cyclosporine 33.9019224547
MESH:D005234 Fatty Liver Dietary Fats 33.9017967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 33.9020387270 21071580
MESH:D005234 Fatty Liver Endotoxins 33.9018641190
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.9015345470
MESH:D005234 Fatty Liver pirinixic acid 33.9019236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 33.9014986274 19224547
MESH:D005234 Fatty Liver Tetracycline 33.9016917069 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.5811858732
MESH:D005334 Fever Arachidonic Acid 6.9111852909
MESH:D005334 Fever Lipopolysaccharides 6.9111852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.6314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.2919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.0418705752
MESH:D005355 Fibrosis Cyclosporine 14.0412168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.0418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.0420067830
MESH:D005756 Gastritis Acetaminophen 2.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.328708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.6810696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 1.7810048152 11294989
MESH:D006331 Heart Diseases Streptozocin 3.6112093613
MESH:D006333 Heart Failure atorvastatin 8.5716360360
MESH:D006333 Heart Failure pirinixic acid 8.5720558911
MESH:D006333 Heart Failure pitavastatin 8.5715502390
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.5215720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.5816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5211000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 6.8318590720
MESH:D006505 Hepatitis Carbon Tetrachloride 6.8319900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 9.3816109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3818467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3815340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.1215709030
MESH:D006689 Hodgkin Disease Vinblastine 3.2918180244 18501091
MESH:D019584 Hot Flashes Estradiol 2.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.1316354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 1.9816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.6316899240
MESH:D006937 Hypercholesterolemia atorvastatin 20.0811583720
MESH:D006937 Hypercholesterolemia Cholesterol 20.0816933029
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 20.0810876104
MESH:D006937 Hypercholesterolemia Dietary Fats 20.0821332399
MESH:D006937 Hypercholesterolemia Pravastatin 20.0817188708
MESH:D006943 Hyperglycemia pirinixic acid 2.3920558911
MESH:D006949 Hyperlipidemias Dietary Fats 2.7921332399
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 4.4316238680
MESH:D006967 Hypersensitivity fexofenadine 4.5517910814
MESH:D006973 Hypertension atorvastatin 8.7317042910
MESH:D006973 Hypertension Cyclosporine 8.7310903974
MESH:D006973 Hypertension Sodium Chloride 8.7311507004
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.2115338365
MESH:D006976 Hypertension, Pulmonary bosentan 4.5716219361
MESH:D007003 Hypoglycemia Glyburide 5.1110918110
MESH:D007021 Hypospadias Ethinyl Estradiol 2.9316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.6312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 1.8617937319
MESH:D007249 Inflammation Arachidonic Acid 15.6815177302 17371808 9831321
MESH:D007249 Inflammation atorvastatin 15.6816908763
MESH:D007249 Inflammation Dietary Fats 15.6820412841
MESH:D007249 Inflammation Diethylnitrosamine 15.6818785209
MESH:D007249 Inflammation Lipopolysaccharides 15.6817963957 9205823 17255318 12878042 17237260
MESH:D007249 Inflammation Tamoxifen 15.6819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.6812878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 16.3018457598 11836018
MESH:D007333 Insulin Resistance Endotoxins 16.3020353583
MESH:D007333 Insulin Resistance Estradiol 16.3016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.3016306350
MESH:D007333 Insulin Resistance Sodium Selenite 16.3014714311
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.7917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.5216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.5315604871
MESH:D007674 Kidney Diseases Acetaminophen 9.5412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.5418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.5415618244
MESH:D007674 Kidney Diseases Streptozocin 9.5412093613
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.3916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 15.3916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 15.3912371664
MESH:D007680 Kidney Neoplasms Estradiol 15.3915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 15.3918625569
MESH:D007859 Learning Disorders Cholesterol 7.7517134702
MESH:D007859 Learning Disorders Colchicine 7.7511749816
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 4.189499605
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.2316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 4.1917077332
MESH:D007970 Leukopenia Lipopolysaccharides 3.8015821434
MESH:D008064 Lipidoses Tamoxifen 2.4717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.5716943688 11903743 11408273 17157831 16221502 21278145 17334410 16239168 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 14.5718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.5719638242 20032147 18407596 18665156 18522880
MESH:D008103 Liver Cirrhosis Endotoxins 14.5720353583
MESH:D008103 Liver Cirrhosis Phenobarbital 14.5721047994
MESH:D008105 Liver Cirrhosis, Biliary Ursodeoxycholic Acid 4.5112468960
MESH:D008106 Liver Cirrhosis, Experimental 6-ethylchenodeoxycholic acid 18.1715980055 15860571
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 18.1717347453
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 18.1717525996 15818738 12667390 17805973 15650968 12586293 17900296 15362042 13678700 17766677 15893842 16248980 18205269 18395914 16097048 17708605 10355542 17714472 17721639 17631135 18279442 12546737 15959796 18412020 17565644 12632512 12741479 18376398 18263696 16192424 15052691 18339082 18429990 15673190 18156304 15931870 16116963 17761835 16027843 17557913 16011737 17922224 18317297 18251166 17976157 12958196 17640975 15123356 12445421 12898905 15876570 12632514 16033810 15996030 18418968 15730626 18481824 15338365 14716833 18210741 14724832 18187930 17869086 16638106 12666154 18705752 17481882 16136751 18420326 12445418 14620537 18395095 15057751 14748882 18472094 12649538 16015684 18166357 15370692 18054572 20821823 18277467 17944888 18006644 12609069 12389079 17823541 14716496 14512876 17698563 15925388 11481614 18472332
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 18.1714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 18.1712878042
MESH:D008106 Liver Cirrhosis, Experimental oltipraz 18.1716544323
MESH:D008106 Liver Cirrhosis, Experimental Phosphatidylcholines 18.1716169303
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 18.1715474484
MESH:D008106 Liver Cirrhosis, Experimental silybin 18.1716169303
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 18.1718564211
MESH:D008106 Liver Cirrhosis, Experimental Taurine 18.1715931870 15893842
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 18.1712878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 11.2717184895
MESH:D008107 Liver Diseases Acetaminophen 11.2711587558 19460945 16610002 19014921 16611625 12969438 19784758 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.2717285989 16246199 15720792 16964402 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 11.2717034775
MESH:D008107 Liver Diseases Docosahexaenoic Acids 11.2717056761
MESH:D008107 Liver Diseases Phenobarbital 11.2719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.2915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 6.7617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 6.7616899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.037678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.0319294768
MESH:D008113 Liver Neoplasms ciprofibrate 21.0312771043
MESH:D008113 Liver Neoplasms Clofibric Acid 21.0317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.0321071580 18754104 20583210 18644402 15175105 12112319 19294768 12771043 18648771 21047994 19254457 19690152 21167192 19073162 19638242 20137499 20101389 19812893 19426721 20452335 19642983 19833225 18977376 19499222 19996281 20434301 2862719 19850985 21278145 20118626 18978307 20501860 16942905 15885732 19255062 19256749 9163691 19427195 19090486 20492335 10737359 2422723 20405173 19551842
MESH:D008113 Liver Neoplasms Phenobarbital 21.0319812893 15975961 19073162 19482888 8742319 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 21.0320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 21.0316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.0316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.236135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.2315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 15.236150874
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.233124819 19519916 18093689 18282651 18544905 19539802 18079962 16842330 18775883 19009564 19126423 18308698 17174075 16267830 21159647 9362446 19004024 17942915 18164116 18253720 2563599 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.236150874 17172636 2563599 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.2312151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.1521114838
MESH:D008175 Lung Neoplasms bexarotene 4.6617849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.666695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms silybin 4.6616788158
MESH:D008175 Lung Neoplasms Tamoxifen 4.6618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.2311422169
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 3.6411422169
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.2214737004
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.2711161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 2.8719428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.1319196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1316891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental LG 100268 9.1312374698
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.1319196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 9.6219453300
MESH:D020149 Manganese Poisoning Tamoxifen 9.6219453300
MESH:D008545 Melanoma Tamoxifen 2.8919393235 12393984
MESH:D008545 Melanoma Vinblastine 2.8918176117 16248763 15577323 12374674 16432458 15577320 16809738 17761969 18505091 18332650
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.2915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.6919513568
MESH:D008569 Memory Disorders Methylmercury Compounds 4.0618436314
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 3.8716801185
MESH:D009069 Movement Disorders Methylmercury Compounds 4.4918436314
MESH:D009101 Multiple Myeloma fluvastatin 3.8616996129
MESH:D009135 Muscular Diseases atorvastatin 12.8916239165
MESH:D009135 Muscular Diseases Bezafibrate 12.8916239165
MESH:D009135 Muscular Diseases pirinixic acid 12.8916239165
MESH:D009164 Mycobacterium Infections Rifampin 4.6418474467
MESH:D009203 Myocardial Infarction pirinixic acid 4.6419151258
MESH:D009203 Myocardial Infarction Pravastatin 4.6417188708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 5.8316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 5.8316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.5817484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 7.3918551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 7.397678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.173581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.1719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1319410462
MESH:D009369 Neoplasms pirinixic acid 1.4917405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 7.9219196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 7.9219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 2.8517289903
MESH:D009395 Nephritis, Interstitial Tetracycline 3.889884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.5317954296
MESH:D009404 Nephrotic Syndrome atorvastatin 7.1319348381
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.1319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 6.6311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 6.6314600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 5.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 5.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.2020387270
MESH:D020258 Neurotoxicity Syndromes Glyburide 4.5516725203
MESH:D009503 Neutropenia Vinblastine 3.7417378895
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 4.8320557099 9802331
MESH:C541083 Non-alcoholic Fatty Liver Disease Endotoxins 5.0820353583
MESH:D009765 Obesity Dietary Fats 3.3321332399 17217161 18674790 20518802 19632207 20132043 16723640 18457598 11836018
MESH:D009765 Obesity pirinixic acid 3.3320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 6.2416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 6.2416049721
MESH:D010018 Osteomalacia Phenobarbital 3.4717016548
MESH:D010051 Ovarian Neoplasms Estradiol 3.8019401270
MESH:D010051 Ovarian Neoplasms Mifepristone 3.8016525653
MESH:D010146 Pain Acetaminophen 1.6916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 3.8316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 3.8316965848
MESH:D010195 Pancreatitis Taurocholic Acid 4.4020035747
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.8511578682
MESH:D010300 Parkinson Disease Cholesterol, Dietary 3.7719014385
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 10.7620133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 10.7612520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.5211026799
MESH:D011014 Pneumonia Lipopolysaccharides 3.6612224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7018163543
MESH:D011230 Precancerous Conditions Cyclosporine 10.7712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 10.772563599
MESH:D011230 Precancerous Conditions Phenobarbital 10.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 6.9418436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 6.9411222880 11896295 11399792 11118676
MESH:D017096 Prion Diseases Tetracycline 4.5110903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1416740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1418760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1415067354
MESH:D011537 Pruritus Ethinyl Estradiol 7.1416919318 15861022
MESH:D011537 Pruritus fexofenadine 7.1417133778
MESH:D019310 Pseudolymphoma Phenobarbital 3.5812752131
MESH:D011565 Psoriasis Cyclosporine 1.8216882103
MESH:D011658 Pulmonary Fibrosis troglitazone 3.4718162602
MESH:D015427 Reperfusion Injury pirinixic acid 1.8619058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.0810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 2.9818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D012640 Seizures Phenobarbital 5.993137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 3.926407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 3.878532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 3.8716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 8.5416709447
MESH:D013088 Spermatocele Tamoxifen 8.5416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.1519457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.6718456281
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 3.6719015929
MESH:D013274 Stomach Neoplasms Sodium Chloride 3.6716646055
MESH:D013274 Stomach Neoplasms troglitazone 3.6715930296
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 7.3920133375
MESH:D013921 Thrombocytopenia Lipopolysaccharides 7.3915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.7811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.3815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 2.9912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 4.817505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 4.811399818
MESH:D013978 Tibial Fractures Estradiol 3.7719048282
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 6.9816040207
MESH:D014376 Tuberculosis Rifampin 6.9818397238 15236969
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.6116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.6116049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.618653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 9.0210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 9.0210091137
MESH:D014581 Urticaria Acetaminophen 2.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.4514692618
MESH:D014605 Uveitis Cyclosporine 9.251336536
MESH:D014605 Uveitis Endotoxins 9.251336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.1715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.6812125929
MESH:D014689 Venous Insufficiency coumarin 4.8612708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3315886252
MESH:D015430 Weight Gain Dietary Fats 2.9616723640
MESH:D014985 Xerophthalmia Cyclosporine 3.5317120751
Pathway ID Pathway Name
KEGG:02010 ABC transporters
KEGG:04976 Bile secretion
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA374
    • Releated gene ID Related gene Name
    PA374ABCB11
    Releated disease ID Related disease Name
    PA443707Cholestasis
    PA445062Neoplasms
    PA443937Drug Toxicity
    PA444801Liver Diseases
    Releated drug ID Related drug Name
    PA449780glutathione
    PA450191lecithin
    PA451089pravastatin
    PA449789glycine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    DB01016 inhibitor Glucovance Hypoglycemic Agents;Antiarrhythmic Agents;Sulfonylureas
    No data
    Drugbank ID Action Drug Name Description
    DB00091 inhibitor Cyclosporine Antirheumatic Agents;Immunomodulatory Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents;Antifungal Agents
    DB00197 inhibitor Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00206 inhibitor SER-AP-ES Tab Antihypertensive Agents;Adrenergic Uptake Inhibitors;Antipsychotics;Peripheral Adrenergic Inhibitors;Antipsychotic Agents
    DB00390 substrate Digoxin Enzyme Inhibitors;Antiarrhythmic Agents;Cardiotonic Agents;Anti-Arrhythmia Agents
    DB00396 inhibitor Synovex S Contraceptives;Progestins
    DB00477 inhibitor Chlorpromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00541 substrate Vincristine Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB00559 inhibitor Bosentan Antihypertensive Agents
    DB00570 inhibitor Vinblastine Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB00661 inhibitor Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00675 inhibitor Tamoxifen Antineoplastic Agents, Hormonal;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents
    DB00693 substrate Fluress Liq Oph Contrast Media;Fluorescent Dyes
    DB00694 substrate Daunorubicin Antineoplastic Agents;Antibiotics;Antibiotics, Antineoplastic
    DB00845 inhibitor Clofazimine Leprostatic Agents;Antimycobacterials;Dyes;Coloring Agents
    DB00908 inhibitor Quinidine Enzyme Inhibitors;Antiarrhythmic Agents;Antimalarials;Muscarinic Antagonists;Adrenergic alpha-Antagonists;Anti-Arrhythmia Agents
    DB00977 inducer Yasmin 28 Estrogens
    DB00997 substrate Doxorubicin Antineoplastic Agents;Antibiotics;Antibiotics, Antineoplastic
    DB01016 inhibitor Glucovance Hypoglycemic Agents;Antiarrhythmic Agents;Sulfonylureas
    DB01026 inhibitor Ketoconazole Antifungals;Antifungal Agents
    DB01045 inhibitor Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01051 inhibitor Special Formula 17900-Forte Suspension Anti-Bacterial Agents;Enzyme Inhibitors;Nucleic Acid Synthesis Inhibitors
    DB01174 inducer Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01229 inhibitor Paclitaxel Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB01234 inducer Tresaderm Dermatologic Solution Anti-inflammatory Agents;Adrenergic Agents;Antiemetics;Antineoplastic Agents, Hormonal;Glucocorticoids
    DB01586 inducer Ursodeoxycholic acid Cholagogues and Choleretics
    DB02123 inhibitor Glycochenodeoxycholic Acid Detergents
    DB02659 inducer Cholic Acid
    DB02703 inhibitor Fucicort Anti-Bacterial Agents;Protein Synthesis Inhibitors;Antibacterial Agents
    DB03619 inducer Deoxycholic Acid Cholagogues and Choleretics
    DB04348 inducer Taurocholic Acid Cholagogues and Choleretics;Detergents
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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