AutismKB 2.0

Annotation Detail for EIF3C


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EIF3C ( EIF3CL,EIF3S8,FLJ78287,MGC189744,eIF3-p110 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit C
Band: 16p11.2
Quick LinksEntrez ID:8663; OMIM: 603916; Uniprot ID:EIF3C_HUMAN; ENSEMBL ID: ENSG00000184110; HGNC ID: 3279
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of proteins
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
IMMUNE
inflammatory bowel disease (early onset)
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of EIF3C mRNAincreases expression 15375163
D000082 Acetaminophen Acetaminophen affects the expression of EIF3C mRNAaffects expression 17562736
C032036 bromobenzene bromobenzene results in increased expression of EIF3C mRNAincreases expression 12628495
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3C mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3C mRNAaffects cotreatment|affects expression 17602206
D007529 Isoflavones Isoflavones results in decreased expression of EIF3C mRNAdecreases expression 17374662
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF3C mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF3C mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in decreased expression of EIF3C mRNAdecreases expression 16140955
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 2.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2419061943 17162532 16434500 19052882 18056438 17620307
MESH:D000505 Alopecia Isoflavones 10.2317569567
MESH:D000505 Alopecia Tretinoin 10.2315955085
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8516197459 16206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1517474063
MESH:D001943 Breast Neoplasms Tretinoin 2.1516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7117428255 18788625 19107877 18785209 16540662 19919837 19383236 19171122 16830150 19539802 20007298 19519916 20524982 18393292 20432363 10672840 16698587 19701751 18494052 19052882 18691550 19208518 16681979 3084413 18056438 19394651 21159647 17138121 20935162 18506893 11831363 16288022 16779866 16502159 20512989 17761372 18978308 18210153 19822196 16807293 20101231 19335982 17162532 20084675 19418558 3581430 20214788 20514400 18665156 17055752 16935385 17173139 16569478 17978847 10737359 16878318 20727157 18971187 16328049
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.711917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D002318 Cardiovascular Diseases Isoflavones 4.3117689850
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0121159647 7505956 2727394 17174075
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D015179 Colorectal Neoplasms Isoflavones 2.9017116718
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839211117 17551590 9664655 10589399 14991402 16925845 9142499 9125849 9224671 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7011834606 14550746 17906064 19739265 16781746 11461765 16227642 10663392 17522070 12153990 11421492 19416960 12958197 12540782 12705907 16081117 15968718 19420014 11287661 2444490 19085960 15619225 10915739 19923254 14986274 12392966 18071297 10774834 16177239 16485898 14725611 16109766 19164858 18713872 16393943 12594235 11529661 19370779 17562736 11743745 11739529
MESH:D056486 Drug-Induced Liver Injury bromobenzene 6.7012628495 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.7019107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005124 Eye Abnormalities Tretinoin 3.759664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4320387270 21071580
MESH:D005355 Fibrosis Tretinoin 3.8217994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.019664655 14991402
MESH:D019584 Hot Flashes Isoflavones 5.3617290160 14716179
MESH:D006930 Hyperalgesia Acetaminophen 8.2716870215
MESH:D006930 Hyperalgesia Tretinoin 8.2716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1417551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 8.7216140954 16140955
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.7216331271 9834237 17217047 16788101 16935935 19642359 17107899 17712046 16140955 17649720 17301526 17294898 19225113 16823087 19029980 19035177 16766008 19075265 17368321 16891316 17339181 17361223 15748426 12679006 17506722
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418665156 18407596 18522880 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.0819460945 11587558 12969438 12587719 19784758 16611625 19014921 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 5.0217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0220452335 19996281 19690152 19256749 15175105 16942905 21278145 21167192 19638242 19833225 20492335 19255062 19426721 20118626 21047994 18978307 12771043 19427195 20405173 15885732 12112319 19850985 18754104 20583210 18644402 20434301 19254457 19073162 10737359 9163691 20137499 20501860 18648771 20101389 19499222 2422723 19812893 19642983 19551842 2862719 21071580 19294768 19090486 18977376
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7719539802 2563599 16267830 19519916 17942915 9362446 19009564 17174075 18079962 21159647 3124819 18093689 18544905 19126423 18775883 18164116 18253720 19004024 16842330 17854601 18282651 18308698
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 20512841 21163286
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.5116946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.209142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D010024 Osteoporosis Isoflavones 4.2416562857
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.2616870215
MESH:D010146 Pain Tretinoin 7.2616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4916540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4915976015
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011471 Prostatic Neoplasms Isoflavones 4.2717219775 17571952 16365062 17374662
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4718456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4717261132
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.787505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved