AutismKB 2.0

Annotation Detail for NUMB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NUMB ( S171 )
Gene Full Name: numb homolog (Drosophila)
Band: 14q24.3
Quick LinksEntrez ID:8650; OMIM: 603728; Uniprot ID:NUMB_HUMAN; ENSEMBL ID: ENSG00000133961; HGNC ID: 8060
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200013Notch signaling pathway
Pathway IDPathway Name
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
coronary artery calcification
CARDIOVASCULAR
Desease Name
Coronary artery calcification
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NUMB mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NUMB mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of NUMB mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in decreased expression of NUMB mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NUMB mRNAdecreases expression 20064835
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NUMB mRNAaffects cotreatment|increases expression 17183730
D018038 Sodium Selenite Sodium Selenite results in increased expression of NUMB mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NUMB mRNAincreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NUMB mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5011798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5020127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5317306315
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9118414634 12569548 16835338 16251483
MESH:D050197 Atherosclerosis Arsenic 3.3619371607 12928151
MESH:D001321 Autistic Disorder Valproic Acid 1.9918558336 18177632 15238991 18775368 18985861 16609825 20603192 17688650 18396377 17507914 18316065 19460635 18940202 17157402 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.1717594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6915504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8116705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8116507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8114691202 11135700 15073043 15553829 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8817687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8820419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2718640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5815738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4916973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15668235 15340226 12621046 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8715322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8717688650 16575769 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.4315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.431733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 8.6115073043
MESH:D005234 Fatty Liver Valproic Acid 8.6119224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3718558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005534 Foot Diseases Arsenic 5.886392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 12621046 15340226
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 8697196 18606429 16354765 16959395
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6517050553
MESH:D006973 Hypertension Arsenic 5.4516076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D006987 Hypesthesia Arsenic 5.8816093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007642 Keratosis Arsenic 5.2816930632 12749816
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1516705839
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0116467208 16968895 20471514 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.2117339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2119075265 12679006 16823087 17217047 17649720 16330433 17869043 9834237 11468182 15622746 19225113 16331271 17107899 15748426 16891316 15336539 16112521 12018890 15213294 11161223 16966277 12712474 17712046 19642359 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Arsenic 2.5811134558
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.987678174
MESH:D008113 Liver Neoplasms Arsenic 14.9816368122
MESH:D008113 Liver Neoplasms arsenic trioxide 14.9814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9820195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.516135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Arsenic 5.0117976673 17306315 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0119825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0120869020 18569708 18520028 18816296 6695378 20064080 20464547 17053015 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0111884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008881 Migraine Disorders Valproic Acid 3.3318803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519417148 11468182 14977855 19549372 15949261
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7816882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7817596541
MESH:D017202 Myocardial Ischemia Arsenic 9.5615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.5612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Arsenic 12.9616620997
MESH:D009436 Neural Tube Defects arsenic trioxide 12.9610525206
MESH:D009436 Neural Tube Defects Valproic Acid 12.968888407 16359493
MESH:D020078 Neurogenic Inflammation Arsenic 4.6017056641
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010051 Ovarian Neoplasms Arsenic 5.2117306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2112452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2815371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D011471 Prostatic Neoplasms Arsenic 2.0616140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0618760546
MESH:D011507 Proteinuria Arsenic 4.2221343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012640 Seizures Valproic Acid 6.3911738929 3137016 17978042 1511512 15475178 16876388 14763951 11044598
MESH:D012871 Skin Diseases Arsenic 2.7918709164 19834688 17050553 17453740 17938729 15952646 17548696 16759981 16702368 6392382 16353154
MESH:D012878 Skin Neoplasms Arsenic 9.9519538983 17050553 15504454 16251483 17976673 17029826
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.9519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.9516192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4120155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.5316049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.5318640142 11144890 17306315 17976673 15987713 19429237 19322015
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.5311780464 12973940 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.5317053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014652 Vascular Diseases Arsenic 5.0217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04330 Notch signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31845
    • No data
    Releated disease ID Related disease Name
    PA443425Arteriosclerosis
    PA443635Cardiovascular Diseases
    PA443797Coronary Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved