AutismKB 2.0

Annotation Detail for RGS11


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Basic Information Top
Gene Symbol:RGS11 ( RS11 )
Gene Full Name: regulator of G-protein signaling 11
Band: 16p13.3
Quick LinksEntrez ID:8786; OMIM: 603895; Uniprot ID:RGS11_HUMAN; ENSEMBL ID: ENSG00000076344; HGNC ID: 9993
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of RGS11 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RGS11 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RGS11 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of RGS11 mRNAincreases expression 20458559
D004041 Dietary Fats Dietary Fats results in increased expression of RGS11 mRNAincreases expression 18503570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RGS11 mRNAaffects expression 17555576
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of RGS11 mRNAaffects cotreatment|increases expression 16996129
D013629 Tamoxifen Tamoxifen affects the expression of RGS11 mRNAaffects expression 17555576
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RGS11 mRNAaffects cotreatment|affects expression 16979875
D014303 Trinitrotoluene Trinitrotoluene affects the expression of RGS11 mRNAaffects expression 21346803
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RGS11 mRNAaffects cotreatment|affects expression 16979875
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of RGS11 mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.497525203
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.497525203
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000169 Acrodermatitis Zinc 5.5616889938 17190629 17202136
MESH:D058186 Acute Kidney Injury zoledronic acid 4.5719715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.6420200999
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3719825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D000544 Alzheimer Disease Zinc 2.7716410023 16580781 17119284 16325427
MESH:D000755 Anemia, Sickle Cell Zinc 5.0316916123
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001249 Asthma Zinc 2.9817085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7816206674
MESH:D001859 Bone Neoplasms zoledronic acid 5.0716778634 16121404 15867366 17312309 19442620 11697798
MESH:D001862 Bone Resorption zoledronic acid 4.8118404659 8053405 11869084 15845617 18496637 16769263
MESH:D001930 Brain Injuries Zinc 4.8317109824
MESH:D001943 Breast Neoplasms Dietary Fats 2.0520435547
MESH:D001943 Breast Neoplasms Tamoxifen 2.0517242785 18855134 16873071 20065188 18997820 19155303 18815881 18629630 20859285 19084267 17440819 19289846 20390343 18351453 19200415 16202921 17261762 18425577 19059307 19142967 19066611 20005174 19288272 11161223 17893378 19011961 19189210 19103187 19244106 20544844 16818667 18984771 19189212 15668708 19410462 20135344 19115204 15565566 21152245 17049068 18821012 21138602 16273361 19221464 19487384
MESH:D001943 Breast Neoplasms zoledronic acid 2.0516096432 18695136
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.633084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6314691202 16217749 15553829 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6316924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5719233551
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.9018507039
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.2218922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.2216543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D002318 Cardiovascular Diseases Zinc 3.7316936243
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.8414694615
MESH:D002386 Cataract Acetaminophen 12.8410977129
MESH:D002386 Cataract Trinitrotoluene 12.8415817613 14694615
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9516105132 15861022 17681005 11677210 17333356 16919318 17110522
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 10.0115095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 10.0115095906
MESH:D003327 Coronary Disease fluvastatin 4.8816142594
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.9310525206
MESH:D019465 Craniofacial Abnormalities Zinc 2.9319302082
MESH:D003490 Cyanosis Trinitrotoluene 5.0618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003920 Diabetes Mellitus Zinc 4.3016479319
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.5621346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5614550746 16109766 15619225 16081117 17906064 19416960 11287661 19370779 18713872 16227642 12594235 19739265 11739529 11834606 2444490 15968718 19923254 16485898 10663392 14986274 12540782 17562736 12705907 19164858 18071297 19085960 11743745 16393943 10915739 12958197 12153990 16177239 11529661 16781746 19420014 11421492 14725611 11461765 17522070 10774834 12392966
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.5618551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.729599246 15177302 8113982 11698051 8273558 16716910 7812673
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1116202921 17893378 20544844 19155303
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8312903497
MESH:D004938 Esophageal Neoplasms Zinc 4.8316543248
MESH:D005234 Fatty Liver arsenic trioxide 19.7215073043
MESH:D005234 Fatty Liver Dietary Fats 19.7217967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7215345470
MESH:D005234 Fatty Liver Tamoxifen 19.7214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005264 Femoral Fractures zoledronic acid 5.9816234978
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Dietary Fats 3.6618296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005756 Gastritis Acetaminophen 11.7616983495
MESH:D005756 Gastritis Zinc 11.7617241300
MESH:D006130 Growth Disorders Zinc 4.0317217573
MESH:D006333 Heart Failure Zinc 3.6717162251
MESH:D006335 Heart Injuries Zinc 5.9417074742
MESH:D016481 Helicobacter Infections Zinc 4.6517241300
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8317276780
MESH:D006529 Hepatomegaly Trinitrotoluene 4.3715817613
MESH:D006930 Hyperalgesia Acetaminophen 8.3016870215
MESH:D006930 Hyperalgesia zoledronic acid 8.3016769263
MESH:D006934 Hypercalcemia zoledronic acid 5.1619622757 18089816
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006996 Hypocalcemia zoledronic acid 6.3712669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1317937319
MESH:D007248 Infertility, Male Trinitrotoluene 7.1312150543
MESH:D007249 Inflammation Dietary Fats 8.7620412841
MESH:D007249 Inflammation Tamoxifen 8.7619457130
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.7615177302 7562506 11698051 8273558 7812673
MESH:D007333 Insulin Resistance Dietary Fats 3.1718457598 11836018
MESH:D007511 Ischemia Zinc 4.7716584753
MESH:D007674 Kidney Diseases Acetaminophen 6.3612587719 15629191
MESH:D007674 Kidney Diseases Zinc 6.3616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5316518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1318625569
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.3412560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 10.3418089816
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1517050201 16467208 20471514 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2816112521 15622746 15336539 11161223 19642359 17217047 19035177 19225113 9834237 16966277 16331271 12679006 17712046 17649720 12712474 17869043 15748426 16823087 17107899 12018890 19075265 15213294 11468182 16330433 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7418564211
MESH:D008107 Liver Diseases Acetaminophen 1.6516610002 12969438 19784758 19460945 12587719 19014921 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7514682389
MESH:D008113 Liver Neoplasms Tamoxifen 4.7516684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8020377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6119825857 11798837
MESH:D008175 Lung Neoplasms Tamoxifen 3.6118625569
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.6111807781
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.9619196723 14580682 16827153 19196722 11731420
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 14.968985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 14.9612773700
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 14.9617312309
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma zoledronic acid 3.7916675582
MESH:D009101 Multiple Myeloma arsenic trioxide 12.8819417148 11468182 19549372 15949261 14977855
MESH:D009101 Multiple Myeloma fluvastatin 12.8816996129
MESH:D009101 Multiple Myeloma zoledronic acid 12.8818089719 19621390 16996129
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016105982 16882451
MESH:D009336 Necrosis Trinitrotoluene 4.9218551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.2619393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 6.2615867366 17312309 19139120
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19200415 19196722
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 2.3111836018 20132043 21332399 17217161 18674790 20518802 18457598 16723640 19632207
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.8114694615
MESH:D009784 Occupational Diseases Trinitrotoluene 9.8112819281 14694615 17852074
MESH:D010014 Osteolysis zoledronic acid 5.5215867366
MESH:D010024 Osteoporosis zoledronic acid 4.1017882678
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4412452020 16624393 19769630
MESH:D010146 Pain Acetaminophen 7.2716870215
MESH:D010146 Pain zoledronic acid 7.2716475674
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6515580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.6515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.438330346 12065085 18922899 18404319
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D011225 Pre-Eclampsia Zinc 4.2617114810
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1419131511
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1415067354
MESH:D011471 Prostatic Neoplasms Zinc 2.1412429649 16606632 16700911 16517595
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.1412438248 19103299
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D012162 Retinal Degeneration Zinc 4.2116584753
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.9616646077
MESH:D012512 Sarcoma, Ewing's zoledronic acid 10.9616121404
MESH:D012640 Seizures Trinitrotoluene 3.5118551238
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.3218404319 11807781 12065085 8985016 8330346
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.3415817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1719014326
MESH:D014062 Tongue Neoplasms Zinc 4.5016543248
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2416712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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