AutismKB 2.0

Annotation Detail for C19orf2


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Basic Information Top
Gene Symbol:C19orf2 ( FLJ10575,NNX3,RMP,URI )
Gene Full Name: chromosome 19 open reading frame 2
Band: 19q12
Quick LinksEntrez ID:8725; OMIM: 603494; Uniprot ID:RMP_HUMAN; ENSEMBL ID: ENSG00000105176; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of C19ORF2 mRNAdecreases expression 19150397
20018196
D002945 Cisplatin C19ORF2 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004317 Doxorubicin C19ORF2 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D019772 Topotecan C19ORF2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.3812690470 17670903 15814532
MESH:D000230 Adenocarcinoma Cisplatin 5.0011798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 5.0017418594
MESH:D000419 Albuminuria Doxorubicin 5.0521441931
MESH:D019046 Bone Marrow Neoplasms Cisplatin 14.6014601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 14.6014601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.2017150277
MESH:D001943 Breast Neoplasms Cisplatin 2.4819526202 18382427
MESH:D001943 Breast Neoplasms Doxorubicin 2.4816264153 15994142 16096432 17426702 15939500 15668708 18628466 11325840 18695136 18382427 19526202 15567936 17369602 17983394 18234424 16115903 15634643 16595493 16935488 15692762 15136595 16322301 16826403 15993339
MESH:D002276 Carcinoid Tumor Doxorubicin 5.5316051944
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.5217982673
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.5218059187 16023760 16234567 17876044
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1416685392 12023789
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.311485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.286189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.286189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7717131338 17924179 17308081 15792986 15476868 17974986 16612575 17007740 16651473 16952015 17519947 16278810 16731534 15811867 17329180 16242529 16364871 17928571 17351982 16455267 16109756 16269455 17382496 15505089 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0517334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D015179 Colorectal Neoplasms Cisplatin 2.8415273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.8418259882 18802399
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5217416283
MESH:D004362 Drug Toxicity Cisplatin 9.5019839026 15033597 12231392 12649298
MESH:D004362 Drug Toxicity Doxorubicin 9.5018602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6917359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.8818037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.9020426865
MESH:D004938 Esophageal Neoplasms Cisplatin 4.9016785472 16481741 15464296 15173087 17638652
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.2219069698
MESH:D005909 Glioblastoma Doxorubicin 3.5917150277
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.8915464296 15102660
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.8915692506
MESH:D034381 Hearing Loss Cisplatin 4.6719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7715464296
MESH:D006331 Heart Diseases Doxorubicin 3.7512587719 18674790 16144979 17875725 16244371 16707910 17888722 16330681 18006777 14766674 16495754 16244372 16879835
MESH:D006333 Heart Failure Doxorubicin 3.5617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.3315692506
MESH:D006689 Hodgkin Disease Cisplatin 8.8816200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 8.8815147373 18501091 17606976
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.8615464296
MESH:D007674 Kidney Diseases Cisplatin 7.1315190930 18289764 12231392 19839026 12649298
MESH:D007674 Kidney Diseases Doxorubicin 7.1315369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.5816707910
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.5211231351
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.8816085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1616439617 16595196
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.2416842330 17085340
MESH:D008175 Lung Neoplasms Cisplatin 2.8911798837 17225452 6189445
MESH:D008175 Lung Neoplasms Doxorubicin 2.896189445 17418594
MESH:D008223 Lymphoma Doxorubicin 3.7316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.1317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.1315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2615458769
MESH:D008545 Melanoma Cisplatin 3.8012393984 16248763 18505091 16432458 15577323 17023156 16809738 12374674 12883367 17761969 18332650 11135225 18176117
MESH:D008545 Melanoma Doxorubicin 3.8016827129
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.4115990972
MESH:D008654 Mesothelioma Cisplatin 6.8817638057
MESH:D008654 Mesothelioma Doxorubicin 6.8817638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.9315792986
MESH:D052016 Mucositis Doxorubicin 5.4217415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0819429709 15857846
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0818259882
MESH:D009369 Neoplasms Cisplatin 3.1016773208
MESH:D009395 Nephritis, Interstitial Cisplatin 5.2115464296
MESH:D009401 Nephrosis Doxorubicin 5.3316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.3715640375 16889571
MESH:D009447 Neuroblastoma Cisplatin 12.618761367
MESH:D009447 Neuroblastoma Doxorubicin 12.6115555623
MESH:D009447 Neuroblastoma Topotecan 12.6115176712
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.338761367
MESH:D012516 Osteosarcoma Doxorubicin 4.4415930896
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9715464296 6897625 17225452 19769630
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.1019003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.8115464296
MESH:D003557 Phyllodes Tumor Doxorubicin 5.8817983394
MESH:D010997 Pleural Neoplasms Cisplatin 16.4817638057
MESH:D010997 Pleural Neoplasms Doxorubicin 16.4817638057
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4916888761 15897917 16729912 15749863 18437689 16868541
MESH:D051437 Renal Insufficiency Cisplatin 12.3215464296
MESH:D051437 Renal Insufficiency Doxorubicin 12.3217922066
MESH:D012509 Sarcoma Doxorubicin 4.3817203757 15625365 15675481 16767912 17710206 18313854
MESH:D012512 Sarcoma, Ewing's Cisplatin 12.1914601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 12.1914601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.4217846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.1115692506
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 6.0715464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.1316767912 17203757 15625365
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 17522103 18396642
MESH:D013736 Testicular Neoplasms Cisplatin 5.0915464296 17225452
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6716010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.8517225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.8517653716
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.6016803524
MESH:D014625 Vaginal Neoplasms Cisplatin 5.1715577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.7817638931 16364871 17678736 17334414
MESH:D014839 Vomiting Cisplatin 5.4411897121
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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