AutismKB 2.0

Annotation Detail for EIF3A


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Basic Information Top
Gene Symbol:EIF3A ( EIF3,EIF3S10,KIAA0139,P167,TIF32,eIF3-p170,eIF3-theta,p180,p185 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit A
Band: 10q26.11
Quick LinksEntrez ID:8661; OMIM: 602039; Uniprot ID:EIF3A_HUMAN; ENSEMBL ID: ENSG00000107581; HGNC ID: 3271
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of proteins
Gene Expression
3' -UTR-mediated translational regulation
Pathway IDPathway Name
200099IL2 signaling events mediated by PI3K
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of EIF3A mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EIF3A mRNAdecreases expression 17275222
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EIF3A mRNAdecreases expression 19150397
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF3A mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3A mRNAaffects cotreatment|increases expression 17942748
D011794 Quercetin Quercetin affects the expression of EIF3A proteinaffects expression 15221776
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3A mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3920127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.8219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8617474063 20146248
MESH:D001943 Breast Neoplasms Quercetin 1.8618628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.133084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.1319519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D006332 Cardiomegaly Quercetin 7.3219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3218670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1011677210 17681005 17110522 16919318 17333356 16105132 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 15668235 8697196 12621046 16354765
MESH:D003110 Colonic Neoplasms Quercetin 2.4611134977 19440933 17148506 19056647 16640504 15741050 17191121
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0019496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8111739529 19164858 10915739 2444490 19085960 14550746 15968718 19923254 11743745 10774834 17906064 12594235 14725611 12153990 19739265 12540782 14986274 16393943 12705907 19370779 18071297 17562736 16177239 11529661 19416960 16485898 11461765 10663392 16227642 19420014 18713872 15619225 11834606 12958197 16081117 11421492 16781746 17522070 16109766 12392966 11287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Quercetin 10.1919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.1920067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma Quercetin 3.5819804834
MESH:D005910 Glioma Quercetin 3.1517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia Quercetin 4.3411834736 18262572
MESH:D006973 Hypertension Quercetin 5.5618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007674 Kidney Diseases Acetaminophen 6.6215629191 12587719
MESH:D007674 Kidney Diseases Quercetin 6.6216962696
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.5212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5212878042
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 11587558 19460945 16611625 19014921 12587719 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0121137059 20195826
MESH:D008113 Liver Neoplasms Quercetin 8.0118980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0116984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.5319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5620064080 20464547 18520028 20135361 20869020 18569708 17053015 18816296 6695378
MESH:D008175 Lung Neoplasms Quercetin 3.5616280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009203 Myocardial Infarction Quercetin 3.1019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.0319207477
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5911141357
MESH:D009369 Neoplasms Quercetin 5.5915185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.7117929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8119005980
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Quercetin 4.2719056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2317292933
MESH:D011471 Prostatic Neoplasms Quercetin 3.2317292933 14715546
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5117053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.5116720314
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27699
    • No data
    No data
    Releated drug ID Related drug Name
    PA451365sirolimus
    PA451365sirolimus
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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