AutismKB 2.0

Annotation Detail for SLC4A4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC4A4 ( DKFZp781H1314,HNBC1,KNBC,NBC1,NBC2,SLC4A5,hhNMC,pNBC )
Gene Full Name: solute carrier family 4, sodium bicarbonate cotransporter, member 4
Band: 4q13.3
Quick LinksEntrez ID:8671; OMIM: 603345; Uniprot ID:S4A4_HUMAN; ENSEMBL ID: ENSG00000080493; HGNC ID: 11030
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
hsa04964Proximal tubule bicarbonate reclamation
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00429Proximal renal tubular acidosis (RTA type 2)
Urinary system diseases
Kidney diseases
No data
No data
No data
Desease Name
Renal tubular acidosis, proximal, with ocular abnormalities
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC4A4 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of SLC4A4 mRNAaffects expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SLC4A4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SLC4A4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC4A4 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased activity of SLC4A4 proteinincreases activity 17325238
C010680 antibiotic G 418 antibiotic G 418 results in increased expression of SLC4A4 protein mutant formincreases expression 18614622
C053541 bicalutamide bicalutamide results in decreased expression of SLC4A4 mRNAdecreases expression 15638997
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC4A4 mRNAaffects expression 17484886
C019304 ciprofibrate ciprofibrate results in increased expression of SLC4A4 mRNAincreases expression 12771043
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC4A4 mRNAdecreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SLC4A4 mRNAincreases expression 12771043
D017878 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC4A4 proteindecreases activity 17325238
D017878 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC4A4 proteindecreases activity 17666794
D004958 Estradiol Estradiol results in decreased expression of SLC4A4 mRNAdecreases expression 20068009
D005419 Flavonoids Flavonoids results in increased expression of SLC4A4 mRNAincreases expression 18035473
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D001556 Lindane Lindane results in increased expression of SLC4A4 mRNAincreases expression 17785943
D005996 Nitroglycerin Nitroglycerin results in increased expression of SLC4A4 mRNAincreases expression 12102619
D010634 Phenobarbital Phenobarbital affects the expression of SLC4A4 mRNAaffects expression 19136022
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC4A4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid affects the expression of SLC4A4 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC4A4 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of SLC4A4 mRNAincreases expression 18301758
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D012643 Selenium Selenium results in decreased expression of SLC4A4 mRNAdecreases expression 19244175
D012964 Sodium SLC4A4 protein results in increased transport of Sodiumincreases transport 18614622
D017693 Sodium Bicarbonate SLC4A4 protein results in increased transport of Sodium Bicarbonateincreases transport 18614622
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC4A4 mRNAincreases expression 16054898
18796159
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of SLC4A4 mRNAincreases expression 17982090
D014415 Tunicamycin Tunicamycin results in decreased expression of SLC4A4 mRNAdecreases expression 17127020
D014810 Vitamin E Vitamin E results in decreased expression of SLC4A4 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 12.837525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.836195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.8311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 10.3718287403
MESH:D000138 Acidosis Sodium Bicarbonate 10.3720061926
MESH:D000141 Acidosis, Renal Tubular marker/mechanism 18614622
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Estradiol 2.0411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.203712494
MESH:D000236 Adenoma Diethylnitrosamine 6.206695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.8218056438 17620307 16434500 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.8216835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1312661182
MESH:D000544 Alzheimer Disease rosiglitazone 2.8019621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3917659584
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7711289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Estradiol 1.9418497071 12948864 14630087 16675129 17261762 19861407 17289903 17018787
MESH:D001943 Breast Neoplasms Lindane 1.9414688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.1315721981 16097048 16227642 16192424 15700767 16011737 10355542 18705752 15673190 3786805 16050911 16124888
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.1316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.4416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.447296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.4418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4418788625 17173139 19383236 19822196 18971187 20007298 16878318 10672840 3581430 20935162 20101231 20727157 16698587 11831363 19107877 19919837 20084675 16569478 16807293 3084413 18691550 20524982 20432363 16288022 18978308 16779866 16830150 18210153 16681979 18506893 17162532 19171122 10737359 17978847 19519916 17055752 18785209 19701751 20512989 18393292 18665156 19208518 16540662 16935385 18494052 17761372 19394651 20214788 17428255 19539802 16328049 21159647 16502159 17138121 20514400 19052882 19418558 18056438 19335982
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.4420935162 1701930 20007298 17173139 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.567296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318850075 18670907 16120746
MESH:D002386 Cataract marker/mechanism 18614622
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.9514694615
MESH:D002386 Cataract Acetaminophen 6.9510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.637505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.6312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.632727394 17174075 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.6318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.3419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.3419486331
MESH:D002779 Cholestasis pirinixic acid 12.3419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.008697196 12621046 15340226 15668235 16354765
MESH:D003092 Colitis Selenium 9.0017936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.0017991707 11698051 16867261 18200517 16804969 16782535 16474422 17936198 18023891
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3617276891
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4515824018
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.5015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.5014669216 17141729
MESH:D003318 Corneal Opacity marker/mechanism 18614622
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.6717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6719769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.252524372 12868966 8156756 11298694 14531868 8970840 11906362 18759878
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.2512438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.263621924 2952479
MESH:D002658 Developmental Disabilities marker/mechanism 18614622
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0917446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7920387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.7912642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D003967 Diarrhea Dexamethasone 3.477237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 20.9221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 20.9218289764 11289319 9653073 6679447 9022650 7440962 18692083 16192314 8291058 9328219 1440618 6482804 18648102
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 20.9221346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 20.9216393943 16109766 18713872 17906064 12540782 16081117 15619225 19416960 2444490 14725611 11834606 18071297 19923254 11529661 19420014 11461765 19164858 11287661 10774834 11739529 16227642 11743745 11421492 12705907 14550746 16781746 17522070 10915739 17562736 19739265 19370779 19085960 16485898 12594235 12958197 15968718 10663392 12392966 16177239 14986274 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 20.923732212 7179309 4309450 3786805 9327722 10915739 16177239 10092053 17522070 6623471 16227642 15027814 7440962 6884620 19336974 21278145 19085960 11566570 15968718 15998439 2869522 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.9219107877
MESH:D056486 Drug-Induced Liver Injury Selenium 20.9215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.9220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004417 Dyspnea Sodium Bicarbonate 6.1120016425
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:C538011 Eales disease Vitamin E 4.459068938
MESH:D004485 Eczema Dexamethasone 4.2212438553
MESH:D004487 Edema Dexamethasone 14.6619703484
MESH:D004487 Edema pirinixic acid 14.6612083418
MESH:D004487 Edema rosiglitazone 14.6612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.6612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6515322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.8211473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.053581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.3115959796 61145 16239168 17595544 12795759 12631006 19224547 16045604
MESH:D005234 Fatty Liver Cyclosporine 22.3119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.3121071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 22.3119236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 22.3119196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D005355 Fibrosis Carbon Tetrachloride 19.1818705752
MESH:D005355 Fibrosis Cyclosporine 19.1812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.1820067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 19.1817994277
MESH:D005739 Gas Poisoning Sodium Bicarbonate 6.4920016425
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005901 Glaucoma marker/mechanism 18614622
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006261 Headache Nitroglycerin 4.9411284996 11554966
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.1416080930
MESH:D006333 Heart Failure pirinixic acid 6.4520558911
MESH:D006333 Heart Failure Selenium 6.4517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.446705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4419110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 12.9816109766
MESH:D006529 Hepatomegaly pirinixic acid 12.9819176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9812621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.687520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.6816863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 9.2217088409
MESH:D019584 Hot Flashes Vitamin E 9.2214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.2516870215
MESH:D006930 Hyperalgesia rosiglitazone 7.2512083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7015034207
MESH:D006973 Hypertension Cyclosporine 8.0410903974
MESH:D006973 Hypertension Dexamethasone 8.0417042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1918306037
MESH:D007249 Inflammation Dexamethasone 14.528960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 14.5218785209
MESH:D007249 Inflammation Flavonoids 14.5217296493
MESH:D007249 Inflammation rosiglitazone 14.5212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.5212200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4818200517
MESH:D007251 Influenza, Human Selenium 10.1316624496
MESH:D007251 Influenza, Human Vitamin E 10.1316624496
MESH:D007333 Insulin Resistance Estradiol 11.4616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.4616306350
MESH:D007333 Insulin Resistance rosiglitazone 11.4616306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.3717994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.778074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1918306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Acetaminophen 13.2512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.2510903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 13.2515618244
MESH:D007674 Kidney Diseases Vitamin E 13.2512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.1116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.116582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.1112371664
MESH:D007680 Kidney Neoplasms Estradiol 16.1115610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2417174718 16943688 11408273 16221502 11903743 21278145 16239168 17334410 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2420032147 18522880 18407596 19638242 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2421047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.4212667390 14716496 17565644 15931870 17721639 17805973 15996030 12609069 18418968 18263696 17525996 18277467 12546737 18251166 10355542 18472094 18156304 12649538 12898905 15730626 12445421 18376398 18395914 12445418 17944888 16011737 16116963 16015684 15057751 18054572 18205269 15650968 12586293 15338365 18339082 16638106 16192424 17922224 18279442 17869086 17557913 16033810 15818738 17976157 18429990 18395095 12958196 15052691 18412020 18472332 12741479 17761835 18187930 14724832 17640975 12632514 12632512 14620537 18166357 18006644 15362042 14716833 17766677 17708605 13678700 16248980 15876570 15925388 18317297 17481882 15123356 15893842 18481824 17698563 16027843 14748882 17631135 15959796 18705752 12389079 15370692 14512876 17823541 18210741 12666154 20821823 18420326 15673190 11481614 17714472 17900296 16136751 16097048
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.4216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.4214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.4215474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 10.4215980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.4216169303
MESH:D008107 Liver Diseases Acetaminophen 11.8219014921 16611625 19460945 16610002 19784758 11587558 12969438 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.8216246199 15720792 15830285 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 11.8217034775
MESH:D008107 Liver Diseases Lindane 11.821715830
MESH:D008107 Liver Diseases Phenobarbital 11.8219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7016899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.7519294768
MESH:D008113 Liver Neoplasms ciprofibrate 16.7512771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.7520101389 20118626 19499222 10737359 18644402 18978307 20137499 15885732 12771043 19642983 9163691 19850985 21278145 20492335 19073162 21071580 18977376 19090486 19426721 20405173 18754104 19551842 19256749 19255062 18648771 21167192 16942905 2422723 19638242 19996281 15175105 2862719 19427195 20501860 19833225 20434301 12112319 20583210 20452335 21047994 19254457 19812893 19690152 19294768
MESH:D008113 Liver Neoplasms Phenobarbital 16.758742319 21047994 15975961 19482888 19812893 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 16.7516377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.7516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.02598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.0215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.0218308698 18775883 18282651 18093689 17942915 19126423 17854601 18253720 3124819 18079962 16842330 18544905 19004024 18164116 9362446 19009564 2563599 21159647 16267830 19539802 19519916 17174075
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.026150874 1399818 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.0212151625
MESH:D008171 Lung Diseases Vitamin E 3.0116863852
MESH:D008175 Lung Neoplasms Dexamethasone 4.6115824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.6121163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.6111062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1511408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.1516827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.1515318939
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008654 Mesothelioma Selenium 2.6915107826
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1817261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.513537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.8914659530
MESH:D009101 Multiple Myeloma Dexamethasone 3.3315744524 15867202 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.409809623
MESH:D009203 Myocardial Infarction Nitroglycerin 5.6714729435
MESH:D009203 Myocardial Infarction pirinixic acid 5.6719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6118551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.373581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.373581430 9029167
MESH:D009369 Neoplasms Lindane 4.8616818664 12807735
MESH:D009369 Neoplasms pirinixic acid 4.8617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.6816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.766679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.9212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.924026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 13.9214694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1419401270
MESH:D010146 Pain Acetaminophen 2.2016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9616540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 4.9616965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9817698068
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.0812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.082563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.082563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4121297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9511399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms bicalutamide 2.2118487222 19011039 17914592 15638997 19240160
MESH:D011471 Prostatic Neoplasms Estradiol 2.2116740699
MESH:D011471 Prostatic Neoplasms Lindane 2.2112661182 14688026
MESH:D011471 Prostatic Neoplasms Vitamin E 2.2115084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
OMIM:604278 RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION marker/mechanism
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7911700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.193692021
MESH:D012640 Seizures 2,4-dinitrotoluene 9.0018551238
MESH:D012640 Seizures Lindane 9.0015475178 12842176 7539098
MESH:D012640 Seizures Phenobarbital 9.0016876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9316192470
MESH:D013272 Stomach Diseases Dexamethasone 4.0815472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Dexamethasone 3.2715138204
MESH:D020521 Stroke Vitamin E 3.3316517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.881399818 7505956 3712494 6587162 6582329
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.887505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.881399818
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.068074119
MESH:D001749 Urinary Bladder Neoplasms Sodium Bicarbonate 8.0616896691
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0710091137
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D014605 Uveitis Cyclosporine 10.941336536
MESH:D014605 Uveitis Dexamethasone 10.941336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04972 Pancreatic secretion
KEGG:04964 Proximal tubule bicarbonate reclamation
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
No data
No data
Drugbank ID Action Drug Name Description
DB01390 substrate Woodward's Gripe Water Antidiarrheals
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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