AutismKB 2.0

Annotation Detail for TNFRSF10D


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Basic Information Top
Gene Symbol:TNFRSF10D ( CD264,DCR2,TRAILR4,TRUNDD )
Gene Full Name: tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Band: 8p21.3
Quick LinksEntrez ID:8793; OMIM: 603614; Uniprot ID:TR10D_HUMAN; ENSEMBL ID: ENSG00000173530; HGNC ID: 11907
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
No data
Pathway IDPathway Name
200101Direct p53 effectors
200056TRAIL signaling pathway
Pathway IDPathway Name
P00006Apoptosis signaling pathway
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of TNFRSF10D mRNAincreases expression 17530438
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TNFRSF10D mRNAincreases expression 19150397
D005472 Fluorouracil Fluorouracil results in increased expression of TNFRSF10D proteinincreases expression 15585621
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in increased expression of TNFRSF10D mRNA]affects reaction|increases expression 15016801
D020849 Raloxifene Raloxifene results in decreased expression of TNFRSF10D mRNAdecreases expression 16202921
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7819825857 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 4.7817638652
MESH:D000419 Albuminuria Raloxifene 5.1017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D000740 Anemia Fluorouracil 4.1117963324 16511603 15504547
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Fluorouracil 2.3819217205 16595493 18608205 16110121 15136595 18357371 16557594
MESH:D001943 Breast Neoplasms Raloxifene 2.3817893378 17242785 15775269 16837676 17440819 17595753 15572757 16912660 17261762 15758505 17049068 17952589
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2915553829 16217749 11135700 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2917045692 17971768 16799960 17088986 16332177 18930000
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5817066447 18986760 16280240 16757204
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.4717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817016597 18772588 17287894 16510598 15001691 17018589 17172411 17169374 17725105 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6220501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6217255274 16524972 16303861 17695437 17454858 18802399 17094418 17016601 17401013 16282729 15148649 17594712 18288408 14970324 18949393 20501625 16331619 18448328 18509181 16391804 18383874 15289873
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003928 Diabetic Nephropathies Raloxifene 4.3015920148 17308373 17451421
MESH:D004487 Edema Raloxifene 3.7615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.5015845917
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.7520426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.7512903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.7517638652 16481741 16785472 15173087 16337965
MESH:D005234 Fatty Liver arsenic trioxide 9.4815073043
MESH:D005234 Fatty Liver Raloxifene 9.4817473493
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6418337622 15162350 15102660
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006973 Hypertension Raloxifene 2.9817577099 15787275
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6516985049
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1917050201 16968895 19850784 16467208 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4616823087 19642359 19075265 17217047 15622746 15748426 16112521 16330433 19225113 17712046 11161223 17107899 12679006 12018890 17649720 16331271 9834237 15336539 16966277 12712474 16891316 15213294 11468182 17869043 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008113 Liver Neoplasms arsenic trioxide 5.1314682389
MESH:D008113 Liver Neoplasms Fluorouracil 5.1315113037 16603448 17045692 18383874
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6619825857 11798837
MESH:D008175 Lung Neoplasms Fluorouracil 2.6615246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9418986760 16757204
MESH:D009101 Multiple Myeloma arsenic trioxide 8.3414977855 15949261 19549372 19417148 11468182
MESH:D009101 Multiple Myeloma Raloxifene 8.3416497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416105982 16882451
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009369 Neoplasms Fluorouracil 2.7718239605 18600527 16928823
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D010024 Osteoporosis Raloxifene 3.6115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5016624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.7415580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.7415113037 16929163 19003803 16500647
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5819131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5819082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5815731164 16536755 16220300
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3818286688 15538739 18722050 16160472
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6017007042
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6019015929 16424979 19084572 17522103 18567086 17498489 15786421 17172411 18396642 16951190
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.7012845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.7017572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
Pathway ID Pathway Name
KEGG:04210 Apoptosis
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:05162 Measles
KEGG:04650 Natural killer cell mediated cytotoxicity
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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