AutismKB 2.0

Annotation Detail for CDS2


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Basic Information Top
Gene Symbol:CDS2 ( FLJ38111 )
Gene Full Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Band: 20p12.3
Quick LinksEntrez ID:8760; OMIM: 603549; Uniprot ID:CDS2_HUMAN; ENSEMBL ID: ENSG00000101290; HGNC ID: 1801
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY4FS-8phosphatidylglycerol biosynthesis II (non-plastidic)
PWY-5667CDP-diacylglycerol biosynthesis I
Pathway IDPathway Name
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CDS2 mRNAincreases expression 20005886
D000082 Acetaminophen Acetaminophen affects the expression of CDS2 mRNAaffects expression 17562736
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CDS2 mRNA]affects reaction|increases expression 18700144
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDS2 mRNAaffects expression 16483693
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CDS2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CDS2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of CDS2 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.9816434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0120935162 17173139 6705139 1701930 20007298
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6611834606 10915739 16227642 12594235 19416960 12153990 11461765 10663392 18071297 19420014 16177239 11529661 16081117 14550746 16109766 11739529 14986274 18713872 12958197 17906064 12705907 2444490 19085960 19164858 14725611 12540782 16781746 19923254 16393943 11287661 15968718 11743745 16485898 19739265 17522070 17562736 15619225 10774834 11421492 12392966 19370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005234 Fatty Liver pirinixic acid 3.1419236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly Phenobarbital 10.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 10.1419176532 19772884 16221962 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1719014921 11587558 12969438 19784758 19460945 12587719 16610002 16611625
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 8.2518644402 16835634
MESH:D008113 Liver Neoplasms Phenobarbital 8.258742319 19812893 19073162 15975961 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 8.2515890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.902563599 1399818 17172636 18308698 6150874
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 5.888820588
MESH:D009369 Neoplasms pirinixic acid 5.8817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures Phenobarbital 2.924039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:00564 Glycerophospholipid metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26347
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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