AutismKB 2.0

Annotation Detail for NCOA1


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Basic Information Top
Gene Symbol:NCOA1 ( F-SRC-1,KAT13A,MGC129719,MGC129720,RIP160,SRC1,bHLHe42,bHLHe74 )
Gene Full Name: nuclear receptor coactivator 1
Band: 2p23.3
Quick LinksEntrez ID:8648; OMIM: 602691; Uniprot ID:NCOA1_HUMAN; ENSEMBL ID: ENSG00000084676; HGNC ID: 7668
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
200142Retinoic acid receptors-mediated signaling
200172HIF-1-alpha transcription factor network
200077Glucocorticoid receptor regulatory network
200112RXR and RAR heterodimerization with other nuclear receptor
200102Regulation of Androgen receptor activity
200196Notch-mediated HES/HEY network
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]affects binding|affects cotreatment|increases reaction 17223708
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]affects binding|increases reaction 17223708
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]affects binding|decreases reaction 18692084
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to NCOA1 protein]affects binding|increases reaction 18692084
15272053
C104006 2',3',4',5'-tetrachloro-4-biphenylol 2',3',4',5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NCOA1 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen inhibits the reaction [ESRRG protein binds to NCOA1 protein]affects binding|decreases reaction 11447273
C105260 4-tert-octylphenol 4-tert-octylphenol promotes the reaction [ESR1 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
C105260 4-tert-octylphenol 4-tert-octylphenol promotes the reaction [ESR2 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NCOA1 protein alternative formaffects binding 15761029
C103303 alitretinoin [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]affects binding|affects cotreatment|increases reaction 17223708
C103303 alitretinoin alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]affects binding|increases reaction 17223708
D013196 Dihydrotestosterone Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]affects binding|increases reaction 16648561
D013196 Dihydrotestosterone methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]affects binding|decreases reaction|increases reaction 16648561
D013196 Dihydrotestosterone NCOA1 protein promotes the reaction [Dihydrotestosterone results in increased expression of AR mRNA]increases expression|increases reaction 16877366
D013196 Dihydrotestosterone NCOA1 protein results in increased activity of [Dihydrotestosterone binds to AR protein]affects binding|increases activity 17804755
C000658 androstan-3-ol androstan-3-ol promotes the reaction [NR1I2 protein binds to NCOA1 protein]affects binding|increases reaction 15833898
D000735 Androstenedione 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]affects binding|decreases reaction 18692084
D000735 Androstenedione Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]affects binding|decreases reaction 18692084
D000735 Androstenedione isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]affects binding|decreases reaction 18692084
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of NCOA1 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NCOA1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOA1 mRNAdecreases expression 19150397
D001629 Bezafibrate Bezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein]affects binding|increases reaction 19263263
C053541 bicalutamide bicalutamide inhibits the reaction [AR protein binds to NCOA1 protein]affects binding|decreases reaction 11981028
C006780 bisphenol A bisphenol A promotes the reaction [ESR1 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
C006780 bisphenol A bisphenol A promotes the reaction [ESR2 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
C006780 bisphenol A bisphenol A promotes the reaction [NCOA1 protein binds to NR1I2 protein]affects binding|increases reaction 11581012
C006780 bisphenol A bisphenol A promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]affects binding|increases expression|increases reaction 11581012
C006780 bisphenol A bisphenol A results in increased expression of NCOA1 mRNAincreases expression 17412439
C006780 bisphenol A bisphenol A results in increased expression of NCOA1 proteinincreases expression 17412439
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]affects binding|increases reaction 14684751
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]affects binding|increases reaction 15307955
D003345 Corticosterone Corticosterone promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]affects binding|increases expression|increases reaction 11581012
D017373 Cyproterone Acetate NCOA1 protein results in increased activity of [Cyproterone Acetate binds to AR protein]affects binding|increases activity 17804755
D003907 Dexamethasone Dexamethasone results in increased expression of NCOA1 mRNAincreases expression 19022236
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]affects binding|increases expression|increases reaction 11581012
D004054 Diethylstilbestrol Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
D004054 Diethylstilbestrol Diethylstilbestrol promotes the reaction [ESR2 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
D004054 Diethylstilbestrol Diethylstilbestrol promotes the reaction [NCOA1 protein binds to HOXA10 promoter]affects binding|increases reaction 15236964
D002117 Calcitriol Calcitriol affects the localization of NCOA1 proteinaffects localization 15647825
D002117 Calcitriol Calcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]affects binding|increases reaction 15647825
D002117 Calcitriol Calcitriol promotes the reaction [NCOA1 protein binds to SPP1 promoter]affects binding|increases reaction 15647825
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to CECR6 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to H19 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to LLGL2 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to NKD1 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NCOA1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
D004958 Estradiol Estradiol promotes the reaction [ESR2 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
D004958 Estradiol Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]affects binding|increases reaction 16489025
D004958 Estradiol Estradiol promotes the reaction [NCOA1 protein binds to ESR1 protein]affects binding|increases reaction 17135255
D004958 Estradiol Estradiol promotes the reaction [NCOA1 protein binds to ESR2 protein]affects binding|increases reaction 17135255
D004958 Estradiol Estradiol promotes the reaction [NCOA1 protein binds to HOXA10 promoter]affects binding|increases reaction 15236964
D004958 Estradiol Estradiol promotes the reaction [NCOA1 protein binds to IGF1 promoter]affects binding|increases reaction 17872375
D004958 Estradiol Estradiol promotes the reaction [NCOA1 protein binds to TFF1 promoter]affects binding|increases reaction 19838210
D004958 Estradiol Estradiol promotes the reaction [NR1I2 protein binds to NCOA1 protein]affects binding|increases reaction 15650019
D004958 Estradiol Estradiol results in decreased expression of NCOA1 mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of NCOA1 mRNAincreases expression 19432593
D004958 Estradiol [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Estradiolaffects binding|increases response to substance 20332105
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D004958 Estradiol Estradiol affects the localization of NCOA1 proteinaffects localization 17556502
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]affects binding|increases reaction 19460436
D004958 Estradiol ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]affects binding|decreases reaction|increases reaction 19460436
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]affects binding|decreases reaction|increases reaction 19460436
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NCOA1 mRNAincreases expression 16183386
D019833 Genistein Genistein promotes the reaction [ESR1 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
D019833 Genistein Genistein promotes the reaction [ESR2 protein binds to NCOA1 protein]affects binding|increases reaction 10964929
C412815 GW 4064 GW 4064 promotes the reaction [NR1H4 protein binds to NCOA1 protein]affects binding|increases reaction 14684751
C412815 GW 4064 GW 4064 promotes the reaction [NR1H4 protein binds to NCOA1 protein]affects binding|increases reaction 15307955
C051890 irinotecan irinotecan metabolite results in increased expression of NCOA1 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of NCOA1 mRNAincreases expression 15956246
C015304 isopimpinellin isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]affects binding|decreases reaction 18692084
C015304 isopimpinellin isopimpinellin promotes the reaction [NR1I3 protein binds to NCOA1 protein]affects binding|increases reaction 18692084
C015304 isopimpinellin isopimpinellin promotes the reaction [NR1I2 protein binds to NCOA1 protein]affects binding|increases reaction 18692084
D007657 Ketone Bodies Ketone Bodies results in increased expression of NCOA1 mRNAincreases expression 16807920
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of NCOA1 mRNAdecreases expression 16847310
C115121 LY 353381 [LY 353381 co-treated with CCND1 protein] results in increased stability of [ESR1 protein binds to NCOA1 protein]affects binding|affects cotreatment|increases stability 19477949
D008468 Meclizine Meclizine inhibits the reaction [NR1I3 protein binds to NCOA1 protein]affects binding|decreases reaction 15272053
D008468 Meclizine Meclizine promotes the reaction [NR1I3 protein binds to NCOA1 protein]affects binding|increases reaction 15272053
D017258 Medroxyprogesterone Acetate Medroxyprogesterone Acetate promotes the reaction [PGR protein binds to NCOA1 protein]affects binding|increases reaction 15937332
D008731 Methoxychlor Methoxychlor metabolite promotes the reaction [ESR1 protein binds to NCOA1 protein]affects binding|increases reaction 14613717
C008493 methylselenic acid methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]affects binding|decreases reaction|increases reaction 16648561
D015741 Metribolone Metribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein]decreases reaction|increases activity 11981028
D019787 Linoleic Acid Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein]affects binding|increases reaction 19263263
C508548 ormeloxifene ormeloxifene inhibits the reaction [ESR2 protein binds to NCOA1 protein]affects binding|decreases reaction 19460436
C508548 ormeloxifene ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]affects binding|decreases reaction|increases reaction 19460436
C032279 phthalic acid phthalic acid promotes the reaction [NR1I2 protein binds to NCOA1 protein]affects binding|increases reaction 15650019
C006253 pirinixic acid pirinixic acid promotes the reaction [PPARA protein binds to NCOA1 protein]affects binding|increases reaction 19263263
C023617 pregna-4,17-diene-3,16-dione pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]affects binding|decreases reaction 15833898
C023617 pregna-4,17-diene-3,16-dione pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]affects binding|increases reaction 15833898
C023617 pregna-4,17-diene-3,16-dione pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]affects binding|increases reaction 15075359
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to NCOA1 protein]affects binding|increases reaction 18692084
D011374 Progesterone Progesterone results in increased expression of NCOA1 proteinincreases expression 17556502
D011794 Quercetin Quercetin results in decreased expression of NCOA1 mRNAdecreases expression 15309432
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNAaffects cotreatment|decreases expression 19059307
D020849 Raloxifene Raloxifene promotes the reaction [NCOA1 protein binds to IGF1 promoter]affects binding|increases reaction 17872375
D020849 Raloxifene Raloxifene results in increased expression of NCOA1 mRNAincreases expression 19432593
D012293 Rifampin Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]affects binding|increases reaction 11581012
D012293 Rifampin Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]affects binding|increases expression|increases reaction 11581012
D012293 Rifampin Rifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]affects binding|increases reaction 17088262
D013629 Tamoxifen [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Tamoxifenaffects binding|increases response to substance 20332105
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen results in increased expression of NCOA1 mRNAincreases expression 20332317
19432593
D013629 Tamoxifen Tamoxifen inhibits the reaction [ESR2 protein binds to NCOA1 protein]affects binding|decreases reaction 19460436
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]affects binding|decreases reaction|increases reaction 19460436
C503890 tanoproget tanoproget promotes the reaction [PGR protein binds to NCOA1 protein]affects binding|increases reaction 15937332
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NCOA1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin NCOA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|increases activity|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin NCOA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]increases expression|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]affects binding|decreases reaction|increases reaction 16489025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1A1 enhancer]affects binding|increases reaction 18842620
12024042
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]affects binding|increases reaction 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1B1 enhancer]affects binding|increases reaction 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]affects binding|increases reaction 18842620
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NCOA1 mRNAdecreases expression 19619570
D014212 Tretinoin NCOA1 protein affects the reaction [Tretinoin results in increased expression of RARB mRNA alternative form]affects reaction|increases expression 16723356
D014212 Tretinoin NCOA1 protein affects the susceptibility to Tretinoinaffects response to substance 16723356
C050319 trimegestone trimegestone promotes the reaction [PGR protein binds to NCOA1 protein]affects binding|increases reaction 15937332
D014801 Vitamin A Vitamin A affects the reaction [NCOA1 protein binds to PCK1 promoter]affects binding|affects reaction 16317119
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9814745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 6.886734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.8811752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.3610992263
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.3411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 7.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.6920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 8.6911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.6914692618
MESH:D000230 Adenocarcinoma Genistein 8.6911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.316695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.0616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.0616835633
MESH:D000419 Albuminuria Raloxifene 4.0717308373 17451421
MESH:D000505 Alopecia Tretinoin 3.1715955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4015800139
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9515469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.3711748828
MESH:D000740 Anemia Vitamin A 7.3716960172
MESH:D000743 Anemia, Hemolytic Quercetin 3.7417084956
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.3116960172
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9211256880
MESH:D001169 Arthritis, Experimental Dexamethasone 10.1717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.1715885639
MESH:D001169 Arthritis, Experimental Tretinoin 10.1716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1116292516
MESH:D001249 Asthma Tretinoin 4.5316456186
MESH:D001249 Asthma Vitamin A 4.5316732791
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4215336622
MESH:D001321 Autistic Disorder Linoleic Acid 3.6918582451
MESH:D001327 Autoimmune Diseases Quercetin 3.8719761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.3919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.3912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.3916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3915746008
MESH:D001862 Bone Resorption bisphenol A 3.3711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7717868700
MESH:D001930 Brain Injuries Progesterone 9.1615665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 9.1616580743
MESH:D001943 Breast Neoplasms marker/mechanism 20332317
MESH:D001943 Breast Neoplasms alitretinoin 11.4216344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.4220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 11.4217123778
MESH:D001943 Breast Neoplasms Calcitriol 11.4211237771
MESH:D001943 Breast Neoplasms Diethylstilbestrol 11.4217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 11.4212948864 18497071 16675129 17289903 14630087 17018787 19861407 17261762
MESH:D001943 Breast Neoplasms Genistein 11.4216873071 16541309 17200150
MESH:D001943 Breast Neoplasms LY 353381 11.4219477949
MESH:D001943 Breast Neoplasms Progesterone 11.4216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 11.4218628248
MESH:D001943 Breast Neoplasms Raloxifene 11.4217242785 16837676 17261762 15758505 15572757 16912660 17049068 17595753 17893378 15775269 17952589 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 11.4218821012 18855134 18997820 17049068 21152245 19189212 19103187 18629630 19142967 19487384 19410462 19155303 16273361 19221464 18425577 11161223 20005174 17261762 17242785 20135344 18984771 19115204 17440819 19084267 16873071 18815881 19289846 20390343 20859285 15668708 19059307 15565566 19244106 19011961 16818667 18351453 19066611 17893378 16202921 19189210 21138602 19288272 19200415 20544844 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.4220435547
MESH:D001943 Breast Neoplasms Tretinoin 11.4216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 11.1716813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 11.1717377406 17426644
MESH:D002105 Cadmium Poisoning Quercetin 4.9816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 12.2416705839
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 12.2415948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.2416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 12.2416924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 12.2412508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.2416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.241917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4317123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4117234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.3820419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 6.3811237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.3816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.8917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.8917572228
MESH:D006332 Cardiomegaly Quercetin 5.6919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.6918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Aldosterone 10.1111230374
MESH:D002318 Cardiovascular Diseases Genistein 10.1116332659
MESH:D002318 Cardiovascular Diseases Raloxifene 10.1115775269
MESH:D002386 Cataract Tretinoin 2.7517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.3420889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.3418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0316129372
MESH:D002659 Child Development Disorders, Pervasive Androstenedione 4.3721398041
MESH:D015362 Child Nutrition Disorders Vitamin A 4.9116153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 11.0915861022 16105132 17333356 16919318 17110522 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 11.0919176532
MESH:D002779 Cholestasis Vitamin A 11.0916175620
MESH:D002822 Choriocarcinoma Tretinoin 4.5916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.3716354765 8697196 15340226 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 8.379407595
MESH:D002972 Cleft Palate Vitamin A 8.3716054864
MESH:D003072 Cognition Disorders Raloxifene 4.0715800139
MESH:D003092 Colitis Tretinoin 3.1717035595
MESH:D003110 Colonic Neoplasms Dexamethasone 9.6315824018
MESH:D003110 Colonic Neoplasms Genistein 9.6317182828
MESH:D003110 Colonic Neoplasms irinotecan 9.6317287894 17725105
MESH:D003110 Colonic Neoplasms Quercetin 9.6319440933 15741050 11134977 16640504 17148506 19056647 17191121
MESH:D003110 Colonic Neoplasms Vitamin A 9.6316267017 17219422
MESH:D015179 Colorectal Neoplasms irinotecan 2.6316391804 16303861 17159606 17454858 18259882 18509181 15273666
MESH:D015179 Colorectal Neoplasms Quercetin 2.6318095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5917141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.7917728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.7915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.7910589399 9224671 17551590 9211117 16925845 9142499 8800419 9664655 14991402 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin A 4.7910992263
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0312952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.4718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.6917474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9012438553
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.0216882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.0218249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.2819496084
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3116506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.7616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7617107852
MESH:D003928 Diabetic Nephropathies Estradiol 12.3019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 12.3015920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.3019279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9517187935
MESH:D003967 Diarrhea Dexamethasone 3.187237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.0718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.0720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3411462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.2416146918
MESH:C538011 Eales disease Vitamin A 5.059068938
MESH:D004480 Ectromelia Vitamin A 5.2516054864
MESH:D004485 Eczema Dexamethasone 3.9312438553
MESH:D004487 Edema Dexamethasone 12.4119703484
MESH:D004487 Edema pirinixic acid 12.4112083418
MESH:D004487 Edema Raloxifene 12.4115860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.0618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 23.1415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 23.1412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 23.1417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 23.1415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 23.1419031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.0416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.0416402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 24.1919148513
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 24.1916804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 24.1919148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 24.1911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 24.1916202921 20544844 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 24.1916569247
MESH:D004715 Endometriosis Progesterone 7.3216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.329294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.8417637181 15821434 15328337
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.7620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.7616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.439664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7015345470
MESH:D005234 Fatty Liver pirinixic acid 14.7020131406 19236843
MESH:D005234 Fatty Liver Raloxifene 14.7017473493
MESH:D005234 Fatty Liver Tamoxifen 14.7019224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.0215751030 16611131 16534752 16513791 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.0216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D005327 Fetal Resorption Vitamin A 4.8016054864
MESH:D005334 Fever Lipopolysaccharides 3.5311852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6319069698
MESH:D005355 Fibrosis Quercetin 11.6919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.6920067830
MESH:D005355 Fibrosis Tretinoin 11.6917994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3916452187
MESH:D005909 Glioblastoma Genistein 9.7416598420
MESH:D005909 Glioblastoma Quercetin 9.7419804834
MESH:D005909 Glioblastoma Tretinoin 9.7417312396
MESH:D005910 Glioma Quercetin 2.8117643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.3820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.3811294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 13.389664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin A 13.3810992263 16080930
MESH:D006331 Heart Diseases Raloxifene 3.1411110106
MESH:D006333 Heart Failure pirinixic acid 2.1820558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9016366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 11.4316109766
MESH:D006529 Hepatomegaly pirinixic acid 11.4318467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.4312621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.557520565
MESH:D006548 Hernia, Diaphragmatic Vitamin A 5.5516877224 17436238 16863852 16292552 15707848 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.4615709030
MESH:D015658 HIV Infections Vitamin A 3.5116960176
MESH:D006679 HIV Seropositivity Vitamin A 5.0417209195
MESH:D019584 Hot Flashes Estradiol 3.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.488697196 16959395 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Tretinoin 2.7716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0216778211
MESH:D006943 Hyperglycemia pirinixic acid 7.6320558911
MESH:D006943 Hyperglycemia Quercetin 7.6318262572 11834736
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8912960047 14722030
MESH:D006973 Hypertension Dexamethasone 10.3917042910
MESH:D006973 Hypertension Quercetin 10.3918356687
MESH:D006973 Hypertension Raloxifene 10.3917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.3918850075 18670907
MESH:D006986 Hypervitaminosis A Vitamin A 5.6016054864
MESH:D007021 Hypospadias Diethylstilbestrol 9.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.4416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8615869954
MESH:D007246 Infertility Diethylstilbestrol 3.8315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8217937319
MESH:D007248 Infertility, Male Methoxychlor 5.8211955947 16467254
MESH:D007249 Inflammation Dexamethasone 12.5111099482 8960868
MESH:D007249 Inflammation Lipopolysaccharides 12.5117237260 9205823 17963957 12878042 17255318
MESH:D007249 Inflammation Progesterone 12.5115869954
MESH:D007249 Inflammation Tamoxifen 12.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5112878042 12200463
MESH:D007251 Influenza, Human Quercetin 3.9416624496
MESH:D007333 Insulin Resistance bisphenol A 10.1116393666
MESH:D007333 Insulin Resistance Estradiol 10.1116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.1116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2317994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.2515955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1217255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.2716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.2717551590 15992940
MESH:D007627 Keloid Quercetin 4.4117086741
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.0816144296
MESH:D007674 Kidney Diseases Estradiol 5.0815618244
MESH:D007674 Kidney Diseases Quercetin 5.0816962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0516705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.0515003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 14.0515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.0518625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5217184923
MESH:D007889 Leiomyoma Raloxifene 3.9816973256
MESH:D007938 Leukemia Genistein 8.7617468513 18980019
MESH:D007938 Leukemia Quercetin 8.7617468513
MESH:D007938 Leukemia Tretinoin 8.7617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9716294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.7717107899 17712046 17339181 19075265 17368321 19035177 17301526 16788101 16140955 17294898 16935935 16823087 17217047 12679006 16766008 16891316 15748426 17506722 16331271 19029980 19225113 19642359 17649720 17361223 9834237
MESH:D007970 Leukopenia Lipopolysaccharides 4.1415821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.149224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.1416054864
MESH:D008064 Lipidoses Tamoxifen 2.7515342952 17567588
MESH:D008103 Liver Cirrhosis Vitamin A 3.5516256175
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 16.1416718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 16.1414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 16.1417823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 16.1412878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 16.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 16.1412741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 16.1418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 16.1412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 16.1418397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 16.1416248980
MESH:D008107 Liver Diseases Vitamin A 3.0016175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.6116762690
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.1221137059 20195826
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 18.1211940454
MESH:D008113 Liver Neoplasms Diethylstilbestrol 18.1215890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 18.1215890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 18.1218980244
MESH:D008113 Liver Neoplasms Tamoxifen 18.1216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.1216984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 7.8819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 7.8812151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 7.8817113696
MESH:D008171 Lung Diseases Vitamin A 3.7116863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 7.5117365036
MESH:D055370 Lung Injury Lipopolysaccharides 7.5121114838
MESH:D008175 Lung Neoplasms alitretinoin 7.3616413115
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.3620464547 18520028 18569708 20064080 18816296 20869020 17053015 20135361 6695378
MESH:D008175 Lung Neoplasms Dexamethasone 7.3611195469 15824018
MESH:D008175 Lung Neoplasms Quercetin 7.3616280456
MESH:D008175 Lung Neoplasms Tamoxifen 7.3618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.3611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.5711422169
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 3.7911422169
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.0715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2119428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 18.7312807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 18.7317203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 18.7314578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental LY 353381 18.7311731420 12374698
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 18.7317203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 18.7319196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 10.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.7619453300
MESH:D008527 Medulloblastoma Tretinoin 2.5417453147
MESH:D008545 Melanoma Tamoxifen 2.9012393984 19393235
MESH:D008545 Melanoma Tretinoin 2.9016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6315990972
MESH:D008591 Meningomyelocele Tretinoin 3.8816940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 2.9416166281 16966607 18303189
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.9915863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7616381670
MESH:D052016 Mucositis irinotecan 4.4517159606
MESH:D009101 Multiple Myeloma Dexamethasone 9.9615867202 16118317 15744524
MESH:D009101 Multiple Myeloma Raloxifene 9.9616497877
MESH:D009101 Multiple Myeloma Vitamin A 9.9616374440
MESH:D009135 Muscular Diseases Bezafibrate 8.9316239165
MESH:D009135 Muscular Diseases pirinixic acid 8.9316239165
MESH:D009164 Mycobacterium Infections Rifampin 4.9818474467
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.409809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.4017596541
MESH:D009203 Myocardial Infarction Genistein 7.9517141266
MESH:D009203 Myocardial Infarction pirinixic acid 7.9519151258
MESH:D009203 Myocardial Infarction Quercetin 7.9519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.7416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.7417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 16.7416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 16.7419207477
MESH:D009232 Myxoma Raloxifene 4.9916343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3018551238
MESH:D009362 Neoplasm Metastasis irinotecan 5.1018259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.1019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3119410462
MESH:D009369 Neoplasms alitretinoin 15.8516946489
MESH:D009369 Neoplasms Benzo(a)pyrene 15.8511141357
MESH:D009369 Neoplasms Diethylstilbestrol 15.8515313581
MESH:D009369 Neoplasms pirinixic acid 15.8517405874
MESH:D009369 Neoplasms Quercetin 15.8515185748
MESH:D009369 Neoplasms Tretinoin 15.8516594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1817289903
MESH:D009421 Nervous System Malformations bisphenol A 31.4411399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 31.4411399458
MESH:D009421 Nervous System Malformations Estradiol 31.4411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 31.4416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 31.4414600291
MESH:D009421 Nervous System Malformations Tretinoin 31.449125849
MESH:D009436 Neural Tube Defects Tretinoin 6.399142499
MESH:D009436 Neural Tube Defects Vitamin A 6.3917400914
MESH:D009447 Neuroblastoma irinotecan 3.178761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.178761367
MESH:D020078 Neurogenic Inflammation Quercetin 3.8517929310
MESH:D009765 Obesity pirinixic acid 1.6620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.9512819281 16049721
MESH:D010024 Osteoporosis Genistein 10.1119401787
MESH:D010024 Osteoporosis ormeloxifene 10.1115261309
MESH:D010024 Osteoporosis Raloxifene 10.1117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.9316169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.9319495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 13.9315758505 17823083 17893378 15579764
MESH:D010049 Ovarian Diseases bisphenol A 4.4311985600
MESH:D010051 Ovarian Neoplasms Estradiol 16.1319401270
MESH:D010051 Ovarian Neoplasms Genistein 16.1319005980
MESH:D010051 Ovarian Neoplasms Medroxyprogesterone Acetate 16.1317393432
MESH:D010051 Ovarian Neoplasms Progesterone 16.1317393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 16.1319005980
MESH:D010051 Ovarian Neoplasms Tretinoin 16.1316936753
MESH:D010146 Pain Tretinoin 2.4716870215
MESH:D010190 Pancreatic Neoplasms Quercetin 4.6316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.6315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1316977796 15687265
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3510923243
MESH:D011014 Pneumonia Lipopolysaccharides 4.0011605937 12224865
MESH:D017499 Porokeratosis alitretinoin 5.4416144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Quercetin 3.5119056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2121297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.0710548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.0717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.0711222880 11896295 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.2215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.8920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.8920887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 12237244
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.8317292933
MESH:D011471 Prostatic Neoplasms bicalutamide 3.8319011039 18487222 15638997 19240160 17914592
MESH:D011471 Prostatic Neoplasms bisphenol A 3.8316740699
MESH:D011471 Prostatic Neoplasms Calcitriol 3.8316289102 16644109 18247401 12479363 15754350
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.8317136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 3.8316740699
MESH:D011471 Prostatic Neoplasms Genistein 3.8315256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.8316205645
MESH:D011471 Prostatic Neoplasms Quercetin 3.8314715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 3.8316220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.8315067354
MESH:D011507 Proteinuria Tretinoin 3.0916636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7615861022 16919318
MESH:D011625 Pterygium Tretinoin 4.2416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2310548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.7917322281 17365031 15814490 17975199
MESH:D011693 Purpura Raloxifene 4.9915770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.0919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.5118379247 11700416
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.2416877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3510835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012554 Schistosomiasis japonica Quercetin 4.9816862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.1718551238
MESH:D012871 Skin Diseases Vitamin A 3.1918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.6919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.6916192470
MESH:D012878 Skin Neoplasms Tretinoin 7.6916467112
MESH:D013088 Spermatocele Diethylstilbestrol 16.8516709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 16.8516709447
MESH:D013088 Spermatocele Tamoxifen 16.8516709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.0216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.0219457130
MESH:D013272 Stomach Diseases Dexamethasone 3.7715472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.022093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 3.0215723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.0217261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.0115138204
MESH:D020521 Stroke Raloxifene 3.3816837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.4316045194 16684133
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.6815821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3312697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.6117045167 16026305
MESH:D013978 Tibial Fractures Estradiol 11.8219048282
MESH:D013978 Tibial Fractures Raloxifene 11.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3016051514
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 11.4916040207
MESH:D014376 Tuberculosis Rifampin 11.4915236969 18397238
MESH:D014376 Tuberculosis Tretinoin 11.4916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 16.6016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.6017053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 16.6017306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Quercetin 16.6016720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 16.6017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 16.6016712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7610091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 7.9016175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.9016129372
MESH:D014591 Uterine Diseases bisphenol A 11.9314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.9314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.7215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.7214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.0416752155
MESH:D014605 Uveitis Dexamethasone 4.251336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0415869587 14671159
MESH:D014802 Vitamin A Deficiency Vitamin A 4.7616175781 16146918 16960172
MESH:D014820 Vitiligo Tretinoin 3.5316761959
MESH:D014846 Vulvar Neoplasms Raloxifene 4.9916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:22258 Metabolism of lipids and lipoproteins
REACT:27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31470
    • Releated gene ID Related gene Name
    PA378NR1I2
    No data
    Releated drug ID Related drug Name
    PA451746tretinoin
    PA452347glucocorticoids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01645 - Genistein Antineoplastic Agents;Enzyme Inhibitors;Growth Inhibitors;Anticarcinogenic Agents;Protein Kinase Inhibitors;Phytoestrogens
    DB04652 - (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE Anti-inflammatory Agents
    DB06832 - 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
    DB06875 - 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE
    DB06908 - (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
    DB06927 - [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
    DB07009 - 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
    DB07080 - N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE
    DB07119 - 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
    DB07150 - 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
    DB07198 - 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
    DB07215 - 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID
    DB07230 - 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
    DB07236 - 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
    DB07530 - (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol
    DB07557 - (5BETA)-PREGNANE-3,20-DIONE
    DB07724 - 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
    DB08220 - (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
    DB08231 - MYRISTIC ACID
    DB08483 - (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
    DB08742 - 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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