AutismKB 2.0

Annotation Detail for ACTN1


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Basic Information Top
Gene Symbol:ACTN1 ( FLJ40884,FLJ54432 )
Gene Full Name: actinin, alpha 1
Band: 14q24.1
Quick LinksEntrez ID:87; OMIM: 102575; Uniprot ID:ACTN1_HUMAN; ENSEMBL ID: ENSG00000072110; HGNC ID: 163
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05146Amoebiasis
hsa05322Systemic lupus erythematosus
hsa04530Tight junction
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
Pathway IDPathway Name
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Hemostasis
Cell junction organization
Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
200115Syndecan-4-mediated signaling events
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500125Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1901Endometriosis
2031Endometrial cancer
Desease Name
CHEMDEPENDENCY
smoking behavior
Desease Name
Smoking behavior
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACTN1 mRNAaffects expression 21346803
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of ACTN1 mRNAdecreases expression 16460773
D000082 Acetaminophen Acetaminophen affects the expression of ACTN1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACTN1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ACTN1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ACTN1 mRNAdecreases expression 19150397
C099813 bromochloroacetic acid bromochloroacetic acid results in decreased expression of ACTN1 mRNAdecreases expression 16460773
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ACTN1 mRNAincreases expression 15336504
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of ACTN1 mRNAincreases expression 17720352
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ACTN1 mRNAincreases expression 17484886
D002330 Carmustine Carmustine results in decreased expression of ACTN1 mRNAdecreases expression 15980968
C014347 decitabine decitabine affects the methylation of ACTN1 geneaffects methylation 17630775
D004317 Doxorubicin ACTN1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACTN1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN1 mRNAaffects cotreatment|increases expression 17942748
D011374 Progesterone Progesterone results in decreased expression of ACTN1 mRNAdecreases expression 18037150
D012643 Selenium Selenium results in increased expression of ACTN1 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of ACTN1 mRNAdecreases expression 20308225
C025462 sulindac sulfide sulindac sulfide results in decreased expression of ACTN1 mRNAdecreases expression 16184548
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACTN1 mRNAdecreases expression 17884332
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ACTN1 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACTN1 mRNAincreases expression 15328365
18796159
17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7914514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9720464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 6.9717418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8516712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.4821441931
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0718759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6414601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 4.1915665606 15380490 15845082
MESH:D001932 Brain Neoplasms Carmustine 8.9316187019
MESH:D001932 Brain Neoplasms Doxorubicin 8.9317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9417474063 20146248
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.9417474063
MESH:D001943 Breast Neoplasms decitabine 2.9419208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 2.9415939500 16096432 19526202 18234424 18695136 11325840 16264153 16115903 18628466 15668708 16826403 16595493 15567936 15634643 15994142 17369602 18382427 16935488 15136595 17426702 15993339 15692762 17983394 16322301
MESH:D001943 Breast Neoplasms Progesterone 2.9415562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.723786805 15673190 16124888 16192424 16097048 16050911 16011737 16227642 10355542 18705752 15721981 15700767
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7516051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.763084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7618788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.7616023760 16234567 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7617306315 16507464 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4212391285
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.131485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.6620419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.6619215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.666189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.6618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.4816364871 16242529 15476868 16455267 16612575 17928571 16651473 15792986 17308081 17382496 17131338 17007740 17329180 15811867 17519947 16278810 15505089 16269455 17924179 16731534 17974986 17351982 16952015 16109756 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9217334414 16243910
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.6214688030
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.936135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.9320889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.9320056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8216105132 16919318 17681005 15861022 17110522 11677210 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 12621046 8697196 16354765 15668235
MESH:D003092 Colitis Selenium 3.7217936198
MESH:D003110 Colonic Neoplasms decitabine 2.3217616700
MESH:D015179 Colorectal Neoplasms decitabine 2.6718981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6718259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9518551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.0121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.0115968718 18071297 16177239 11461765 16227642 16781746 15619225 11287661 14986274 12705907 19164858 17906064 11834606 12153990 16081117 19416960 19923254 18713872 19420014 14725611 16109766 10774834 10915739 19370779 19085960 17562736 12958197 16485898 12594235 12392966 17522070 16393943 11421492 11529661 2444490 12540782 19739265 11743745 14550746 11739529 10663392
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.016884620 19336974 15027814 3732212 7179309 3786805 2869522 7120509 10915739 4309450 16227642 6623471 9327722 7440962 10092053 17522070 21278145 16177239 15968718 11566570 19085960 15998439
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.0117416283
MESH:D056486 Drug-Induced Liver Injury Selenium 15.0115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.0120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Doxorubicin 7.9418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.8217692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0619294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4117359293
MESH:D004715 Endometriosis Progesterone 8.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.7310568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1018037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.4915959796 12631006 16045604 12795759 16239168 19224547 17595544 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5319069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3920067830
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005909 Glioblastoma Carmustine 7.4416187019
MESH:D005909 Glioblastoma Doxorubicin 7.4417150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.8119215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.8115692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3311294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4416707910 18006777 16330681 16495754 18674790 16244372 16879835 16244371 17875725 17888722 14766674 12587719 16144979
MESH:D006333 Heart Failure Doxorubicin 7.1117481944
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 9.4513678655
MESH:D006394 Hemangiosarcoma Doxorubicin 9.4515692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8312621046 15340226 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 7.2817606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 7.2812676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 16354765 18606429 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male decitabine 10.9717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.9717937319
MESH:D007248 Infertility, Male sodium arsenite 10.9712646999 15346721
MESH:D007249 Inflammation Progesterone 4.8615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8612878042 12200463
MESH:D007251 Influenza, Human Selenium 4.1416624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases Acetaminophen 9.8815629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 9.8815699352 15369732 16775033
MESH:D007674 Kidney Diseases sodium arsenite 9.8820008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.7816707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.7816518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9216705839
MESH:D007938 Leukemia decitabine 3.0418980019 19235587
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1016085563
MESH:D007951 Leukemia, Myeloid decitabine 3.9418454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3717679729 18704418 18460780 19010910 18206229 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4118055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7717334410 17157831 21278145 16239168 16943688 16221502 11408273 17174718 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4512546737 18705752 15925388 18481824 18006644 16033810 14620537 16136751 18412020 12609069 17761835 15123356 12389079 18166357 17698563 15893842 15818738 16638106 17557913 18420326 12666154 17766677 17823541 14716833 14512876 17900296 15370692 18339082 14716496 15650968 17714472 18472332 17708605 17922224 18395914 16011737 18376398 14724832 12898905 14748882 18251166 15362042 16015684 20821823 12445418 18277467 18054572 15959796 17721639 17869086 18156304 11481614 18429990 18317297 12586293 15931870 10355542 12649538 17631135 15052691 18210741 17976157 18205269 18395095 16248980 17481882 12741479 17565644 16027843 18472094 12667390 17944888 18279442 16116963 15996030 16097048 17525996 18187930 15730626 18263696 17640975 15057751 16192424 15876570 12632514 18418968 15673190 12445421 13678700 12958196 12632512 17805973 15338365
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4516439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008107 Liver Diseases Acetaminophen 3.8412587719 16611625 19784758 12969438 19460945 16610002 19014921 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8417285989 15830285 16964402 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.977678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.9721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.9719294768
MESH:D008113 Liver Neoplasms sodium arsenite 13.9715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.9716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.782876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.7815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.7816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.7812151625
MESH:D008171 Lung Diseases sodium arsenite 3.1319095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7818569708 18520028 20064080 20464547 20869020 17053015 6695378 20135361 18816296
MESH:D008175 Lung Neoplasms Doxorubicin 4.786189445 17418594
MESH:D008175 Lung Neoplasms sodium arsenite 4.7816712894 17306315 15276417 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7819555203 11884234
MESH:D008223 Lymphoma decitabine 7.5719470736
MESH:D008223 Lymphoma Doxorubicin 7.5716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5015621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.8015458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.8011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.8015318939
MESH:D008545 Melanoma Carmustine 7.2812393984
MESH:D008545 Melanoma decitabine 7.2816505122 17785578
MESH:D008545 Melanoma Doxorubicin 7.2816827129
MESH:D008545 Melanoma sodium arsenite 7.2819082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Doxorubicin 6.2017638057
MESH:D008654 Mesothelioma Selenium 6.2015107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4415792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D052016 Mucositis Doxorubicin 4.7317415656
MESH:D009101 Multiple Myeloma decitabine 3.3018172295
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.6313678655
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3416882708 19157545 19010910 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 2.9215857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.807678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9318259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.1211141357
MESH:D009369 Neoplasms decitabine 8.1217925555 19470736 19116145
MESH:D009369 Neoplasms sodium arsenite 8.1211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009401 Nephrosis Doxorubicin 4.7016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9415640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1012854658
MESH:D009447 Neuroblastoma Doxorubicin 3.2315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3716049721
MESH:D012516 Osteosarcoma Doxorubicin 4.0615930896
MESH:D010051 Ovarian Neoplasms decitabine 7.8419259094 19331143
MESH:D010051 Ovarian Neoplasms Progesterone 7.8416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.8417306315 15276417
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.7419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1017983394
MESH:D010954 Plasmacytoma Selenium 4.8315087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.6617616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6117292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6116888761 15897917 15749863 18437689 16729912 16868541
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6116039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D051437 Renal Insufficiency Doxorubicin 4.1617922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3419155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012509 Sarcoma Doxorubicin 3.9315625365 17710206 17203757 16767912 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7317846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.6019755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 17.6015692506
MESH:D012878 Skin Neoplasms sodium arsenite 17.6019524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.608532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.6016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5017203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2216503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4420155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 2.4419037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms decitabine 7.2517967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.2517909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 19.5716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.5717053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 19.5715537745
MESH:D001749 Urinary Bladder Neoplasms decitabine 19.5717616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 19.5717653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 19.5716712894 16452187 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2610091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.4814692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 9.4818645019
MESH:D014604 Uveal Neoplasms decitabine 4.8617785578
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4815869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1616364871 17638931 17334414 17678736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05146 Amoebiasis
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:20676 Cell junction organization
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:04670 Leukocyte transendothelial migration
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05322 Systemic lupus erythematosus
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24
    • No data
    Releated disease ID Related disease Name
    PA445876Tobacco Use Disorder
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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