Annotation Detail for MBTPS1
Basic Information
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| Gene Symbol: | MBTPS1 ( KIAA0091,MGC138711,MGC138712,PCSK8,S1P,SKI-1 ) |
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| Gene Full Name: | membrane-bound transcription factor peptidase, site 1 |
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| Band: | 16q23.3-q24.1 |
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| Quick Links | Entrez ID:8720; OMIM: 603355; Uniprot ID:MBTP1_HUMAN; ENSEMBL ID: ENSG00000140943; HGNC ID: 15456 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa04141 | Protein processing in endoplasmic reticulum |
| Pathway ID | Pathway Name |
|---|
| Diabetes pathways |
| Pathway ID | Pathway Name |
|---|
| 500130 | Activation of Chaperones by ATF6-alpha |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of MBTPS1 mRNA | affects expression | 16483693
|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MBTPS1 mRNA | decreases expression | 19150397
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in decreased expression of MBTPS1 mRNA | decreases expression | 15336504
|
| C121718 |
dicyclanil |
dicyclanil results in increased expression of MBTPS1 mRNA | increases expression | 15664270
|
| D005419 |
Flavonoids |
Flavonoids results in decreased expression of MBTPS1 mRNA | decreases expression | 18035473
|
| D010665 |
Phenylpropanolamine |
Phenylpropanolamine results in decreased expression of MBTPS1 mRNA | decreases expression | 16465460
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MBTPS1 mRNA | affects binding|increases activity|increases expression | 19710929
|
| C006253 |
pirinixic acid |
pirinixic acid results in decreased expression of MBTPS1 mRNA | decreases expression | 18445702
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
3.95 | 18287403 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.42 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
dicyclanil |
11.89 | 17162532 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
11.89 | 16434500 |
| MESH:D000855 |
Anorexia |
|
Phenylpropanolamine |
5.99 | 17684035 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.43 | 19483382 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
dicyclanil |
3.06 | 17162532 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.90 | 20889678 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.03 | 19176532 |
| MESH:D019465 |
Craniofacial Abnormalities |
marker/mechanism |
|
| 16759393 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.53 | 18249437 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.76 | 12083418 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.13 | 20426865 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.04 | 19236843 20131406 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.69 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.35 | 16221962 19772884 19176532 18467677 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.45 | 20558911 |
| MESH:D007249 |
Inflammation |
|
Flavonoids |
2.77 | 17296493 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.80 | 16306350 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
dicyclanil |
5.17 | 20118626 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
5.17 | 20007298 15890375 16377806 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.86 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.24 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.16 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.06 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.86 | 20558911 |
| MESH:D011471 |
Prostatic Neoplasms |
marker/mechanism |
|
| 17013881 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.50 | 19058328 |
| MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
2.80 | 8532709 |
| Pathway ID |
Pathway Name |
|---|
| REACT:15380 |
Diabetes pathways |
| KEGG:04141 |
Protein processing in endoplasmic reticulum |
Related Diseases/Disorders