AutismKB 2.0

Annotation Detail for CBS


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Basic Information Top
Gene Symbol:CBS ( HIP4 )
Gene Full Name: cystathionine-beta-synthase
Band: 21q22.3
Quick LinksEntrez ID:875; OMIM: 613381; Uniprot ID:CBS_HUMAN; ENSEMBL ID: ENSG00000160200; HGNC ID: 1550
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5328superpathway of methionine degradation
PWY-6292cysteine biosynthesis III (mammalia)
HOMOCYSDEGR-PWYcysteine biosynthesis/homocysteine degradation
Pathway IDPathway Name
hsa00450Selenoamino acid metabolism
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
hsa00270Cysteine and methionine metabolism
No data
No data
Pathway IDPathway Name
P02737Cysteine biosynthesis
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of amino acid metabolism
Genetic disorders
H00183Homocystinuria
Desease IDDesease Name
1740Alzheimer's disease
1848Embryoma
1918Atherosclerosis
1954Stroke
1983Down syndrome
2066Lung cancer
2039Hyperhomocysteinemia
2126Encephalopathies
2191Meningioma
Desease Name
Atherosclerosis
cystathionine beta-synthase deficiency
atherosclerosis, coronary
CARDIOVASCULAR
Coronary Artery Disease
cerebral venous thrombosis
plasma homocysteine
homocysteine
cervical artery dissection, spontaneous
CANCER
PSYCH
hyperhomocystinemia
breast cancer
reduced CBS activity and elevated post-load homocysteine levels
schizophrenia
METABOLIC
plasma levels of homocysteine
mild homocystinuria
Desease Name
Plasma homocysteine
Desease Name
Thrombosis, hyperhomocysteinemic
Homocystinuria, B6-responsive and nonresponsive types
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CBS mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CBS mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of CBS proteindecreases expression 17854288
D006710 Homocysteine CBS protein affects the abundance of Homocysteine metaboliteaffects abundance 19204075
D001151 Arsenic Arsenic results in increased expression of CBS mRNAincreases expression 18487201
C006780 bisphenol A bisphenol A results in decreased expression of CBS mRNAdecreases expression 20678512
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CBS mRNAdecreases expression 15336504
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBS mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of CBS mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBS mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of CBS mRNAdecreases expression 19638242
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of CBS mRNA]affects reaction|decreases expression 15016801
D005978 Glutathione CBS gene mutant form results in decreased abundance of Glutathionedecreases abundance 15016621
D007213 Indomethacin Indomethacin results in increased expression of CBS mRNAincreases expression 17401462
D008701 Methapyrilene Methapyrilene results in decreased expression of CBS mRNAdecreases expression 16393664
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of CBS mRNAdecreases expression 17616710
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of CBS mRNAaffects expression 18281256
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CBS mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of CBS mRNAdecreases expression 19270015
19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of CBS mRNAdecreases expression 17164430
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CBS mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of CBS mRNAaffects binding|decreases expression 16214954
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.096195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0914514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Fluorouracil 4.6417638652
MESH:D000230 Adenocarcinoma Indomethacin 4.6416537180
MESH:D000236 Adenoma Diethylnitrosamine 6.806695378 10737359
MESH:D000236 Adenoma Indomethacin 6.8011497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 24.3719052882 19061943 18056438 16434500 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 24.3717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 24.3716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 24.3716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1617306315
MESH:D016301 Alveolar Bone Loss Indomethacin 5.3217225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6917627676 15579461
MESH:D000740 Anemia Fluorouracil 8.4817963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4811748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.7810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8110388637
MESH:D020261 Arsenic Poisoning Arsenic 2.8516835338 18414634 12569548 16251483
MESH:D018771 Arthralgia Indomethacin 5.112160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8111248219
MESH:D050197 Atherosclerosis Arsenic 3.2112928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 2.3718445737
MESH:D001321 Autistic Disorder Glutathione 2.3718929414 19056591 19267885 16917939
MESH:D001321 Autistic Disorder Homocysteine 2.3720468076 16297937
MESH:D001477 Bartter Syndrome Indomethacin 4.9210684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001862 Bone Resorption bisphenol A 3.8011985600
MESH:D001929 Brain Edema Indomethacin 4.9711481608
MESH:D002545 Brain Ischemia Indomethacin 4.3612524144
MESH:D001943 Breast Neoplasms bisphenol A 2.3217123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3217474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.3215136595 19217205 18608205 16595493 18357371 16557594 16110121
MESH:D001943 Breast Neoplasms Indomethacin 2.3217401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3220435547
MESH:D002056 Burns Indomethacin 4.6410459503
MESH:D002100 Cachexia Indomethacin 4.9415625704 16537180 15141370 11239499
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6116051944
MESH:D002277 Carcinoma Fluorouracil 8.0017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0016835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.9416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.943084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.9417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.9416540662 19919837 16779866 20514400 18494052 10672840 19418558 17173139 20524982 16288022 16569478 18506893 10737359 17055752 16935385 19539802 21159647 17978847 19208518 19171122 18665156 17138121 20007298 17761372 11831363 16878318 16681979 18788625 19822196 19519916 18971187 19394651 16502159 17428255 19383236 19335982 20101231 16807293 18978308 3581430 16328049 20935162 18691550 18785209 16830150 18210153 19107877 3084413 20727157 20084675 16698587 19701751 18056438 18393292 20512989 19052882 20214788 20432363 17162532
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.9417971768 18930000 17088986 16332177 16799960 17045692
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 13.9416391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.9420007298 6705139 1701930 20935162 17173139
MESH:D002278 Carcinoma in Situ bisphenol A 4.9317123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.6611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2914736730 11352223 18791128
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6518695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.6517341418
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.7515504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.7517066447 18986760 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Glutathione 10.7517015178
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.7512636206 15482327
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0218640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases marker/mechanism 16791140
MESH:D002318 Cardiovascular Diseases Arsenic 3.4015738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.2518022660 16973168
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.4512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.457505956 21159647 17174075 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.194080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002764 Cholecystitis Indomethacin 5.1111181007
MESH:D002779 Cholestasis Cyclosporine 7.5919486331
MESH:D002779 Cholestasis pirinixic acid 7.5919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 8697196 15668235 12621046 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9217172411 18772588 17016597 17018589 17287894 16340194 17169374 17725105 15001691 16510598
MESH:D003110 Colonic Neoplasms Indomethacin 3.9215963497 15936596 11260862 15786552 15637740 15625704
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7115289873 17695437 18949393 18802399 17594712 16524972 17016601 18448328 18288408 16391804 16282729 17094418 16303861 20501625 18509181 17255274 16331619 14970324 18383874 15148649 17454858 17401013
MESH:D015179 Colorectal Neoplasms Indomethacin 2.7112606626 18059344 11197048 17054584
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D003324 Coronary Artery Disease Homocysteine 3.7316379339
MESH:D018352 Coronavirus Infections Indomethacin 5.6617302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9518551238
MESH:D003550 Cystic Fibrosis Glutathione 4.4319747007
MESH:D007644 Darier Disease Fluorouracil 4.7316733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D003967 Diarrhea Indomethacin 3.737907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7811739529 11421492 11743745 16781746 19420014 14986274 18713872 12705907 19164858 11834606 15619225 17906064 11529661 17522070 12594235 11287661 12392966 19416960 10774834 14725611 19085960 10663392 16109766 19739265 16393943 14550746 16081117 12153990 19923254 16227642 19370779 11461765 17562736 10915739 12958197 12540782 16177239 18071297 15968718 16485898 2444490
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.7819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0912774134 17190690 16133044 18446180 18043480 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.0717045617 17202747 17329845 11595431 11535926 11595415 17151854 11991626 16699067 17351913 10671773
MESH:D004421 Dystonia Phenobarbital 3.941851702
MESH:D004487 Edema Indomethacin 15.9610653021 16100529 8985016 19703484 8273558 7907874 7990266
MESH:D004487 Edema perfluorooctanoic acid 15.9617259670 12083418
MESH:D004487 Edema pirinixic acid 15.9612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.9612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004715 Endometriosis Indomethacin 8.8715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.879294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.4418509659
MESH:D004751 Enteritis Indomethacin 4.6916328016 17763956 10567023
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.9217980183
MESH:D004802 Eosinophilia Indomethacin 3.9911298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.043659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.823922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.486401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.963659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3316785472 15173087 16481741 16337965 17638652
MESH:D004938 Esophageal Neoplasms Indomethacin 7.3311005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.3315150132 15547733 15264214 16510608 16704527 15878914 15623463 16805852 15547721
MESH:D017889 Exfoliation Syndrome Homocysteine 5.6416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Cyclosporine 12.6919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.6920387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 12.6919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005334 Fever Indomethacin 4.0610431976 17627676 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.8310962813
MESH:D005355 Fibrosis Cyclosporine 14.4312168785 12639820
MESH:D005355 Fibrosis Indomethacin 14.4317994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.4320067830
MESH:D005499 Folliculitis Indomethacin 5.1111298111
MESH:D005534 Foot Diseases Arsenic 5.506392382
MESH:D005756 Gastritis Acetaminophen 10.9616983495
MESH:D005756 Gastritis Indomethacin 10.9615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005901 Glaucoma Homocysteine 5.2216504073
MESH:D005909 Glioblastoma Indomethacin 3.5212870263
MESH:D005910 Glioma Fluorouracil 6.1616145905
MESH:D005910 Glioma Indomethacin 6.1618371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2311849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006073 Gout Indomethacin 5.2911248219
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.8515162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.8515482327
MESH:D006330 Heart Defects, Congenital Homocysteine 6.8319638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6215135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 20.183609246
MESH:D006529 Hepatomegaly Phenobarbital 20.1816109766
MESH:D006529 Hepatomegaly pirinixic acid 20.1818467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.1815340226 12621046 16120746
MESH:D006712 Homocystinuria marker/mechanism
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9915340226 16354765 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 12.8516870215
MESH:D006930 Hyperalgesia Indomethacin 12.8512727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 12.8512083418
MESH:D034321 Hyperamylasemia Indomethacin 5.6617883296
MESH:D006940 Hyperemia Indomethacin 4.9412524144
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D020138 Hyperhomocysteinemia marker/mechanism 19204075 17292331
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.6518234410 17292331 17369066
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3917050553
MESH:D006949 Hyperlipidemias Indomethacin 4.1017546600
MESH:D006973 Hypertension Arsenic 8.449931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 8.4410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4418670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.5016093927
MESH:D007077 Ileal Diseases Indomethacin 4.9710574470 18306037
MESH:D007079 Ileitis Indomethacin 5.2910647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.3216133044
MESH:D007249 Inflammation Diethylnitrosamine 11.7218785209
MESH:D007249 Inflammation Indomethacin 11.723291741 12568917 7812673
MESH:D007249 Inflammation perfluorooctanoic acid 11.7212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7212878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.1716393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1716306350
MESH:D007410 Intestinal Diseases Indomethacin 4.2617994277 11686837 11855677 18236018 15831440 11713966 17329856 15610444 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.3215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007579 Jejunal Diseases Indomethacin 4.9716133968 10574470 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007642 Keratosis Arsenic 4.9312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.8515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.858314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 9.8517190690
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.0916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.0912371664
MESH:D007680 Kidney Neoplasms Fluorouracil 12.0916985049
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8510320625 12228301 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8710785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6218360721
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5117339181
MESH:D007964 Leukocytosis Indomethacin 5.3216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.6617980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.178812269
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.6611479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5218407596 18522880 19638242 18665156 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 6.5221047994
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 3.4318194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008107 Liver Diseases Acetaminophen 9.2516611625 16610002 19784758 11587558 19460945 12587719 12969438 19014921
MESH:D008107 Liver Diseases Arsenic 9.2511134558
MESH:D008107 Liver Diseases Diethylnitrosamine 9.2517034775
MESH:D008107 Liver Diseases Phenobarbital 9.2519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 29.7516368122
MESH:D008113 Liver Neoplasms Clofibric Acid 29.7517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.7520101389 20405173 19073162 10737359 19090486 19426721 18977376 19833225 19996281 9163691 2422723 19256749 19642983 19427195 21167192 21047994 20118626 20492335 19254457 18754104 19255062 18644402 21071580 12771043 19850985 20137499 20583210 20452335 20434301 19812893 15885732 15175105 2862719 12112319 18978307 21278145 18648771 19690152 16942905 19638242 19294768 19499222 20501860 19551842
MESH:D008113 Liver Neoplasms Fluorouracil 29.7515113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms Methapyrilene 29.7515890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 29.7514757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 29.7519073162 21047994 15975961 8742319 19812893 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 29.7520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.7516984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.5618253720 16267830 17942915 18544905 18164116 18079962 3124819 19009564 18093689 19539802 16842330 18775883 18282651 19519916 19004024 17854601 2563599 19126423 18308698 17174075 9362446 21159647
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.562563599 1399818 6150874 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5612151625
MESH:D008175 Lung Neoplasms Arsenic 6.5217976673 17306315 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5220512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 6.5215246190
MESH:D008175 Lung Neoplasms Indomethacin 6.5211053908 11497255 16537180
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7315086387
MESH:D008228 Lymphoma, Non-Hodgkin marker/mechanism 17119116
MESH:D044342 Malnutrition marker/mechanism 16709328
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008591 Meningomyelocele Homocysteine 5.4716602021
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D008881 Migraine Disorders Indomethacin 3.6311903285
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6516757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 8.6512636206
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009203 Myocardial Infarction Homocysteine 5.9017412321
MESH:D009203 Myocardial Infarction pirinixic acid 5.9019151258
MESH:D017202 Myocardial Ischemia Arsenic 8.8215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8018551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.873581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 5.8711239499 16537180 11053908
MESH:D009369 Neoplasms Fluorouracil 4.8718239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 4.8717405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.0715625704 10663608
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 9.3716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3714600291
MESH:D009436 Neural Tube Defects Arsenic 3.4116620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.7518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.7520387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 13.7512349958
MESH:D020078 Neurogenic Inflammation Arsenic 4.3117056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3916436463
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.899802331
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.116374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3716049721 12819281
MESH:D010003 Osteoarthritis Indomethacin 3.637009135
MESH:D010018 Osteomalacia Phenobarbital 4.3017016548
MESH:D010049 Ovarian Diseases bisphenol A 4.9311985600
MESH:D010051 Ovarian Neoplasms Arsenic 2.7317306315
MESH:D010146 Pain Acetaminophen 6.6116870215
MESH:D010146 Pain Indomethacin 6.613291741 17627676 13679232 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.6218702446 12538197
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.5016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.5015113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.5016965848
MESH:D010195 Pancreatitis Indomethacin 3.8615028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.6616537180
MESH:D010300 Parkinson Disease Homocysteine 3.5516275827
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0612349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.6611903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0911148446
MESH:D010518 Periodontitis Indomethacin 4.8617225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9315371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.9412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.942563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.942563599
MESH:D047928 Premature Birth Indomethacin 5.0617000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.9710548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 15.9717132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.9711118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1420887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6916140617
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6918626508 19082440
MESH:D011507 Proteinuria Arsenic 9.2721343184
MESH:D011507 Proteinuria Indomethacin 9.2711849393
MESH:D019310 Pseudolymphoma Phenobarbital 4.4412752131
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7210548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9518722050 16160472 15538739 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012559 Schizophrenia Homocysteine 3.1016641680
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures Phenobarbital 5.773137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.766407741
MESH:D012871 Skin Diseases Arsenic 2.7317548696 17938729 18709164 17453740 6392382 19834688 16702368 16353154 15952646 16759981 17050553
MESH:D012878 Skin Neoplasms Arsenic 9.3019538983 17050553 15504454 16251483 17976673 17029826
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.308532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3016192470
MESH:D013272 Stomach Diseases Indomethacin 4.3616280098 10192188 16184426 17207306 15038085 15472012 18545984 10215738 18209964 10486359 16113693 17160473 17638125
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7317522103 15786421 16424979 19084572 18396642 17172411 17498489 16951190 18567086 19015929
MESH:D013274 Stomach Neoplasms Indomethacin 4.7315609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.7317575124 12958204
MESH:D013276 Stomach Ulcer Indomethacin 3.5211595415 12500499 17918041 15255614 18299717 16252198 12467913 11523592 14567935 11145282 17654042 16397915 18181030 15104355 16934674 18237397 11729361 12077510 16631530 15138204 12787963 1323529 17977527 10423059 16169175 16150113 18193104 16755016 17657623 10750652 18087811 18431645 11595431 17135157 11906479 10878458 17895592 18543354 18209962 17627676 12498302 18726076
MESH:D019966 Substance-Related Disorders bisphenol A 3.9216045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.757505956
MESH:D013964 Thyroid Neoplasms Indomethacin 11.7511352223 14736730 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.751399818
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9316280240
MESH:D014456 Ulcer Indomethacin 4.8317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1216049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.1217976673 19322015 15987713 11144890 19429237 17306315 18640142
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2510091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8216803524
MESH:D014591 Uterine Diseases bisphenol A 4.9514652134
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014652 Vascular Diseases Arsenic 4.6717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D014839 Vomiting Indomethacin 4.6911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:00270 Cysteine and methionine metabolism
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26123
    • No data
    Releated disease ID Related disease Name
    PA443635Cardiovascular Diseases
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA446892Hyperhomocysteinemia
    PA443319Alzheimer Disease
    PA443736Cleft Lip
    PA444487Homocystinuria
    PA445095Neural Tube Defects
    PA446286Spina Bifida Cystica
    PA444367Heart Defects, Congenital
    Releated drug ID Related drug Name
    PA451089pravastatin
    PA450428methotrexate
    PA449692folic acid
    PA451897pyridoxine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00118 - S-Adenosylmethionine Dietary supplement;Micronutrient
    DB00133 - L-Serine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00151 - Vamin N Dietary supplement;Nutritional Supplement
    DB00165 - Pyridoxine Essential Vitamin;Vitamins (Vitamin B Complex);Anti-inflammatory Agents;Vitamin B Complex
    DB03014 - Heme
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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