AutismKB 2.0

Annotation Detail for DLK1


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Basic Information Top
Gene Symbol:DLK1 ( DLK,FA1,PREF1,Pref-1,ZOG,pG2 )
Gene Full Name: delta-like 1 homolog (Drosophila)
Band: 14q32.2
Quick LinksEntrez ID:8788; OMIM: 176290; Uniprot ID:DLK1_HUMAN; ENSEMBL ID: ENSG00000185559; HGNC ID: 2907
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200013Notch signaling pathway
200073FOXA2 and FOXA3 transcription factor networks
Pathway IDPathway Name
P00005Angiogenesis
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
type 1 diabetes
IMMUNE
Desease Name
Type 1 diabetes
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DLK1 mRNAincreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DLK1 mRNAaffects expression 20406850
C006632 arsenic trioxide DLK1 protein affects the susceptibility to arsenic trioxideaffects response to substance 18575777
D001374 Azacitidine Azacitidine results in decreased methylation of DLK1 promoterdecreases methylation 19194470
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DLK1 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DLK1 mRNAdecreases expression 20127859
C014347 decitabine decitabine results in decreased methylation of DLK1 promoterdecreases methylation 19194470
C014347 decitabine decitabine results in increased expression of DLK1 mRNAincreases expression 19194470
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DLK1 mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of DLK1 mRNAincreases expression 18035473
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of DLK1 mRNAincreases expression 17187413
15567716
17538966
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of DLK1 proteinincreases expression 17538966
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of DLK1 mRNA]affects reaction|decreases expression 15016801
D019833 Genistein Genistein results in increased expression of DLK1 mRNAincreases expression 18359623
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of DLK1 mRNAdecreases expression 12057914
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DLK1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DLK1 mRNAincreases expression 19933214
D014212 Tretinoin Tretinoin results in decreased expression of DLK1 mRNAdecreases expression 16012519
D014212 Tretinoin Tretinoin results in increased expression of DLK1 mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0918653653 11850527
MESH:D000230 Adenocarcinoma arsenic trioxide 13.7011798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.7020464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.7014692618
MESH:D000230 Adenocarcinoma Fluorouracil 13.7017638652
MESH:D000230 Adenocarcinoma Genistein 13.7011473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.0610737359
MESH:D000236 Adenoma Benzo(a)pyrene 7.066695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.116705139
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000740 Anemia Fluorouracil 8.8515504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D000741 Anemia, Aplastic marker/mechanism 18575777
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.6716206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.6712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.6716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9820146248 17474063
MESH:D001943 Breast Neoplasms decitabine 2.9819208741 18320071
MESH:D001943 Breast Neoplasms Fluorouracil 2.9815136595 16110121 19217205 18357371 16595493 18608205 16557594
MESH:D001943 Breast Neoplasms Genistein 2.9816873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3911589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 8.3317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.5216705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.5217761372 6705139 3084413 10737359 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.5215073043 11135700 14691202 15553829 16217749
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.5217045692 18930000 16332177 16799960 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.5216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.521917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9719014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0418695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1712490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.9320419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.9319215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.9317066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.9316051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.816135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9117681005 15861022 16919318 17333356 11677210 17110522 16105132
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.838697196 15340226 12621046 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms decitabine 5.9517616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9517725105 18772588 17018589 16510598 17172411 15001691 17016597 17169374 17287894 16340194
MESH:D003110 Colonic Neoplasms Genistein 5.9517182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.8820501625
MESH:D015179 Colorectal Neoplasms Azacitidine 4.8819934284
MESH:D015179 Colorectal Neoplasms decitabine 4.8818981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.8815148649 16524972 18509181 16391804 17401013 20501625 16303861 17695437 18383874 18288408 17594712 14970324 15289873 17255274 16282729 18448328 17454858 17094418 17016601 18949393 18802399 16331619
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.799224671 8800419 9211117 17551590 16925845 10589399 9142499 9664655 14991402 9125849
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1515213294
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.7521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2716714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.6716402032
MESH:D016889 Endometrial Neoplasms Genistein 7.6711473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4815328337 15821434 17637181
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.3412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3415173087 17638652 16337965 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9716938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 7.9215073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005334 Fever Lipopolysaccharides 4.069205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8620067830
MESH:D005355 Fibrosis Tretinoin 8.8617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3316904648
MESH:D005909 Glioblastoma Genistein 7.3216598420
MESH:D005909 Glioblastoma Tretinoin 7.3217312396
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms decitabine 13.1819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 13.1815102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 13.1816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.2511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.259664655 14991402
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.416705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.466705139
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9616120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male decitabine 6.8417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8417937319
MESH:D007249 Inflammation Flavonoids 8.5317296493
MESH:D007249 Inflammation Lipopolysaccharides 8.539205823 17963957 12878042 17237260 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5312200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1215992940 17551590
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6316705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.6316985049
MESH:D007938 Leukemia arsenic trioxide 19.9915070760
MESH:D007938 Leukemia Azacitidine 19.9919148494
MESH:D007938 Leukemia decitabine 19.9918980019 19235587
MESH:D007938 Leukemia Genistein 19.9917468513 18980019
MESH:D007938 Leukemia Tretinoin 19.9917143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 23.3219077051
MESH:D007951 Leukemia, Myeloid Azacitidine 23.3219077051
MESH:D007951 Leukemia, Myeloid decitabine 23.3219117987 18454857 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 23.3219285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.9020471514 19850784 16467208 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 8.9017596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.9017679729 18704418 19010910 19387464 18460780 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.9019850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.2519299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.7515622746 17649720 12018890 19035177 16331271 19642359 17869043 16823087 12712474 16112521 15336539 17712046 16330433 11468182 15748426 9834237 12679006 17107899 17217047 16891316 16966277 19075265 19225113 15213294 11161223
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.7519029980 16891316 12679006 19075265 19035177 17506722 16331271 17107899 16766008 16823087 19642359 17294898 17301526 17339181 16935935 17361223 16140955 16788101 17368321 9834237 17217047 17649720 19225113 17712046 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4216882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0317823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.0312878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0318397230 16248980
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.267678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 18.2610672840 10737359 18001218 14678523 16273603 11376686
MESH:D008113 Liver Neoplasms arsenic trioxide 18.2614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.2620195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 18.2615113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.2616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.432876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 14.436150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.4320377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3915213294
MESH:D055370 Lung Injury Lipopolysaccharides 4.0821114838
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 8.6511376686
MESH:D008175 Lung Neoplasms arsenic trioxide 8.6519825857 11798837
MESH:D008175 Lung Neoplasms Azacitidine 8.6521224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.6520869020 6695378 18816296 20064080 18569708 20464547 18520028 17053015 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 8.6515246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.6519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D008223 Lymphoma decitabine 3.4619470736
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9714578162 12929590
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma decitabine 3.4516505122 17785578
MESH:D008545 Melanoma Tretinoin 3.4516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D009006 Monosomy Azacitidine 6.1819299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.6716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6716757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 12.4819417148 15949261 14977855 11468182 19549372
MESH:D009101 Multiple Myeloma Azacitidine 12.4818443271 19549372
MESH:D009101 Multiple Myeloma decitabine 12.4818172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7718349030
MESH:D009190 Myelodysplastic Syndromes marker/mechanism 18575777
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 17.8616105982 16882451
MESH:D009190 Myelodysplastic Syndromes Azacitidine 17.8619805378 17596541 17611569 18720364
MESH:D009190 Myelodysplastic Syndromes decitabine 17.8618608210 19010910 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 17.8617596541
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7017141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0216624393
MESH:D009369 Neoplasms Benzo(a)pyrene 12.1011141357
MESH:D009369 Neoplasms decitabine 12.1017925555 19116145 19470736
MESH:D009369 Neoplasms Fluorouracil 12.1018600527 16928823 18239605
MESH:D009369 Neoplasms Tretinoin 12.1016946489 16594593
MESH:D009421 Nervous System Malformations Genistein 16.7816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.7814600291
MESH:D009421 Nervous System Malformations Tretinoin 16.789125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4210525206
MESH:D009436 Neural Tube Defects Tretinoin 7.429142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4816049721
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.4619769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms decitabine 11.4619259094 19331143
MESH:D010051 Ovarian Neoplasms Genistein 11.4619005980
MESH:D010051 Ovarian Neoplasms Tretinoin 11.4616936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.5115580305
MESH:D010190 Pancreatic Neoplasms decitabine 12.5119294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.5119003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.5115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.6411605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11896295 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Azacitidine 1.8818324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 1.8815378649 15256057 16925846
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0616160472 15538739 18722050 18286688
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.1519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.1516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0216646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.5319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5316192470
MESH:D012878 Skin Neoplasms Tretinoin 9.5316467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.4617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.4620155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 6.4619037991
MESH:D013274 Stomach Neoplasms Fluorouracil 6.4616424979 16951190 17172411 19015929 17522103 17498489 19084572 18567086 15786421 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 6.4617261132
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.2719014326
MESH:D013964 Thyroid Neoplasms decitabine 12.2717967635
MESH:D013964 Thyroid Neoplasms Tretinoin 12.2717045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.0016280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.0016051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0415213294
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.0416049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 16.0415289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 16.0411780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.0417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 16.0419087683 17616700
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.6216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014604 Uveal Neoplasms decitabine 13.1617785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.1616752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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