AutismKB 2.0

Annotation Detail for EIF3H


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Basic Information Top
Gene Symbol:EIF3H ( EIF3S3,MGC102958,eIF3-gamma,eIF3-p40 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit H
Band: 8q23.3-q24.11
Quick LinksEntrez ID:8667; OMIM: 603912; Uniprot ID:EIF3H_HUMAN; ENSEMBL ID: ENSG00000147677; HGNC ID: 3273
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of proteins
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
colorectal cancer
CANCER
Desease Name
Colorectal cancer
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of EIF3H mRNAincreases expression 18648102
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3H mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3H mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EIF3H mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3H mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of EIF3H proteinincreases expression 16803524
15585135
D007657 Ketone Bodies Ketone Bodies results in increased expression of EIF3H mRNAincreases expression 16807920
C025299 polyphenols polyphenols results in decreased expression of EIF3H mRNAdecreases expression 16293270
D018038 Sodium Selenite Sodium Selenite results in increased expression of EIF3H mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3H mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4914692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4917638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.0410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0317162532 19061943 16434500 17620307 19052882 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0316835633
MESH:D000740 Anemia Fluorouracil 9.3317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8617474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.8616557594 16110121 19217205 18608205 15136595 16595493 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 14578863
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.777296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7719208518 18978308 16878318 19394651 3084413 20935162 20214788 16698587 16935385 11831363 17173139 20084675 16288022 20512989 19052882 18494052 20727157 19519916 16569478 16830150 17978847 16807293 18210153 18785209 16502159 17162532 17761372 18056438 16328049 20514400 17138121 17428255 19171122 10737359 18506893 20432363 19919837 18665156 18788625 18971187 19701751 16540662 21159647 16779866 18393292 10672840 19539802 19418558 20524982 20101231 20007298 17055752 3581430 16681979 19383236 18691550 19335982 19822196 19107877
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7717971768 17045692 16799960 16332177 17088986 18930000
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.787296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7818695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5417066447 16757204 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.157505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.152727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.369022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3616105132 17333356 17681005 17110522 16919318 15861022 11677210
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 8697196 16354765 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 4.1016510598 16340194 17725105 17169374 15001691 18772588 17172411 17287894 17016597 17018589
MESH:D003110 Colonic Neoplasms polyphenols 4.1016293270
MESH:D015179 Colorectal Neoplasms marker/mechanism 18372905
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016391804 17401013 14970324 16282729 17594712 17695437 15289873 18802399 18949393 17454858 18448328 15148649 17016601 18383874 17255274 18509181 18288408 16524972 17094418 16303861 16331619 20501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.062524372 11906362 8970840 14531868 11298694 18759878 8156756 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.611440618 18289764 11289319 18692083 18648102 9328219 6482804 9653073 6679447 9022650 8291058 7440962 16192314
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.6119107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 12.6119370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.6115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.673581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6716785472 15173087 17638652 16337965 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16959395 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Diethylnitrosamine 8.9418785209
MESH:D007249 Inflammation polyphenols 8.9416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9412878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.066582329
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0616985049
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318522880 18665156 20032147 18407596 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4817034775
MESH:D008107 Liver Diseases polyphenols 4.4816698588
MESH:D008113 Liver Neoplasms Clofibric Acid 11.3017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.3019427195 18978307 18644402 20501860 19426721 19642983 16942905 19850985 19690152 2862719 19254457 9163691 19294768 21167192 12771043 20118626 18754104 2422723 20137499 20405173 19499222 20492335 18977376 19073162 19638242 20434301 20452335 19255062 12112319 19833225 20101389 10737359 19812893 21071580 21278145 19551842 18648771 19090486 15175105 19256749 19996281 21047994 20583210 15885732
MESH:D008113 Liver Neoplasms Fluorouracil 11.3017045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.501399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5019009564 18164116 16267830 19126423 19539802 18253720 18079962 18308698 18544905 2563599 18775883 16842330 17854601 19519916 19004024 3124819 18282651 17174075 21159647 18093689 9362446 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5012151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5121163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 3.5115246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7918986760 16757204
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009369 Neoplasms Fluorouracil 2.7018600527 16928823 18239605
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5416500647 16929163 19003803 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms marker/mechanism 14997205
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3419082440 18626508
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918286688 18722050 15538739 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5318567086 18396642 16951190 17522103 19084572 16424979 17172411 17498489 19015929 15786421
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5717997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.643712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.647505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
KEGG:05162 Measles
REACT:17015 Metabolism of proteins
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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