AutismKB 2.0

Annotation Detail for DGAT1


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Basic Information Top
Gene Symbol:DGAT1 ( ARGP1,DGAT )
Gene Full Name: diacylglycerol O-acyltransferase 1
Band: 8q24.3
Quick LinksEntrez ID:8694; OMIM: 604900; Uniprot ID:DGAT1_HUMAN; ENSEMBL ID: ENSG00000185000; HGNC ID: 2843
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
TRIGLSYN-PWYtriacylglycerol biosynthesis
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
cholesterol, HDL
blood pressure
body mass
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DGAT1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DGAT1 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DGAT1 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of DGAT1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DGAT1 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of DGAT1 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DGAT1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DGAT1 mRNAincreases expression 19150397
D002104 Cadmium Cadmium results in decreased expression of DGAT1 mRNAdecreases expression 17066326
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of DGAT1 mRNAdecreases expression 17066326
C039671 ciglitazone ciglitazone results in increased expression of DGAT1 mRNAincreases expression 16847310
D002994 Clofibrate Clofibrate affects the expression of DGAT1 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of DGAT1 mRNAdecreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D004041 Dietary Fats Dietary Fats results in increased expression of DGAT1 mRNAincreases expression 15736121
D004041 Dietary Fats Dietary Fats results in decreased expression of DGAT1 mRNAdecreases expression 18042831
D000431 Ethanol Ethanol results in increased expression of DGAT1 mRNAincreases expression 18620774
D005001 Ethionine Ethionine affects the expression of DGAT1 mRNAaffects expression 19483382
D005632 Fructose Fructose results in increased expression of DGAT1 mRNAincreases expression 15736121
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D007657 Ketone Bodies Ketone Bodies results in decreased expression of DGAT1 mRNAdecreases expression 16807920
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of DGAT1 mRNAdecreases expression 16847310
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of DGAT1 mRNAdecreases expression 20024957
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of DGAT1 mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of DGAT1 mRNAaffects expression 19483382
D010171 Palmitoyl Coenzyme A DGAT1 protein results in increased metabolism of [Palmitoyl Coenzyme A co-treated with Vitamin A]affects cotreatment|increases metabolic processing 16214399
C041786 palm oil palm oil results in decreased expression of DGAT1 mRNAdecreases expression 18042831
C006253 pirinixic acid ACAA1B protein inhibits the reaction [pirinixic acid results in increased expression of DGAT1 mRNA]decreases reaction|increases expression 19772884
C006253 pirinixic acid pirinixic acid results in increased expression of DGAT1 mRNAincreases expression 18301758
19772884
15777286
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of DGAT1 mRNA]affects reaction|increases expression 15777286
C006253 pirinixic acid pirinixic acid affects the expression of DGAT1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of DGAT1 mRNAaffects expression 19483382
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C017947 sodium arsenite sodium arsenite results in decreased expression of DGAT1 mRNAdecreases expression 19822182
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of DGAT1 mRNAaffects cotreatment|decreases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of DGAT1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DGAT1 mRNAdecreases expression 16054899
D013853 Thioacetamide Thioacetamide affects the expression of DGAT1 mRNAaffects expression 19483382
D014801 Vitamin A DGAT1 protein results in increased metabolism of [Palmitoyl Coenzyme A co-treated with Vitamin A]affects cotreatment|increases metabolic processing 16214399
C506265 XP 620 XP 620 results in decreased activity of DGAT1 proteindecreases activity 16214399
C506265 XP 620 XP 620 results in decreased activity of DGAT1 proteindecreases activity 16214399
D015032 Zinc Zinc affects the expression of DGAT1 mRNAaffects expression 17181878
D015032 Zinc Zinc results in increased expression of DGAT1 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of DGAT1 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.2517676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.2511752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Vitamin A 4.5310992263
MESH:D000138 Acidosis Ammonium Chloride 15.7218287403
MESH:D000138 Acidosis Ethanol 15.7211192467
MESH:D000138 Acidosis Zinc Sulfate 15.727265320
MESH:D000169 Acrodermatitis Zinc 5.0317190629 16889938 17202136
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.9218653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.9218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.8920127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.446695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5317306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9415451039 15451040
MESH:D000544 Alzheimer Disease rosiglitazone 4.2919621015
MESH:D000544 Alzheimer Disease Zinc 4.2916580781 16410023 17119284 16325427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9211748828
MESH:D000740 Anemia Vitamin A 7.9216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.4816960172
MESH:D000755 Anemia, Sickle Cell Zinc 4.5516916123
MESH:D000853 Anophthalmos Ethanol 4.4615513904
MESH:D000860 Anoxia Zinc Sulfate 4.657265320
MESH:D001008 Anxiety Disorders Ethanol 3.7211141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7119183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4920041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 3.5315238619
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3117659584
MESH:D001249 Asthma Vitamin A 5.0316732791
MESH:D001249 Asthma Zinc 5.0317085522
MESH:D050197 Atherosclerosis Cadmium 3.4215687053
MESH:D001281 Atrial Fibrillation Amiodarone 3.6318651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 51.7819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 51.7819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 51.7819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 51.7819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 51.7819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 51.7819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 51.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 51.7812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 51.7819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5315746008
MESH:D001930 Brain Injuries Zinc 4.3317109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8217474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.8220435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.2317426644 17377406
MESH:D002056 Burns Ethanol 4.2916374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.0316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.0316705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.0312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.031701930
MESH:D006528 Carcinoma, Hepatocellular Ethanol 13.0318788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.0317306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.0317997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.9020419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.9018572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 6.9016543248
MESH:D006332 Cardiomegaly Ethanol 6.1519332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1518850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7615710769 19225199
MESH:D002318 Cardiovascular Diseases Zinc 3.4116936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7218974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 27.916135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 27.9120889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 27.9117332340
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 27.911399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 27.9112371664
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 27.9119716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 27.9119524636 20056578
MESH:D002637 Chest Pain Omeprazole 4.7315447763
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1016153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.5218291259
MESH:D002779 Cholestasis Cyclosporine 11.9619486331
MESH:D002779 Cholestasis pirinixic acid 11.9619176532
MESH:D002779 Cholestasis Vitamin A 11.9616175620
MESH:D002971 Cleft Lip Ethanol 3.3915513904
MESH:D002972 Cleft Palate Ethanol 9.0415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.0412621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Vitamin A 9.0416054864
MESH:D003110 Colonic Neoplasms Dexamethasone 3.9715824018
MESH:D003110 Colonic Neoplasms Vitamin A 3.9717219422 16267017
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7517141729 14669216
MESH:D003327 Coronary Disease Fructose 4.2418504504
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.8617728286
MESH:D019465 Craniofacial Abnormalities Ethanol 6.8619302082 11198716 10194807 15513904 15451039 15451040 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin A 6.8610992263
MESH:D019465 Craniofacial Abnormalities Zinc 6.8619302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.7018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.7018551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0712438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2518249437
MESH:D003920 Diabetes Mellitus rosiglitazone 8.5617446233
MESH:D003920 Diabetes Mellitus Zinc 8.5616479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.2018603373
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3916506275
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.7318603373
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.7312642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7317107852
MESH:D003967 Diarrhea Dexamethasone 3.367237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 13.6921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 13.6921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 13.6918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.6911566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.6920420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 13.6912963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4911462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.4316146918
MESH:D004381 Duodenal Ulcer Omeprazole 3.9815991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 7.9416707586
MESH:D050171 Dyslipidemias Dietary Fats 7.9418367378
MESH:C538011 Eales disease Vitamin A 5.249068938
MESH:D004480 Ectromelia Vitamin A 5.4516054864
MESH:D004485 Eczema Dexamethasone 4.1112438553
MESH:D004487 Edema Dexamethasone 13.7919703484
MESH:D004487 Edema pirinixic acid 13.7912083418
MESH:D004487 Edema rosiglitazone 13.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.7912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental ciglitazone 5.1216844232
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7110568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0315821434 15328337 17637181
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.7120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.7116530937
MESH:D004938 Esophageal Neoplasms Ethanol 12.7116704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.7116510608 15623463 15878914 15150132 15547733 16805852 15264214 15547721 16704527
MESH:D004938 Esophageal Neoplasms Zinc 12.7116543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7411564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3516456712
MESH:D005234 Fatty Liver Amiodarone 37.5914986274
MESH:D005234 Fatty Liver Clofibrate 37.5919224547
MESH:D005234 Fatty Liver Cyclosporine 37.5919224547
MESH:D005234 Fatty Liver Dietary Fats 37.5917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethanol 37.5919236843 18620774 16409862
MESH:D005234 Fatty Liver Fructose 37.5919196556 18641190 18395287
MESH:D005234 Fatty Liver pirinixic acid 37.5919236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 37.5919196556
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2917920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9315451040 10194807 15513904 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1011858732
MESH:D005327 Fetal Resorption Vitamin A 4.9916054864
MESH:D005334 Fever Lipopolysaccharides 3.7011852909 9205823
MESH:D005355 Fibrosis Cyclosporine 18.2412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 18.2418296743
MESH:D005355 Fibrosis Fructose 18.2418504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.2420067830
MESH:D005756 Gastritis Ethanol 10.2915046732
MESH:D005756 Gastritis Zinc 10.2917241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3116452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.858708960
MESH:D018149 Glucose Intolerance Fructose 4.9819165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2210696789
MESH:D006130 Growth Disorders Zinc 3.7217217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.0720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.0711294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin A 10.0710992263 16080930
MESH:D006333 Heart Failure pirinixic acid 6.3920558911
MESH:D006333 Heart Failure Zinc 6.3917162251
MESH:D006335 Heart Injuries Zinc 5.3917074742
MESH:D016481 Helicobacter Infections Zinc 4.1917241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0515720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0111000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2417276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 3.8716456712
MESH:D006527 Hepatolenticular Degeneration Zinc 10.1217276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.1217063115
MESH:D006529 Hepatomegaly Amiodarone 12.3415265979
MESH:D006529 Hepatomegaly pirinixic acid 12.3419772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.3412621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.857520565
MESH:D006548 Hernia, Diaphragmatic Vitamin A 5.8516877224 16490937 16863852 17436238 15707848 16292552
MESH:D015658 HIV Infections Vitamin A 3.6316960176
MESH:D006679 HIV Seropositivity Vitamin A 5.2317209195
MESH:D006689 Hodgkin Disease sodium arsenite 2.8512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6716354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Ethanol 7.3018783367
MESH:D006930 Hyperalgesia rosiglitazone 7.3012083418
MESH:D006937 Hypercholesterolemia Amiodarone 8.089751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.0821332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8720558911
MESH:D006946 Hyperinsulinism Fructose 4.5918563319 14757778 15752949 19008412 18360027
MESH:D006949 Hyperlipidemias Dietary Fats 8.4321332399
MESH:D006949 Hyperlipidemias Fructose 8.4315752949
MESH:D006973 Hypertension Cyclosporine 11.1910903974
MESH:D006973 Hypertension Dexamethasone 11.1917042910
MESH:D006973 Hypertension Fructose 11.1914568997 14573337 19008412 14633139 16843071
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.1918670907 18850075
MESH:D015228 Hypertriglyceridemia Fructose 4.7619342510 19799862
MESH:D006986 Hypervitaminosis A Vitamin A 5.7916054864
MESH:D007022 Hypotension Zinc Sulfate 4.147265320
MESH:D007037 Hypothyroidism Amiodarone 10.4218020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.428137927 18031379
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.0718306037
MESH:D007248 Infertility, Male sodium arsenite 2.7512646999 15346721
MESH:D007249 Inflammation Dexamethasone 13.7811099482 8960868
MESH:D007249 Inflammation Dietary Fats 13.7820412841
MESH:D007249 Inflammation Lipopolysaccharides 13.7817237260 17963957 12878042 9205823 17255318
MESH:D007249 Inflammation rosiglitazone 13.7812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.7812200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 15.7411836018 18457598
MESH:D007333 Insulin Resistance Fructose 15.7418057795 19008412 19586609 19799862 18563319 18981581 14573337 14757778 14633139 17133782 19342510
MESH:D007333 Insulin Resistance pirinixic acid 15.7416306350
MESH:D007333 Insulin Resistance rosiglitazone 15.7416306350
MESH:D019586 Intracranial Hypertension Vitamin A 5.4515955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2917255318
MESH:D007511 Ischemia Zinc 4.2716584753
MESH:D007569 Jaw Abnormalities Ethanol 9.0315513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0316580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.0718306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0715604871
MESH:D007674 Kidney Diseases Cadmium 16.8016226777 16322080 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 16.8016962696
MESH:D007674 Kidney Diseases Cyclosporine 16.808314463 18776723 10903974
MESH:D007674 Kidney Diseases sodium arsenite 16.8020008137
MESH:D007674 Kidney Diseases Zinc 16.8016960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.0916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.6516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.6516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 10.6512371664
MESH:D007859 Learning Disorders Ethanol 3.8515451040
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 7.8919248655
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 7.8915237267
MESH:D007970 Leukopenia Lipopolysaccharides 4.3315821434
MESH:D017880 Limb Deformities, Congenital Ethanol 7.8117676605
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.8116054864
MESH:D008064 Lipidoses Amiodarone 3.2517567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 10.0318296743
MESH:D008103 Liver Cirrhosis Ethanol 10.0315289165
MESH:D008103 Liver Cirrhosis Vitamin A 10.0316256175
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7318295389
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 12.3116718785
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 12.3118166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 12.3112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.3115474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 12.3117347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.3112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 12.3118032466 16097051 11682029 18295389 16248980 15075984 15474484 16489207 15078482 17629604 11172339 15334695 18458672 14739098 15288472 18416461 15095483 18263696 18031379 12679928 15716488 15465738 16343077 12175628 18380797 15288473 15316131 11481614 16126171 16098781 17292413 12531686 18615449 18395095 12085344 17050028 10677585 17127702 17355460 15362042 18606216 12557150 15158331 12891558 16511523
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 12.3116248980
MESH:D008107 Liver Diseases Thioacetamide 4.3415158337 18374380 16337175
MESH:D008107 Liver Diseases Vitamin A 4.3416175620
MESH:D008108 Liver Diseases, Alcoholic Ethanol 10.3517347304 17207112
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 10.3516762690
MESH:D017114 Liver Failure, Acute Thioacetamide 3.9915633222 17276928 12479984 15313186
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.037678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 16.039163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.0320195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 16.0316377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 16.0316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.0316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.252876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.258603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.2512151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 12.2517113696
MESH:D008133 Long QT Syndrome Amiodarone 3.3011989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 11.0512587719
MESH:D008171 Lung Diseases sodium arsenite 11.0519095001
MESH:D008171 Lung Diseases Vitamin A 11.0516863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1018516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.6521114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 7.8814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.886695378 17053015 20064080 20464547 20135361 18816296 18520028 18569708 20869020
MESH:D008175 Lung Neoplasms ciglitazone 7.8815899809
MESH:D008175 Lung Neoplasms Dexamethasone 7.8811195469 15824018
MESH:D008175 Lung Neoplasms sodium arsenite 7.8819931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 5.7416827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 5.7412773700
MESH:D008545 Melanoma sodium arsenite 1.9816487513 19082730
MESH:D008569 Memory Disorders Ethanol 3.8418411066 15451040
MESH:D024821 Metabolic Syndrome X Fructose 9.0418497449 17261469 19165636 17098227 16815490
MESH:D024821 Metabolic Syndrome X rosiglitazone 9.0417261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9116381670
MESH:D009101 Multiple Myeloma Dexamethasone 6.9216118317 15867202 15744524
MESH:D009101 Multiple Myeloma Vitamin A 6.9216374440
MESH:D009135 Muscular Diseases pirinixic acid 3.1516239165
MESH:D009181 Mycoses Amiodarone 4.5317974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.339809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.9919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.1218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.1218551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 7.1111141357
MESH:D009369 Neoplasms pirinixic acid 7.1117405874
MESH:D009369 Neoplasms sodium arsenite 7.1111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3120056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8714600291
MESH:D009436 Neural Tube Defects sodium arsenite 6.8812854658
MESH:D009436 Neural Tube Defects Vitamin A 6.8817400914
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.589802331
MESH:D009765 Obesity Dietary Fats 6.9218457598 21332399 11836018 17217161 16723640 19632207 18674790 20132043 20518802
MESH:D009765 Obesity Fructose 6.9217707055 18585860
MESH:D009765 Obesity pirinixic acid 6.9220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.8312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.8316049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.3217306315 15276417
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8412384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8712520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0115687053
MESH:D011014 Pneumonia Lipopolysaccharides 4.1912224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2118163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9212371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3421297632
MESH:D011225 Pre-Eclampsia Zinc 3.8917114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2117292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.2117075824
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.2116039940
MESH:D011471 Prostatic Neoplasms Zinc 2.2116700911 16517595 16606632 12429649
MESH:D011565 Psoriasis Cyclosporine 2.1016882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7112832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6818379247 11700416
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.4316877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4910835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4918990726
MESH:D012162 Retinal Degeneration Zinc 3.8516584753
MESH:D012640 Seizures 2,4-dinitrotoluene 8.4218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.4218551238
MESH:D012640 Seizures Ethanol 8.429754883
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7218724381
MESH:D012871 Skin Diseases monomethylarsonous acid 5.2617431481
MESH:D012871 Skin Diseases Vitamin A 5.2618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.3519755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 8.3519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3516192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5112854658
MESH:D013272 Stomach Diseases Dexamethasone 9.2215472012
MESH:D013272 Stomach Diseases Omeprazole 9.2218545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.252093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 3.2518456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.2517575124 12958204
MESH:D013276 Stomach Ulcer Amiodarone 14.5618087811
MESH:D013276 Stomach Ulcer Dexamethasone 14.5615138204
MESH:D013276 Stomach Ulcer Ethanol 14.5617189318 16755016 9211565 11906479 9562338 17918041
MESH:D013276 Stomach Ulcer Omeprazole 14.5618237397 10750652 17977527 16755016 11906479 15991576
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.949754883
MESH:D013610 Tachycardia Amiodarone 3.9411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8419225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8515821434
MESH:D013959 Thyroid Diseases Amiodarone 10.8019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.8012697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.4115710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5018020914 19584973
MESH:D014062 Tongue Neoplasms Zinc 4.0816543248
MESH:D016171 Torsades de Pointes Amiodarone 3.8211989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.1816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.1817053015
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 14.1820375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.1816712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.7610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.7610091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4511813266
MESH:D014605 Uveitis Cyclosporine 10.521336536
MESH:D014605 Uveitis Dexamethasone 10.521336536
MESH:D014652 Vascular Diseases sodium arsenite 4.0617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2212125929
MESH:D014802 Vitamin A Deficiency Vitamin A 4.9416960172 16146918 16175781
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8715886252
MESH:D015430 Weight Gain Dietary Fats 3.4316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0717120751
Pathway ID Pathway Name
KEGG:04975 Fat digestion and absorption
KEGG:00561 Glycerolipid metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00830 Retinol metabolism
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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