AutismKB 2.0

Annotation Detail for MPDZ


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Basic Information Top
Gene Symbol:MPDZ ( DKFZp781P216,FLJ25909,FLJ34626,FLJ90240,MUPP1 )
Gene Full Name: multiple PDZ domain protein
Band: 9p23
Quick LinksEntrez ID:8777; OMIM: 603785; Uniprot ID:MPDZ_HUMAN; ENSEMBL ID: ENSG00000107186; HGNC ID: 7208
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
alcohol consumption
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MPDZ mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MPDZ mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MPDZ mRNAaffects expression 16483693
D001640 Bicuculline MPDZ protein affects the susceptibility to Bicucullineaffects response to substance 14960011
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MPDZ mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of MPDZ mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MPDZ mRNAaffects cotreatment|affects expression 17602206
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of MPDZ mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of MPDZ mRNAdecreases expression 17557909
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of MPDZ mRNAaffects cotreatment|increases expression 17347304
D007608 Kainic Acid MPDZ protein affects the susceptibility to Kainic Acidaffects response to substance 14960011
C034818 methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate MPDZ protein affects the susceptibility to methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylateaffects response to substance 14960011
D010433 Pentylenetetrazole MPDZ protein affects the susceptibility to Pentylenetetrazoleaffects response to substance 14960011
C006253 pirinixic acid pirinixic acid results in decreased expression of MPDZ mRNAdecreases expression 18445702
C004648 testosterone enanthate testosterone enanthate affects the expression of MPDZ mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.9717676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 10.6418287403
MESH:D000138 Acidosis Ethanol 10.6411192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.723712494
MESH:D000236 Adenoma Diethylnitrosamine 6.7210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.2618056438 17620307 16434500 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.2616434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.3815451039 15451040
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D000853 Anophthalmos Ethanol 4.8615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0311141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.081440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2317474063
MESH:D002056 Burns Ethanol 4.6916374292
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.613581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.613084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6119822196 19208518 18785209 20214788 19383236 16935385 17428255 10672840 20101231 16878318 19701751 3084413 19107877 16288022 18494052 16569478 16698587 17173139 18691550 20727157 19394651 20512989 16540662 18788625 20007298 19919837 19539802 18210153 18056438 17055752 19335982 17978847 16807293 18665156 3581430 16328049 17162532 17761372 20432363 18506893 21159647 16502159 16681979 18971187 18978308 20514400 20084675 19418558 20524982 17138121 20935162 19052882 19519916 19171122 16830150 10737359 11831363 18393292 16779866
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.6118788625 15763234 15289165
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D006332 Cardiomegaly Ethanol 3.4519332462
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.277505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.2712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.2717174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7119052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.399022650 19486331
MESH:D002779 Cholestasis Cyclosporine 19.3919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.3916105132 17681005 16919318 17110522 17333356 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 19.3919176532
MESH:D002971 Cleft Lip Ethanol 3.6015513904
MESH:D002972 Cleft Palate Ethanol 3.1815513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3311198716 10194807 19302082 15451040 15451039 15513904 11873399
MESH:D003643 Death Pentylenetetrazole 6.806431079
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.848970840 18759878 2524372 12868966 11298694 8156756 11906362 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.522952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.079653073 18289764 16192314 18692083 18648102 7440962 8291058 1440618 9328219 6482804 11289319 6679447 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0712153990 17522070 11743745 17906064 12540782 12705907 18713872 16177239 19420014 17562736 18071297 16781746 14550746 15968718 10774834 14986274 19416960 11287661 10663392 10915739 11739529 19164858 12392966 19739265 11529661 14725611 11461765 19923254 15619225 11421492 16393943 16109766 19370779 19085960 16485898 16081117 2444490 12958197 16227642 12594235 11834606
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.0719107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.0711566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004832 Epilepsy, Absence Pentylenetetrazole 5.676426943
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.663581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.6616704527
MESH:D005234 Fatty Liver Cyclosporine 31.1819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 31.1821071580 20387270
MESH:D005234 Fatty Liver Ethanol 31.1819236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 31.1815345470
MESH:D005234 Fatty Liver Fish Oils 31.1818620774
MESH:D005234 Fatty Liver pirinixic acid 31.1819236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.7317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.3515451040 10194807 16946407 15513904
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Cyclosporine 3.1812639820 12168785
MESH:D005756 Gastritis Acetaminophen 11.3416983495
MESH:D005756 Gastritis Ethanol 11.3415046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0419176532 16221962 19772884 18467677
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006930 Hyperalgesia Acetaminophen 7.8816870215
MESH:D006930 Hyperalgesia Ethanol 7.8818783367
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Fish Oils 4.7915752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.5711484837
MESH:D006973 Hypertension Cyclosporine 2.1110903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Diethylnitrosamine 2.3918785209
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 4.4315513904
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.858314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.356582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.3512371664
MESH:D007859 Learning Disorders Ethanol 4.2515451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8317676605
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8718407596 18665156 19638242 18522880 20032147
MESH:D008103 Liver Cirrhosis Ethanol 6.8715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.1518295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.5418166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008107 Liver Diseases Acetaminophen 3.9311587558 16611625 12587719 12969438 16610002 19784758 19014921 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9317034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.6917207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 7.5317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.5320434301 21071580 19499222 20405173 19294768 9163691 12771043 19996281 20137499 19073162 19638242 20583210 19850985 10737359 18754104 19426721 12112319 2862719 20452335 19255062 20101389 2422723 19090486 18978307 19812893 21167192 18648771 19642983 19551842 16942905 18977376 19690152 15175105 21047994 21278145 19427195 19254457 15885732 18644402 20118626 20501860 19833225 19256749 20492335
MESH:D008113 Liver Neoplasms pirinixic acid 7.5320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.981399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.9817854601 18282651 18079962 9362446 16267830 18308698 19009564 18253720 2563599 17942915 18544905 18093689 18775883 19126423 19539802 3124819 19519916 17174075 18164116 16842330 21159647 19004024
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008569 Memory Disorders Ethanol 4.2215451040 18411066
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.743581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.743581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.936679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.456482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4716540662
MESH:D010190 Pancreatic Neoplasms Ethanol 5.4712384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D011230 Precancerous Conditions Cyclosporine 9.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012640 Seizures marker/mechanism 14960011
MESH:D012640 Seizures Ethanol 10.549754883
MESH:D012640 Seizures Kainic Acid 10.5416336964 18657176 1641125 10686065 15686955 19414003 17827730 19186208 14637104
MESH:D012640 Seizures Pentylenetetrazole 10.5416054440 2616065 3037702 3352866 18164287 6431079 8954991 19660546 15475178 18657176
MESH:D012893 Sleep Disorders Kainic Acid 5.7519414003
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6118456281
MESH:D013274 Stomach Neoplasms Ethanol 2.6118456281
MESH:D013276 Stomach Ulcer Ethanol 3.5617189318 17918041 9562338 9211565 11906479 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.289754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.191399818 6587162 6582329 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.197505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.298074119
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5715869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30914
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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