AutismKB 2.0

Annotation Detail for MATN4


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Basic Information Top
Gene Symbol:MATN4 ( FLJ14417,HE6WCR54 )
Gene Full Name: matrilin 4
Band: 20q13.12
Quick LinksEntrez ID:8785; OMIM: 603897; Uniprot ID:MATN4_HUMAN; ENSEMBL ID: ENSG00000124159; HGNC ID: 6910
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of MATN4 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of MATN4 mRNAaffects cotreatment|decreases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MATN4 mRNAincreases expression 16922920
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5911752688 15322242 14514962
MESH:D000230 Adenocarcinoma Estradiol 2.1811473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.2017868700
MESH:D001930 Brain Injuries Progesterone 4.9115665606 15380490 15845082
MESH:D001943 Breast Neoplasms Estradiol 1.8412948864 14630087 17289903 16675129 17018787 17261762 19861407 18497071
MESH:D001943 Breast Neoplasms Progesterone 1.8416175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.2116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5816120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2515340226 8697196 12621046 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.8319279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.1517187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.3617692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.2511473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 10.4516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.459294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.6020067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5412621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.9015709030
MESH:D019584 Hot Flashes Estradiol 4.6217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9116959395 8697196 18606429 15340226 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 5.0515869954
MESH:D007249 Inflammation Progesterone 5.6415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6412878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.2316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007674 Kidney Diseases Estradiol 2.8015618244
MESH:D007680 Kidney Neoplasms Estradiol 3.3615610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.9511807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.9517203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.3519453300
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6216810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.4717289903
MESH:D009421 Nervous System Malformations Estradiol 11.4811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.4814600291
MESH:D010051 Ovarian Neoplasms Estradiol 5.2319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2317393432 16525653
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9718045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013119 Spinal Cord Injuries Progesterone 5.0216503802 15862959
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D013978 Tibial Fractures Estradiol 5.5519048282
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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