Annotation Detail for TNKS
Basic Information
Top
| Gene Symbol: | TNKS ( PARP-5a,PARP5A,PARPL,TIN1,TINF1,TNKS1,pART5 ) |
|---|
| Gene Full Name: | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase |
|---|
| Band: | 8p23.1 |
|---|
| Quick Links | Entrez ID:8658; OMIM: 603303; Uniprot ID:TNKS1_HUMAN; ENSEMBL ID: ENSG00000173273; HGNC ID: 11941 |
|---|
| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| 200072 | Regulation of Telomerase |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D005047 |
Etoposide |
TNKS protein affects the susceptibility to Etoposide | affects response to substance | 16217747
|
| D008942 |
Mitoxantrone |
TNKS protein affects the susceptibility to Mitoxantrone | affects response to substance | 16217747
|
| C025643 |
vinclozolin |
vinclozolin affects the expression of TNKS mRNA | affects expression | 19015723
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D001008 |
Anxiety Disorders |
|
vinclozolin |
4.00 | 19015723 |
| MESH:D019046 |
Bone Marrow Neoplasms |
|
Etoposide |
6.03 | 14601052 |
| MESH:D001943 |
Breast Neoplasms |
|
Etoposide |
3.03 | 16322251 |
| MESH:D003456 |
Cryptorchidism |
|
vinclozolin |
4.93 | 14966744 |
| MESH:D030342 |
Genetic Diseases, Inborn |
|
vinclozolin |
5.68 | 16973722 |
| MESH:D005832 |
Genital Diseases, Male |
|
vinclozolin |
6.17 | 16417039 |
| MESH:D006331 |
Heart Diseases |
|
Mitoxantrone |
4.44 | 16019553 |
| MESH:D006561 |
Herpes Simplex |
|
Etoposide |
5.30 | 10809021 |
| MESH:D006689 |
Hodgkin Disease |
|
Etoposide |
4.28 | 17606976 16200630 15147373 18180244 16135485 |
| MESH:D007248 |
Infertility, Male |
|
vinclozolin |
3.32 | 16467254 |
| MESH:D015451 |
Leukemia, Lymphocytic, Chronic, B-Cell |
|
Mitoxantrone |
3.93 | 18172266 |
| MESH:D007984 |
Leydig Cell Tumor |
|
vinclozolin |
5.47 | 16417039 |
| MESH:D008223 |
Lymphoma |
|
Etoposide |
4.23 | 12556972 12854902 |
| MESH:D009369 |
Neoplasms |
|
Mitoxantrone |
3.60 | 16640825 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
Etoposide |
3.39 | 19003803 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
vinclozolin |
4.64 | 18220299 19015723 18042343 |
| MESH:D011469 |
Prostatic Diseases |
|
vinclozolin |
5.68 | 18220299 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Etoposide |
3.95 | 17172428 |
| MESH:D011472 |
Prostatitis |
|
vinclozolin |
5.68 | 18629315 |
| MESH:D012512 |
Sarcoma, Ewing's |
|
Etoposide |
5.29 | 14601052 |
PharmGKB Accession:PA36631
| Releated drug ID |
Related drug Name |
| PA451581 | tamoxifen |
Drug Bank