AutismKB 2.0

Annotation Detail for MARCO


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Basic Information Top
Gene Symbol:MARCO ( SCARA2 )
Gene Full Name: macrophage receptor with collagenous structure
Band: 2q14.2
Quick LinksEntrez ID:8685; OMIM: 604870; Uniprot ID:MARCO_HUMAN; ENSEMBL ID: ENSG00000019169; HGNC ID: 6895
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MARCO mRNAaffects expression 17562736
C042138 BCG lipopolysaccharide BCG lipopolysaccharide results in increased expression of MARCO mRNAincreases expression 10223745
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MARCO mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MARCO mRNAincreases expression 15963578
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MARCO mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MARCO mRNAaffects cotreatment|increases expression 17942748
C056933 fumonisin B1 fumonisin B1 results in increased expression of MARCO mRNAincreases expression 16221962
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MARCO mRNAincreases expression 10223745
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MARCO proteinincreases expression 10223745
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of MARCO mRNA]affects reaction|increases expression 19555225
C030984 pyrene pyrene results in decreased expression of MARCO mRNAdecreases expression 15963578
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MARCO mRNAaffects cotreatment|increases expression 17942748
D015054 Zymosan Zymosan results in increased expression of MARCO mRNAincreases expression 10223745
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2118653653 11850527
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.5411748828
MESH:D000740 Anemia Zymosan 9.5418664788
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.9215885639
MESH:D001169 Arthritis, Experimental Zymosan 7.9216872482 15142272 15944321 17659584 15188379
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Ozone 2.6817854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8116777450 17626835 18315731 18417511 15516495 14754758 19059883
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915721981 10355542 16227642 16097048 15673190 16192424 15700767 16050911 18705752 16011737 16124888 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9118788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017110522 17681005 15861022 16919318 11677210 16105132 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 12621046 8697196 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3714986274 12540782 11834606 18713872 16109766 18071297 16081117 12392966 11287661 11743745 11461765 19420014 2444490 19164858 17522070 12594235 10915739 19370779 16227642 10774834 16177239 16485898 19739265 12705907 19085960 16393943 15968718 10663392 19416960 12153990 11421492 15619225 14725611 17562736 19923254 11739529 12958197 11529661 16781746 14550746 17906064
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.373732212 19085960 6623471 2869522 11566570 21278145 15027814 15968718 7120509 9327722 7440962 6884620 16177239 10092053 15998439 16227642 19336974 17522070 3786805 4309450 7179309 10915739
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 9.3716221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6611000095 12711302
MESH:D004487 Edema Zymosan 7.667907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.6315821434 15328337 17637181
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2715959796 16239168 12795759 16045604 61145 17595544 12631006 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005334 Fever Lipopolysaccharides 4.1711852909 9205823
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 10.3319110552 19900420
MESH:D006505 Hepatitis Zymosan 10.3319110552
MESH:D006529 Hepatomegaly fumonisin B1 9.4616221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4615340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Lipopolysaccharides 8.9717237260 9205823 12878042 17963957 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9712200463 12878042
MESH:D007249 Inflammation Zymosan 8.978014878 11289658
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8117255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 6.0717553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007970 Leukopenia Lipopolysaccharides 4.9315821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916943688 16221502 11408273 17174718 17334410 21278145 16239168 11903743 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6020821823 15338365 17640975 18277467 17900296 14716496 12609069 17922224 11481614 10355542 15123356 17481882 15362042 15370692 15931870 16027843 18481824 16015684 18156304 17721639 18166357 15925388 18187930 17869086 17525996 18210741 15876570 18279442 18339082 17698563 15959796 18006644 18418968 12389079 18420326 15673190 12667390 18429990 18705752 12632514 15057751 18251166 16116963 15730626 16033810 18412020 17631135 17823541 18317297 12666154 12632512 16248980 12958196 14512876 14716833 18472332 17565644 17761835 17976157 12649538 16192424 17805973 16097048 12546737 15650968 12445418 15893842 16136751 16011737 12898905 14724832 17557913 17944888 17714472 18395095 18205269 18263696 18054572 12445421 14620537 17766677 16638106 15052691 18472094 13678700 15818738 12586293 17708605 15996030 14748882 12741479 18376398 18395914
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.6012878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6012878042
MESH:D008107 Liver Diseases Acetaminophen 4.0316611625 12969438 16610002 19014921 11587558 19460945 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0315720792 16964402 16246199 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008171 Lung Diseases Ozone 3.4919066396 8266340
MESH:D055370 Lung Injury Lipopolysaccharides 9.9721114838
MESH:D055370 Lung Injury Ozone 9.9720417186
MESH:D008175 Lung Neoplasms Ozone 2.428597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4219555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D009102 Multiple Organ Failure Zymosan 5.3715834315 10479408 17724436 18160304 15259001 15241586 12130978 10890648 15213630 12879239
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010538 Peritonitis Ozone 11.1416369182
MESH:D010538 Peritonitis Zymosan 11.1417826846 11985352 18557954 15979727 15259001 18977430 19641140 18760300 19088179 14761945 17371808
MESH:D011014 Pneumonia Lipopolysaccharides 11.9112224865 11605937
MESH:D011014 Pneumonia Ozone 11.9118007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11222880 11118676 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D018805 Sepsis Zymosan 4.7911441115
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3315821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Zymosan 5.6611006244
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:04145 Phagosome
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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