AutismKB 2.0

Annotation Detail for TNFRSF11A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TNFRSF11A ( CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TRANCER )
Gene Full Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Band: 18q21.33
Quick LinksEntrez ID:8792; OMIM: 603499; Uniprot ID:TNR11_HUMAN; ENSEMBL ID: ENSG00000141655; HGNC ID: 11908
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Bone mineral density (spine)
height
bone density
METABOLIC
DEVELOPMENTAL
Desease Name
Paget's disease
Bone mineral density (hip)
Bone mineral density (spine)
Desease Name
Osteopetrosis, autosomal recessive 7
Osteosarcoma
Paget disease of bone
Osteolysis, familial expansile
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TNFRSF11A mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TNFRSF11A mRNAincreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TNFRSF11A mRNAdecreases expression 19769630
C006632 arsenic trioxide arsenic trioxide results in increased expression of TNFRSF11A mRNAincreases expression 17530438
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TNFRSF11A mRNAdecreases expression 19730151
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TNFRSF11A mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of TNFRSF11A mRNAincreases expression 20106945
D004967 Estrogens Estrogens results in decreased expression of TNFRSF11A mRNAdecreases expression 16005483
D005665 Furosemide Furosemide affects the expression of TNFRSF11A mRNAaffects expression 17497460
C071834 glycidamide glycidamide results in increased expression of TNFRSF11A mRNAincreases expression 17822822
D007530 Isoflurane Isoflurane results in decreased expression of TNFRSF11A mRNAdecreases expression 16978161
C006552 kaempferol kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]decreases reaction|increases expression 16434028
C013592 mangiferin mangiferin results in decreased expression of TNFRSF11A mRNAdecreases expression 15135318
D010424 Pentobarbital Pentobarbital results in decreased expression of TNFRSF11A mRNAdecreases expression 16978161
C006253 pirinixic acid pirinixic acid results in decreased expression of TNFRSF11A mRNAdecreases expression 17426115
D011794 Quercetin Quercetin inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]decreases reaction|increases expression 16434028
D020849 Raloxifene Raloxifene results in decreased expression of TNFRSF11A mRNAdecreases expression 16005483
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A mRNA]affects cotreatment|decreases reaction|increases expression 16267019
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A protein]affects cotreatment|decreases reaction|increases expression 16267019
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNFRSF11A mRNAincreases expression 20106945
D014025 Titanium Titanium results in increased expression of TNFRSF11A mRNAincreases expression 18449944
D014635 Valproic Acid Valproic Acid results in increased expression of TNFRSF11A mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1111752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8619490988
MESH:D058186 Acute Kidney Injury resveratrol 3.7916538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.9719825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.9711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.973712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.976695378
MESH:D000236 Adenoma resveratrol 10.9715688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D000419 Albuminuria Raloxifene 4.5317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 4.3715800139
MESH:D000544 Alzheimer Disease resveratrol 4.3716183991 16162502
MESH:D000550 Amblyopia Valproic Acid 5.1817688650
MESH:D000707 Anaphylaxis mangiferin 5.4114669257 16536907
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1817084956
MESH:D001008 Anxiety Disorders Pentobarbital 9.0718313124 11141031
MESH:D001008 Anxiety Disorders Valproic Acid 9.0717497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001169 Arthritis, Experimental resveratrol 3.4617115116
MESH:D001260 Ataxia Telangiectasia Quercetin 4.9215336622
MESH:D050197 Atherosclerosis mangiferin 7.0718450471
MESH:D050197 Atherosclerosis resveratrol 7.0716873680 17967414
MESH:D001321 Autistic Disorder Valproic Acid 2.0118316065 17688650 17507914 16609825 17157402 18775368 18177632 18985861 18940202 19232924 19460635 15238991 20603192 18396377 18558336
MESH:D001327 Autoimmune Diseases Quercetin 4.3419761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.961440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0420046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.9216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.9219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.888888407
MESH:D001862 Bone Resorption mangiferin 4.859881647
MESH:D001930 Brain Injuries Raloxifene 4.4116580743
MESH:D002545 Brain Ischemia resveratrol 4.2217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7417474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 3.7416675129 14630087 12948864 19861407 18497071 17289903 17261762 17018787
MESH:D001943 Breast Neoplasms kaempferol 3.7416756079
MESH:D001943 Breast Neoplasms Quercetin 3.7418628248
MESH:D001943 Breast Neoplasms Raloxifene 3.7416837676 15775269 17242785 17952589 17440819 15758505 17595753 17261762 16912660 17893378 17049068 15572757
MESH:D001943 Breast Neoplasms resveratrol 3.7417534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002105 Cadmium Poisoning Quercetin 5.4916962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.9516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.953581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.9515553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.9516924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 13.9515341023
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.9519519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.9519321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5316675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8917234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6620419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.6616227395
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0117572228
MESH:D006332 Cardiomegaly Quercetin 6.6819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6816120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases kaempferol 12.1316756079
MESH:D002318 Cardiovascular Diseases Raloxifene 12.1315775269
MESH:D002318 Cardiovascular Diseases resveratrol 12.1315458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.916135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.917505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.9118566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.6819486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.6819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 15340226 16354765 8697196 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.5515800139
MESH:D003092 Colitis resveratrol 4.0616474422
MESH:D003110 Colonic Neoplasms Quercetin 3.9417191121 17148506 16640504 19440933 11134977 15741050 19056647
MESH:D003110 Colonic Neoplasms resveratrol 3.9416338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.4820501625
MESH:D015179 Colorectal Neoplasms Quercetin 3.4818095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 3.4816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7116507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7317688650 8888407 16575769
MESH:D016638 Critical Illness Estrogens 5.8816670151
MESH:D003457 Cryptosporidiosis mangiferin 5.8016547730
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1017474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7414531868 18759878 11906362 8970840 8156756 11298694 12868966 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.432952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 13.8012093613 19028559
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 13.8019496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 13.8016873680
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 4.649881663 11315760
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 21.0219279558
MESH:D003928 Diabetic Nephropathies mangiferin 21.0219706694 19960420
MESH:D003928 Diabetic Nephropathies Raloxifene 21.0215920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies resveratrol 21.0216286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.8121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.816482804 16192314 9653073 1440618 9022650 9328219 18289764 6679447 18648102 18692083 8291058 7440962 11289319
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.811733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004417 Dyspnea Furosemide 4.8916935035
MESH:D004421 Dystonia Valproic Acid 3.991851702
MESH:D004487 Edema Furosemide 21.0211834646
MESH:D004487 Edema pirinixic acid 21.0212083418
MESH:D004487 Edema Raloxifene 21.0215860553
MESH:D004487 Edema resveratrol 21.028985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 21.0211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8516714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.2115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.2117872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.9418566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7817923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.093659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.863922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.536426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.237750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.003659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.123581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.1212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver arsenic trioxide 24.0315073043
MESH:D005234 Fatty Liver mangiferin 24.0315975614
MESH:D005234 Fatty Liver pirinixic acid 24.0319236843 20131406
MESH:D005234 Fatty Liver Raloxifene 24.0317473493
MESH:D005234 Fatty Liver Valproic Acid 24.0319224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0718558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis Quercetin 8.5519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005909 Glioblastoma Quercetin 3.3519804834
MESH:D005910 Glioma Quercetin 3.0317643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D034381 Hearing Loss Furosemide 4.7717868369
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3311294989 10048152
MESH:D006331 Heart Diseases mangiferin 8.0212093613
MESH:D006331 Heart Diseases Raloxifene 8.0211110106
MESH:D006333 Heart Failure Furosemide 7.1812660669 16011733 16845234
MESH:D006333 Heart Failure pirinixic acid 7.1820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.456705139
MESH:D006529 Hepatomegaly pirinixic acid 8.0519176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D006561 Herpes Simplex mangiferin 10.0610715843
MESH:D006561 Herpes Simplex resveratrol 10.0616876885
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006849 Hydrocephalus Valproic Acid 4.8117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.998697196 18606429 16959395 15340226 16354765
MESH:D006934 Hypercalcemia Furosemide 5.0117652376
MESH:D053565 Hypercalciuria Furosemide 5.5917652376
MESH:D006937 Hypercholesterolemia resveratrol 3.9417188708
MESH:D006943 Hyperglycemia kaempferol 15.4618262572
MESH:D006943 Hyperglycemia pirinixic acid 15.4620558911
MESH:D006943 Hyperglycemia Quercetin 15.4618262572 11834736
MESH:D006946 Hyperinsulinism mangiferin 4.9411315760 9881663
MESH:D006949 Hyperlipidemias mangiferin 9.5315975614
MESH:D006949 Hyperlipidemias resveratrol 9.5316873680
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.8215086907
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006967 Hypersensitivity mangiferin 4.6316536907
MESH:D006973 Hypertension Quercetin 8.5418356687
MESH:D006973 Hypertension Raloxifene 8.5417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5418850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.2216612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2417488730
MESH:C537153 Hypomagnesemia primary Furosemide 5.5911041285
MESH:D007019 Hypoproteinemia Furosemide 5.8216096441
MESH:D007022 Hypotension Furosemide 9.6511041285
MESH:D007022 Hypotension Isoflurane 9.6512967683
MESH:D007024 Hypotension, Orthostatic Furosemide 5.3615811171
MESH:D007154 Immune System Diseases mangiferin 5.8016076520
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5817600658
MESH:D007249 Inflammation mangiferin 8.3115222974
MESH:D007249 Inflammation resveratrol 8.3116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3112878042 12200463
MESH:D007251 Influenza, Human Quercetin 11.0116624496
MESH:D007251 Influenza, Human resveratrol 11.0116624496
MESH:D007333 Insulin Resistance Estradiol 12.2116393666 16627594
MESH:D007333 Insulin Resistance mangiferin 12.2111315760
MESH:D007333 Insulin Resistance pirinixic acid 12.2116306350
MESH:D007511 Ischemia mangiferin 5.2016806951
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007627 Keloid Quercetin 4.8917086741
MESH:D007674 Kidney Diseases Estradiol 14.2715618244
MESH:D007674 Kidney Diseases Furosemide 14.2711041285
MESH:D007674 Kidney Diseases mangiferin 14.2712093613
MESH:D007674 Kidney Diseases Quercetin 14.2716962696
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.0716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.076582329
MESH:D007680 Kidney Neoplasms Estradiol 12.0715610895
MESH:D007859 Learning Disorders mangiferin 4.8919182383
MESH:D007889 Leiomyoma Raloxifene 4.4316973256
MESH:D007938 Leukemia arsenic trioxide 10.5115070760
MESH:D007938 Leukemia kaempferol 10.5117468513
MESH:D007938 Leukemia Quercetin 10.5117468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell marker/mechanism 16270354
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.6414633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 8.6415498116
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8716467208 19850784 20471514 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8717596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.6416823087 17217047 17869043 19035177 16330433 17712046 15622746 12018890 15213294 16112521 16891316 19642359 16966277 17107899 11161223 12712474 19225113 9834237 19075265 15748426 17649720 11468182 12679006 15336539 16331271
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.6416087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2916882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8715474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.8712741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8712878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.547678174
MESH:D008113 Liver Neoplasms arsenic trioxide 21.5414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.5420195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 21.5416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 21.5418980244
MESH:D008113 Liver Neoplasms resveratrol 21.5420405173 19073162 19321006 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.5416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.212876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.211399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 18.2120377131
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.2119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.2112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2117228818
MESH:D008175 Lung Neoplasms arsenic trioxide 6.5211798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5218520028 17053015 20464547 18569708 20064080 6695378 20135361 18816296 20869020
MESH:D008175 Lung Neoplasms mangiferin 6.5218520028 18569708 18816296
MESH:D008175 Lung Neoplasms Quercetin 6.5216280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5219555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1915688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0016891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.0011606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008545 Melanoma resveratrol 2.3617992120
MESH:D008569 Memory Disorders mangiferin 4.8719182383
MESH:D008659 Metabolic Diseases resveratrol 4.3117112576
MESH:D008881 Migraine Disorders Valproic Acid 3.1418765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009101 Multiple Myeloma arsenic trioxide 11.9119549372 14977855 11468182 19417148 15949261
MESH:D009101 Multiple Myeloma Raloxifene 11.9116497877
MESH:D009101 Multiple Myeloma resveratrol 11.9116267019 17164350 17049120 14749477 17935668 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.968888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.2917596541
MESH:D009203 Myocardial Infarction mangiferin 13.4016538859 17052832 19172585 16697266 16584858
MESH:D009203 Myocardial Infarction pirinixic acid 13.4019151258
MESH:D009203 Myocardial Infarction Quercetin 13.4019595682
MESH:D009203 Myocardial Infarction resveratrol 13.4016317513 16456233 17188708 17125593 17015251 16525036
MESH:D017202 Myocardial Ischemia resveratrol 8.8317125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.8916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.8916411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.8919207477
MESH:D009205 Myocarditis resveratrol 4.7017322642
MESH:D009232 Myxoma Raloxifene 5.5016343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.807678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.443581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0511141357
MESH:D009369 Neoplasms pirinixic acid 8.0517405874
MESH:D009369 Neoplasms Quercetin 8.0515185748
MESH:D009374 Neoplasms, Experimental resveratrol 3.948985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009397 Nephrocalcinosis Furosemide 5.8215086907
MESH:D009410 Nerve Degeneration mangiferin 4.5617433543
MESH:D009421 Nervous System Malformations Estradiol 9.2516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.886679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.8810525206
MESH:D009436 Neural Tube Defects Valproic Acid 11.888888407 16359493
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7517652729
MESH:D020078 Neurogenic Inflammation Quercetin 10.4817929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.4817929310
MESH:D053206 Nocturnal Enuresis Furosemide 5.8217945291
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010001 Osteitis Deformans marker/mechanism 20436471
OMIM:612301 OSTEOPETROSIS, AUTOSOMAL RECESSIVE 7 marker/mechanism
MESH:D010024 Osteoporosis kaempferol 7.6016756079
MESH:D010024 Osteoporosis Raloxifene 7.6015775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 16.5619495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 16.5615758505 15579764 17893378 17823083
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 16.5617513867
MESH:D012516 Osteosarcoma marker/mechanism
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.8016624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 7.8019401270
MESH:D010051 Ovarian Neoplasms Quercetin 7.8019005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3515580305
MESH:D010190 Pancreatic Neoplasms Quercetin 5.3516965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010300 Parkinson Disease mangiferin 3.6917433543
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010518 Periodontitis mangiferin 5.5519026997
MESH:D010538 Peritonitis Isoflurane 5.1617414419
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:C536335 Polyostotic osteolytic dysplasia, hereditary expansile marker/mechanism
MESH:D011141 Polyuria Furosemide 5.5917945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Quercetin 3.9219056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.9316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.9311896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.9320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Quercetin 1.8914715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8916536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms resveratrol 1.8917804756 17636462 15767336 16731767 17718901 17675339
MESH:D019310 Pseudolymphoma Valproic Acid 4.4912752131 11422049
MESH:D011693 Purpura Raloxifene 5.5015770314
MESH:D011833 Radiation Injuries, Experimental mangiferin 6.3515830843
MESH:D012021 Reflex, Abnormal Pentobarbital 5.9610930210
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5316325855
MESH:D015427 Reperfusion Injury Furosemide 10.8816526316
MESH:D015427 Reperfusion Injury pirinixic acid 10.8819058328
MESH:D015427 Reperfusion Injury resveratrol 10.8815827377 17520802 16317513 16314181 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.5516096441 12394941 15912074
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1119155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.4916862918
MESH:D012559 Schizophrenia Valproic Acid 2.0619110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 9.7418551238
MESH:D012640 Seizures Pentobarbital 9.749754883 10087439
MESH:D012640 Seizures Valproic Acid 9.7411044598 16876388 3137016 14763951 1511512 15475178 11738929 17978042
MESH:D018805 Sepsis Isoflurane 4.9317414419
MESH:D012772 Shock, Septic mangiferin 5.1815177305
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2610029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 9.2615837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2616192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4912833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4520155912 2093021
MESH:D013274 Stomach Neoplasms Furosemide 3.4517052386
MESH:D013276 Stomach Ulcer mangiferin 4.2117918041
MESH:D020521 Stroke Raloxifene 3.7716837676
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4216321402
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.929754883 11529278
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.981399818 7505956 6582329 6587162 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.9819014326
MESH:D013978 Tibial Fractures Estradiol 13.5319048282
MESH:D013978 Tibial Fractures Raloxifene 13.5319048282
MESH:D014062 Tongue Neoplasms resveratrol 4.1516227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.1817262798
MESH:D014235 Trichinellosis mangiferin 6.0014669257
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.463119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 19.5616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 19.568074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 19.5612845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.5617053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 19.5616720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 19.5617572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.588888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2610091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.0417473185
MESH:D014594 Uterine Neoplasms resveratrol 4.0717044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1516837676
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2417488730
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D014947 Wounds and Injuries Estrogens 4.6811172683
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04380 Osteoclast differentiation
KEGG:05323 Rheumatoid arthritis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36601
    • No data
    Releated disease ID Related disease Name
    PA445190Osteoporosis
    PA443294Agammaglobulinemia
    PA445188Osteopetrosis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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