AutismKB 2.0

Annotation Detail for CDC23


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Basic Information Top
Gene Symbol:CDC23 ( ANAPC8,APC8 )
Gene Full Name: cell division cycle 23 homolog (S. cerevisiae)
Band: 5q31.2
Quick LinksEntrez ID:8697; OMIM: 603462; Uniprot ID:CDC23_HUMAN; ENSEMBL ID: ENSG00000094880; HGNC ID: 1724
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04114Oocyte meiosis
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Cell Cycle, Mitotic
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500399Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
500391Regulation of APC/C activators between G1/S and early anaphase
500395Phosphorylation of the APC/C
500390APC/C-mediated degradation of cell cycle proteins
500401Autodegradation of Cdh1 by Cdh1:APC/C
500328Inactivation of APC/C via direct inhibition of the APC/C complex
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CDC23 mRNAaffects expression 17562736
D004958 Estradiol Estradiol results in increased expression of CDC23 mRNAincreases expression 20068009
D012643 Selenium Selenium results in decreased expression of CDC23 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1811473722
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001943 Breast Neoplasms Estradiol 2.1019861407 14630087 18497071 17018787 17261762 12948864 16675129 17289903
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.2116111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9716924424
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0618566989
MESH:D003092 Colitis Selenium 4.4317936198
MESH:D003928 Diabetic Nephropathies Estradiol 3.8319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1311834606 18071297 19370779 11461765 12392966 14725611 16227642 15968718 16109766 16781746 10774834 17522070 16393943 11421492 14986274 12705907 16177239 12958197 16081117 19416960 17562736 19739265 16485898 18713872 19164858 2444490 19085960 19420014 12540782 12153990 15619225 11529661 19923254 11287661 17906064 14550746 10663392 11739529 11743745 12594235 10915739
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D016889 Endometrial Neoplasms Estradiol 3.2519148513 11473722 18566989
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006333 Heart Failure Selenium 3.3217162251
MESH:D006558 Herpes Genitalis Estradiol 5.9015709030
MESH:D019584 Hot Flashes Estradiol 4.6217088409
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007251 Influenza, Human Selenium 5.0616624496
MESH:D007333 Insulin Resistance Estradiol 3.2316393666 16627594
MESH:D007674 Kidney Diseases Acetaminophen 6.6412587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.6415618244
MESH:D007676 Kidney Failure, Chronic Selenium 4.3716518626
MESH:D007680 Kidney Neoplasms Estradiol 3.3615610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6914659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.7119460945 11587558 19014921 12587719 12969438 16611625 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.9111408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.9115318939
MESH:D020149 Manganese Poisoning Estradiol 5.3519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D008654 Mesothelioma Selenium 2.9315107826
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6216810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.4717289903
MESH:D009421 Nervous System Malformations Estradiol 4.2316427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010051 Ovarian Neoplasms Estradiol 2.3219401270
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010954 Plasmacytoma Selenium 5.7615087411
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D013978 Tibial Fractures Estradiol 5.5519048282
MESH:D014581 Urticaria Acetaminophen 3.5010982225
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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