AutismKB 2.0

Annotation Detail for ADAM9


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ADAM9 ( CORD9,KIAA0021,MCMP,MDC9,Mltng )
Gene Full Name: ADAM metallopeptidase domain 9
Band: 8p11.22
Quick LinksEntrez ID:8754; OMIM: 602713; Uniprot ID:ADAM9_HUMAN; ENSEMBL ID: ENSG00000168615; HGNC ID: 216
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ADAM9 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ADAM9 mRNAincreases expression 18648102
D013196 Dihydrotestosterone AR protein affects the reaction [Dihydrotestosterone results in increased expression of ADAM9 protein]affects reaction|increases expression 17342749
D013196 Dihydrotestosterone bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAM9 protein]decreases reaction|increases expression 17342749
C041524 aluminum sulfate aluminum sulfate results in decreased expression of ADAM9 mRNAdecreases expression 15961160
C053541 bicalutamide bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAM9 protein]decreases reaction|increases expression 17342749
D003513 Cycloheximide Cycloheximide inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]decreases reaction|increases expression 17018608
D003609 Dactinomycin Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]decreases reaction|increases expression 17018608
C042986 ebselen ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]decreases reaction|increases expression 17018608
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ADAM9 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADAM9 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM9 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in decreased expression of ADAM9 mRNAdecreases expression 16169203
D006861 Hydrogen Peroxide CAT protein inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]decreases reaction|increases expression 17018608
17342749
D006861 Hydrogen Peroxide Cycloheximide inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]decreases reaction|increases expression 17018608
D006861 Hydrogen Peroxide Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]decreases reaction|increases expression 17018608
D006861 Hydrogen Peroxide ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]decreases reaction|increases expression 17018608
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of ADAM9 proteinincreases expression 17342749
17018608
C025462 sulindac sulfide sulindac sulfide results in decreased expression of ADAM9 mRNAdecreases expression 16184548
D013629 Tamoxifen Tamoxifen affects the expression of ADAM9 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of ADAM9 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM9 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4014692618
MESH:D000230 Adenocarcinoma Genistein 4.4011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1018759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1211289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.6314601052
MESH:D001943 Breast Neoplasms Genistein 1.8616541309 17200150 16873071
MESH:D001943 Breast Neoplasms Tamoxifen 1.8618984771 19066611 18855134 20390343 20005174 19059307 19103187 17242785 18629630 19288272 18351453 17261762 16202921 21138602 20135344 16273361 11161223 19410462 19289846 20065188 19155303 18821012 19115204 18997820 18425577 17049068 19142967 19487384 20544844 16818667 19189210 19244106 15565566 16873071 15668708 17893378 19084267 19189212 19011961 19200415 18815881 21152245 17440819 20859285 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.657296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6516924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4612391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Genistein 7.6516332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.6516936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.786135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.787505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.999022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9916919318 17333356 17681005 17110522 16105132 15861022 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.128697196 16354765 15340226 15668235 12621046
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
OMIM:612775 CONE-ROD DYSTROPHY 9 marker/mechanism
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8712868966 18759878 8156756 11298694 11906362 8970840 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.2518692083 9328219 11289319 7440962 18648102 6679447 16192314 1440618 9653073 18289764 9022650 6482804 8291058
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.1619031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.6716402032
MESH:D016889 Endometrial Neoplasms Genistein 7.6511473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6519155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8715345470
MESH:D005234 Fatty Liver Tamoxifen 7.8714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2619069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005909 Glioblastoma Genistein 3.2916598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9616120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 15340226 16354765 16959395 8697196
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tamoxifen 4.9819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.129022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.3316518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.686582329
MESH:D007680 Kidney Neoplasms Tamoxifen 12.6818625569
MESH:D007938 Leukemia Genistein 3.0518980019 17468513
MESH:D008064 Lipidoses Tamoxifen 3.1915342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5117823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.497678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.4916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.962876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.96598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9612151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2619555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.2212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2219196723 19196722 16827153 11731420 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7017141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.763581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019189210 19200415 19196722
MESH:D009421 Nervous System Malformations Genistein 9.8216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.054026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6119005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.567296757
MESH:D010212 Papilloma Hydrogen Peroxide 9.5612065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms marker/mechanism 17018608
MESH:D011471 Prostatic Neoplasms bicalutamide 2.7215638997 19011039 19240160 18487222 17914592
MESH:D011471 Prostatic Neoplasms Genistein 2.7215378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012512 Sarcoma, Ewing's Dactinomycin 5.1414601052
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 5.8112065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.8916709447
MESH:D013088 Spermatocele Tamoxifen 11.8916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.921399818 7505956 6582329 3712494 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.408074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4017572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.9114692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 9.9118645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24534
    • No data
    Releated disease ID Related disease Name
    PA445532Retinal Diseases
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved