AutismKB 2.0

Annotation Detail for CTNNAL1


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Basic Information Top
Gene Symbol:CTNNAL1 ( CLLP,FLJ08121,alpha-CATU )
Gene Full Name: catenin (cadherin-associated protein), alpha-like 1
Band: 9q31.3
Quick LinksEntrez ID:8727; OMIM: 604785; Uniprot ID:CTNL1_HUMAN; ENSEMBL ID: ENSG00000119326; HGNC ID: 2512
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CTNNAL1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CTNNAL1 mRNAaffects expression 21346803
D002330 Carmustine Carmustine results in increased expression of CTNNAL1 mRNAincreases expression 15980968
D016572 Cyclosporine Cyclosporine results in increased expression of CTNNAL1 mRNAincreases expression 20106945
D002945 Cisplatin CTNNAL1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in increased expression of CTNNAL1 mRNAincreases expression 18042831
C011890 kojic acid kojic acid results in decreased expression of CTNNAL1 mRNAdecreases expression 16595896
D015735 Mifepristone Mifepristone results in increased expression of CTNNAL1 mRNAincreases expression 17584828
C041786 palm oil palm oil results in increased expression of CTNNAL1 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of CTNNAL1 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.1317670903 15814532 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Cisplatin 2.7917638652 11798837
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1514601052
MESH:D001932 Brain Neoplasms Carmustine 4.5516187019
MESH:D001943 Breast Neoplasms Cisplatin 2.3718382427 19526202
MESH:D001943 Breast Neoplasms Dietary Fats 2.3720435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.7817982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0912023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8617066447 18337622 6189445
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0018551238 21346803
MESH:D004362 Drug Toxicity Cisplatin 3.9812649298 12231392 15033597 19839026
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004715 Endometriosis Mifepristone 4.5316134523
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8116481741 15173087 17638652 15464296 16785472
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Dietary Fats 14.0817967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 14.0819236843 20131406
MESH:D005355 Fibrosis Cyclosporine 9.4212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.4218296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Carmustine 4.0316187019
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8215464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.4519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5615464296
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 19176532 19772884 18467677
MESH:D006689 Hodgkin Disease Cisplatin 3.7416170182 16200630
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4115464296
MESH:D007674 Kidney Diseases Cisplatin 6.4918289764 12649298 12231392 15190930 19839026
MESH:D007674 Kidney Diseases Cyclosporine 6.498314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0611231351
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.607678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6015890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.526135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.5218544905
MESH:D008175 Lung Neoplasms Cisplatin 2.3317225452 11798837 6189445
MESH:D008545 Melanoma Carmustine 3.9212393984
MESH:D008545 Melanoma Cisplatin 3.9217761969 18505091 12883367 16809738 16432458 18176117 17023156 11135225 18332650 12374674 15577323 12393984 16248763
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0115990972
MESH:D008654 Mesothelioma Cisplatin 3.3017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009369 Neoplasms Cisplatin 5.3616773208
MESH:D009369 Neoplasms pirinixic acid 5.3617405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009447 Neuroblastoma Cisplatin 3.538761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.938761367
MESH:D009765 Obesity Dietary Fats 4.5621332399 11836018 20518802 18674790 17217161 18457598 16723640 19632207 20132043
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010051 Ovarian Neoplasms Cisplatin 5.4915464296 19769630 6897625 17225452
MESH:D010051 Ovarian Neoplasms Mifepristone 5.4916525653
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0419003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.6117638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D051437 Renal Insufficiency Cisplatin 4.6215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.6314601052
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6115464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 17522103 18396642
MESH:D013736 Testicular Neoplasms Cisplatin 4.8117225452 15464296
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7216049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.7212973940 17225452 15464296
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3716803524
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8215577323
MESH:D014839 Vomiting Cisplatin 4.9811897121
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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