AutismKB 2.0

Annotation Detail for TNFRSF10C


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Basic Information Top
Gene Symbol:TNFRSF10C ( CD263,DCR1,DCR1-TNFR,LIT,MGC149501,MGC149502,TRAIL-R3,TRAILR3,TRID )
Gene Full Name: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Band: 8p21.3
Quick LinksEntrez ID:8794; OMIM: 603613; Uniprot ID:TR10C_HUMAN; ENSEMBL ID: ENSG00000173535; HGNC ID: 11906
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
No data
Pathway IDPathway Name
200101Direct p53 effectors
200056TRAIL signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TNFRSF10C mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TNFRSF10C mRNAincreases expression 20382639
C402665 CP 31398 CP 31398 results in increased expression of TNFRSF10C mRNAincreases expression 15155752
D005472 Fluorouracil Fluorouracil results in increased expression of TNFRSF10C proteinincreases expression 15585621
D012643 Selenium Selenium results in increased expression of TNFRSF10C mRNAincreases expression 17293063
D014212 Tretinoin Tretinoin results in increased expression of TNFRSF10C proteinincreases expression 16242776
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6220127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000740 Anemia Fluorouracil 4.0215504547 17963324 16511603
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.9116595493 16110121 15136595 18357371 19217205 16557594 18608205
MESH:D001943 Breast Neoplasms Tretinoin 1.9116443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2516332177 17971768 17045692 17088986 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.251917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.9720419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.9716757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9716096774 16051514
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Selenium 10.9217936198
MESH:D003092 Colitis Tretinoin 10.9217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717018589 17725105 17016597 16510598 17169374 17172411 17287894 16340194 15001691 18772588
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016282729 15148649 18448328 18802399 16524972 16331619 17695437 18949393 16391804 18383874 17594712 18288408 14970324 17401013 20501625 16303861 18509181 17255274 17454858 17094418 15289873 17016601
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839664655 9224671 9125849 9211117 14991402 9142499 8800419 16925845 17551590 10589399
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2415131321
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.6216481741 15173087 17638652 16785472 16337965
MESH:D005124 Eye Abnormalities Tretinoin 3.8116938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.4715162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.1420471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.149664655 14991402
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2315992940 17551590
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3416823087 19035177 17361223 15748426 17294898 19225113 16891316 17107899 17649720 17217047 19075265 19029980 16788101 16766008 17712046 19642359 16935935 16140955 16331271 17339181 17301526 17506722 17368321 12679006 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9421137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 4.9415113037 18383874 17045692 16603448
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.546695378 18816296 18520028 20869020 17053015 20064080 20464547 20135361 18569708
MESH:D008175 Lung Neoplasms Fluorouracil 2.5415246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.3416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.3416757204 18986760
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009369 Neoplasms Benzo(a)pyrene 9.0911141357
MESH:D009369 Neoplasms Fluorouracil 9.0918600527 18239605 16928823
MESH:D009369 Neoplasms Tretinoin 9.0916946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6519003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1618626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018722050 18286688 16160472 15538739
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516116481 16283617
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1110029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 6.1116467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.492093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4916951190 19084572 18567086 17522103 18396642 17498489 19015929 17172411 16424979 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 3.4917261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2616026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 10.8616280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.4816803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.4816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
Pathway ID Pathway Name
KEGG:04210 Apoptosis
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:05162 Measles
KEGG:04650 Natural killer cell mediated cytotoxicity
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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