AutismKB 2.0

Annotation Detail for RAB11A


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Basic Information Top
Gene Symbol:RAB11A ( MGC1490,YL8 )
Gene Full Name: RAB11A, member RAS oncogene family
Band: 15q22.31
Quick LinksEntrez ID:8766; OMIM: 605570; Uniprot ID:RB11A_HUMAN; ENSEMBL ID: ENSG00000103769; HGNC ID: 9760
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04962Vasopressin-regulated water reabsorption
hsa04972Pancreatic secretion
No data
Pathway IDPathway Name
200013Notch signaling pathway
200079Arf6 downstream pathway
200069Thromboxane A2 receptor signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RAB11A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RAB11A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAB11A mRNAaffects expression 16483693
D004958 Estradiol Estradiol affects the expression of RAB11A mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RAB11A mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB11A mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RAB11A mRNAincreases expression 17557909
15576828
17108234
D005472 Fluorouracil Fluorouracil results in decreased expression of RAB11A mRNAdecreases expression 17039268
D006220 Haloperidol Haloperidol results in increased expression of RAB11A mRNAincreases expression 15860345
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of RAB11A mRNAincreases expression 17616710
D010269 Paraquat Paraquat affects the expression of RAB11A mRNAaffects expression 15206577
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in increased expression of RAB11A mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of RAB11A mRNAincreases expression 18301758
C009277 sodium arsenate sodium arsenate results in increased expression of RAB11A mRNAincreases expression 16882884
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB11A mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RAB11A proteindecreases expression 19201780
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Estradiol 7.1811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1814692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.1817638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.8811874814
MESH:D000740 Anemia Fluorouracil 8.9416511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1219368416 18080171
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Estradiol 1.8517289903 18497071 12948864 14630087 19861407 17018787 17261762 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 1.8519217205 18608205 16110121 16557594 18357371 15136595 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.663084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.6616799960 17088986 17045692 17971768 18930000 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5118986760 16757204 17066447 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 5.0315215559 1977408
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.856135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8518566989
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9411677210 16105132 17681005 17110522 17333356 15861022 16919318
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 15668235 15340226 8697196
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6720423518
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417172411 17725105 17018589 15001691 17287894 16510598 17016597 18772588 17169374 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018949393 17695437 14970324 16524972 16391804 16303861 17594712 20501625 17401013 16331619 15289873 18509181 18288408 16282729 15148649 17454858 18383874 18802399 17255274 18448328 17016601 17094418
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.8010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8015322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9320210726
MESH:D003704 Dementia Haloperidol 4.6611575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1811834606 19923254 14986274 12153990 16227642 16485898 15968718 11739529 16081117 19164858 17906064 12392966 16109766 11529661 19420014 19370779 10915739 18713872 19085960 12705907 19739265 11743745 11421492 10663392 16177239 17562736 17522070 11461765 10774834 19416960 11287661 12594235 12958197 14550746 15619225 14725611 16781746 16393943 12540782 2444490 18071297
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 9.1818186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.8316337965 16481741 15173087 17638652 16785472
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.8315547721 15623463 15264214 15150132 16510608 16805852 16704527 15547733 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8215345470
MESH:D005234 Fatty Liver pirinixic acid 7.8220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D005911 Gliosis Paraquat 5.3011124998
MESH:D018149 Glucose Intolerance sodium arsenate 5.1719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4418337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9217937319
MESH:D007248 Infertility, Male Paraquat 6.924850670
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.3716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.0315629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.0315618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.8516705839
MESH:D007680 Kidney Neoplasms Estradiol 12.8515610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.8516985049
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519014921 12969438 19460945 19784758 12587719 11587558 16611625 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.927678174
MESH:D008113 Liver Neoplasms Fluorouracil 10.9215113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 10.9220007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.902876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.3715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6116891317 17203775 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D001523 Mental Disorders Haloperidol 4.1316856516
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6916757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.9418186108
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.987678174 18551238
MESH:D009369 Neoplasms Fluorouracil 5.1118239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 5.1117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009410 Nerve Degeneration Paraquat 3.7816893418
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009436 Neural Tube Defects sodium arsenate 4.0111749123 18186108 10525206 19446573
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6915113037 16929163 16500647 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010300 Parkinson Disease Paraquat 2.8411445065 15824117 12911755 11181820 15451049 11124998 16140633 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.5316190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011014 Pneumonia Paraquat 4.5712504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2519082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 5.0611575062
MESH:D011618 Psychotic Disorders Haloperidol 4.3111575062
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9417997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0816160472 18286688 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.9911700416
MESH:D012135 Respiratory Sounds Paraquat 4.1611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration Paraquat 3.9316458197
MESH:D012559 Schizophrenia Haloperidol 2.8120107430 1830565 19369910 18513383
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7218396642 17172411 17522103 17498489 18567086 16951190 15786421 19084572 16424979 19015929
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.7212958204 17575124
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8020210726
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.0615864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9516803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
KEGG:04972 Pancreatic secretion
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34101
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01864 - 5'-Guanosine-Diphosphate-Monothiophosphate
    DB04315 - Guanosine-5'-Diphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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