AutismKB 2.0

Annotation Detail for EIF3B


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Basic Information Top
Gene Symbol:EIF3B ( EIF3-ETA,EIF3-P110,EIF3-P116,EIF3S9,MGC104664,MGC131875,PRT1 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit B
Band: 7p22.3
Quick LinksEntrez ID:8662; OMIM: 603917; Uniprot ID:EIF3B_HUMAN; ENSEMBL ID: ENSG00000106263; HGNC ID: 3280
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of proteins
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EIF3B mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EIF3B mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of EIF3B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of EIF3B mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EIF3B mRNAdecreases expression 20018196
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3B mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3B mRNAaffects cotreatment|affects expression 17602206
D002117 Calcitriol Calcitriol results in decreased expression of EIF3B mRNAdecreases expression 12875902
D004958 Estradiol Estradiol affects the expression of EIF3B mRNAaffects expression 15598610
D012643 Selenium Selenium results in increased expression of EIF3B mRNAincreases expression 19244175
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF3B mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF3B mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in decreased expression of EIF3B mRNAdecreases expression 12875902
16140955
D014810 Vitamin E Vitamin E results in increased expression of EIF3B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.067525203
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D000236 Adenoma Diethylnitrosamine 2.896695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0216434500 17620307 18056438 19052882 17162532 19061943
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6916197459 16206674
MESH:D001943 Breast Neoplasms Calcitriol 1.9811237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9817474063
MESH:D001943 Breast Neoplasms Estradiol 1.9817289903 17261762 12948864 18497071 14630087 19861407 17018787 16675129
MESH:D001943 Breast Neoplasms Tretinoin 1.9816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.5616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.5616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.563084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.5616830150 19919837 17428255 16288022 20432363 16502159 16540662 17055752 18494052 10672840 20084675 20512989 16698587 3084413 11831363 19171122 16681979 17138121 20524982 10737359 19383236 18665156 19107877 20214788 19519916 18210153 18691550 17173139 16807293 16328049 18978308 17978847 17162532 19539802 18785209 18971187 18056438 17761372 20101231 18393292 20935162 16569478 19394651 16935385 20007298 18788625 18506893 19208518 19701751 19418558 19822196 20727157 21159647 20514400 16779866 16878318 19335982 19052882 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.5616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.561917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8511237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8516051514 16096774
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.6414694615
MESH:D002386 Cataract Acetaminophen 12.6410977129
MESH:D002386 Cataract Tretinoin 12.6417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.496135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.4920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.4917174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.4918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Selenium 9.8517936198
MESH:D003092 Colitis Tretinoin 9.8517035595
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2315095906
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.719142499 9125849 9211117 14991402 9224671 16925845 8800419 17551590 10589399 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7119769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.5821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5812392966 17522070 17562736 17906064 18713872 12705907 19416960 15968718 10663392 19085960 18071297 16781746 11743745 16177239 12540782 10915739 11739529 11287661 12594235 19739265 10774834 14725611 11461765 11421492 16393943 11834606 11529661 16227642 16485898 14986274 14550746 16081117 19370779 12958197 19420014 16109766 19164858 19923254 12153990 2444490 15619225
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5819107877
MESH:D056486 Drug-Induced Liver Injury Selenium 15.5815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0315138306
MESH:D016889 Endometrial Neoplasms Estradiol 7.5911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.5916569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tretinoin 3.6416938888 9664655
MESH:D005234 Fatty Liver Diethylnitrosamine 3.2720387270 21071580
MESH:D005355 Fibrosis Tretinoin 3.6217994277
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 6.919664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9116080930
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 10.5017088409
MESH:D019584 Hot Flashes Vitamin E 10.5014716179
MESH:D006930 Hyperalgesia Acetaminophen 7.8416870215
MESH:D006930 Hyperalgesia Tretinoin 7.8416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance Estradiol 3.0216627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9817551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 10.3012587719 15629191
MESH:D007674 Kidney Diseases Estradiol 10.3015618244
MESH:D007674 Kidney Diseases Vitamin E 10.3012488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.8016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.8016705839
MESH:D007680 Kidney Neoplasms Estradiol 12.8015610895
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 8.4016140954 16140955
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.409834237 16788101 17368321 17339181 19029980 16891316 16140955 17649720 17294898 19035177 16766008 19642359 16823087 19075265 12679006 17107899 16935935 17712046 19225113 17506722 15748426 16331271 17361223 17301526 17217047
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718665156 19638242 18522880 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5816248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5816169303
MESH:D008107 Liver Diseases Acetaminophen 3.9719784758 11587558 19460945 16610002 12969438 19014921 16611625 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.687678174
MESH:D008113 Liver Neoplasms Clofibric Acid 7.6817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6819294768 19426721 18644402 19499222 19850985 21278145 19812893 19073162 18648771 19638242 15175105 19427195 19551842 21047994 18754104 16942905 20137499 21071580 20434301 21167192 2422723 19996281 20452335 19255062 12112319 9163691 19090486 19833225 12771043 20583210 19690152 15885732 19254457 20118626 20101389 20405173 18977376 10737359 20492335 20501860 2862719 18978307 19256749 19642983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.092876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.0918164116 19009564 18253720 17854601 19519916 18775883 18093689 18544905 19004024 2563599 18282651 19539802 17942915 18079962 16842330 16267830 9362446 19126423 17174075 3124819 21159647 18308698
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5220970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Vitamin E 2.5211062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1916891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1915318939
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.4416946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 9.9911399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 9.999125849
MESH:D009436 Neural Tube Defects Tretinoin 3.109142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.6116049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.6116049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.6114694615
MESH:D010051 Ovarian Neoplasms Estradiol 4.8819401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8816936753
MESH:D010146 Pain Acetaminophen 6.8116870215
MESH:D010146 Pain Tretinoin 6.8116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3416540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3415976015
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5916289102 16644109 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5915084515
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tretinoin 2.6416467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4418456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4417261132
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.387505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
KEGG:03013 RNA transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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