AutismKB 2.0

Annotation Detail for VAMP8


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Basic Information Top
Gene Symbol:VAMP8 ( EDB,VAMP-8 )
Gene Full Name: vesicle-associated membrane protein 8 (endobrevin)
Band: 2p11.2
Quick LinksEntrez ID:8673; OMIM: 603177; Uniprot ID:VAMP8_HUMAN; ENSEMBL ID: ENSG00000118640; HGNC ID: 12647
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04130SNARE interactions in vesicular transport
Pathway IDPathway Name
Membrane Trafficking
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P04377Beta1 adrenergic receptor signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00044Nicotinic acetylcholine receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P00037Ionotropic glutamate receptor pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P043765HT4 type receptor mediated signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P043755HT3 type receptor mediated signaling pathway
Pathway IDPathway Name
500013Clathrin derived vesicle budding
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
myocardial infarct
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of VAMP8 mRNAdecreases expression 12958071
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VAMP8 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of VAMP8 mRNAincreases expression 20106945
C095105 bexarotene bexarotene results in increased expression of VAMP8 mRNAincreases expression 17178900
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VAMP8 mRNAaffects cotreatment|decreases expression 20360939
D016572 Cyclosporine Cyclosporine results in decreased expression of VAMP8 mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the expression of VAMP8 mRNAaffects expression 17145863
D004041 Dietary Fats Dietary Fats results in increased expression of VAMP8 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VAMP8 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of VAMP8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VAMP8 mRNAaffects cotreatment|increases expression 17942748
D017239 Paclitaxel VAMP8 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C041786 palm oil palm oil results in increased expression of VAMP8 mRNAincreases expression 18042831
D012643 Selenium Selenium results in increased expression of VAMP8 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of VAMP8 mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VAMP8 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VAMP8 mRNAaffects cotreatment|increases expression 17942748
C015559 trimellitic anhydride trimellitic anhydride results in increased expression of VAMP8 mRNAincreases expression 16141432
C025643 vinclozolin vinclozolin affects the expression of VAMP8 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1814692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.646695378
MESH:D000236 Adenoma Diethylnitrosamine 6.6410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.1217620307 19052882 17162532 19061943 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001249 Asthma trimellitic anhydride 3.9316141432
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.5715867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7817474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 3.7816344269 16818667
MESH:D001943 Breast Neoplasms decitabine 3.7818320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 3.7820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.7817474063
MESH:D001943 Breast Neoplasms Paclitaxel 3.7811325840 15136595 18323546 16244791 16115903 18223236 16273361 18234424
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.2819383236 16935385 20514400 20935162 18691550 16698587 16830150 16569478 20432363 19539802 16540662 17173139 16878318 21159647 16502159 3084413 20512989 3581430 18056438 16779866 16328049 19052882 18971187 18785209 19418558 16807293 20101231 19394651 18665156 16288022 16681979 18506893 18788625 20524982 18978308 20007298 17162532 19171122 10737359 17428255 18494052 19701751 19107877 19519916 17138121 11831363 20727157 20084675 18393292 18210153 17978847 19208518 19822196 17055752 17761372 19335982 19919837 10672840 20214788
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 3.2816313753
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2316247446
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6820419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6819215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.612727394 21159647 7505956 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.3319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.3316835633
MESH:D002779 Cholestasis Cyclosporine 7.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7816919318 15861022 16105132 17110522 11677210 17333356 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1012621046 8697196 15668235 16354765 15340226
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.8018981723
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.8018802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2217107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2119107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6516530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.6516481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 18.8119224547
MESH:D005234 Fatty Liver Dietary Fats 18.8118296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 18.8121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 14.8112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.8118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.8120067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4919215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4511294989 10048152
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0818606429 15340226 16959395 8697196 16354765
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male decitabine 11.2517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.2517937319
MESH:D007248 Infertility, Male vinclozolin 11.2516467254
MESH:D007249 Inflammation Dietary Fats 8.2920412841
MESH:D007249 Inflammation Diethylnitrosamine 8.2918785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2912878042 12200463
MESH:D007251 Influenza, Human Selenium 4.2316624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1118457598 11836018
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.5910783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.3015369732
MESH:D007674 Kidney Diseases Cyclosporine 6.308314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7412371664
MESH:D007938 Leukemia decitabine 3.0719235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0117236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3817679729 19010910 18206229 19387464 18460780 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.9916766008
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D008080 Liposarcoma Paclitaxel 4.8317353645
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6420032147 18522880 18407596 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1017034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3720195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.3720101389 15885732 18644402 19090486 21278145 19551842 10737359 19996281 18754104 19850985 20492335 18978307 19638242 2862719 19073162 21071580 9163691 2422723 18648771 20434301 19426721 20501860 12112319 20118626 18977376 19642983 20583210 19255062 19256749 21167192 20405173 16942905 15175105 19690152 19427195 19833225 19499222 20452335 12771043 19254457 20137499 19812893 21047994 19294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.7721159647 18164116 9362446 18775883 16842330 18093689 17854601 19126423 19519916 18253720 17174075 18079962 2563599 3124819 19009564 18544905 16267830 17942915 18282651 19004024 19539802 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7712151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8620135361 18816296 20869020 18569708 18520028 20064080 6695378 17053015 20464547
MESH:D008175 Lung Neoplasms bexarotene 4.8617849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.866695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8619555203 11884234
MESH:D008223 Lymphoma decitabine 3.4219470736
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.0914749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.3415591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3415318939
MESH:D008545 Melanoma decitabine 3.6617785578 16505122
MESH:D008545 Melanoma Paclitaxel 3.6612040289 12025231 16342250
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009101 Multiple Myeloma decitabine 7.6018172295
MESH:D009101 Multiple Myeloma Paclitaxel 7.6014749477
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3819157545 19010910 16882708 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.993581430 9029167
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.9915867366
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1111141357
MESH:D009369 Neoplasms decitabine 5.1119116145 17925555 19470736
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8119196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009765 Obesity Dietary Fats 2.2920132043 21332399 18457598 19632207 11836018 17217161 20518802 18674790 16723640
MESH:D010014 Osteolysis Paclitaxel 5.0015867366
MESH:D010051 Ovarian Neoplasms decitabine 5.2019259094 19331143
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.2011161223
MESH:D010190 Pancreatic Neoplasms decitabine 5.3619294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.9512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.952563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.5618220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3917292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.3916729912 16356831 17136230 17172428
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 4.8720219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4119155313
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.7520155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.7519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7518456281
MESH:D013274 Stomach Neoplasms Paclitaxel 4.7518506536 18396642
MESH:D024801 Tauopathies Paclitaxel 4.8316930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms decitabine 7.2917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.297505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.1317616700 19087683
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014604 Uveal Neoplasms decitabine 4.9417785578
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:11123 Membrane Trafficking
KEGG:04130 SNARE interactions in vesicular transport
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37271
    • No data
    Releated disease ID Related disease Name
    PA443797Coronary Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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