AutismKB 2.0

Annotation Detail for ADAM7


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Basic Information Top
Gene Symbol:ADAM7 ( EAPI,GP-83 )
Gene Full Name: ADAM metallopeptidase domain 7
Band: 8p21.2
Quick LinksEntrez ID:8756; OMIM: 607310; Uniprot ID:ADAM7_HUMAN; ENSEMBL ID: ENSG00000069206; HGNC ID: 214
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ADAM7 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADAM7 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in increased expression of ADAM7 mRNAincreases expression 17103032
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADAM7 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADAM7 mRNAaffects cotreatment|decreases expression 20360939
D015741 Metribolone Metribolone results in increased expression of ADAM7 mRNAincreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.223712494
MESH:D000236 Adenoma Diethylnitrosamine 7.2210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3619052882 17620307 16434500 19061943 18056438 17162532
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.107296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1020432363 17978847 16878318 18506893 17162532 17138121 19418558 16288022 20514400 19335982 10672840 3581430 18971187 19171122 18691550 16779866 16681979 20524982 18788625 20935162 18978308 20084675 20512989 17173139 17055752 20007298 19107877 21159647 18056438 19519916 19919837 11831363 20101231 19822196 17428255 19394651 18665156 18785209 19383236 17761372 18494052 16807293 10737359 20214788 16698587 16935385 16830150 18210153 16540662 16569478 20727157 18393292 19052882 16328049 19701751 16502159 19539802 19208518 3084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.397505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.392727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2114531868 2524372 11906362 12868966 11298694 18759878 8156756 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.147440962 18289764 6679447 9022650 1440618 11289319 9328219 8291058 9653073 18692083 16192314 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.1419107877
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Diethylnitrosamine 3.5121071580 20387270
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8910783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.7115369732
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1816766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9819638242 20032147 18407596 18522880 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3315175105 9163691 19294768 20434301 19426721 18978307 18644402 19833225 18977376 20583210 18754104 19255062 19690152 19642983 18648771 21071580 20101389 15885732 19254457 19551842 19812893 19850985 19073162 20501860 19427195 2862719 12112319 19996281 16942905 20118626 21278145 19090486 20137499 21167192 21047994 2422723 20492335 10737359 19499222 20405173 20452335 19256749 12771043 19638242
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.53598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5319126423 18775883 17942915 16267830 18079962 21159647 18253720 18308698 18164116 2563599 18544905 19004024 3124819 19519916 17854601 9362446 18093689 19539802 17174075 16842330 19009564 18282651
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 6695378 21163286 20512841
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.053581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.053581430 9029167
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.933712494 1399818 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.937505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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