AutismKB 2.0

Annotation Detail for BECN1


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Basic Information Top
Gene Symbol:BECN1 ( ATG6,VPS30,beclin1 )
Gene Full Name: beclin 1, autophagy related
Band: 17q21.31
Quick LinksEntrez ID:8678; OMIM: 604378; Uniprot ID:BECN1_HUMAN; ENSEMBL ID: ENSG00000126581; HGNC ID: 1034
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04140Regulation of autophagy
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D014013 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Rotenone results in increased expression of BECN1 protein]decreases reaction|increases expression 18032788
D014013 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Thenoyltrifluoroacetone results in increased expression of BECN1 protein]decreases reaction|increases expression 18032788
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BECN1 mRNAaffects expression 21346803
C025946 3-methyladenine 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine]decreases reaction|decreases response to substance 16497721
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BECN1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BECN1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of BECN1 proteinincreases expression 16882451
C006632 arsenic trioxide Cycloheximide inhibits the reaction [arsenic trioxide results in increased expression of BECN1 protein]decreases reaction|increases expression 16882451
D002330 Carmustine Carmustine results in decreased expression of BECN1 mRNAdecreases expression 15980968
D003513 Cycloheximide Cycloheximide inhibits the reaction [arsenic trioxide results in increased expression of BECN1 protein]decreases reaction|increases expression 16882451
D003520 Cyclophosphamide BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C014347 decitabine decitabine inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]decreases reaction|increases expression 19577553
D004317 Doxorubicin BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004317 Doxorubicin BECN1 protein affects the susceptibility to Doxorubicinaffects response to substance 16718815
D004317 Doxorubicin Doxorubicin results in increased expression of BECN1 mRNAincreases expression 19001878
D004317 Doxorubicin Doxorubicin results in increased expression of BECN1 proteinincreases expression 19001878
D004317 Doxorubicin PARP1 protein promotes the reaction [Doxorubicin results in increased expression of BECN1 mRNA]increases expression|increases reaction 19001878
D004317 Doxorubicin PARP1 protein promotes the reaction [Doxorubicin results in increased expression of BECN1 protein]increases expression|increases reaction 19001878
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BECN1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of BECN1 proteinincreases expression 19451193
D007657 Ketone Bodies Ketone Bodies results in decreased expression of BECN1 mRNAdecreases expression 16807920
D017239 Paclitaxel BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D012402 Rotenone 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Rotenone results in increased expression of BECN1 protein]decreases reaction|increases expression 18032788
D012402 Rotenone BECN1 protein affects the susceptibility to Rotenoneaffects response to substance 18032788
D012402 Rotenone Rotenone results in increased expression of BECN1 proteinincreases expression 18032788
D012402 Rotenone SOD2 protein inhibits the reaction [Rotenone results in increased expression of BECN1 protein]decreases reaction|increases expression 18032788
C017947 sodium arsenite decitabine inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]decreases reaction|increases expression 19577553
C017947 sodium arsenite sodium arsenite results in increased expression of BECN1 proteinincreases expression 19577553
17683884
C017947 sodium arsenite U 0126 inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]decreases reaction|increases expression 19577553
D019311 Staurosporine 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine]decreases reaction|decreases response to substance 16497721
D019311 Staurosporine BECN1 protein results in decreased susceptibility to Staurosporinedecreases response to substance 16497721
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BECN1 mRNAaffects cotreatment|increases expression 17942748
D013804 Thenoyltrifluoroacetone 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Thenoyltrifluoroacetone results in increased expression of BECN1 protein]decreases reaction|increases expression 18032788
D013804 Thenoyltrifluoroacetone BECN1 protein affects the susceptibility to Thenoyltrifluoroacetoneaffects response to substance 18032788
D013804 Thenoyltrifluoroacetone SOD2 protein inhibits the reaction [Thenoyltrifluoroacetone results in increased expression of BECN1 protein]decreases reaction|increases expression 18032788
D013804 Thenoyltrifluoroacetone Thenoyltrifluoroacetone results in increased expression of BECN1 proteinincreases expression 18032788
C113580 U 0126 U 0126 inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]decreases reaction|increases expression 19577553
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7214514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.3417694057
MESH:D000230 Adenocarcinoma arsenic trioxide 9.9211798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 9.9217418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9214692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.9217638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.683712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7716712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.4221441931
MESH:D000740 Anemia Fluorouracil 8.2917963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2911748828
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.7415014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5815885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.5616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5714601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.4415867366
MESH:D001932 Brain Neoplasms Carmustine 8.7416187019
MESH:D001932 Brain Neoplasms Doxorubicin 8.7417150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.9112006526 11325840 15093573 18323546 15136595 18234424 16978400 17388661 17020986
MESH:D001943 Breast Neoplasms decitabine 2.9119208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 2.9116096432 19526202 18695136 17369602 15939500 18234424 18628466 16595493 16264153 15136595 16115903 17983394 17426702 15634643 15993339 16935488 15692762 16322301 16826403 15668708 15567936 11325840 18382427 15994142
MESH:D001943 Breast Neoplasms Fluorouracil 2.9119217205 15136595 16110121 18608205 18357371 16595493 16557594
MESH:D001943 Breast Neoplasms Paclitaxel 2.9118323546 15136595 11325840 16244791 16115903 16273361 18234424 18223236
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2011589617
MESH:D002276 Carcinoid Tumor Doxorubicin 11.9216051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.9216051944
MESH:D002277 Carcinoma Fluorouracil 7.8417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.5816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.583581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.5815073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 16.5819701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.5818059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.5817971768 17045692 17088986 16799960 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 16.5816313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.5815276417 16507464 17306315
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7616152834
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7519014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 14.897296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 14.8916201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 14.891485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 14.8918695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0012490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.5219215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.526189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.5218986760 17066447 16280240 16757204
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.5218572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4417007740 16731534 17924179 17519947 15811867 17308081 16952015 15476868 16278810 17131338 16242529 17329180 17974986 16364871 17928571 16612575 15792986 17351982 16455267 16109756 18627295 15505089 16651473 16269455 17382496
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9016243910 17334414
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4216936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.686135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.687505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.6820056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.5419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5417110522 15861022 17333356 16105132 17681005 16919318 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0515340226 8697196 15668235 12621046 16354765
MESH:D003110 Colonic Neoplasms decitabine 3.7917616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7915001691 17016597 16510598 17169374 17725105 18772588 17172411 17018589 17287894 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.3520501625
MESH:D015179 Colorectal Neoplasms decitabine 6.3518981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.3518259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.3517094418 17695437 15289873 16282729 18288408 18383874 16331619 16524972 17401013 18802399 15148649 18509181 17016601 16303861 17255274 17454858 17594712 16391804 14970324 18448328 18949393 20501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 6.3518802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4315322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8918551238
MESH:D003556 Cystitis Cyclophosphamide 4.8618372110 16651033 16989017 16614059 15276878 10498854 11948286 17010015 16413132 12913760 12388444 18093676 17979934 15643279 18295254 18710439 18483878 18433785 10700343 12161096
MESH:D007644 Darier Disease Fluorouracil 4.6616733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9715213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.682524372 11906362 12868966 8970840 8156756 11298694 14531868 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.372952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9615331540 10990075 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1818772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.6621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.6618692083 7440962 11289319 9328219 8291058 1440618 6679447 16192314 18648102 18289764 6482804 9653073 9022650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.6617416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6620420201
MESH:D004362 Drug Toxicity Doxorubicin 7.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7911462148
MESH:D004487 Edema Staurosporine 6.838273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0612538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9919294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3717359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0318037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.0911006010
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.163581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.1612903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.1616785472 15173087 16481741 16337965 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.1616481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver arsenic trioxide 7.3415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.3415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.896705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4619069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1316904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5516452187
MESH:D005909 Glioblastoma Carmustine 7.3016187019
MESH:D005909 Glioblastoma Doxorubicin 7.3017150277
MESH:D005910 Glioma Fluorouracil 2.8216145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3811389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.917505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.9011014644 16376943 15172196
MESH:D006258 Head and Neck Neoplasms decitabine 12.5119215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.5115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.5115102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3912587719 16495754 16144979 18006777 18674790 16879835 17888722 17875725 16244371 16244372 16707910 14766674 16330681
MESH:D006333 Heart Failure Doxorubicin 3.2617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7815692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.1611918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.4014986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.396705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7615340226 16120746 12621046
MESH:D006689 Hodgkin Disease Cyclophosphamide 11.7216135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 11.7215147373 17606976 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 11.7212676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9216959395 16354765 18606429 8697196 15340226
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8618670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 5.2016076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Cyclophosphamide 15.3716517039 7193160
MESH:D007248 Infertility, Male decitabine 15.3717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 15.3717937319
MESH:D007248 Infertility, Male sodium arsenite 15.3715346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7912878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.899022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007674 Kidney Diseases Doxorubicin 6.0315699352 15369732 16775033
MESH:D007674 Kidney Diseases sodium arsenite 6.0320008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.7216707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.7216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.8216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.826582329
MESH:D007680 Kidney Neoplasms Fluorouracil 11.8216985049
MESH:D007938 Leukemia arsenic trioxide 10.2315070760
MESH:D007938 Leukemia Cyclophosphamide 10.2310602166
MESH:D007938 Leukemia decitabine 10.2319235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4417008537 17658394 17296974 17802794 18587576 18172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 11.3116972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 11.3116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.2914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.2910373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.1819077051
MESH:D007951 Leukemia, Myeloid decitabine 9.1817236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9119850784 20471514 16467208 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9118704418 17679729 19387464 18460780 18206229 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3318055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1319225113 12679006 15748426 17649720 16331271 19075265 15336539 15213294 15622746 11161223 16330433 17869043 16966277 16891316 17712046 19035177 12018890 17107899 17217047 19642359 9834237 11468182 16112521 12712474 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2216882451
MESH:D007970 Leukopenia Cyclophosphamide 4.8311830472 10052129
MESH:D008080 Liposarcoma Paclitaxel 4.7017353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.3916595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3912878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.727678174
MESH:D008113 Liver Neoplasms arsenic trioxide 13.7214682389
MESH:D008113 Liver Neoplasms Fluorouracil 13.7217045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms sodium arsenite 13.7215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.7216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.786135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.786587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.7820377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.7816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.7812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2515213294
MESH:D008171 Lung Diseases sodium arsenite 3.0819095001
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4219825857 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 6.4217418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 6.4215246190
MESH:D008175 Lung Neoplasms sodium arsenite 6.4216712894 17306315 19931552 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6615086387
MESH:D008223 Lymphoma Cyclophosphamide 12.1412854902
MESH:D008223 Lymphoma decitabine 12.1419470736
MESH:D008223 Lymphoma Doxorubicin 12.1416098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4716675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 14.0511911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 14.0517654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 14.0514749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 2.9515458769
MESH:D008545 Melanoma Carmustine 9.5812393984
MESH:D008545 Melanoma decitabine 9.5817785578 16505122
MESH:D008545 Melanoma Doxorubicin 9.5816827129
MESH:D008545 Melanoma Paclitaxel 9.5812025231 16342250 12040289
MESH:D008545 Melanoma sodium arsenite 9.5819082730 16487513
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.6716388313
MESH:D008654 Mesothelioma Doxorubicin 3.0117638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5316757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.6617415656
MESH:D009101 Multiple Myeloma arsenic trioxide 11.6715949261 19549372 14977855 19417148 11468182
MESH:D009101 Multiple Myeloma decitabine 11.6718172295
MESH:D009101 Multiple Myeloma Paclitaxel 11.6714749477
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2516105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.2519010910 19157545 18608210 16882708
MESH:D009203 Myocardial Infarction Doxorubicin 2.9019429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7318551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8316624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.313581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.3118259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.3115867366
MESH:D009369 Neoplasms Cyclophosphamide 11.4118854779
MESH:D009369 Neoplasms decitabine 11.4119116145 17925555 19470736
MESH:D009369 Neoplasms Fluorouracil 11.4118600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 11.4111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5420056578
MESH:D009401 Nephrosis Doxorubicin 4.6416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8915640375 16889571
MESH:D009410 Nerve Degeneration Rotenone 3.7817356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.646679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.6410525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.6412854658
MESH:D009447 Neuroblastoma Cyclophosphamide 6.998761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 6.9915555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.768761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3516436463
MESH:D009503 Neutropenia Cyclophosphamide 4.208291058
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.4916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.494026338 6482804
MESH:D009845 Oligospermia Cyclophosphamide 4.5816517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.893988306
MESH:D010014 Osteolysis Paclitaxel 4.8515867366
MESH:D012516 Osteosarcoma Doxorubicin 4.0115930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.5716624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms decitabine 14.5719331143 19259094
MESH:D010051 Ovarian Neoplasms Paclitaxel 14.5711161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.5715276417 17306315
MESH:D010051 Ovarian Neoplasms U 0126 14.5716211241
MESH:D010146 Pain Cyclophosphamide 3.5212161096 18093676
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.0115580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 12.0111332152
MESH:D010190 Pancreatic Neoplasms decitabine 12.0119294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.0119003803 16929163 16500647 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.887296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.8812065085
MESH:D010235 Paraganglioma arsenic trioxide 4.0419927285
MESH:D010300 Parkinson Disease Rotenone 2.9315451049 16412576 19114014 18619942 11535288 19232380 11445065 18191903 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 3.9618197244 15795934 15574749 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.346228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7321297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.6017616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.8917136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8915897917 16868541 18437689 15749863 16888761 16729912
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8916356831 17172428 17136230 16729912
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.1815861022 16919318
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2316636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9018722050 15538739 16160472 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 4.0917922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.283692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.2819155313
MESH:D012509 Sarcoma Doxorubicin 3.8718313854 16767912 15625365 15675481 17710206 17203757
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.8516646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.8516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6617846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.7016636934
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4518551238
MESH:D012878 Skin Neoplasms Doxorubicin 13.1015692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.1012065085
MESH:D012878 Skin Neoplasms sodium arsenite 13.1019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.1016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4416767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8116709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3816517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6912854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6717007042
MESH:D013274 Stomach Neoplasms decitabine 4.6719037991
MESH:D013274 Stomach Neoplasms Fluorouracil 4.6718567086 16424979 19015929 16951190 18396642 19084572 17522103 17498489 15786421 17172411
MESH:D013274 Stomach Neoplasms Paclitaxel 4.6718506536 18396642
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.9312837982
MESH:D024801 Tauopathies Paclitaxel 4.6816930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.303712494 1399818 6582329 7505956 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 16.3019014326
MESH:D013964 Thyroid Neoplasms decitabine 16.3017967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.3017909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8716280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8315213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 23.3816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 23.388074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 23.3811780464 12845720 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 23.3814692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 23.3819087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 23.3817653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 23.3817306315 16452187 16712894 11723127
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1910091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.1016803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1011813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D014604 Uveal Neoplasms decitabine 4.7817785578
MESH:D014652 Vascular Diseases sodium arsenite 4.2917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4215869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0917334414 17678736 16364871 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
Pathway ID Pathway Name
KEGG:04140 Regulation of autophagy
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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