AutismKB 2.0

Annotation Detail for FBP2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FBP2 ( MGC142192 )
Gene Full Name: fructose-1,6-bisphosphatase 2
Band: 9q22.32
Quick LinksEntrez ID:8789; OMIM: 603027; Uniprot ID:F16P2_HUMAN; ENSEMBL ID: ENSG00000130957; HGNC ID: 3607
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCOLYSISglycolysis I
PWY-5484glycolysis II
GLUCONEO-PWYgluconeogenesis I
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa01100Metabolic pathways
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
No data
No data
Pathway IDPathway Name
500678Gluconeogenesis
Related Diseases/Disorders Top
No data
No data
Desease Name
height
DEVELOPMENTAL
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FBP2 mRNAincreases expression 16644059
C014347 decitabine [decitabine affects the methylation of FBP2 promoter] which affects the expression of FBP2 mRNAaffects expression|affects methylation 18938139
D004041 Dietary Fats Dietary Fats results in increased expression of FBP2 mRNAincreases expression 18042831
C025589 ochratoxin A ochratoxin A results in increased expression of FBP2 mRNAincreases expression 16251485
C041786 palm oil palm oil results in increased expression of FBP2 mRNAincreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in increased expression of FBP2 mRNAincreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FBP2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of FBP2 mRNAincreases expression 18301758
20059764
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of FBP2 mRNA]increases expression|increases reaction 20059764
17950772
C030984 pyrene pyrene results in decreased expression of FBP2 mRNAdecreases expression 15963578
D014212 Tretinoin Tretinoin results in increased expression of FBP2 mRNAincreases expression 16604517
C012589 trichostatin A [trichostatin A affects the methylation of FBP2 promoter] which affects the expression of FBP2 mRNAaffects expression|affects methylation 18938139
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4720106747
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5516206674 16197459
MESH:D001943 Breast Neoplasms decitabine 2.0718320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 2.0720435547
MESH:D001943 Breast Neoplasms ochratoxin A 2.0711921183
MESH:D001943 Breast Neoplasms Tretinoin 2.0716443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915700767 3786805 15721981 16192424 16227642 16050911 15673190 16124888 16097048 18705752 16011737 10355542
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1018788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.101917145
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9119215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9116051514 16096774
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities ochratoxin A 3.2120036863
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.219125849 9211117 10589399 9142499 17551590 9664655 16925845 8800419 9224671 14991402
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.086884620 9327722 6623471 21278145 7120509 16177239 7179309 2869522 15998439 16227642 15027814 10915739 3786805 7440962 3732212 19085960 10092053 19336974 17522070 11566570 15968718 4309450
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.9319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.9319294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.1315959796 12795759 61145 12631006 16239168 17595544 16045604 19224547
MESH:D005234 Fatty Liver Dietary Fats 14.1319004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 14.1320131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 16.1518705752
MESH:D005355 Fibrosis Dietary Fats 16.1518296743
MESH:D005355 Fibrosis Tretinoin 16.1517994277
MESH:D005909 Glioblastoma Tretinoin 7.7817312396
MESH:D005909 Glioblastoma trichostatin A 7.7818801729
MESH:D006258 Head and Neck Neoplasms decitabine 8.2019215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007248 Infertility, Male decitabine 3.3117581917
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007674 Kidney Diseases ochratoxin A 4.1911409539
MESH:D007680 Kidney Neoplasms ochratoxin A 4.6416251485
MESH:D007938 Leukemia decitabine 6.6919235587 18980019
MESH:D007938 Leukemia Tretinoin 6.6917143497
MESH:D007951 Leukemia, Myeloid decitabine 10.1418454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 10.1419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.4219010910 19387464 17679729 18206229 18460780 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.4217596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.4218206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617107899 17217047 16788101 17506722 19075265 17712046 16823087 16140955 17294898 17368321 19642359 15748426 17339181 9834237 19035177 16766008 17649720 16331271 17301526 12679006 16891316 19029980 16935935 19225113 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9221278145 11903743 11408273 17334410 16221502 17174718 16239168 16943688 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5614748882 13678700 17869086 17640975 12389079 12958196 14512876 15730626 17805973 15673190 17900296 12632514 18006644 15876570 18277467 18156304 18472332 12445421 17714472 18418968 15370692 12898905 15925388 12667390 17481882 18187930 15931870 17557913 15338365 17525996 17698563 12546737 16015684 17766677 16248980 16027843 18376398 18205269 16638106 18420326 18395914 18166357 18054572 15123356 12666154 18481824 18251166 12609069 14716496 17565644 16033810 15057751 17922224 18705752 18412020 16116963 17823541 17944888 17708605 17721639 18210741 18317297 15052691 17631135 16136751 18395095 16097048 12632512 14620537 16192424 15818738 10355542 17761835 14716833 18472094 18263696 12445418 15996030 12649538 18279442 12741479 18429990 14724832 15893842 15650968 16011737 17976157 12586293 15959796 20821823 18339082 11481614 15362042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5618397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216964402 17285989 15830285 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6219294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.6215890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7115583823 12014681
MESH:D008223 Lymphoma decitabine 3.5419470736
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 4.1811921183
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma decitabine 5.4016505122 17785578
MESH:D008545 Melanoma Tretinoin 5.4016752155
MESH:D008545 Melanoma trichostatin A 5.4016505122
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008850 Microphthalmos ochratoxin A 5.9920036863
MESH:D009101 Multiple Myeloma decitabine 8.0618172295
MESH:D009101 Multiple Myeloma trichostatin A 8.0618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7819157545 18608210 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.7817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms decitabine 8.7219116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 8.7217405874
MESH:D009369 Neoplasms Tretinoin 8.7216946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects ochratoxin A 8.1520036863
MESH:D009436 Neural Tube Defects Tretinoin 8.159142499
MESH:D009765 Obesity Dietary Fats 4.5616723640 18674790 18457598 20132043 21332399 20518802 17217161 19632207 11836018
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D010051 Ovarian Neoplasms decitabine 8.3119259094 19331143
MESH:D010051 Ovarian Neoplasms Tretinoin 8.3116936753
MESH:D010051 Ovarian Neoplasms trichostatin A 8.3119331143
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms decitabine 9.0819294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.0815976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 9.0819294695
MESH:D055728 Primary Myelofibrosis decitabine 13.1617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.1617616702
MESH:D011471 Prostatic Neoplasms trichostatin A 4.0118798265 19789329
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012208 Rhabdomyosarcoma decitabine 11.5719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.5716283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D013274 Stomach Neoplasms decitabine 2.5819037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5817261132
MESH:D013964 Thyroid Neoplasms decitabine 7.7417967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7817616700 19087683
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms decitabine 13.7317785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.7316752155
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:04910 Insulin signaling pathway
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00030 Pentose phosphate pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28019
    • No data
    No data
    Releated drug ID Related drug Name
    PA448625biotin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved