AutismKB 2.0

Annotation Detail for SOCS1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SOCS1 ( CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3 )
Gene Full Name: suppressor of cytokine signaling 1
Band: 16p13.13
Quick LinksEntrez ID:8651; OMIM: 603597; Uniprot ID:SOCS1_HUMAN; ENSEMBL ID: ENSG00000185338; HGNC ID: 19383
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa05145Toxoplasmosis
hsa04630Jak-STAT signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04930Type II diabetes mellitus
No data
Pathway IDPathway Name
200034IL12-mediated signaling events
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200082IL2-mediated signaling events
200018IL4-mediated signaling events
200110IFN-gamma pathway
Pathway IDPathway Name
P00038JAK/STAT signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of SOCS1 mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of SOCS1 mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in decreased expression of SOCS1 mRNAdecreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SOCS1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased methylation of SOCS1 genedecreases methylation 19000444
C006632 arsenic trioxide arsenic trioxide results in increased expression of SOCS1 mRNAincreases expression 18928596
19000444
C015001 arsenite arsenite results in decreased expression of SOCS1 mRNAdecreases expression 18191166
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SOCS1 mRNAdecreases expression 20382639
D001761 Bleomycin Bleomycin results in decreased expression of SOCS1 mRNAdecreases expression 17374387
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SOCS1 mRNAincreases expression 15003993
C459604 candoxin candoxin results in increased expression of SOCS1 mRNAincreases expression 16309724
D002330 Carmustine Carmustine results in decreased expression of SOCS1 mRNAdecreases expression 17374387
D003513 Cycloheximide [hydroxytamoxifen co-treated with Cycloheximide] results in increased expression of SOCS1 mRNAaffects cotreatment|increases expression 16849584
C014347 decitabine decitabine results in decreased methylation of SOCS1 promoterdecreases methylation 19551406
C014347 decitabine decitabine results in increased expression of SOCS1 mRNAincreases expression 19551406
C007262 deoxynivalenol deoxynivalenol results in increased expression of SOCS1 mRNAincreases expression 19625342
D003907 Dexamethasone Dexamethasone results in increased expression of SOCS1 mRNAincreases expression 12782123
12732289
D002945 Cisplatin Cisplatin results in decreased expression of SOCS1 mRNAdecreases expression 17374387
D004958 Estradiol Estradiol inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]decreases reaction|increases expression 16849584
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of SOCS1 mRNAaffects cotreatment|increases expression 17404688
D004958 Estradiol Estradiol affects the expression of SOCS1 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of SOCS1 mRNAincreases expression 16557594
C070081 fulvestrant fulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen ESR2 protein inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen Estradiol inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen fulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen [hydroxytamoxifen co-treated with Cycloheximide] results in increased expression of SOCS1 mRNAaffects cotreatment|increases expression 16849584
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of SOCS1 mRNAincreases expression 16849584
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of SOCS1 mRNAincreases expression 12057914
D008130 Lomustine Lomustine results in decreased expression of SOCS1 mRNAdecreases expression 17374387
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of SOCS1 mRNAaffects cotreatment|increases expression 17404688
D015474 Isotretinoin Isotretinoin results in decreased expression of SOCS1 mRNAdecreases expression 15982314
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS1 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin metabolite results in decreased expression of SOCS1 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of SOCS1 mRNAdecreases expression 15982314
C066075 vanadium pentoxide vanadium pentoxide results in decreased expression of SOCS1 mRNAdecreases expression 17459161
D015054 Zymosan STAT1 protein affects the reaction [Zymosan results in increased expression of SOCS1 mRNA]affects reaction|increases expression 15188379
D015054 Zymosan Zymosan results in increased expression of SOCS1 mRNAincreases expression 15188379
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 7.8218769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8214514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.7418769834
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.0216232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.1117505938
MESH:D000152 Acne Vulgaris Isotretinoin 11.1116185265 18769834
MESH:D058186 Acute Kidney Injury Cisplatin 3.7212690470 17670903 15814532
MESH:D055371 Acute Lung Injury Bleomycin 8.8817118201
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.8811850527 18653653
MESH:D000230 Adenocarcinoma arsenic trioxide 12.8011798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 12.8017638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 12.8011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.8014692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.8017638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1216835633
MESH:D000505 Alopecia Tretinoin 3.4115955085
MESH:D000740 Anemia Fluorouracil 13.6016511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 13.6011748828
MESH:D000740 Anemia Zymosan 13.6018664788
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D000860 Anoxia Bleomycin 5.1415782499
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Dexamethasone 16.2617659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 16.2615885639
MESH:D001169 Arthritis, Experimental Tretinoin 16.2616412693
MESH:D001169 Arthritis, Experimental Zymosan 16.2616872482 15142272 15944321 17659584 15188379
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001284 Atrophy fulvestrant 4.6011514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1516935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.9816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6214601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 4.0015665606 15845082 15380490
MESH:D001932 Brain Neoplasms Carmustine 4.1616187019
MESH:D001943 Breast Neoplasms alitretinoin 5.5616344269
MESH:D001943 Breast Neoplasms Cisplatin 5.5619526202 18382427
MESH:D001943 Breast Neoplasms decitabine 5.5618320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 5.5612948864 17261762 18497071 16675129 17018787 19861407 17289903 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 5.5619217205 16110121 16557594 15136595 18608205 18357371 16595493
MESH:D001943 Breast Neoplasms fulvestrant 5.5618984771
MESH:D001943 Breast Neoplasms Progesterone 5.5616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5620435547
MESH:D001943 Breast Neoplasms Tretinoin 5.5616443354 16166294 16873071
MESH:D001991 Bronchitis vanadium pentoxide 5.9717459161
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4016051944
MESH:D002277 Carcinoma Fluorouracil 7.5017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.803084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.8015553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 10.8017982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 10.8017971768 18930000 17088986 16799960 17045692 16332177
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.801917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9512023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6119014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8912490120
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 17.066189445
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 17.0617066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 17.0619215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 17.0616757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 17.0611237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 17.0616051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 6.7210977129
MESH:D002386 Cataract Tretinoin 6.7217460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.0520889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.0518566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6815861022 17333356 11677210 16919318 17110522 17681005 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.8916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4015340226 15668235 8697196 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 5.409407595
MESH:D003092 Colitis Tretinoin 3.4517035595
MESH:D003110 Colonic Neoplasms arsenite 7.9215037631
MESH:D003110 Colonic Neoplasms decitabine 7.9217616700
MESH:D003110 Colonic Neoplasms Dexamethasone 7.9215824018
MESH:D003110 Colonic Neoplasms Fluorouracil 7.9218772588 16510598 17172411 15001691 17169374 17725105 17018589 16340194 17016597 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.6020501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.6015273666
MESH:D015179 Colorectal Neoplasms decitabine 4.6018981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.6016282729 18949393 18509181 18288408 16391804 17094418 16303861 17594712 18448328 15289873 18383874 17255274 20501625 14970324 15148649 17016601 17454858 16331619 16524972 17695437 18802399 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.0110525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 7.0117728286
MESH:D019465 Craniofacial Abnormalities Isotretinoin 7.0118769834 9879862
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.0120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.019211117 14991402 9142499 16925845 9224671 17551590 9125849 10589399 8800419 9664655
MESH:D007644 Darier Disease Fluorouracil 4.5316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8515213294
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1612438553
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D003967 Diarrhea Dexamethasone 3.457237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.3012958197 11743745 16081117 12392966 16109766 19420014 11421492 11739529 16781746 12540782 16393943 15619225 2444490 11529661 16227642 18713872 16485898 10915739 17522070 12153990 19370779 12594235 15968718 18071297 11834606 14550746 16177239 10663392 19923254 10774834 12705907 17906064 14986274 19739265 14725611 19164858 19085960 11287661 17562736 11461765 19416960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Cisplatin 7.5412231392 12649298 19839026 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5411462148
MESH:D004485 Eczema Dexamethasone 4.2112438553
MESH:D004487 Edema Bleomycin 14.6517118201
MESH:D004487 Edema Dexamethasone 14.6519703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.6512711302 11000095
MESH:D004487 Edema Zymosan 14.657907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.2017692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8519294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.8511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.8516569247
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1315328337 17637181 15821434
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.8420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.8412903497
MESH:D004938 Esophageal Neoplasms Cisplatin 9.8415173087 16481741 15464296 16785472 17638652
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.8416785472 16337965 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1911564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1916938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 11.8415073043
MESH:D005234 Fatty Liver arsenite 11.8418296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.8415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005334 Fever Lipopolysaccharides 3.7911852909 9205823
MESH:D005355 Fibrosis arsenite 13.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.3520067830
MESH:D005355 Fibrosis Tretinoin 13.3517994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0116904648
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005909 Glioblastoma Carmustine 6.8916187019
MESH:D005909 Glioblastoma Tretinoin 6.8917312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.8116524712 15173396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 17.0315102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 17.0319215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 17.0315162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 17.0316096774
MESH:D034381 Hearing Loss Cisplatin 4.0819898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8916084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2115464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0811294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.089664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Zymosan 4.4519110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6412621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.987520565
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006689 Hodgkin Disease Bleomycin 11.5418501091 17606976 15147373
MESH:D006689 Hodgkin Disease Cisplatin 11.5416200630 16170182
MESH:D006689 Hodgkin Disease Lomustine 11.5416135485
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7816959395 15340226 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.9416870215
MESH:D006930 Hyperalgesia Tretinoin 6.9416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3116778211
MESH:D006973 Hypertension Dexamethasone 4.9117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male decitabine 10.3317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.3317937319
MESH:D007248 Infertility, Male fulvestrant 10.3311514358
MESH:D007249 Inflammation Bleomycin 18.2017118201
MESH:D007249 Inflammation Dexamethasone 18.2011099482 8960868
MESH:D007249 Inflammation Lipopolysaccharides 18.2017237260 17963957 12878042 17255318 9205823
MESH:D007249 Inflammation Progesterone 18.2015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.2012200463 12878042
MESH:D007249 Inflammation Zymosan 18.208014878 11289658
MESH:D007333 Insulin Resistance Estradiol 2.8016393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5117994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3917255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5717553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1515992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3716144296
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8715464296
MESH:D007674 Kidney Diseases Acetaminophen 9.2215629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 9.2212231392 18289764 19839026 12649298 15190930
MESH:D007674 Kidney Diseases Estradiol 9.2215618244
MESH:D007680 Kidney Neoplasms Estradiol 6.7815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 6.7816985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5311231351
MESH:D007938 Leukemia arsenic trioxide 9.7415070760
MESH:D007938 Leukemia decitabine 9.7418980019 19235587
MESH:D007938 Leukemia Tretinoin 9.7417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 14.6419077051
MESH:D007951 Leukemia, Myeloid decitabine 14.6417236224 18454857 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 14.6416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.8419850784 17050201 16467208 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.8419010910 19387464 17679729 18206229 18460780 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.8416294345 19850784 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1918055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0717712046 17217047 15748426 12679006 16112521 17649720 9834237 15213294 11468182 16330433 19642359 11161223 12018890 19225113 16331271 16891316 19075265 16966277 17107899 17869043 12712474 15622746 19035177 16823087 15336539
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0712679006 16891316 17301526 17107899 19029980 17339181 16331271 17217047 16935935 9834237 15748426 17649720 17294898 19035177 17361223 17712046 19225113 17368321 19075265 16766008 16788101 19642359 16823087 16140955 17506722
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1016882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.4315821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.129224671
MESH:D008103 Liver Cirrhosis arsenite 3.2818296743
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 15197228
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.3716718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.3712878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3716248980 18397230
MESH:D008107 Liver Diseases marker/mechanism 15197228
MESH:D008107 Liver Diseases Acetaminophen 1.5719460945 19784758 16611625 16610002 12969438 11587558 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0117185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 6.8514682389
MESH:D008113 Liver Neoplasms Fluorouracil 6.8515113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.8516984957
MESH:D008114 Liver Neoplasms, Experimental marker/mechanism 15197228
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.2720377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.2712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1515213294
MESH:D055370 Lung Injury Lipopolysaccharides 3.7521114838
MESH:D008175 Lung Neoplasms alitretinoin 17.2016413115
MESH:D008175 Lung Neoplasms arsenic trioxide 17.2019825857 11798837
MESH:D008175 Lung Neoplasms arsenite 17.2016809336
MESH:D008175 Lung Neoplasms Bleomycin 17.206189445
MESH:D008175 Lung Neoplasms Cisplatin 17.206189445 11798837 17225452
MESH:D008175 Lung Neoplasms Dexamethasone 17.2015824018 11195469
MESH:D008175 Lung Neoplasms Fluorouracil 17.2015246190
MESH:D008175 Lung Neoplasms Isotretinoin 17.2015899809
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 17.2019555203 11884234
MESH:D008175 Lung Neoplasms vanadium pentoxide 17.2012376484
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5315086387
MESH:D008223 Lymphoma decitabine 3.2319470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5117203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.5117203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D008527 Medulloblastoma Tretinoin 2.6817453147
MESH:D008545 Melanoma Bleomycin 14.6615577320
MESH:D008545 Melanoma Carmustine 14.6612393984
MESH:D008545 Melanoma Cisplatin 14.6615577323 18332650 16248763 18176117 17761969 12374674 17023156 16432458 16809738 12393984 11135225 12883367 18505091
MESH:D008545 Melanoma decitabine 14.6616505122 17785578
MESH:D008545 Melanoma Isotretinoin 14.6617237267
MESH:D008545 Melanoma Lomustine 14.6615577320
MESH:D008545 Melanoma Tretinoin 14.6616752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008591 Meningomyelocele Tretinoin 4.1716940565
MESH:D008654 Mesothelioma Cisplatin 3.1417638057
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4316757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 11.1115949261 19417148 11468182 19549372 14977855
MESH:D009101 Multiple Myeloma decitabine 11.1118172295
MESH:D009101 Multiple Myeloma Dexamethasone 11.1115744524 16118317 15867202
MESH:D009102 Multiple Organ Failure Zymosan 4.9615834315 10890648 17724436 12879239 15259001 15241586 15213630 12130978 18160304 10479408
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 16.3616882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 16.3619010910 19157545 16882708 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 16.369809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 16.3617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0816810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7116624393
MESH:D009369 Neoplasms alitretinoin 14.3716946489
MESH:D009369 Neoplasms Cisplatin 14.3716773208
MESH:D009369 Neoplasms decitabine 14.3719470736 19116145 17925555
MESH:D009369 Neoplasms Fluorouracil 14.3716928823 18239605 18600527
MESH:D009369 Neoplasms Tretinoin 14.3716946489 16594593
MESH:D009389 Neovascularization, Pathologic arsenite 9.2715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.2717289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2315464296
MESH:D009421 Nervous System Malformations Estradiol 14.8816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.8814600291
MESH:D009421 Nervous System Malformations Tretinoin 14.889125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.7410525206
MESH:D009436 Neural Tube Defects Tretinoin 6.749142499
MESH:D009447 Neuroblastoma Cisplatin 6.988761367
MESH:D009447 Neuroblastoma Isotretinoin 6.9817368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6618514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.438761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2616436463
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.7612452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Cisplatin 17.7619769630 6897625 17225452 15464296
MESH:D010051 Ovarian Neoplasms decitabine 17.7619331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 17.7619401270
MESH:D010051 Ovarian Neoplasms Progesterone 17.7616525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 17.7616936753
MESH:D010146 Pain Acetaminophen 5.8916870215
MESH:D010146 Pain Tretinoin 5.8916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.3015580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 15.3019003803
MESH:D010190 Pancreatic Neoplasms decitabine 15.3019294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.3015113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.3015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0615464296
MESH:D010538 Peritonitis Zymosan 4.6318760300 18557954 18977430 19641140 15259001 17826846 11985352 17371808 15979727 19088179 14761945
MESH:D010997 Pleural Neoplasms Cisplatin 5.0817638057
MESH:D011014 Pneumonia Bleomycin 10.6017071938 16317386 18024389
MESH:D011014 Pneumonia Lipopolysaccharides 10.6012224865 11605937
MESH:D017499 Porokeratosis alitretinoin 5.7416144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4021297632
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 8.9718769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9711118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.4717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6619131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.6616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6618626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.3616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0516919318 15861022
MESH:D011596 Psychomotor Disorders Isotretinoin 5.6518769834
MESH:D011625 Pterygium Tretinoin 4.5316723453
MESH:D011654 Pulmonary Edema Bleomycin 5.0515808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.7712574379 16115399 15322207 18162602 21435439 16314464 17177178 15541506 17241526 12624602 17434272 14609568 11554783 18008008
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7916160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Cisplatin 4.1515464296
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7718379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.1419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1416116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.5116646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.5114601052
MESH:D012513 Sarcoma, Experimental Lomustine 7.107150475
MESH:D018805 Sepsis Zymosan 4.4411441115
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.708532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7016192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7016467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0815464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0215862959 16503802
MESH:D013272 Stomach Diseases Dexamethasone 4.0615472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.1017007042
MESH:D013274 Stomach Neoplasms Cisplatin 6.1018396642 17522103 15958060
MESH:D013274 Stomach Neoplasms decitabine 6.1019037991
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1017522103 17172411 18396642 15786421 19015929 17498489 16424979 18567086 16951190 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 6.1017261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.2615138204
MESH:D013736 Testicular Neoplasms Cisplatin 4.3917225452 15464296
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9415821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.8819014326
MESH:D013964 Thyroid Neoplasms decitabine 10.8817967635
MESH:D013964 Thyroid Neoplasms Tretinoin 10.8817045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.0716280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.0716051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7015213294
MESH:D014376 Tuberculosis Tretinoin 3.0716040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.8411780464 12845720 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 7.8415464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.8417616700 19087683
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 14.6016803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.6016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.6016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014604 Uveal Neoplasms decitabine 11.9417785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.9416752155
MESH:D014605 Uveitis Dexamethasone 11.401336536
MESH:D014605 Uveitis Zymosan 11.4011006244
MESH:D014625 Vaginal Neoplasms Cisplatin 4.3515577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8116761959
MESH:D014839 Vomiting Cisplatin 4.4511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D015431 Weight Loss Bleomycin 5.3812624602
MESH:D009396 Wilms Tumor Tretinoin 3.7516287080
Pathway ID Pathway Name
KEGG:04910 Insulin signaling pathway
KEGG:04630 Jak-STAT signaling pathway
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
KEGG:05145 Toxoplasmosis
KEGG:04930 Type II diabetes mellitus
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134863068
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA10804imatinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved