AutismKB 2.0

Annotation Detail for MYOM1


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Basic Information Top
Gene Symbol:MYOM1 ( MGC134946,MGC134947,SKELEMIN )
Gene Full Name: myomesin 1, 185kDa
Band: 18p11.31
Quick LinksEntrez ID:8736; OMIM: 603508; Uniprot ID:MYOM1_HUMAN; ENSEMBL ID: ENSG00000101605; HGNC ID: 7613
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MYOM1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MYOM1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYOM1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine affects the expression of MYOM1 mRNAaffects expression 12205029
D003913 Dextroamphetamine SOD1 affects the reaction [Dextroamphetamine affects the expression of MYOM1 mRNA]affects expression|affects reaction 12205029
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of MYOM1 mRNAaffects cotreatment|increases expression 17183730
D008345 Manganese Manganese results in increased expression of MYOM1 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of MYOM1 mRNAincreases expression 17175027
D010126 Ozone Ozone results in increased expression of MYOM1 mRNAincreases expression 17095637
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MYOM1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MYOM1 mRNAincreases expression 18301758
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MYOM1 mRNAdecreases expression 18175754
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of MYOM1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000756 Anemia, Sideroblastic Manganese 11.5016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.5016910769
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6717854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8619232924 17507914 17688650 16609825 17157402 18558336 18396377 15238991 19460635 18177632 18940202 18775368 18316065 20603192 18985861
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7915516495 17626835 18315731 18417511 14754758 19059883 16777450
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.873581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.873084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.857505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.199022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.1919176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9711906362 18759878 14531868 12868966 8156756 2524372 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.308291058 18289764 7440962 18692083 18648102 9653073 9328219 1440618 11289319 6679447 16192314 6482804 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3016485898 16227642 12594235 11461765 15968718 11834606 14550746 16081117 19164858 14986274 19420014 12153990 16393943 16781746 19370779 19739265 11529661 18071297 11743745 12958197 19085960 10663392 12540782 17906064 17562736 14725611 11739529 16109766 2444490 17522070 10774834 12705907 19923254 10915739 12392966 11421492 18713872 19416960 16177239 11287661 15619225
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3015131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.301733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005234 Fatty Liver pirinixic acid 8.1920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 8.1914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma Manganese 4.0017043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1719176532 19772884 16221962 18467677
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6611587558 16610002 19784758 16611625 12969438 12587719 19014921 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8620007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.616587162 1399818 3712494 598648
MESH:D008171 Lung Diseases Ozone 3.4719066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D055370 Lung Injury Ozone 4.0220417186
MESH:D008175 Lung Neoplasms Ozone 2.108597069 7614698
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D020149 Manganese Poisoning Manganese 5.7419453300 16568477 16551646
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009041 Motion Sickness Dextroamphetamine 5.741613127
MESH:D009069 Movement Disorders Manganese 5.1616551646
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009410 Nerve Degeneration Manganese 4.3816551646
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.556679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.558888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010300 Parkinson Disease Manganese 3.4211181820
MESH:D020734 Parkinsonian Disorders Manganese 4.6016140633
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011014 Pneumonia Ozone 4.5918929643 18381685 18007984
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D019310 Pseudolymphoma Valproic Acid 4.7611422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8316876388 3137016 14763951 17978042 11044598 11738929 15475178 1511512
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996582329 6587162 1399818 3712494 7505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.328074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014581 Urticaria Acetaminophen 3.1210982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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