AutismKB 2.0

Annotation Detail for TNFRSF10A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TNFRSF10A ( APO2,CD261,DR4,MGC9365,TRAILR-1,TRAILR1 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 10a
Band: 8p21.3
Quick LinksEntrez ID:8797; OMIM: 603611; Uniprot ID:TR10A_HUMAN; ENSEMBL ID: ENSG00000104689; HGNC ID: 11904
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
No data
Pathway IDPathway Name
200101Direct p53 effectors
200056TRAIL signaling pathway
Pathway IDPathway Name
P00006Apoptosis signaling pathway
P00059p53 pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1932Pancreatitis
1934Cancer
1942Emphysema
2011Leukoencephalopathy
2074Asthma
2118Adenovirus infection
Desease Name
leukemia, chronic lymphocytic
CANCER
breast cancer
chronic lymphocytic leukaemia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10Aincreases expression 15942663
C480030 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased expression of TNFRSF10A proteinincreases expression 15930313
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TNFRSF10A proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of TNFRSF10A mRNAincreases expression 16449964
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TNFRSF10A mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFRSF10A mRNAdecreases expression 19150397
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TNFRSF10A mRNAincreases expression 20382639
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TNFRSF10A proteinincreases expression 16287099
C006862 butylphen butylphen results in increased expression of TNFRSF10A proteinincreases expression 15816839
C099555 CD 437 CD 437 results in increased expression of TNFRSF10A proteinincreases expression 16024638
C099555 CD 437 helenalin inhibits the reaction [CD 437 results in increased expression of TNFRSF10A protein]decreases reaction|increases expression 16024638
C099555 CD 437 NFKBIA protein affects the reaction [CD 437 results in increased expression of TNFRSF10A protein]affects reaction|increases expression 16024638
D002699 Chlorambucil Chlorambucil affects the expression of TNFRSF10A mRNAaffects expression 14614459
D003474 Curcumin Curcumin results in increased expression of TNFRSF10A proteinincreases expression 18226269
D003474 Curcumin TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]increases expression|increases reaction 18226269
D016572 Cyclosporine Cyclosporine results in increased expression of TNFRSF10A mRNAincreases expression 20106945
C014347 decitabine decitabine affects the methylation of TNFRSF10A promoteraffects methylation 17653094
D004317 Doxorubicin Doxorubicin results in increased expression of TNFRSF10A proteinincreases expression 17437844
15897917
D004317 Doxorubicin TNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]affects reaction|increases activity 17437844
D004317 Doxorubicin TNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP6 protein]affects reaction|increases activity 17437844
D004317 Doxorubicin TNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]affects reaction|increases activity 17437844
D004317 Doxorubicin TNFRSF10A protein affects the reaction [Doxorubicin results in increased activity of CASP9 protein]affects reaction|increases activity 17437844
D004317 Doxorubicin TNFRSF10A protein affects the susceptibility to Doxorubicinaffects response to substance 17437844
16098063
D004958 Estradiol Estradiol results in increased expression of TNFRSF10A mRNAincreases expression 20106945
C024352 fludarabine fludarabine affects the expression of TNFRSF10A mRNAaffects expression 14614459
D005472 Fluorouracil Fluorouracil results in increased expression of TNFRSF10A proteinincreases expression 15585621
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNAaffects cotreatment|increases expression 16996129
C001329 helenalin helenalin inhibits the reaction [CD 437 results in increased expression of TNFRSF10A protein]decreases reaction|increases expression 16024638
D008727 Methotrexate Methotrexate results in increased expression of TNFRSF10A proteinincreases expression 17637740
D009151 Mustard Gas IL10 protein affects the reaction [Mustard Gas affects the expression of TNFRSF10A mRNA]affects expression|affects reaction 16173061
C058815 N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide results in increased expression of TNFRSF10A proteinincreases expression 15520213
D009761 Nystatin Nystatin inhibits the reaction [Quercetin affects the localization of TNFRSF10A protein]affects localization|decreases reaction 17876056
D011794 Quercetin Nystatin inhibits the reaction [Quercetin affects the localization of TNFRSF10A protein]affects localization|decreases reaction 17876056
D011794 Quercetin Quercetin affects the localization of TNFRSF10A proteinaffects localization 17876056
D011794 Quercetin Quercetin promotes the reaction [TNFSF10 protein affects the localization of TNFRSF10A protein]affects localization|increases reaction 17876056
C059514 resveratrol resveratrol results in increased expression of TNFRSF10A proteinincreases expression 17636462
C025462 sulindac sulfide sulindac sulfide results in increased expression of TNFRSF10A mRNAincreases expression 15180942
C025462 sulindac sulfide sulindac sulfide results in increased expression of TNFRSF10A proteinincreases expression 15180942
D013792 Thalidomide Thalidomide results in decreased expression of TNFRSF10A proteindecreases expression 16531263
D014212 Tretinoin Tretinoin results in decreased expression of TNFRSF10A proteindecreases expression 16242776
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNAaffects cotreatment|increases expression 16996129
C088658 zoledronic acid zoledronic acid results in increased expression of TNFRSF10A mRNAincreases expression 19036117
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 8.3512039119
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 8.358333272
MESH:D058186 Acute Kidney Injury resveratrol 8.2916538975
MESH:D058186 Acute Kidney Injury zoledronic acid 8.2919715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.2220200999
MESH:D000230 Adenocarcinoma marker/mechanism 21472143
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 9.6117418594
MESH:D000230 Adenocarcinoma Estradiol 9.6111473722
MESH:D000230 Adenocarcinoma Fluorouracil 9.6117638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.306695378
MESH:D000236 Adenoma resveratrol 6.3015688382
MESH:D000419 Albuminuria Doxorubicin 4.2921441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8117887948
MESH:D000505 Alopecia Tretinoin 3.4115955085
MESH:D000544 Alzheimer Disease Curcumin 6.4415590663
MESH:D000544 Alzheimer Disease resveratrol 6.4416183991 16162502
MESH:D000544 Alzheimer Disease sulindac sulfide 6.4418759972
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.1916510725
MESH:D000740 Anemia Fluorouracil 3.4916511603 17963324 15504547
MESH:D000743 Anemia, Hemolytic Quercetin 4.0017084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001169 Arthritis, Experimental resveratrol 11.5517115116
MESH:D001169 Arthritis, Experimental Thalidomide 11.559598899
MESH:D001169 Arthritis, Experimental Tretinoin 11.5516412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 7.1516807698
MESH:D001172 Arthritis, Rheumatoid Methotrexate 7.1517286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.1516292516
MESH:D001249 Asthma Mustard Gas 4.7010378619
MESH:D001249 Asthma Tretinoin 4.7016456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7115336622
MESH:D050197 Atherosclerosis Curcumin 6.4018704882
MESH:D050197 Atherosclerosis resveratrol 6.4016873680 17967414
MESH:D001327 Autoimmune Diseases Curcumin 10.0119761891
MESH:D001327 Autoimmune Diseases Quercetin 10.0119761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1516935849
MESH:D001768 Blister Mustard Gas 4.9019167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3716197459 16206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4314601052
MESH:D001859 Bone Neoplasms zoledronic acid 4.7116121404 11697798 15867366 19442620 17312309 16778634
MESH:D001862 Bone Resorption zoledronic acid 4.4718496637 15845617 11869084 8053405 16769263 18404659
MESH:D002545 Brain Ischemia Curcumin 9.4516770732
MESH:D002545 Brain Ischemia resveratrol 9.4517600658
MESH:D001932 Brain Neoplasms Curcumin 8.2117596214
MESH:D001932 Brain Neoplasms Doxorubicin 8.2117150277
MESH:D001943 Breast Neoplasms alitretinoin 9.3516344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.3520146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 9.3518593918 18462866 16243823 19250217
MESH:D001943 Breast Neoplasms decitabine 9.3519208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 9.3516322301 16096432 15634643 18628466 15567936 18695136 18382427 16115903 16826403 16264153 17426702 17369602 16595493 17983394 15994142 11325840 16935488 18234424 15993339 19526202 15692762 15939500 15136595 15668708
MESH:D001943 Breast Neoplasms Estradiol 9.3516675129 18497071 12948864 14630087 17289903 19861407 17261762 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 9.3516557594 15136595 18608205 19217205 16595493 18357371 16110121
MESH:D001943 Breast Neoplasms Methotrexate 9.3516978400
MESH:D001943 Breast Neoplasms Quercetin 9.3518628248
MESH:D001943 Breast Neoplasms resveratrol 9.3517534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tretinoin 9.3516873071 16166294 16443354
MESH:D001943 Breast Neoplasms zoledronic acid 9.3518695136 16096432
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7117687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3316813970
MESH:D002105 Cadmium Poisoning Quercetin 5.2816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.4616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.4616051944
MESH:D002277 Carcinoma Curcumin 7.8818593918
MESH:D002277 Carcinoma Fluorouracil 7.8817121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8916168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.1421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.1417876044 16234567 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.1416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.1417971768 16799960 17045692 16332177 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Quercetin 16.1412508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.1416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 16.1416313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.141917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3316675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 8.6518414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 8.6512391285
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 8.6519233551
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7017234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.221485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.2218695887
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 10.2218507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 20.7920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 20.7918462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 20.7919215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 20.796189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 20.7917066447 16280240 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 20.7916227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 20.7916051514 16096774
MESH:D006332 Cardiomegaly Quercetin 3.1719794523
MESH:D009202 Cardiomyopathies Doxorubicin 3.3615476868 16455267 17519947 15792986 17308081 17928571 17329180 16651473 16364871 16731534 17131338 17382496 16612575 16109756 17007740 17974986 16242529 16952015 17924179 16278810 18627295 15811867 17351982 16269455 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8616243910 17334414
MESH:D002318 Cardiovascular Diseases resveratrol 3.3015458977
MESH:D002386 Cataract Tretinoin 2.9417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.1012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.1018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3316129372
MESH:D018281 Cholangiocarcinoma Thalidomide 4.6518291259
MESH:D002779 Cholestasis Cyclosporine 2.7219486331
MESH:D002822 Choriocarcinoma Tretinoin 4.8916461808
MESH:D002972 Cleft Palate Tretinoin 2.569407595
MESH:D003092 Colitis Curcumin 20.7818200517 16804969 16782535
MESH:D003092 Colitis resveratrol 20.7816474422
MESH:D003092 Colitis Thalidomide 20.7816680017
MESH:D003092 Colitis Tretinoin 20.7817035595
MESH:D003103 Coloboma Curcumin 4.3118809619
MESH:D003110 Colonic Neoplasms marker/mechanism 17075118
MESH:D003110 Colonic Neoplasms Curcumin 10.5516340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 10.5517616700
MESH:D003110 Colonic Neoplasms Fluorouracil 10.5517018589 15001691 17172411 17725105 16340194 16510598 18772588 17287894 17016597 17169374
MESH:D003110 Colonic Neoplasms Quercetin 10.5517191121 11134977 19056647 15741050 19440933 16640504 17148506
MESH:D003110 Colonic Neoplasms resveratrol 10.5516338953
MESH:D015179 Colorectal Neoplasms decitabine 6.1918981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.1918259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.1915289873 16391804 17016601 18448328 14970324 20501625 17594712 16282729 18288408 18383874 17255274 17454858 17094418 16303861 18949393 18509181 16331619 18802399 17401013 15148649 17695437 16524972
MESH:D015179 Colorectal Neoplasms Quercetin 6.1918852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 6.1916550006
MESH:D016510 Corneal Neovascularization Curcumin 11.7518497527
MESH:D016510 Corneal Neovascularization Thalidomide 11.759301478
MESH:D003327 Coronary Disease fluvastatin 8.3516142594
MESH:D003327 Coronary Disease resveratrol 8.3516507316
MESH:D003389 Cranial Nerve Diseases Thalidomide 6.049200351
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.9212039119 9562676
MESH:D019465 Craniofacial Abnormalities Thalidomide 3.929200351
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.929211117 10589399 9142499 16925845 9224671 8800419 9664655 17551590 9125849 14991402
MESH:D003424 Crohn Disease Thalidomide 4.0416078585
MESH:D003550 Cystic Fibrosis Methotrexate 4.0119747007
MESH:D007644 Darier Disease Fluorouracil 4.5316733453
MESH:D003882 Dermatomyositis Methotrexate 4.8720191521
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.8519496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.8516873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6418403477
MESH:D003928 Diabetic Nephropathies Curcumin 13.8318204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.8319279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.8316286809
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.3817416283
MESH:D004362 Drug Toxicity Doxorubicin 3.4818602426
MESH:D004381 Duodenal Ulcer Curcumin 3.8017351913
MESH:D004487 Edema Mustard Gas 6.4411402378 11428631 11428647 9260866
MESH:D004487 Edema resveratrol 6.448985016
MESH:D004489 Edema, Cardiac Tretinoin 4.2018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.7817872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8519294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.5017359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.5011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 11.5016569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8918037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5917923197
MESH:D004890 Erythema Mustard Gas 4.909357497
MESH:D004938 Esophageal Neoplasms marker/mechanism 21472143
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.8115173087 16481741 16337965 16785472 17638652
MESH:D005124 Eye Abnormalities Tretinoin 3.3816938888 9664655
MESH:D005234 Fatty Liver Curcumin 7.1319297423
MESH:D005234 Fatty Liver Cyclosporine 7.1319224547
MESH:D005264 Femoral Fractures zoledronic acid 5.5616234978
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3219069698
MESH:D005355 Fibrosis Curcumin 19.0818705752
MESH:D005355 Fibrosis Cyclosporine 19.0812639820 12168785
MESH:D005355 Fibrosis Quercetin 19.0819474275
MESH:D005355 Fibrosis Tretinoin 19.0817994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4418462866
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 6.0412701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Curcumin 15.5917596214
MESH:D005909 Glioblastoma Doxorubicin 15.5917150277
MESH:D005909 Glioblastoma Quercetin 15.5919804834
MESH:D005909 Glioblastoma Tretinoin 15.5917312396
MESH:D005910 Glioma Fluorouracil 9.4716145905
MESH:D005910 Glioma Quercetin 9.4717643826
MESH:D005910 Glioma Thalidomide 9.4716327979
MESH:D006086 Graft vs Host Disease Methotrexate 4.8916518429
MESH:D006258 Head and Neck Neoplasms Curcumin 22.3318829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 22.3319215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 22.3315692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 22.3315162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 22.3316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2020471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.209664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.3112587719 17875725 16879835 18674790 16330681 17888722 14766674 16244372 16707910 18006777 16144979 16244371 16495754
MESH:D006333 Heart Failure Doxorubicin 3.1817481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6715692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7817701891
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006561 Herpes Simplex resveratrol 3.9216876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.1917606976 18501091 15147373
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006930 Hyperalgesia Tretinoin 7.5116870215
MESH:D006930 Hyperalgesia zoledronic acid 7.5116769263
MESH:D006934 Hypercalcemia zoledronic acid 4.8119622757 18089816
MESH:D006937 Hypercholesterolemia Curcumin 8.6018704882
MESH:D006937 Hypercholesterolemia resveratrol 8.6017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3116778211
MESH:D006943 Hyperglycemia Quercetin 3.8018262572 11834736
MESH:D006949 Hyperlipidemias resveratrol 3.7916873680
MESH:D006973 Hypertension Cyclosporine 4.9610903974
MESH:D006973 Hypertension Quercetin 4.9618356687
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0717488730
MESH:D006996 Hypocalcemia zoledronic acid 5.9312669777
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.3917600658
MESH:D007248 Infertility, Male decitabine 3.0317581917
MESH:D007249 Inflammation Curcumin 10.9616956363 17151092 18403477
MESH:D007249 Inflammation Mustard Gas 10.9616001271 11428620 11402378 8975870 11428631 17524151 11428647 9260866 9357497
MESH:D007249 Inflammation resveratrol 10.9616366677
MESH:D007249 Inflammation Thalidomide 10.9616134734
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1018200517 18596194
MESH:D007251 Influenza, Human Quercetin 10.3016624496
MESH:D007251 Influenza, Human resveratrol 10.3016624496
MESH:D007333 Insulin Resistance Estradiol 2.8016393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5117994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9910783313
MESH:D007569 Jaw Abnormalities Tretinoin 3.6617551590 15992940
MESH:D007627 Keloid Quercetin 4.7017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3716144296
MESH:D007674 Kidney Diseases Cyclosporine 13.238314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 13.2315699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 13.2315618244
MESH:D007674 Kidney Diseases Quercetin 13.2316962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9216707910
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1912371664
MESH:D007680 Kidney Neoplasms Estradiol 11.1915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.1916985049
MESH:D007805 Language Development Disorders Methotrexate 4.869562676
MESH:D007889 Leiomyoma Curcumin 4.3318555241
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.1416514283
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 18.3312970779
MESH:D007938 Leukemia Curcumin 18.3318462866
MESH:D007938 Leukemia decitabine 18.3319235587 18980019
MESH:D007938 Leukemia Quercetin 18.3317468513
MESH:D007938 Leukemia Tretinoin 18.3317143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8916085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell fludarabine 4.4617296974 18172266 18587576 17802794 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.3416106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 9.3418089816
MESH:D007951 Leukemia, Myeloid decitabine 8.7817236224 18454857 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.9917679729 19010910 18704418 19387464 18460780 18206229
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 5.9918720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.9919850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1918055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.2016087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.209834237 12679006 17107899 17506722 17368321 17361223 17217047 16823087 19035177 16891316 16331271 19029980 19642359 16935935 17712046 17649720 16766008 17301526 17339181 19075265 15748426 16140955 16788101 19225113 17294898
MESH:D015458 Leukemia, T-Cell Curcumin 4.5116106398
MESH:D017880 Limb Deformities, Congenital Thalidomide 7.9310473037
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.939224671
MESH:D008103 Liver Cirrhosis Methotrexate 6.8914986274
MESH:D008103 Liver Cirrhosis Thalidomide 6.8917174718 16943688
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.3018705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.3016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.3012741479
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 8.3015465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3016248980 18397230
MESH:D008107 Liver Diseases Curcumin 2.5516956363
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.179163691 2125692 15890375 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.1721137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 13.1715113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Quercetin 13.1718980244
MESH:D008113 Liver Neoplasms resveratrol 13.1719321006 19073162 20405173 19812893
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.058603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.0517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Quercetin 9.0519519916
MESH:D008171 Lung Diseases Mustard Gas 3.2818161513 18702808
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.7618516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.3914755239
MESH:D008175 Lung Neoplasms alitretinoin 12.3916413115
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.3920869020 18520028 18816296 17053015 20135361 20464547 6695378 20064080 18569708
MESH:D008175 Lung Neoplasms Curcumin 12.3918462866 16243823 19359593
MESH:D008175 Lung Neoplasms Doxorubicin 12.396189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 12.3915246190
MESH:D008175 Lung Neoplasms Mustard Gas 12.398781369 3148597
MESH:D008175 Lung Neoplasms Quercetin 12.3916280456
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5315086387
MESH:D008223 Lymphoma Chlorambucil 21.5210745627
MESH:D008223 Lymphoma Curcumin 21.5218462866
MESH:D008223 Lymphoma decitabine 21.5219470736
MESH:D008223 Lymphoma Doxorubicin 21.5216098063
MESH:D008223 Lymphoma Methotrexate 21.5217352296
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0617088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.1717654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.1714749477
MESH:D016399 Lymphoma, T-Cell Curcumin 10.7016173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.7015621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9815688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.9715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.9711408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 12.978985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 12.9717312309
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D008527 Medulloblastoma Tretinoin 2.6817453147
MESH:D008545 Melanoma Curcumin 11.8718462866 17885582
MESH:D008545 Melanoma decitabine 11.8716505122 17785578
MESH:D008545 Melanoma Doxorubicin 11.8716827129
MESH:D008545 Melanoma resveratrol 11.8717992120
MESH:D008545 Melanoma Thalidomide 11.8712829675 17089043 16098027
MESH:D008545 Melanoma Tretinoin 11.8716752155
MESH:D008569 Memory Disorders Curcumin 3.9017263510
MESH:D008591 Meningomyelocele Tretinoin 4.1716940565
MESH:D008654 Mesothelioma Doxorubicin 6.2917638057
MESH:D008654 Mesothelioma zoledronic acid 6.2916675582
MESH:D008659 Metabolic Diseases resveratrol 4.1417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.8716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.8718986760 16757204
MESH:D052016 Mucositis Doxorubicin 11.6417415656
MESH:D052016 Mucositis Methotrexate 11.6417488658
MESH:D009101 Multiple Myeloma Curcumin 25.8719372569
MESH:D009101 Multiple Myeloma decitabine 25.8718172295
MESH:D009101 Multiple Myeloma fluvastatin 25.8716996129
MESH:D009101 Multiple Myeloma resveratrol 25.8716267019 17164350 17049120 17935668 14749477 16490592
MESH:D009101 Multiple Myeloma Thalidomide 25.8719372569 19112817 16445831 19112201 15741222 17168659 15920492 15939924 15744524 15867202
MESH:D009101 Multiple Myeloma zoledronic acid 25.8719621390 16996129 18089719
MESH:D009134 Muscular Atrophy, Spinal Curcumin 11.5317962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 11.5317962980
MESH:D009181 Mycoses Nystatin 6.5016374455
MESH:D009190 Myelodysplastic Syndromes decitabine 11.6219157545 19010910 16882708 18608210
MESH:D009190 Myelodysplastic Syndromes Thalidomide 11.6218720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.6217596541
MESH:D009203 Myocardial Infarction Doxorubicin 8.9819429709 15857846
MESH:D009203 Myocardial Infarction Quercetin 8.9819595682
MESH:D009203 Myocardial Infarction resveratrol 8.9816317513 17015251 16525036 16456233 17188708 17125593
MESH:D017202 Myocardial Ischemia resveratrol 3.8017015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9016810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.9019207477
MESH:D009205 Myocarditis resveratrol 4.5017322642
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1218495463
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9218259882
MESH:D009362 Neoplasm Metastasis zoledronic acid 5.9215867366 19139120 17312309
MESH:D009369 Neoplasms alitretinoin 18.1116946489
MESH:D009369 Neoplasms Benzo(a)pyrene 18.1111141357
MESH:D009369 Neoplasms decitabine 18.1119470736 17925555 19116145
MESH:D009369 Neoplasms Fluorouracil 18.1118239605 18600527 16928823
MESH:D009369 Neoplasms Quercetin 18.1115185748
MESH:D009369 Neoplasms Tretinoin 18.1116946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.758985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2712497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009401 Nephrosis Doxorubicin 4.5116636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.5619348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.5615640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 15.1111399458 16427766
MESH:D009421 Nervous System Malformations Thalidomide 15.1116859833
MESH:D009421 Nervous System Malformations Tretinoin 15.119125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.3618462866
MESH:D009436 Neural Tube Defects Tretinoin 2.899142499
MESH:D009447 Neuroblastoma Doxorubicin 3.1315555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.6017652729
MESH:D020078 Neurogenic Inflammation Quercetin 9.8917929310
MESH:D020078 Neurogenic Inflammation resveratrol 9.8917929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2616436463
MESH:D009503 Neutropenia Mustard Gas 3.7316761898 7688884
MESH:D009765 Obesity Curcumin 2.6819297423
MESH:D010014 Osteolysis zoledronic acid 5.1115867366
MESH:D010024 Osteoporosis Curcumin 7.1118719352
MESH:D010024 Osteoporosis zoledronic acid 7.1117882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.3919495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.3917513867
MESH:D012516 Osteosarcoma Doxorubicin 3.9115930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25.6616211241
MESH:D010051 Ovarian Neoplasms CD 437 25.6617474084
MESH:D010051 Ovarian Neoplasms Curcumin 25.6618462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 25.6619331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 25.6619401270
MESH:D010051 Ovarian Neoplasms Quercetin 25.6619005980
MESH:D010051 Ovarian Neoplasms Thalidomide 25.6616288038
MESH:D010051 Ovarian Neoplasms Tretinoin 25.6616936753
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010146 Pain zoledronic acid 6.4616475674
MESH:D010190 Pancreatic Neoplasms Curcumin 15.3019401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms decitabine 15.3019294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.3019003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 15.3016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.3015976015
MESH:D010291 Paresis Thalidomide 6.049200351
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8917638057
MESH:D011041 Poisoning Mustard Gas 3.5615727166
MESH:D017499 Porokeratosis alitretinoin 5.7416144296
MESH:D011230 Precancerous Conditions Cyclosporine 8.3712371664
MESH:D011230 Precancerous Conditions Quercetin 8.3719056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.0817031469
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.9216679765
MESH:D055728 Primary Myelofibrosis decitabine 4.4717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8617292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.8618226269 12497104 18156803 18769126 15129424 10851300 11398177
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.8616868541 15897917 16888761 18437689 16729912 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 2.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.8618626508 19082440
MESH:D011471 Prostatic Neoplasms Quercetin 2.8614715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 2.8617675339 17804756 17636462 16731767 15767336 17718901
MESH:D011471 Prostatic Neoplasms Thalidomide 2.8616729912
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.8612438248 19103299
MESH:D011507 Proteinuria Tretinoin 3.3616636307
MESH:D011536 Prurigo Thalidomide 6.0412755975
MESH:D011537 Pruritus Mustard Gas 3.8318058305
MESH:D011565 Psoriasis Cyclosporine 5.6016882103
MESH:D011565 Psoriasis Methotrexate 5.6017410198
MESH:D011625 Pterygium Tretinoin 4.5316723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.3019168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8317266442 17720292 17894541 10334151 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7916160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 9.6317922066
MESH:D051437 Renal Insufficiency Methotrexate 9.6317352296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3216325855
MESH:D015427 Reperfusion Injury resveratrol 3.1416317513 16314181 17058453 17520802 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7818379247 10666014
MESH:D012208 Rhabdomyosarcoma decitabine 10.1419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1416116481 16283617
MESH:D012509 Sarcoma Curcumin 8.8118462866
MESH:D012509 Sarcoma Doxorubicin 8.8115625365 17203757 18313854 16767912 15675481 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.8016326096 14601052
MESH:D012512 Sarcoma, Ewing's zoledronic acid 9.8016121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5317846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.2816862918
MESH:D019873 Schnitzler Syndrome Thalidomide 5.6816096327
MESH:D018805 Sepsis Curcumin 3.8618389075
MESH:D012871 Skin Diseases Mustard Gas 2.6516961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.5810029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 12.5815692506
MESH:D012878 Skin Neoplasms resveratrol 12.5815837718 8985016
MESH:D012878 Skin Neoplasms Tretinoin 12.5816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3117203757 16767912 15625365
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5020155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.5019037991
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5019015929 17172411 16951190 17498489 18396642 15786421 16424979 19084572 17522103 18567086
MESH:D013274 Stomach Neoplasms Tretinoin 4.5017261132
MESH:D013276 Stomach Ulcer Curcumin 7.0219188055 16631530
MESH:D013276 Stomach Ulcer Thalidomide 7.0215138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2516321402
MESH:D013576 Syndactyly Methotrexate 4.789562676
MESH:D013964 Thyroid Neoplasms decitabine 10.9217967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.9216010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9217045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 15.2616280240
MESH:D014062 Tongue Neoplasms resveratrol 15.2616227395
MESH:D014062 Tongue Neoplasms Tretinoin 15.2616051514
MESH:D014376 Tuberculosis Tretinoin 3.0716040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.5317053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 18.5316720286
MESH:D001749 Urinary Bladder Neoplasms Curcumin 18.5318593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.5317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.5317653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 18.5316720314
MESH:D014565 Urogenital Neoplasms Curcumin 5.0018462866
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.5916803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.5917473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.5916129372
MESH:D014594 Uterine Neoplasms resveratrol 9.1617044934
MESH:D014594 Uterine Neoplasms sulindac sulfide 9.1618645019
MESH:D014604 Uveal Neoplasms decitabine 11.9417785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.9416752155
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014652 Vascular Diseases Thalidomide 5.2215741222
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.4817638931 16364871 17678736 17334414
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.4817488730
MESH:D014820 Vitiligo Tretinoin 3.8116761959
MESH:D009396 Wilms Tumor Tretinoin 3.7516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
KEGG:04210 Apoptosis
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:05162 Measles
KEGG:04650 Natural killer cell mediated cytotoxicity
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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